Benadryl Pain Side Effect Reports


The following Benadryl Pain side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Pain, can occur, and what you can do about them.

A side effect could appear soon after you start Benadryl or it might take time to develop.


Burning Sensation, Pruritus, Rash, Pain, Contusion, Scar, Insomnia, Skin Discolouration, Anxiety

This Pain side effect was reported by a health professional from US. A 55-year-old female patient (weight:NA) experienced the following symptoms/conditions: erythema,pruritus. The patient was prescribed Benadryl (dosage: NA), which was started on Mar 23, 2012. Concurrently used drugs: NA. When starting to take Benadryl the consumer reported the following symptoms:
  • Burning Sensation
  • Pruritus
  • Rash
  • Pain
  • Contusion
  • Scar
  • Insomnia
  • Skin Discolouration
  • Anxiety
These side effects may potentially be related to Benadryl.
Adrenal Disorder, Hypersensitivity, Pain, Malaise, Disorientation, Off Label Use, Adverse Reaction, Abdominal Pain Upper

This Pain Benadryl side effect was reported by a consumer or non-health professional from US on Nov 28, 2012. A male , weighting 75.00 lb, was treated with Benadryl. The patient presented the following health conditions:
  • Adrenal Disorder
  • Hypersensitivity
  • Pain
  • Malaise
  • Disorientation
  • Off Label Use
  • Adverse Reaction
  • Abdominal Pain Upper
. Benadryl dosage: NA. Additional drugs used at the same time: NA.
Fall, Pain, Rib Fracture

This is a Benadryl side effect report of a female patient (weight:NA) from CANADA, suffering from the following symptoms/conditions: NA, who was treated with Benadryl (dosage:NA, start time: Jul 21, 2011), combined with:
  • Remicade (52 Weeks)
  • Lipitor (For Approximately 10 Years)
, and developed a serious reaction and a Pain side effect. The patient presented with:
  • Fall
  • Pain
  • Rib Fracture
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Benadryl treatment in female patients suffering from NA, resulting in Pain.
Feeling Abnormal, Crying, Glossodynia, Pain, Pruritus

A 3-year-old patient (weight: NA) from UNITED STATES with the following symptoms: multiple allergies,asthma started Benadryl treatment (dosage: NA) on Nov 01, 2011. Soon after starting Benadryl treatment, the consumer experienced several side effects, including:
  • Feeling Abnormal
  • Crying
  • Glossodynia
  • Pain
  • Pruritus
. Concurrently used drugs:
  • Singulair
  • Albuterol
  • Pulmicort (0.5 Mg/ 2 Ml Daily)
This finding indicates that some patients can be more vulnerable to developing Benadryl side effects, such as Pain.
Deep Vein Thrombosis, Post Thrombotic Syndrome, Pain, Anhedonia, Pain In Extremity, Anxiety, Injury, Oedema Peripheral

A female patient from UNITED STATES was prescribed and started Benadryl on May 30, 2012. Patient felt the following Benadryl side effects: deep vein thrombosis, post thrombotic syndrome, pain, anhedonia, pain in extremity, anxiety, injury, oedema peripheral Additional patient health information: Female , 49 years of age, weighting 135.0 lb, The consumer reported the following symptoms: . Benadryl dosage: 12.5 Mg, Prn. Concurrently used drugs:
  • Yasmin (Unk)
  • Drospirenone And Ethinyl Estradiol (Unk)
  • Aciphex (20 Mg 2 [times] Day Every Day)
  • Yasmin
  • Aciphex (Unk)
  • Phenazopyridine Hcl Tab (200 Mg, Tid)
  • Multi-vitamin (Unk)
  • Phenazopyridine Hcl Tab (200 Mg, [one] Tid Prn)
Pain, Chills, Rash Erythematous, Headache, Face Oedema, Flushing, Pyrexia

This report suggests a potential Benadryl Pain side effect(s) that can have serious consequences. A female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): NA and used Benadryl (dosage: NA) starting Apr 27, 2009. Soon after starting Benadryl the patient began experiencing various side effects, including:
  • Pain
  • Chills
  • Rash Erythematous
  • Headache
  • Face Oedema
  • Flushing
  • Pyrexia
Drugs used concurrently:
  • Rituxan (66.6667 Milligram;)
  • Decadron
  • Tylenol (caplet)
  • Pepcid
  • Aloxi
  • Treanda
Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pain, may still occur.
Prostatomegaly, Contusion, Oedema Peripheral, Hypoglycaemic Unconsciousness, Local Swelling, Mass, Feeling Hot, Pain, Urine Analysis Abnormal

An adverse event was reported by a health professional on Apr 24, 2012 by a male taking Benadryl (dosage: Unk) . Location: UNITED STATES , 46 years of age, weighting 240.0 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Benadryl side effects: prostatomegaly, contusion, oedema peripheral, hypoglycaemic unconsciousness, local swelling, mass, feeling hot, pain, urine analysis abnormal. Additional medications/treatments:
Associated medications used:
  • Enbrel (50 Mg, Qwk)
The patient was hospitalized.
Pain, Nausea, Vomiting, Asthenia, Muscle Spasms, Loss Of Consciousness, Hallucination, Headache, Feeling Of Body Temperature Change

This Pain problem was reported by a consumer or non-health professional from UNITED STATES. A 60-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): sinus disorder,gastrooesophageal reflux disease,hypertension,arthritis.On Jan 30, 2012 a consumer started treatment with Benadryl (dosage: Two Liquigels). The following drugs/medications were being taken at the same time:
  • Nexium
  • Benazepril Hydrochloride
  • Tramadol Hcl (Up To Four Times Daily.)
  • Triamterene And Hydrochlorothiazide (37.5 Mg / 25 Mg)
  • Ranitidine
  • Levoxyl (0.137 Mcg)
When commencing Benadryl, the patient experienced the following unwanted symptoms /side effects:
  • Pain
  • Nausea
  • Vomiting
  • Asthenia
  • Muscle Spasms
  • Loss Of Consciousness
  • Hallucination
  • Headache
  • Feeling Of Body Temperature Change
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Pain, may become evident only after a product is in use by the general population.
Anxiety, Cough, Pain, Tremor, Food Allergy, Pain In Extremity, Choking, Malaise, Rash

This is a Benadryl side effect report of a 38-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: NA and was treated with Benadryl (dosage: NA) starting Aug 05, 2011. Concurrently used drugs:
  • Avonex
  • Avonex
  • Tysabri
Soon after that, the consumer experienced the following of symptoms:
  • Anxiety
  • Cough
  • Pain
  • Tremor
  • Food Allergy
  • Pain In Extremity
  • Choking
  • Malaise
  • Rash
This opens a possibility that Benadryl could cause Pain and that some female patients may be more susceptible.
Pyrexia, Injection Site Discharge, Injection Site Swelling, Injection Site Haematoma, Depression, Anxiety, Pain, Injection Site Dryness, Chills

This Pain side effect was reported by a physician from UNITED STATES on May 03, 2011. A female patient from UNITED STATES , 49 years of age, was treated with Benadryl. Directly after treatment started, patient experienced the unwanted or unexpected Benadryl side effects: pyrexia, injection site discharge, injection site swelling, injection site haematoma, depression, anxiety, pain, injection site dryness, chills. Benadryl dosage: NA.
Associated medications used:
  • Extavia (0.062 Mg, Qod, Subcutaneous 0.125 Mg, Qod, Subcutaneous 0.25 Mg, Qod, Subcutaneous)
  • Extavia (0.062 Mg, Qod, Subcutaneous 0.125 Mg, Qod, Subcutaneous 0.25 Mg, Qod, Subcutaneous)
  • Extavia (0.062 Mg, Qod, Subcutaneous 0.125 Mg, Qod, Subcutaneous 0.25 Mg, Qod, Subcutaneous)
  • Lisinopril
  • Acetaminophen
  • Tizanidine Hcl
  • Metformin Hcl
  • Synthroid
These side effects may potentially be related to Benadryl.
Rash, Scab, Oral Herpes, Headache, Asthenia, Paraesthesia, Pain, Dizziness, Dyspnoea

This Pain side effect was reported by a health professional from UNITED STATES. A 64-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Benadryl ^ache^ (ammonium Chloride, Diphenhydramine Hydrochloride,ment (dosage: NA), which was started on Dec 31, 2010. Concurrently used drugs:
  • Gammagard
  • Acetaminophen
  • Extavia (0.062 Mg, Qod, Subcutaneous)
When starting to take Benadryl ^ache^ (ammonium Chloride, Diphenhydramine Hydrochloride,ment the consumer reported the following symptoms:
  • Rash
  • Scab
  • Oral Herpes
  • Headache
  • Asthenia
  • Paraesthesia
  • Pain
  • Dizziness
  • Dyspnoea
These side effects may potentially be related to Benadryl ^ache^ (ammonium Chloride, Diphenhydramine Hydrochloride,ment.
Paraesthesia, Dizziness, Diarrhoea, Pain, Dyspnoea, Rash, Scab, Headache, Influenza Like Illness

This Pain Benadryl ^ache^ (ammonium Chloride, Diphenhydramine Hydrochloride, Men side effect was reported by a health professional from UNITED STATES on Jan 03, 2011. A Female , 64 years of age, was treated with Benadryl ^ache^ (ammonium Chloride, Diphenhydramine Hydrochloride, Men. The patient presented the following health conditions:
  • Paraesthesia
  • Dizziness
  • Diarrhoea
  • Pain
  • Dyspnoea
  • Rash
  • Scab
  • Headache
  • Influenza Like Illness
. Benadryl ^ache^ (ammonium Chloride, Diphenhydramine Hydrochloride, Men dosage: NA. Additional drugs used at the same time:
  • Gammagard
  • Extavia (0.062 Mg, Qod, Subcutaneous)
  • Acetaminophen
Injury, Bile Duct Stone, Gallbladder Disorder, Pancreatitis, Pain, Anxiety, Emotional Distress, Cholecystitis Chronic, Depression

This is a Benadryl side effect report of a 24-year-old female patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Benadryl (dosage:25 Mg, Q4hr As Needed, start time: Jun 23, 2009), combined with:
  • Demerol (Unk)
  • Percocet (5-325 Mg, 1 Every 6 Hours As Needed)
  • Yaz (Unk)
  • Dilaudid (Unk)
  • Morphine (4 Mg, As Directed)
  • Zofran (4 Mg, Unk)
  • Tylenol (Unk)
  • Potassium (20 Meq, Unk)
, and developed a serious reaction and a Pain side effect. The patient presented with:
  • Injury
  • Bile Duct Stone
  • Gallbladder Disorder
  • Pancreatitis
  • Pain
  • Anxiety
  • Emotional Distress
  • Cholecystitis Chronic
  • Depression
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Benadryl treatment in female patients suffering from NA, resulting in Pain.
Pruritus, Arthralgia, Hypersensitivity, Skin Burning Sensation, Myalgia, Pain, Hypersomnia

A female patient (weight: NA) from UNITED STATES with the following symptoms: NA started Benadryl treatment (dosage: 25 Mg, Unk) on Aug 01, 2011. Soon after starting Benadryl treatment, the consumer experienced several side effects, including:
  • Pruritus
  • Arthralgia
  • Hypersensitivity
  • Skin Burning Sensation
  • Myalgia
  • Pain
  • Hypersomnia
. Concurrently used drugs:
  • Bisoprolol Fumarate And Hydrochlorothiazide (5/6.25mg, Daily)
  • Metformin (1000 Mg, 2x/day)
  • Ultram Er (100 Mg, 2x/day)
  • Glimepiride (2 Mg, Daily)
  • Lyrica (150 Mg, 2x/day)
  • Levothyroxine (175 Ug, Daily)
  • Aldactone (25 Mg, Daily)
  • Codeine Sulfate (Unk)
This finding indicates that some patients can be more vulnerable to developing Benadryl side effects, such as Pain.
Paraesthesia, Infusion Related Reaction, Pain

A female patient from CANADA was prescribed and started Benadryl on Oct 31, 2011. After Benadryl was administered, patient encountered several Benadryl side effects: paraesthesia, infusion related reaction, pain Additional patient health information: Female , weighting 125.2 lb, The consumer reported the following symptoms: . Benadryl dosage: NA. Concurrently used drugs:
  • Solu-cortef
  • Synthroid
  • Remicade
  • Remicade
Biliary Adenoma, Fatigue, Injury, Hepatic Cyst, Incisional Hernia, Anxiety, Asthenia, Pain

This report suggests a potential Benadryl Pain side effect(s) that can have serious consequences. A 50-year-old female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): NA and used Benadryl (dosage: 25 Mg, Unk) starting Mar 13, 2008. Soon after starting Benadryl the patient began experiencing various side effects, including:
  • Biliary Adenoma
  • Fatigue
  • Injury
  • Hepatic Cyst
  • Incisional Hernia
  • Anxiety
  • Asthenia
  • Pain
Drugs used concurrently:
  • Elimite (Unk)
  • Prednisone Tab (20 Mg, Unk)
  • Ambien (10 Mg, Hs)
  • Yaz (Unk)
  • Triamcinolone (Unk Unk, Bid)
  • Cymbalta (60 Mg, Unk)
  • Bupropion Hydrochloride (150 Mg, Unk)
  • Prednisone Tab (20 Mg, Unk)
The patient was hospitalized. Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pain, may still occur.
Abdominal Pain Upper, Diarrhoea, Vomiting, Pain In Extremity, Nausea, Convulsion, Sickle Cell Anaemia With Crisis

An adverse event was reported by a consumer or non-health professional on Nov 09, 2011 by a Female taking Benadryl (dosage: 50 Mg, Prn) . Location: UNITED STATES , weighting 121.3 lb, patient began experiencing various side effects, including: Patient felt the following Benadryl side effects: abdominal pain upper, diarrhoea, vomiting, pain in extremity, nausea, convulsion, sickle cell anaemia with crisis. Additional medications/treatments:
Multiple prescriptions taken:
  • Diphenhydramine Hcl (Unk)
  • Exjade (1000 Mg, Daily)
  • Exjade
  • Oxycontin (160 Mg,)
  • Folic Acid (Unk)
  • Elavil
  • Topamax (Unk)
  • Aspirin (Unk)
The patient was hospitalized.
Arthropathy, Somnolence, Pain In Extremity, Chills, Arthralgia, Osteoarthritis, Nodule

This Pain problem was reported by a consumer or non-health professional from UNITED STATES. A female patient (weight: NA) was diagnosed with the following medical condition(s): pruritus,rheumatoid arthritis,asthma,chills.On Oct 01, 2011 a consumer started treatment with Benadryl (dosage: 1-3 Times A Day As Needed). The following drugs/medications were being taken at the same time:
  • Plaquenil
  • Theophylline
  • Hydroxyzine
  • Singulair
  • Humira
  • Mobic
  • Kenalog (As Needed)
When commencing Benadryl, the patient experienced the following unwanted symptoms /side effects:
  • Arthropathy
  • Somnolence
  • Pain In Extremity
  • Chills
  • Arthralgia
  • Osteoarthritis
  • Nodule
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Pain, may become evident only after a product is in use by the general population.
Cholecystitis Acute, Gallbladder Non-functioning, Gallbladder Disorder, Pain

This is a Benadryl side effect report of a 22-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: multiple allergies and was treated with Benadryl (dosage: NA) starting Jun 16, 2006. Concurrently used drugs:
  • Zyban (150 Mg, Daily)
  • Ibuprofen
  • Prilosec (20 Mg, Qd)
  • Yasmin (Unk)
  • Wellbutrin (Unk)
  • Emergen-c
  • Drospirenone And Ethinyl Estradiol (Unk)
  • Naproxen (aleve)
Soon after that, the consumer experienced the following of symptoms:
  • Cholecystitis Acute
  • Gallbladder Non-functioning
  • Gallbladder Disorder
  • Pain
The patient was hospitalized. This opens a possibility that Benadryl could cause Pain and that some female patients may be more susceptible.
Pain, Pulmonary Embolism, Emotional Distress, Dyspnoea

This Pain side effect was reported by a consumer or non-health professional from UNITED STATES on Oct 13, 2011. A female patient from UNITED STATES , 36 years of age, weighting 220.5 lb, was diagnosed with and was treated with Benadryl. Patient felt the following Benadryl side effects: pain, pulmonary embolism, emotional distress, dyspnoea. Benadryl dosage: 100 Mg, Unk.
Multiple prescriptions taken:
  • Fluoxetine Hcl (20 Mg, Unk)
  • Depo-provera
  • Drospirenone And Ethinyl Estradiol (Unk)
  • Metformin Hcl (Unk)
  • Amoxicillin (500 Mg, Unk)
  • Yasmin (Unk)
  • Venlafaxine (37.5 Mg, Unk)
  • Diamox Src (10 Mg, Qd)
The patient was hospitalized. These side effects may potentially be related to Benadryl.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Benadryl Pain Causes and Reviews


Pain is a feeling triggered in the nervous system. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel Pain in one area of your body, such as your back, abdomen, chest, or pelvis. Or you may feel Pain all over, such as when your muscles ache from the flu.

Pain can be helpful in diagnosing a problem. Without Pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. Once you take care of the problem, Pain usually goes away. However, sometimes Pain goes on for weeks, months or even years. This is called chronic Pain. Sometimes chronic Pain is due to an ongoing cause, such as cancer or arthritis. Sometimes the cause is unknown.

Fortunately, there are many ways to treat Pain. Treatment varies depending on the cause of Pain. Pain relievers, acupuncture, and sometimes surgery are helpful.


Benadryl Pain Reviews

Sun, 04 Sep 2011

Can I die from taking this many. Is it physicly addicting? Sorry about my spelling.

Mon, 18 Jul 2011

I loved these strips. I have had allergic reactions to my own allergy shots. After waiting at the Dr.'s office for 15 minutes after my allergy shot, I leave to go shopping. Sometimes I can feel a little thickening in my throat, similar to when I've had a really bad reaction and had to go to the ER for help, or went back to the Dr.'s office for a shot of epinepherine. When I feel just a small reaction beginning, I have put one of the Benadryl Quick Dissolve Strips on my tongue. I get a pretty fast result and I can continue shopping rather than worrying about a worse reaction.

Now, when I went to buy more of this product, it isn't available at any local stores, or on line at safe sites. Each store tells me that people are coming in and wanting them and getting upset when they can't find them.

Why were these strips taken off the market?

Sun, 21 Mar 2010
Does taking too much Benadryl cause a person to fall asleep and not wake up?
Wed, 01 Sep 2010
It was given to me in a hospital through emergency room, for nauseau. Nusrse said that they use it for that as well. Is true and can it be usedat home for the same?
Thu, 24 Mar 2011
My son is allergic to children's Benadryl. It causes him to develop eye infections (conjunctivitus).
Sat, 30 Apr 2011
I've noticed that it when I am with my partner it makes me sensitive, but I am not able to be aroused. Is anyone else having the same issue. I've been taking it for alergies since I was a teenager. Its the only thing that has ever worked for me.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Benadryl Side Effects

Off Label Use (181)
Dyspnoea (162)
Nausea (141)
Hypersensitivity (139)
Urticaria (126)
Somnolence (119)
Vomiting (116)
Loss Of Consciousness (113)
Rash (109)
Pain (109)
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Headache (108)
Overdose (105)
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Product Quality Issue (102)
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Heart Rate Increased (86)
Hallucination (80)
Feeling Abnormal (79)
Condition Aggravated (78)
Anxiety (46)
Infusion Related Reaction (46)
Tremor (45)
Fatigue (45)
Diarrhoea (43)
Convulsion (42)
Erythema (38)
Malaise (38)
Pyrexia (38)
Asthenia (37)
Swelling Face (37)
Blood Pressure Increased (37)
Pharyngeal Oedema (35)
Throat Tightness (34)
Dehydration (32)
Chest Pain (31)
Swollen Tongue (30)
Pain In Extremity (30)
Cough (30)
Oedema Peripheral (29)
Hypoaesthesia (29)
Chest Discomfort (29)
Incorrect Dose Administered (28)
Abdominal Pain Upper (27)
Eye Swelling (27)
Flushing (26)
Fall (26)
Confusional State (25)
Lip Swelling (24)
Syncope (24)

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