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Diphenhydramine and Promethazine

Compare Side Effects

% of total side effects reported by users. DISCLAIMER: ALL DATA PROVIDED AS-IS. Data Source: openfda.gov.
Side EffectDiphenhydraminePromethazine
NAUSEA2.7% 5%
TOXICITY TO VARIOUS AGENTS4.2% 1.6%
COMPLETED SUICIDE4.2% 1.2%
VOMITING1.9% 3.2%
PAIN1.8% 3.2%
DRUG ABUSE2.9% 1%
FATIGUE2.5% 2.7%
DIARRHOEA1.8% 2.6%
DEATH2.6% 1.5%
HEADACHE2.5% 2.3%
DYSPNOEA2.3% 2.2%
ANXIETY0.9% 2.1%
PYREXIA2% 1.5%
SINUSITIS2% 0.6%
DRUG INEFFECTIVE1.6% 1.8%
DIZZINESS1.3% 1.7%
ASTHENIA1.1% 1.7%
DEPRESSION0.6% 1.7%
INFUSION RELATED REACTION1.7% 0%
PNEUMONIA1.6% 1.5%
MALAISE1% 1.6%
HYPOTENSION1.5% 1%
FALL0.9% 1.5%
ABDOMINAL PAIN0.8% 1.5%
ARTHRALGIA1.4% 1.2%
RASH1.4% 1%
WEIGHT DECREASED0.9% 1.4%
CARDIAC ARREST1.4% 0.7%
CARDIO-RESPIRATORY ARREST1.4% 0.6%
BACK PAIN0.9% 1.3%
COUGH1.2% 0.9%
CHEST PAIN0.9% 1.2%
PAIN IN EXTREMITY0.8% 1.2%
OFF LABEL USE1.2% 0.8%
INSOMNIA0.8% 1.2%
DEHYDRATION0.7% 1.2%
HYPERTENSION1% 1.1%
ANAEMIA0.8% 1.1%
PRURITUS1.1% 0.7%
OVERDOSE1.1% 0.7%
BLOOD PRESSURE INCREASED1.1% 0.6%
INJURY0% 1.1%
CONSTIPATION0.6% 1%
DECREASED APPETITE0.6% 1%
RESPIRATORY ARREST1% 0.5%
NASOPHARYNGITIS1% 0%
URINARY TRACT INFECTION0.8% 0.9%
SOMNOLENCE0.7% 0.9%
BRONCHITIS0.9% 0.6%
ABDOMINAL PAIN UPPER0.5% 0.9%
CHILLS0.9% 0.5%
WEIGHT INCREASED0.8% 0.8%
TREMOR0.6% 0.8%
CONFUSIONAL STATE0.6% 0.8%
DRUG HYPERSENSITIVITY0.6% 0.8%
MUSCLE SPASMS0.5% 0.8%
CONDITION AGGRAVATED0.5% 0.8%
OEDEMA PERIPHERAL0.5% 0.8%
DEEP VEIN THROMBOSIS0% 0.8%
DRUG DOSE OMISSION0% 0.8%
PULMONARY EMBOLISM0% 0.8%
URTICARIA0.8% 0%
TACHYCARDIA0.8% 0%
DRUG INTERACTION0.7% 0.6%
SEPSIS0.7% 0.5%
HYPERHIDROSIS0.5% 0.7%
HYPOAESTHESIA0.5% 0.7%
HYPERSENSITIVITY0.7% 0.5%
GAIT DISTURBANCE0.4% 0.7%
FEELING ABNORMAL0.4% 0.7%
MIGRAINE0% 0.7%
CHOLECYSTITIS CHRONIC0% 0.7%
EMOTIONAL DISTRESS0% 0.7%
ERYTHEMA0.7% 0%
FEBRILE NEUTROPENIA0.7% 0%
DRUG TOXICITY0.7% 0%
UPPER RESPIRATORY TRACT INFECTION0.7% 0%
FLUSHING0.7% 0%
INTENTIONAL DRUG MISUSE0.7% 0%
HEART RATE INCREASED0.7% 0%
INTENTIONAL OVERDOSE0.7% 0%
DIABETES MELLITUS0% 0.7%
LOSS OF CONSCIOUSNESS0.6% 0.6%
PARAESTHESIA0.5% 0.6%
HAEMOGLOBIN DECREASED0.5% 0.6%
AGITATION0.5% 0.6%
RENAL FAILURE0.5% 0.6%
SUICIDE ATTEMPT0.4% 0.6%
SYNCOPE0% 0.6%
CHOLELITHIASIS0% 0.6%
GASTROOESOPHAGEAL REFLUX DISEASE0% 0.6%
CARDIAC FAILURE CONGESTIVE0% 0.6%
MYOCARDIAL INFARCTION0% 0.6%
CEREBROVASCULAR ACCIDENT0% 0.6%
NEUTROPENIA0.6% 0%
PULMONARY OEDEMA0.6% 0%
RHEUMATOID ARTHRITIS0.6% 0%
OXYGEN SATURATION DECREASED0.6% 0%
THROMBOCYTOPENIA0.6% 0%
INFECTION0.6% 0%
MYALGIA0.5% 0.5%
DYSPHAGIA0.4% 0.5%
ATRIAL FIBRILLATION0.4% 0.5%
BLOOD GLUCOSE INCREASED0% 0.5%
GALLBLADDER DISORDER0% 0.5%
VISION BLURRED0% 0.5%
ABDOMINAL DISCOMFORT0% 0.5%
NEUROPATHY PERIPHERAL0% 0.5%
RENAL FAILURE ACUTE0% 0.5%
CONTUSION0% 0.5%
OSTEOPOROSIS0% 0.5%
CONVULSION0% 0.5%
CHRONIC OBSTRUCTIVE PULMONARY DISEASE0% 0.5%
ALOPECIA0% 0.5%
PALPITATIONS0% 0.5%
ABDOMINAL DISTENSION0% 0.5%
MEMORY IMPAIRMENT0% 0.5%
PERIPHERAL SWELLING0.5% 0%
INFLUENZA0.5% 0%
WHITE BLOOD CELL COUNT DECREASED0.5% 0%
JOINT SWELLING0.5% 0%
PLEURAL EFFUSION0.5% 0%
POISONING0.5% 0%
CHEST DISCOMFORT0.5% 0%
DYSPEPSIA0% 0.5%
RESPIRATORY FAILURE0.5% 0%
ACCIDENTAL OVERDOSE0.4% 0%
UNRESPONSIVE TO STIMULI0.4% 0%
OROPHARYNGEAL PAIN0.4% 0%

New treatments are found every day. View current Diphenhydramine research studies and Promethazine clinical trials


Top 5 Diphenhydramine Reported Side Effects

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Top 5 Promethazine Reported Side Effects

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Patient Forum

Recent Comments and Reports

**The reason i reccomend 300-350mg is because i did that ammount 2 times with benadryl and it wasnt the best but i dont think it was horrible, and the second time i did 325mg and mixed it with weed and a few mood helper pills i found at my sisters ho

A few days ago i took 450 mg of diphenhydramine in sleeping pills, i know it is extremely stupid and i regret it 100%, first off when i took it i was very stoned and i thought they were benadryl because all i read was the diphenhydramine, about a hal

I loved these strips. I have had allergic reactions to my own allergy shots. After waiting at the Dr.'s office for 15 minutes after my allergy shot, I leave to go shopping. Sometimes I can feel a little thickening in my throat, similar to when I'v

Ive been taking Diphenhydramine 25-50mgms nightly for some years,and my pharmacist is concerned that there may be some long-term psychological problems if I continue taking them,is this a serious concern?

NEVER AGAIN....!! I have never felt more out of control whilst taking these pills. Pounding headaches, nightmares, fear of falling asleep. Who ever came up with this should be locked in a room with the stuff...!!

A few days ago i took 450 mg of diphenhydramine in sleeping pills, i know it is extremely stupid and i regret it 100%, first off when i took it i was very stoned and i thought they were benadryl because all i read was the diphenhydramine, about a hal

Ive been taking Diphenhydramine 25-50mgms nightly for some years,and my pharmacist is concerned that there may be some long-term psychological problems if I continue taking them,is this a serious concern?

Took it at midday the day before (1, 250mg), this morning my face was slightly swollen, my cheeks and lips are tender (tingling). Took some antihistamine (Diphenhydramine). Waiting to see what happens.