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Diclofenac and Methotrexate

Compare Side Effects

% of total side effects reported by users. DISCLAIMER: ALL DATA PROVIDED AS-IS. Data Source: openfda.gov.
Side EffectDiclofenacMethotrexate
DRUG INEFFECTIVE3.3% 6.7%
ARTHRALGIA2.4% 3.5%
RHEUMATOID ARTHRITIS1% 3.2%
NAUSEA3.1% 2.7%
PAIN2.9% 2.9%
INJECTION SITE PAIN0.7% 2.9%
FATIGUE2.3% 2.5%
VOMITING2.5% 1.6%
HEADACHE2.4% 2.3%
DIARRHOEA2.3% 1.7%
DYSPNOEA2.2% 1.5%
DIZZINESS2.1% 1.1%
PAIN IN EXTREMITY1.8% 2%
MALAISE1.9% 1.6%
PYREXIA1.6% 1.9%
PNEUMONIA1.3% 1.8%
DRUG INTERACTION1.7% 0.6%
JOINT SWELLING0.7% 1.6%
FALL1.5% 1.2%
ASTHENIA1.5% 1.1%
WEIGHT DECREASED1.4% 1%
BACK PAIN1.4% 1%
ABDOMINAL PAIN1.4% 0.9%
INJECTION SITE ERYTHEMA0% 1.4%
RASH1.3% 1.3%
CONDITION AGGRAVATED1.1% 1.3%
COUGH0.9% 1.3%
RENAL FAILURE ACUTE1.3% 0%
ANAEMIA1.2% 0.8%
PRURITUS1.2% 0.8%
NASOPHARYNGITIS0.6% 1.2%
DEPRESSION1.1% 0.6%
ABDOMINAL PAIN UPPER1.1% 0.6%
DECREASED APPETITE1.1% 0.5%
DRUG HYPERSENSITIVITY0.9% 1%
GAIT DISTURBANCE1% 0.9%
HYPERTENSION1% 0.8%
OFF LABEL USE0.8% 1%
CHEST PAIN1% 0.7%
INSOMNIA1% 0.5%
INFECTION0.5% 1%
PSORIASIS0% 1%
SOMNOLENCE1% 0%
SINUSITIS0% 1%
SEPSIS0.7% 0.9%
URINARY TRACT INFECTION0.7% 0.9%
OEDEMA PERIPHERAL0.9% 0.7%
MUSCULOSKELETAL STIFFNESS0.5% 0.9%
ALOPECIA0.5% 0.9%
HYPOTENSION0.9% 0.5%
ANXIETY0.9% 0.5%
CONFUSIONAL STATE0.9% 0%
HAEMOGLOBIN DECREASED0.9% 0%
GASTROINTESTINAL HAEMORRHAGE0.9% 0%
ERYTHEMA0.8% 0.7%
ARTHRITIS0.6% 0.8%
ABDOMINAL DISCOMFORT0.8% 0.6%
PARAESTHESIA0.8% 0.6%
PERIPHERAL SWELLING0.5% 0.8%
FEELING ABNORMAL0.8% 0.5%
MYOCARDIAL INFARCTION0.8% 0.4%
MUSCLE SPASMS0.8% 0.4%
MYALGIA0.8% 0.4%
RENAL FAILURE0.8% 0.4%
DRUG INTOLERANCE0% 0.8%
CONSTIPATION0.8% 0%
INJECTION SITE SWELLING0% 0.8%
INJECTION SITE PRURITUS0% 0.8%
DEHYDRATION0.8% 0%
WEIGHT INCREASED0.7% 0.7%
HYPERSENSITIVITY0.7% 0.6%
HYPOAESTHESIA0.7% 0.6%
BRONCHITIS0.5% 0.7%
DRUG DOSE OMISSION0.5% 0.7%
DEATH0.7% 0.5%
URTICARIA0.7% 0.4%
TREATMENT FAILURE0% 0.7%
PANCYTOPENIA0% 0.7%
INJECTION SITE BRUISING0% 0.7%
DRUG EFFECT INCOMPLETE0% 0.7%
DRUG EFFECT DECREASED0% 0.7%
INJECTION SITE REACTION0% 0.7%
BLOOD CREATININE INCREASED0.7% 0%
TREMOR0.7% 0%
TOXICITY TO VARIOUS AGENTS0.7% 0%
ACUTE KIDNEY INJURY0.7% 0%
LOSS OF CONSCIOUSNESS0.7% 0%
OSTEOARTHRITIS0.6% 0.6%
MUSCULOSKELETAL PAIN0.5% 0.6%
BLOOD PRESSURE INCREASED0.6% 0.5%
MUSCULAR WEAKNESS0.6% 0.4%
HERPES ZOSTER0% 0.6%
HYPERHIDROSIS0.6% 0%
OVERDOSE0.6% 0%
INCORRECT DOSE ADMINISTERED0% 0.6%
OROPHARYNGEAL PAIN0% 0.6%
NEUTROPENIA0% 0.6%
ARTHROPATHY0% 0.6%
FEBRILE NEUTROPENIA0% 0.6%
INFLUENZA0% 0.6%
HEPATIC ENZYME INCREASED0% 0.6%
ANAPHYLACTIC REACTION0.6% 0%
RENAL IMPAIRMENT0.6% 0%
GENERAL PHYSICAL HEALTH DETERIORATION0.6% 0%
GASTRIC ULCER0.6% 0%
ALANINE AMINOTRANSFERASE INCREASED0.6% 0%
MELAENA0.6% 0%
CONTUSION0.5% 0.5%
SWELLING0.5% 0.5%
THROMBOCYTOPENIA0% 0.5%
CHILLS0% 0.5%
STOMATITIS0% 0.5%
INJECTION SITE HAEMORRHAGE0% 0.5%
INFUSION RELATED REACTION0% 0.5%
MOBILITY DECREASED0% 0.5%
ANGIOEDEMA0.5% 0%
PULMONARY EMBOLISM0.5% 0%
COMPLETED SUICIDE0.5% 0%
VISION BLURRED0.5% 0%
GASTROINTESTINAL DISORDER0.5% 0%
ASPARTATE AMINOTRANSFERASE INCREASED0.5% 0%
SYNCOPE0.5% 0%
CEREBROVASCULAR ACCIDENT0.5% 0%
SUICIDE ATTEMPT0.5% 0%
CARDIAC ARREST0.5% 0%
MEMORY IMPAIRMENT0.5% 0%
PSORIATIC ARTHROPATHY0% 0.4%
INFLAMMATION0% 0.4%
CELLULITIS0% 0.4%
MUCOSAL INFLAMMATION0% 0.4%
RESPIRATORY FAILURE0% 0.4%

New treatments are found every day. View current Diclofenac research studies and Methotrexate clinical trials


Top 5 Diclofenac Reported Side Effects

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Top 5 Methotrexate Reported Side Effects

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Patient Forum

Recent Comments and Reports

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spo

I have been on methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is

I injected diclofenac injection without any accident

I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause diss

I only took it for 21 days but in that time, it put me into a full panic attack that lasted almost 8 days after I went off the medication. I had mental confusion, could not speak properly (I knew what I wanted to say but the words would not come out

I was diagnosed with Rheumatoid Arthritis about 4 years ago when I was 13 or 14, they looked at me and said I had it, they didn't do any blood tests and when they did, nothing showed. But they started me on about 5 mg of Methotrexate, Prednisone, and

Im a 44yrs old female who took methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.

Im general practioner i gave on intra mascular diclofenac for fever and body and about 8 or less he is dead inspite of using diclofeac tablet before and there is no prblem

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it

Painful cough after 2 days of 1st dose lasting-- to date-- 6 days

What did you have?

I got an Intramuscular injection of diclofenac 2weeks and i have this big induration of about 6 by 3cm.what do i do

I injected diclofenac injection without any accident

I was recently diagnosed with high cholesterol level so started taking simvastatin a week ago. Two weeks befroe that, my podiatrist prescribed diclofenac sodium for my plantar fasciitis for a month. Are these two drugs conter-indicated????&

Im general practioner i gave on intra mascular diclofenac for fever and body and about 8 or less he is dead inspite of using diclofeac tablet before and there is no prblem

Take 100mg sustained release tablets of diclofenac once every 3-4 days for arthralgia. I am 69 years old male. About one hour after taking the drug I notice I pass no urine and despite drinking several glasses of water I have no urge to urinate for

U was prescribed Lamaline to be taken with Volterene=Diclofenac sodium for arthritus pains. Can not complain. One of each three times per day and I feel like a new man. I am 71 and I feel 50. Woopie thank god for Lamailne.

What is an effective alternative to diclofenac ?

What treetment purple spot in all the body cause of diclofenac inj