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Benadryl Depression Side Effects

Benadryl Depression Side Effect Reports


The following Benadryl Depression side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Depression, can occur, and what you can do about them.

A side effect could appear soon after you start Benadryl or it might take time to develop.



Depression, Off Label Use, Therapeutic Response Unexpected, Product Packaging Issue

This Depression side effect was reported by a consumer or non-health professional from US. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Benadryl Allergy Dye-free (dosage: 1 Liquidgel At Night Before Bed), which was started on NS. Concurrently used drugs:
  • Trepiline
When starting to take Benadryl Allergy Dye-free the consumer reported the following symptoms:
  • Depression
  • Off Label Use
  • Therapeutic Response Unexpected
  • Product Packaging Issue
These side effects may potentially be related to Benadryl Allergy Dye-free.
Headache, Tachycardia, Soft Tissue Inflammation, Diarrhoea, Ileus, Pneumonia, Depression, Osteopenia, Blood Magnesium Decreased

This Depression Benadryl ^pfizer Warner-lambert^ side effect was reported by a consumer or non-health professional from UNITED STATES on Jun 22, 2012. A Female , weighting 111.0 lb, was treated with Benadryl ^pfizer Warner-lambert^. The patient presented the following health conditions:
  • Headache
  • Tachycardia
  • Soft Tissue Inflammation
  • Diarrhoea
  • Ileus
  • Pneumonia
  • Depression
  • Osteopenia
  • Blood Magnesium Decreased
. Benadryl ^pfizer Warner-lambert^ dosage: NA. Additional drugs used at the same time:
  • Tagamet
  • Morphine Sulfate
  • Taxol
  • Uro-mag
  • Calcium With Vitamin D
  • Prozac
  • Potassium Chloride
  • Temazepam
The patient was hospitalized.
Pyrexia, Injection Site Discharge, Injection Site Swelling, Injection Site Haematoma, Depression, Anxiety, Pain, Injection Site Dryness, Chills

This is a Benadryl side effect report of a 49-year-old female patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Benadryl (dosage:NA, start time: Dec 28, 2010), combined with:
  • Extavia (0.062 Mg, Qod, Subcutaneous 0.125 Mg, Qod, Subcutaneous 0.25 Mg, Qod, Subcutaneous)
  • Extavia (0.062 Mg, Qod, Subcutaneous 0.125 Mg, Qod, Subcutaneous 0.25 Mg, Qod, Subcutaneous)
  • Extavia (0.062 Mg, Qod, Subcutaneous 0.125 Mg, Qod, Subcutaneous 0.25 Mg, Qod, Subcutaneous)
  • Lisinopril
  • Acetaminophen
  • Tizanidine Hcl
  • Metformin Hcl
  • Synthroid
, and developed a serious reaction and a Depression side effect. The patient presented with:
  • Pyrexia
  • Injection Site Discharge
  • Injection Site Swelling
  • Injection Site Haematoma
  • Depression
  • Anxiety
  • Pain
  • Injection Site Dryness
  • Chills
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Benadryl treatment in female patients suffering from NA, resulting in Depression.

Injury, Bile Duct Stone, Gallbladder Disorder, Pancreatitis, Pain, Anxiety, Emotional Distress, Cholecystitis Chronic, Depression

A 24-year-old female patient (weight: NA) from UNITED STATES with the following symptoms: NA started Benadryl treatment (dosage: 25 Mg, Q4hr As Needed) on Jun 23, 2009. Soon after starting Benadryl treatment, the consumer experienced several side effects, including:
  • Injury
  • Bile Duct Stone
  • Gallbladder Disorder
  • Pancreatitis
  • Pain
  • Anxiety
  • Emotional Distress
  • Cholecystitis Chronic
  • Depression
. Concurrently used drugs:
  • Demerol (Unk)
  • Percocet (5-325 Mg, 1 Every 6 Hours As Needed)
  • Yaz (Unk)
  • Dilaudid (Unk)
  • Morphine (4 Mg, As Directed)
  • Zofran (4 Mg, Unk)
  • Tylenol (Unk)
  • Potassium (20 Meq, Unk)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Benadryl side effects, such as Depression.
Feeling Abnormal, Depression, Off Label Use

A patient from UNITED STATES was prescribed and started Benadryl on Jul 29, 2011. Patient felt the following Benadryl side effects: feeling abnormal, depression, off label use Additional patient health information: male , 21 years of age, weighting 140.0 lb, The consumer reported the following symptoms: was diagnosed with and. Benadryl dosage: NA. Concurrently used drugs:
  • Neurontin
  • Lamictal
Feeling Abnormal, Blister, Rash, Pruritus, Pain, Diarrhoea, Depression

This report suggests a potential Benadryl Depression side effect(s) that can have serious consequences. A patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): rash,mood swings and used Benadryl (dosage: Unk) starting Nov 01, 2010. Soon after starting Benadryl the patient began experiencing various side effects, including:
  • Feeling Abnormal
  • Blister
  • Rash
  • Pruritus
  • Pain
  • Diarrhoea
  • Depression
Drugs used concurrently:
  • Neurontin (Unk)
  • Lamictal (Unk)
Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Depression, may still occur.
Parvovirus Infection, Thrombosis, Depression, Dyspnoea, Urticaria, Rash, Myalgia, Nausea, Syncope

An adverse event was reported by a consumer or non-health professional on Oct 08, 2010 by a Female taking Benadryl (dosage: NA) . Location: UNITED STATES , 28 years of age, weighting 130.1 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Benadryl side effects: parvovirus infection, thrombosis, depression, dyspnoea, urticaria, rash, myalgia, nausea, syncope. Additional medications/treatments:
Associated medications used:
  • Zoloft
  • Darvocet
  • Alprazolam
  • Solu-medrol
  • Yaz
  • Ocella
  • Spironolactone (Unk)
  • Allegra
The patient was hospitalized.
Cerebrovascular Accident, Cardiac Disorder, Pain, Injury, Renal Failure, Depression, Anhedonia, Renal Injury, Organ Failure

This Depression problem was reported by a consumer or non-health professional from UNITED STATES. A patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Mar 30, 2005 a consumer started treatment with Benadryl (dosage: 50 Mg, Unk). The following drugs/medications were being taken at the same time:
  • Epinephrine (Unk)
  • Ancef (2 G, Unk)
  • Midazolam (Unk)
  • Etomidate (Unk)
  • Inocor (Unk)
  • Trasylol (200 Ml, Unk)
  • Neo Synephrin (Unk)
  • Nitroglycerin (Unk)
When commencing Benadryl, the patient experienced the following unwanted symptoms /side effects:
  • Cerebrovascular Accident
  • Cardiac Disorder
  • Pain
  • Injury
  • Renal Failure
  • Depression
  • Anhedonia
  • Renal Injury
  • Organ Failure
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Depression, may become evident only after a product is in use by the general population.
Skin Discolouration, Depression, Vomiting, Multiple Sclerosis Relapse, Muscular Weakness, Nausea, Fatigue, Nasopharyngitis

This is a Benadryl side effect report of a female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: NA and was treated with Benadryl (dosage: NA) starting Sep 21, 2010. Concurrently used drugs:
  • Tysabri
Soon after that, the consumer experienced the following of symptoms:
  • Skin Discolouration
  • Depression
  • Vomiting
  • Multiple Sclerosis Relapse
  • Muscular Weakness
  • Nausea
  • Fatigue
  • Nasopharyngitis
This opens a possibility that Benadryl could cause Depression and that some female patients may be more susceptible.
Dyspnoea, Bronchitis, Lethargy, Suicidal Ideation, Psychotic Disorder, Depression, Agitation, Hostility, White Blood Cell Count Increased

This Depression side effect was reported by a consumer or non-health professional from UNITED STATES on Jan 31, 2011. A patient from UNITED STATES , weighting 227.1 lb, was treated with Benadryl. Directly after treatment started, patient experienced the unwanted or unexpected Benadryl side effects: dyspnoea, bronchitis, lethargy, suicidal ideation, psychotic disorder, depression, agitation, hostility, white blood cell count increased. Benadryl dosage: 50 Mg, 2x/day.
Associated medications used:
  • Chantix (0.5 Mg, 1x/day)
  • Chantix (1 Mg, 2x/day)
  • Vistaril (Unk)
  • Chantix (Unk)
  • Prolixin (10 Mg, Unk)
  • Chantix (1 Mg, Unk)
  • Prolixin (10 Mg, Unk)
The patient was hospitalized. These side effects may potentially be related to Benadryl.
Depression, Off Label Use

This Depression side effect was reported by a consumer or non-health professional from UNITED STATES. A 55-year-old patient (weight:NA) experienced the following symptoms/conditions: lymphadenopathy. The patient was prescribed Benadryl (dosage: NA), which was started on Jan 08, 2010. Concurrently used drugs: NA. When starting to take Benadryl the consumer reported the following symptoms:
  • Depression
  • Off Label Use
These side effects may potentially be related to Benadryl.
Alcohol Poisoning, Anion Gap Increased, Blood Sodium Increased, Cognitive Disorder, Depressed Level Of Consciousness, Depression, Disease Recurrence, Dizziness, Dysthymic Disorder

This Depression Benadryl side effect was reported by a consumer or non-health professional from UNITED STATES on Mar 11, 2008. A Female , 23 years of age, was diagnosed with and was treated with Benadryl. The patient presented the following health conditions:
  • Alcohol Poisoning
  • Anion Gap Increased
  • Blood Sodium Increased
  • Cognitive Disorder
  • Depressed Level Of Consciousness
  • Depression
  • Disease Recurrence
  • Dizziness
  • Dysthymic Disorder
. Benadryl dosage: 10 Pills, Oral. Additional drugs used at the same time:
  • Excedrin P.m. (diphenhydramine Citrate, Paracetamol) (10 Pills, Oral)
  • Celexa (3 Pills (20 Mg), Oral)
  • Alcohol (alcohol) (Up To Six Beers, Oral)
  • Celexa
The patient was hospitalized.
Depression, Hallucination, Auditory, Homicidal Ideation, Insomnia, Schizophrenia, Self Injurious Behaviour, Thinking Abnormal, Tinnitus

This is a Benadryl side effect report of a patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Benadryl (dosage:Qd, Oral, start time: NS), combined with:
  • Depakote
  • Lipitor
  • Risperdal
  • Lopid
, and developed a serious reaction and a Depression side effect. The patient presented with:
  • Depression
  • Hallucination, Auditory
  • Homicidal Ideation
  • Insomnia
  • Schizophrenia
  • Self Injurious Behaviour
  • Thinking Abnormal
  • Tinnitus
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Benadryl treatment in patients suffering from NA, resulting in Depression.
Abnormal Behaviour, Anger, Depression, Pruritus, Psychotic Disorder, Rash

A 53-year-old female patient (weight: NA) from UNITED STATES with the following symptoms: rash,hepatitis c started Benadryl treatment (dosage: 50 Mg Nightly, Oral) on Aug 15, 2006. Soon after starting Benadryl treatment, the consumer experienced several side effects, including:
  • Abnormal Behaviour
  • Anger
  • Depression
  • Pruritus
  • Psychotic Disorder
  • Rash
. Concurrently used drugs:
  • Peginterferon Alfa-2a (peginterferon Alfa-2a (180 Mcg 1 Per Week, Subcutaneous)
  • Ribavirin (1000 Mg Daily, Oral)
  • Tramadol Hcl
  • Hyzaar
  • Citalopram Hydrobromide
This finding indicates that some patients can be more vulnerable to developing Benadryl side effects, such as Depression.
Anhedonia, Anorexia, Choking, Dehydration, Depression, Dysphagia, Dysuria, Throat Tightness

A patient from UNITED STATES was prescribed and started Benadryl on Jun 20, 2006. After Benadryl was administered, patient encountered several Benadryl side effects: anhedonia, anorexia, choking, dehydration, depression, dysphagia, dysuria, throat tightness Additional patient health information: male , weighting 160.0 lb, The consumer reported the following symptoms: was diagnosed with and. Benadryl dosage: 2 Tablets Daily. Concurrently used drugs: NA. The patient was hospitalized and became disabled.
Depression, Dry Mouth, Middle Insomnia

This report suggests a potential Benadryl Depression side effect(s) that can have serious consequences. A 35-year-old female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): insomnia and used Benadryl (dosage: 2 Ultratabs Oral) starting Jan 01, 2006. Soon after starting Benadryl the patient began experiencing various side effects, including:
  • Depression
  • Dry Mouth
  • Middle Insomnia
Drugs used concurrently:
  • Quetiapine Fumarate
  • Sertraline Hcl
Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Depression, may still occur.
Depression, Disorientation, Hallucination, Malaise

An adverse event was reported by a consumer or non-health professional on Jan 28, 2006 by a male taking Benadryl (dosage: 24 Ultratabs Once, Oral) was diagnosed with and. Location: UNITED STATES , 17 years of age, weighting 160.0 lb, patient began experiencing various side effects, including: Patient felt the following Benadryl side effects: depression, disorientation, hallucination, malaise. Additional medications/treatments:
Amnesia, Cognitive Disorder, Colonic Polyp, Dementia, Depression, Emotional Distress, Sinus Disorder, Speech Disorder

This Depression problem was reported by a physician from UNITED STATES. A female patient (weight: NA) was diagnosed with the following medical condition(s): hypersensitivity.On Jan 01, 1995 a consumer started treatment with Benadryl (dosage: 1-2x A Week To 1-2 Tabs Daily As Needed, Oral). The following drugs/medications were being taken at the same time:
  • Nifedipine
  • Escitalopram Oxalate
  • Progesterone
  • Telmisartan (telmisartan)
  • Pravastatin
  • Triamcinolone Acetonide
  • Ibuprofen
  • Captopril
When commencing Benadryl, the patient experienced the following unwanted symptoms /side effects:
  • Amnesia
  • Cognitive Disorder
  • Colonic Polyp
  • Dementia
  • Depression
  • Emotional Distress
  • Sinus Disorder
  • Speech Disorder
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Depression, may become evident only after a product is in use by the general population.
Abdominal Pain, Anorexia, Bacteriuria, Benign Prostatic Hyperplasia, Cardiac Murmur, Constipation, Cystitis, Depression

This is a Benadryl Allergy/sinus (diphenhydramine, Pseudoephedrine side effect report of a 86-year-old patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: rhinorrhoea and was treated with Benadryl Allergy/sinus (diphenhydramine, Pseudoephedrine (dosage: 2 Tablets A Day, Oral) starting May 04, 2005. Concurrently used drugs:
  • Docusate Sodium (docusate Sodium)
  • Senna Fruit (senna Fruit)
Soon after that, the consumer experienced the following of symptoms:
  • Abdominal Pain
  • Anorexia
  • Bacteriuria
  • Benign Prostatic Hyperplasia
  • Cardiac Murmur
  • Constipation
  • Cystitis
  • Depression
The patient was hospitalized. This opens a possibility that Benadryl Allergy/sinus (diphenhydramine, Pseudoephedrine could cause Depression and that some patients may be more susceptible.
Amnesia, Cognitive Disorder, Dementia, Depression, Disease Progression, Hypersensitivity

This Depression side effect was reported by a consumer or non-health professional from UNITED STATES on Sep 27, 2005. A female patient from UNITED STATES , weighting 175.0 lb, was diagnosed with and was treated with Benadryl. Patient felt the following Benadryl side effects: amnesia, cognitive disorder, dementia, depression, disease progression, hypersensitivity. Benadryl dosage: 1-2x A Week To 1-2 Tabs Daily As Needed, Oral.
Multiple prescriptions taken:
  • Nifedipine
  • Escitalopram Oxalate
  • Progesterone
  • Telmisartan (telmisartan)
  • Pravastatin
  • Triamcinolone Acetonide
  • Ibuprofen
These side effects may potentially be related to Benadryl.

DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Benadryl Depression Causes and Reviews


Depression is a serious medical illness. It's more than just a feeling of being sad or "blue" for a few days. If you are one of the more than 19 million teens and adults in the United States who have Depression, the feelings do not go away. They persist and interfere with your everyday life. Symptoms can include

  • Feeling sad or "empty"
  • Loss of interest in favorite activities
  • Overeating, or not wanting to eat at all
  • Not being able to sleep, or sleeping too much
  • Feeling very tired
  • Feeling hopeless, irritable, anxious, or guilty
  • Aches or pains, headaches, cramps, or digestive problems
  • Thoughts of death or suicide

Depression is a disorder of the brain. There are a variety of causes, including genetic, biological, environmental, and psychological factors. Depression can happen at any age, but it often begins in teens and young adults. It is much more common in women. Women can also get postpartum Depression after the birth of a baby. Some people get seasonal affective disorder in the winter. Depression is one part of bipolar disorder.

There are effective treatments for Depression, including antidepressants, talk therapy, or both.

NIH: National Institute of Mental Health


Benadryl Depression Reviews

Sun, 04 Sep 2011

Can I die from taking this many. Is it physicly addicting? Sorry about my spelling.

Mon, 18 Jul 2011

I loved these strips. I have had allergic reactions to my own allergy shots. After waiting at the Dr.'s office for 15 minutes after my allergy shot, I leave to go shopping. Sometimes I can feel a little thickening in my throat, similar to when I've had a really bad reaction and had to go to the ER for help, or went back to the Dr.'s office for a shot of epinepherine. When I feel just a small reaction beginning, I have put one of the Benadryl Quick Dissolve Strips on my tongue. I get a pretty fast result and I can continue shopping rather than worrying about a worse reaction.

Now, when I went to buy more of this product, it isn't available at any local stores, or on line at safe sites. Each store tells me that people are coming in and wanting them and getting upset when they can't find them.

Why were these strips taken off the market?

Sun, 21 Mar 2010
Does taking too much Benadryl cause a person to fall asleep and not wake up?
Wed, 01 Sep 2010
It was given to me in a hospital through emergency room, for nauseau. Nusrse said that they use it for that as well. Is true and can it be usedat home for the same?
Thu, 24 Mar 2011
My son is allergic to children's Benadryl. It causes him to develop eye infections (conjunctivitus).
Sat, 30 Apr 2011
I've noticed that it when I am with my partner it makes me sensitive, but I am not able to be aroused. Is anyone else having the same issue. I've been taking it for alergies since I was a teenager. Its the only thing that has ever worked for me.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Benadryl Side Effects

Off Label Use (140)
Dyspnoea (137)
Nausea (100)
Hypersensitivity (99)
Urticaria (85)
Somnolence (78)
Dizziness (76)
Vomiting (75)
Loss Of Consciousness (72)
Headache (68)
Rash (68)
Pruritus (67)
Pain (66)
Overdose (63)
Product Quality Issue (61)
Condition Aggravated (56)
Insomnia (50)
Feeling Abnormal (49)
Heart Rate Increased (49)
Hallucination (48)
Infusion Related Reaction (46)
Anxiety (46)
Tremor (45)
Fatigue (45)
Diarrhoea (43)
Convulsion (42)
Malaise (38)
Pyrexia (38)
Erythema (38)
Blood Pressure Increased (37)
Swelling Face (37)
Asthenia (37)
Pharyngeal Oedema (35)
Throat Tightness (34)
Dehydration (32)
Chest Pain (31)
Swollen Tongue (30)
Cough (30)
Pain In Extremity (30)
Chest Discomfort (29)
Oedema Peripheral (29)
Hypoaesthesia (29)
Incorrect Dose Administered (28)
Abdominal Pain Upper (27)
Eye Swelling (27)
Flushing (26)
Fall (26)
Confusional State (25)
Chills (24)
Depression (24)

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Benadryl Common Side Effects

If you experienced any harmful or unwanted effects of Mucinex, please share your experience. This could help to raise awareness about Mucinex side effects, identify uknown risks and inform health professionals and patients taking Mucinex.

Examples: headache, dizziness

The most commonly reported Benadryl side effects (click to view or check a box to report):

Off Label Use (140)
Dyspnoea (137)
Nausea (100)
Hypersensitivity (99)
Urticaria (85)
Somnolence (78)
Dizziness (76)
Vomiting (75)
Loss Of Consciousness (72)
Headache (68)
Rash (68)
Pruritus (67)
Pain (66)
Overdose (63)
Product Quality Issue (61)
Condition Aggravated (56)
Insomnia (50)
Heart Rate Increased (49)
Feeling Abnormal (49)
Hallucination (48)

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