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Diphenhydramine and Zyrtec

Compare Side Effects

% of total side effects reported by users. DISCLAIMER: ALL DATA PROVIDED AS-IS. Data Source: openfda.gov.
Side EffectDiphenhydramineZyrtec
DRUG INEFFECTIVE1.6% 4.7%
TOXICITY TO VARIOUS AGENTS4.2% 0%
COMPLETED SUICIDE4.2% 0%
FATIGUE2.5% 3.2%
NAUSEA2.7% 3.1%
HEADACHE2.5% 2.9%
DRUG ABUSE2.9% 0%
OFF LABEL USE1.2% 2.6%
DEATH2.6% 0%
DYSPNOEA2.3% 2.4%
PAIN1.8% 2.3%
DIZZINESS1.3% 2.2%
PRURITUS1.1% 2.1%
DIARRHOEA1.8% 2%
PYREXIA2% 1.2%
SINUSITIS2% 1.1%
SOMNOLENCE0.7% 2%
VOMITING1.9% 1.7%
PRODUCT USE ISSUE0% 1.8%
INFUSION RELATED REACTION1.7% 0%
RASH1.4% 1.6%
PNEUMONIA1.6% 1%
ANXIETY0.9% 1.6%
INSOMNIA0.8% 1.6%
MALAISE1% 1.5%
HYPOTENSION1.5% 0.5%
ARTHRALGIA1.4% 1.4%
COUGH1.2% 1.4%
URTICARIA0.8% 1.4%
CARDIO-RESPIRATORY ARREST1.4% 0%
CARDIAC ARREST1.4% 0%
ASTHENIA1.1% 1.3%
DEPRESSION0.6% 1.3%
FEELING ABNORMAL0.4% 1.3%
FALL0.9% 1.2%
PAIN IN EXTREMITY0.8% 1.2%
THERAPEUTIC RESPONSE UNEXPECTED0% 1.2%
PRODUCT QUALITY ISSUE0% 1.2%
HYPERSENSITIVITY0.7% 1.1%
OVERDOSE1.1% 0.6%
BLOOD PRESSURE INCREASED1.1% 0.6%
CHEST PAIN0.9% 1%
BACK PAIN0.9% 1%
WEIGHT DECREASED0.9% 1%
HYPERTENSION1% 0.9%
ABDOMINAL PAIN0.8% 1%
WEIGHT INCREASED0.8% 1%
NASOPHARYNGITIS1% 0.6%
ASTHMA0% 1%
RESPIRATORY ARREST1% 0%
BRONCHITIS0.9% 0.6%
ABDOMINAL PAIN UPPER0.5% 0.9%
CONDITION AGGRAVATED0.5% 0.9%
CHILLS0.9% 0.5%
INCORRECT DOSE ADMINISTERED0% 0.9%
URINARY TRACT INFECTION0.8% 0.6%
CONSTIPATION0.6% 0.8%
ANAEMIA0.8% 0.5%
MUSCLE SPASMS0.5% 0.8%
PARAESTHESIA0.5% 0.8%
INJECTION SITE PAIN0% 0.8%
TACHYCARDIA0.8% 0%
DRUG DOSE OMISSION0% 0.8%
ERYTHEMA0.7% 0.7%
FLUSHING0.7% 0.6%
DECREASED APPETITE0.6% 0.7%
TREMOR0.6% 0.7%
DEHYDRATION0.7% 0.6%
OEDEMA PERIPHERAL0.5% 0.7%
HYPOAESTHESIA0.5% 0.7%
MYALGIA0.5% 0.7%
HEART RATE INCREASED0.7% 0.5%
DRUG TOXICITY0.7% 0%
FEBRILE NEUTROPENIA0.7% 0%
UPPER RESPIRATORY TRACT INFECTION0.7% 0%
SEPSIS0.7% 0%
INTENTIONAL DRUG MISUSE0.7% 0%
DRUG INTERACTION0.7% 0%
INTENTIONAL OVERDOSE0.7% 0%
DRUG HYPERSENSITIVITY0.6% 0.6%
CONFUSIONAL STATE0.6% 0.5%
LOSS OF CONSCIOUSNESS0.6% 0.5%
HYPERHIDROSIS0.5% 0.6%
CHEST DISCOMFORT0.5% 0.6%
GAIT DISTURBANCE0.4% 0.6%
INFECTION0.6% 0%
PULMONARY OEDEMA0.6% 0%
GASTROOESOPHAGEAL REFLUX DISEASE0% 0.6%
RHEUMATOID ARTHRITIS0.6% 0%
OXYGEN SATURATION DECREASED0.6% 0%
THROMBOCYTOPENIA0.6% 0%
NEUTROPENIA0.6% 0%
PULMONARY EMBOLISM0% 0.6%
PALPITATIONS0% 0.6%
ALOPECIA0% 0.6%
VISION BLURRED0% 0.6%
ABDOMINAL DISCOMFORT0% 0.6%
MIGRAINE0% 0.6%
DRUG INEFFECTIVE FOR UNAPPROVED INDICATION0% 0.6%
PRODUCT USE IN UNAPPROVED INDICATION0% 0.6%
PERIPHERAL SWELLING0.5% 0.4%
OROPHARYNGEAL PAIN0.4% 0.5%
DRY MOUTH0% 0.5%
BLOOD GLUCOSE INCREASED0% 0.5%
INJURY0% 0.5%
HAEMOGLOBIN DECREASED0.5% 0%
DEEP VEIN THROMBOSIS0% 0.5%
MEMORY IMPAIRMENT0% 0.5%
DYSPEPSIA0% 0.5%
WHEEZING0% 0.5%
DYSGEUSIA0% 0.5%
WRONG TECHNIQUE IN PRODUCT USAGE PROCESS0% 0.5%
CONTUSION0% 0.5%
POISONING0.5% 0%
INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION0% 0.5%
PLEURAL EFFUSION0.5% 0%
RESPIRATORY FAILURE0.5% 0%
JOINT SWELLING0.5% 0%
WHITE BLOOD CELL COUNT DECREASED0.5% 0%
AGITATION0.5% 0%
RENAL FAILURE0.5% 0%
INFLUENZA0.5% 0%
DYSPHAGIA0.4% 0.4%
DRUG EFFECT INCOMPLETE0% 0.4%
CEREBROVASCULAR ACCIDENT0% 0.4%
ABDOMINAL DISTENSION0% 0.4%
MUSCULAR WEAKNESS0% 0.4%
RHINORRHOEA0% 0.4%
DRUG ADMINISTERED TO PATIENT OF INAPPROPRIATE AGE0% 0.4%
INJECTION SITE ERYTHEMA0% 0.4%
ATRIAL FIBRILLATION0.4% 0%
SUICIDE ATTEMPT0.4% 0%
ACCIDENTAL OVERDOSE0.4% 0%
EXPIRED PRODUCT ADMINISTERED0% 0.4%
UNRESPONSIVE TO STIMULI0.4% 0%

New treatments are found every day. View current Diphenhydramine research studies and Zyrtec clinical trials


Top 5 Diphenhydramine Reported Side Effects

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Top 5 Zyrtec Reported Side Effects

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Patient Forum

Recent Comments and Reports

**The reason i reccomend 300-350mg is because i did that ammount 2 times with benadryl and it wasnt the best but i dont think it was horrible, and the second time i did 325mg and mixed it with weed and a few mood helper pills i found at my sisters ho

A few days ago i took 450 mg of diphenhydramine in sleeping pills, i know it is extremely stupid and i regret it 100%, first off when i took it i was very stoned and i thought they were benadryl because all i read was the diphenhydramine, about a hal

Bad gastritis or abdominal pain; had to get into tub with hot shower on my belly;never had a worse experience or pain; thought I was going to die; malaise; moderate ear pain

Does Zyrtec inrease blood sugar levels? I have been taking 10m a day for 10 days and have notices symptoms of high blood sugar, when tested it was in the high 100's. Has anyone heard of this side effect?

Have you had him checked for P.A.N.D.A.S which is a syndrome related to strep throat. One major symptom can be sudden onset of Tourette's. ALso can cause OCD, depression, and other psychiatric conditions. My son has it. SOme doctors don't believe in

I have a 12 year old son who took Zyrtec for year-round allergies. He now has tourettes syndrome and westrongly feelthe Zyrtec played a role in this health issue. I started searching the web for info regarding

I have had and am having a bad reaction to Zyrtec. My eyes are inflamed and my throat is sore. Lips are swollen. My tongue is white. I will be forced to go to the Emergency at the hospital.

I have Type 2 Diabetes, when taking my level in the morning I noticed my level was elevated, and the only thing I had ingested was a Zyrtec pill about 2 hours prior? Could the pill be the cause?

I loved these strips. I have had allergic reactions to my own allergy shots. After waiting at the Dr.'s office for 15 minutes after my allergy shot, I leave to go shopping. Sometimes I can feel a little thickening in my throat, similar to when I'v

I took one dose and experienced a bout of pancreatitis. I suffer from chronic pancreatitis and know what most of my 'triggers' are.....never thought a simple allergy medication would cause such a problem, I think I would rather suffer allergies than

I took Zyrtec for a week and while it does solve my allergy issues, it makes me a raving lunatic. Severe aggression, mood swings, and nightmares are the norm for me n this medicine. I would not recommend it if you are taking any a

Ive been taking Diphenhydramine 25-50mgms nightly for some years,and my pharmacist is concerned that there may be some long-term psychological problems if I continue taking them,is this a serious concern?

A few days ago i took 450 mg of diphenhydramine in sleeping pills, i know it is extremely stupid and i regret it 100%, first off when i took it i was very stoned and i thought they were benadryl because all i read was the diphenhydramine, about a hal

Ive been taking Diphenhydramine 25-50mgms nightly for some years,and my pharmacist is concerned that there may be some long-term psychological problems if I continue taking them,is this a serious concern?

Took it at midday the day before (1, 250mg), this morning my face was slightly swollen, my cheeks and lips are tender (tingling). Took some antihistamine (Diphenhydramine). Waiting to see what happens.