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Amitriptyline Serotonin Syndrome Side Effects

Amitriptyline Serotonin Syndrome Side Effect Reports


The following Amitriptyline Serotonin Syndrome side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Serotonin Syndrome, can occur, and what you can do about them.

A side effect could appear soon after you start Amitriptyline or it might take time to develop.



Serotonin Syndrome, Body Temperature Increased, Mydriasis

This Serotonin Syndrome side effect was reported by a pharmacist from NL. A 59-year-old patient (weight:NA) experienced the following symptoms/conditions: pain,infection. The patient was prescribed Amitriptyline Hydrochloride (dosage: 75 Mg, Qd), which was started on Jan 28, 2014. Concurrently used drugs:
  • Linezolid (1 Df, Bid,concentration-2mg/ml)
  • Budesonide (1 Df, Bid)
  • Meropenem (1 Df, Tid)
  • Acenocoumarol (Unk)
  • Fentanyl (Unk, Hs)
  • Midazolam (Concentration-5mg/ml)
  • Acetaminophen (500 Mg, Qid)
  • Zopiclone
When starting to take Amitriptyline Hydrochloride the consumer reported the following symptoms:
  • Serotonin Syndrome
  • Body Temperature Increased
  • Mydriasis
The patient was hospitalized. These side effects may potentially be related to Amitriptyline Hydrochloride.
Serotonin Syndrome, Agitation, Anxiety, Decreased Appetite, Hallucinations, Mixed, Blood Sodium Decreased, Cyanosis, Vision Blurred, Cogwheel Rigidity

This Serotonin Syndrome Amitriptyline side effect was reported by a health professional from GB on Jan 02, 2014. A Female , 27 years of age, weighting 140.0 lb, was diagnosed with and was treated with Amitriptyline. The patient presented the following health conditions:
  • Serotonin Syndrome
  • Agitation
  • Anxiety
  • Decreased Appetite
  • Hallucinations, Mixed
  • Blood Sodium Decreased
  • Cyanosis
  • Vision Blurred
  • Cogwheel Rigidity
. Amitriptyline dosage: 25 Milligram Daily; At Night. Additional drugs used at the same time: NA. The patient was hospitalized and became disabled.
Serotonin Syndrome, Confusional State, Dyskinesia, Weight Bearing Difficulty, Nystagmus

This is a Amitriptyline side effect report of a 73-year-old patient (weight:NA) from GB, suffering from the following symptoms/conditions: neuralgia,depression,pain, who was treated with Amitriptyline (dosage:75 Mg, Qhs, start time: Aug 08, 2013), combined with: NA., and developed a serious reaction and a Serotonin Syndrome side effect. The patient presented with:
  • Serotonin Syndrome
  • Confusional State
  • Dyskinesia
  • Weight Bearing Difficulty
  • Nystagmus
which developed after the beginning of treatment. The patient was hospitalized and became disabled. This side effect report can indicate a possible existence of increased vulnerability to Amitriptyline treatment in patients suffering from neuralgia,depression,pain, resulting in Serotonin Syndrome.

Serotonin Syndrome, Confusional State, Dyskinesia, Weight Bearing Difficulty, Nystagmus

A 73-year-old patient (weight: NA) from GB with the following symptoms: neuralgia,pain,depression started Amitriptyline treatment (dosage: 75 Milligram Daily; Taken At Night.) on Aug 08, 2013. Soon after starting Amitriptyline treatment, the consumer experienced several side effects, including:
  • Serotonin Syndrome
  • Confusional State
  • Dyskinesia
  • Weight Bearing Difficulty
  • Nystagmus
. Concurrently used drugs:
  • Tramadol (400 Milligram Daily; Modified Release.)
  • Citalopram (20 Milligram Daily;)
  • Cymbalta (60 Milligram Daily;)
  • Adcal-d3
  • Alendronate
  • Bumetanide
  • Metformin
  • Omeprazole
The patient was hospitalized and became disabled. This finding indicates that some patients can be more vulnerable to developing Amitriptyline side effects, such as Serotonin Syndrome.
Serotonin Syndrome, Abdominal Pain, Pyrexia, Altered State Of Consciousness

A female patient from CH was prescribed and started Amitriptyline on May 10, 2013. Patient felt the following Amitriptyline side effects: serotonin syndrome, abdominal pain, pyrexia, altered state of consciousness Additional patient health information: Female , 52 years of age, The consumer reported the following symptoms: was diagnosed with and. Amitriptyline dosage: 50 Mg, Unk. Concurrently used drugs:
  • Quetiapine (50 Mg, Unk)
  • Quetiapine (150 Mg, Unk)
  • Oxycodone Hydrochloride (20 Mg, Unk)
  • Pregabalin (150 Mg, Bid)
  • Clonazepam (0.25 Mg, Qd)
  • Baclofen (15 Mg, Qd)
  • Paracetamol (1 G, Tid)
  • Levothyroxin (0.1 Mg, Qd)
The patient was hospitalized.
Serotonin Syndrome

This report suggests a potential Amitriptyline Serotonin Syndrome side effect(s) that can have serious consequences. A 77-year-old patient from BR (weight:NA) was diagnosed with the following health condition(s): NA and used Amitriptyline (dosage: NA) starting NS. Soon after starting Amitriptyline the patient began experiencing various side effects, including:
  • Serotonin Syndrome
Drugs used concurrently:
  • Fluoxetine
Although Amitriptyline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Serotonin Syndrome, may still occur.
Serotonin Syndrome

An adverse event was reported by a health professional on May 08, 2013 by a Patient taking Amitriptyline (dosage: Unk) . Location: BR , 77 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Amitriptyline side effects: serotonin syndrome. Additional medications/treatments:
Associated medications used:
  • Fluoxetine (Unk)
Serotonin Syndrome

This Serotonin Syndrome problem was reported by a physician from BR. A 77-year-old patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Amitriptyline Hydrochloride (dosage: NA). The following drugs/medications were being taken at the same time:
  • Fluoxetine
When commencing Amitriptyline Hydrochloride, the patient experienced the following unwanted symptoms /side effects:
  • Serotonin Syndrome
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Serotonin Syndrome, may become evident only after a product is in use by the general population.
Serotonin Syndrome

This is a Amitriptyline Hydrochloride side effect report of a 74-year-old patient (weight: NA) from JP. The patient developed the following symptoms/conditions: post herpetic neuralgia and was treated with Amitriptyline Hydrochloride (dosage: 25 Mg, Tid) starting Aug 29, 2012. Concurrently used drugs:
  • Lansap (2 Df, Unk)
  • Biofermin R (Unk)
Soon after that, the consumer experienced the following of symptoms:
  • Serotonin Syndrome
This opens a possibility that Amitriptyline Hydrochloride could cause Serotonin Syndrome and that some patients may be more susceptible.
Serotonin Syndrome

This Serotonin Syndrome side effect was reported by a health professional from DENMARK on Mar 29, 2012. A patient from DENMARK , 64 years of age, was treated with Amitriptyline Hydrochloride. Directly after treatment started, patient experienced the unwanted or unexpected Amitriptyline side effects: serotonin syndrome. Amitriptyline Hydrochloride dosage: NA.
Associated medications used:
  • Torsemide
  • Prednisolone
  • Ibuprofen
  • Citalopram Hydrobromide (20 Mg)
  • Metformin Hcl
  • Carbimazol
  • Fentanyl Citrate
  • Hydrochlorothiazide
These side effects may potentially be related to Amitriptyline Hydrochloride.
Serotonin Syndrome, Proteinuria, Dyspnoea, Chills, Extrapyramidal Disorder, Anxiety, Masked Facies, Myoglobinaemia

This Serotonin Syndrome side effect was reported by a physician from GERMANY. A patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Amitriptyline Hcl (dosage: 50 Mg And 100 Mg Capsules, 50-150 Mg), which was started on Sep 01, 2010. Concurrently used drugs:
  • Palexia Retard (2 Per Day)
  • Simvastatin (20 Mg)
  • Pantoprazole (40 Mg)
  • Metoclopramide (4 Mg/1 Ml Oral Drops, 30 Mg/day)
  • Losartan Potassium/hydrochlorthiazide (50/12.5 Mg)
When starting to take Amitriptyline Hcl the consumer reported the following symptoms:
  • Serotonin Syndrome
  • Proteinuria
  • Dyspnoea
  • Chills
  • Extrapyramidal Disorder
  • Anxiety
  • Masked Facies
  • Myoglobinaemia
These side effects may potentially be related to Amitriptyline Hcl.
Proteinuria, Masked Facies, Serotonin Syndrome, Electrocardiogram Qt Prolonged, Myoglobinaemia, Dyspnoea, Extrapyramidal Disorder

This Serotonin Syndrome Amitriptyline Hcl side effect was reported by a physician from GERMANY on Oct 13, 2011. A male , weighting 149.9 lb, was treated with Amitriptyline Hcl. The patient presented the following health conditions:
  • Proteinuria
  • Masked Facies
  • Serotonin Syndrome
  • Electrocardiogram Qt Prolonged
  • Myoglobinaemia
  • Dyspnoea
  • Extrapyramidal Disorder
. Amitriptyline Hcl dosage: 50 Mg And 100mg Capsules, 50-150mg, Previously Reported As 100mg-150mg. Additional drugs used at the same time:
  • Pantoprazole
  • Metoclopramide (4mg/1ml Oral Drops, 30 Mg/day)
  • Losartan Potassium And Hydrochlorothiazide
  • Palexia Retard
  • Simvastatin
Anxiety, Blood Sodium Decreased, Delirium, Swelling Face, Heart Rate Increased, Sensory Loss, Serotonin Syndrome, Vomiting, Gait Disturbance

This is a Amitriptyline Hcl side effect report of a 31-year-old female patient (weight:NA) from UNITED KINGDOM, suffering from the following symptoms/conditions: NA, who was treated with Amitriptyline Hcl (dosage:NA, start time: Aug 01, 1999), combined with:
  • Clonazepam
  • Codeine
  • Paroxetine Hcl
  • Omeprazole
  • Tramadol Hcl
  • Tramadol Hcl
  • Tramadol Hcl
  • Lorazepam
, and developed a serious reaction and a Serotonin Syndrome side effect. The patient presented with:
  • Anxiety
  • Blood Sodium Decreased
  • Delirium
  • Swelling Face
  • Heart Rate Increased
  • Sensory Loss
  • Serotonin Syndrome
  • Vomiting
  • Gait Disturbance
which developed after the beginning of treatment. The patient was hospitalized and became disabled. This side effect report can indicate a possible existence of increased vulnerability to Amitriptyline Hcl treatment in female patients suffering from NA, resulting in Serotonin Syndrome.
Serotonin Syndrome, Nervous System Disorder, Hepatic Steatosis, Poisoning, Disseminated Intravascular Coagulation, Hepatic Failure, Multi-organ Failure

A 59-year-old patient (weight: NA) from NORWAY with the following symptoms: depression started Amitriptyline Hcl treatment (dosage: 125 Mg, 1x/day) on NS. Soon after starting Amitriptyline Hcl treatment, the consumer experienced several side effects, including:
  • Serotonin Syndrome
  • Nervous System Disorder
  • Hepatic Steatosis
  • Poisoning
  • Disseminated Intravascular Coagulation
  • Hepatic Failure
  • Multi-organ Failure
. Concurrently used drugs:
  • Nortriptyline Hcl
  • Mirtazapine (60 Mg, 1x/day)
  • Atenolol (Unk)
  • Isosorbide Mononitrate (Unk)
  • Centyl (Unk)
  • Alprazolam (4 Mg, 1x/day)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Amitriptyline Hcl side effects, such as Serotonin Syndrome.
Nervous System Disorder, Disseminated Intravascular Coagulation, Multi-organ Failure, Poisoning, Serotonin Syndrome, Toxicity To Various Agents

A patient from NORWAY was prescribed and started Amitriptyline Hcl on Aug 04, 2011. After Amitriptyline was administered, patient encountered several Amitriptyline side effects: nervous system disorder, disseminated intravascular coagulation, multi-organ failure, poisoning, serotonin syndrome, toxicity to various agents Additional patient health information: male , 59 years of age, The consumer reported the following symptoms: was diagnosed with and. Amitriptyline Hcl dosage: 125 Mg, 1x/day. Concurrently used drugs:
  • Nortriptyline Hcl
  • Centyl (Unk)
  • Atenolol (Unk)
  • Isosorbide Mononitrate (Unk)
  • Alprazolam (4 Mg, 1x/day)
  • Mirtazapine (60 Mg, 1x/day)
The patient was hospitalized.
Myalgia, Disseminated Intravascular Coagulation, Headache, Serotonin Syndrome, Hepatic Steatosis, Metabolic Acidosis, Multi-organ Failure, Fatigue

This report suggests a potential Amitriptyline Hydrochloride Serotonin Syndrome side effect(s) that can have serious consequences. A 59-year-old patient from NORWAY (weight:NA) was diagnosed with the following health condition(s): depression and used Amitriptyline Hydrochloride (dosage: 125 Mg; Qd; Po) starting NS. Soon after starting Amitriptyline Hydrochloride the patient began experiencing various side effects, including:
  • Myalgia
  • Disseminated Intravascular Coagulation
  • Headache
  • Serotonin Syndrome
  • Hepatic Steatosis
  • Metabolic Acidosis
  • Multi-organ Failure
  • Fatigue
Drugs used concurrently:
  • Paracet
  • Alprazolam (4 Mg; Qd)
  • Fentanyl
  • Remeron (60 Mg; Qd; Po)
  • Atenolol
  • Isosorbide Mononitrate
  • Centyl (vendroflumethiazide) (Po)
The patient was hospitalized. Although Amitriptyline Hydrochloride demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Serotonin Syndrome, may still occur.
Fatigue, Metabolic Acidosis, Serotonin Syndrome, Myalgia, Multi-organ Failure, Dysstasia, Depressed Level Of Consciousness, Pyrexia, Disseminated Intravascular Coagulation

An adverse event was reported by a health professional on Jul 14, 2011 by a male taking Amitriptyline Hcl (dosage: 125 Mg, Qd) . Location: NORWAY , 59 years of age, patient began experiencing various side effects, including: Patient felt the following Amitriptyline side effects: fatigue, metabolic acidosis, serotonin syndrome, myalgia, multi-organ failure, dysstasia, depressed level of consciousness, pyrexia, disseminated intravascular coagulation. Additional medications/treatments:
Multiple prescriptions taken:
  • Isosorbide Mononitrate
  • Mirtazapine (60 Mg, Qd)
  • Alprazolam (4 Mg, Qd)
  • Atenolol
  • Bendroflumethiazide
Multi-organ Failure, Serotonin Syndrome, Poisoning, Disseminated Intravascular Coagulation

This Serotonin Syndrome problem was reported by a physician from NORWAY. A 59-year-old patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Amitriptyline Hcl (dosage: NA). The following drugs/medications were being taken at the same time:
  • Alprazolam
  • Atenolol
  • Mirtazapine
  • Isosorbide Mononitrate
  • Centyl
When commencing Amitriptyline Hcl, the patient experienced the following unwanted symptoms /side effects:
  • Multi-organ Failure
  • Serotonin Syndrome
  • Poisoning
  • Disseminated Intravascular Coagulation
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Serotonin Syndrome, may become evident only after a product is in use by the general population.
Serotonin Syndrome

This is a Amitriptyline Hcl side effect report of a 59-year-old patient (weight: NA) from NORWAY. The patient developed the following symptoms/conditions: NA and was treated with Amitriptyline Hcl (dosage: 125 Mg) starting NS. Concurrently used drugs:
  • Bendroflumethiazide
  • Alprazolam (4 Mg)
  • Atenolol
  • Mirtazapine (60 Mg)
  • Isosorbide
Soon after that, the consumer experienced the following of symptoms:
  • Serotonin Syndrome
This opens a possibility that Amitriptyline Hcl could cause Serotonin Syndrome and that some patients may be more susceptible.
Serotonin Syndrome, Tremor, Pyrexia, Heart Rate Increased, Vomiting, Restlessness, Nausea, Tachycardia

This Serotonin Syndrome side effect was reported by a physician from GERMANY on Jun 12, 2011. A female patient from GERMANY , weighting 103.6 lb, was treated with Amitriptyline Hcl. Patient felt the following Amitriptyline side effects: serotonin syndrome, tremor, pyrexia, heart rate increased, vomiting, restlessness, nausea, tachycardia. Amitriptyline Hcl dosage: NA.
Multiple prescriptions taken:
  • Tapentadol
  • Tapentadol
  • Tapentadol
  • Tapentadol
  • Tapentadol
  • Laxatives
  • Tapentadol
The patient was hospitalized. These side effects may potentially be related to Amitriptyline Hcl.

DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Amitriptyline Serotonin Syndrome Causes and Reviews


Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They work to balance some of the natural chemicals in our brains. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try a few before finding what works best for you.

Antidepressants may cause mild side effects that usually do not last long. These may include headache, nausea, sleep problems, restlessness, and sexual problems. Tell your doctor if you have any side effects. You should also let your doctor know if you take any other medicines, vitamins, or herbal supplements.

It is important to keep taking your medicines, even if you feel better. Do not stop taking your medicines without talking to your doctor. You often need to stop antidepressants gradually.

NIH: National Institute of Mental Health


Amitriptyline Serotonin Syndrome Reviews

Fri, 09 Sep 2011

can Amitriptyline can cause thrombocytopenia ?

Wed, 16 Nov 2011

After having been on elavil for 9 years, mostly at 100mg/night, I spent the last 6 months weaning off. Shortly after stopping Amitriptyline I now have high blood pressure. Before stopping, and for years before starting, my usual pressure was 115/65, now have 150/68. Can this be a withdrawal symptom or has the drug been masking a heart problem all this time or did it cause damage that did not show up before stopping the drug?

Sun, 03 Jul 2011
Is a GG 40 with a Sandoz label made in a different laboratory than a GG 40 with a Geneva label? (I know they are both 10 mg of Amitriptyline.) Thank you. Appreciate reply as soon as possible.
Wed, 14 Dec 2011
im on Amitriptyline 25mg,i have my xmas party this weekend and wanted to drink alchol. i wonder is it a good idea
Thu, 10 Dec 2009
took Amitriptyline 200mg in a signle dose is it safe
Wed, 20 Jan 2010
Does Amtriptyline help tinnitus. I'm taking it at a low dose for jaw problems and fibromyalgia. the 25 mg dose seems to make my tinnitus worse but my pain better. I don't know what to do?
Wed, 20 Jan 2010
I'm taking Amitriptyline to relax my jaw and for pain and it seem to help tinnitus sonmetimes. Should I be taking noratfiptyline?
Mon, 07 Jun 2010
I HAVE JUST BEEN GIVEN AMITRIPTYLINE ,10MG FOR PAIN AND SLEEP BUT I HAVE BEEN READING ABOUT SIDE AFFECTS
Sun, 20 Jun 2010
Hey i took 500mg of Amitriptyline and overdosed and almost Died.. Dont take that much
Sun, 11 Jul 2010
been on amitrip 25mg at night for 8 nights now and have felt and look alot better. although i have diarrihea now and felt abit of nausea here and there . feel a tad tired throughout the day but i think for me the postives outweigh the negatives for now
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Amitriptyline Side Effects

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Toxicity To Various Agents (72)
Overdose (61)
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Pain (47)
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Anxiety (42)
Death (42)
Headache (42)
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Agitation (31)
Hypotension (31)
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Insomnia (26)
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Pyrexia (25)
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Delirium (24)
Abdominal Pain (23)
Feeling Abnormal (23)
Suicide Attempt (23)
Dysarthria (22)
Constipation (21)
Deep Vein Thrombosis (21)
Depressed Level Of Consciousness (21)
Electrocardiogram Qt Prolonged (21)
Palpitations (21)
Serotonin Syndrome (21)
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Dry Mouth (19)
Metabolic Acidosis (19)

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Amitriptyline Common Side Effects

If you experienced any harmful or unwanted effects of Mucinex, please share your experience. This could help to raise awareness about Mucinex side effects, identify uknown risks and inform health professionals and patients taking Mucinex.

Examples: headache, dizziness

The most commonly reported Amitriptyline side effects (click to view or check a box to report):

Completed Suicide (96)
Toxicity To Various Agents (72)
Overdose (61)
Cardiac Arrest (56)
Somnolence (48)
Pain (47)
Convulsion (45)
Anxiety (42)
Death (42)
Headache (42)
Vomiting (40)
Confusional State (39)
Intentional Overdose (39)
Dyspnoea (38)
Dizziness (37)
Loss Of Consciousness (37)
Fatigue (35)
Nausea (34)
Coma (33)
Respiratory Arrest (33)

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