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Metformin and Methotrexate

Compare Side Effects

% of total side effects reported by users. DISCLAIMER: ALL DATA PROVIDED AS-IS. Data Source: openfda.gov.
Side EffectMetforminMethotrexate
DRUG INEFFECTIVE2.9% 7.7%
BLOOD GLUCOSE INCREASED4.6% 0%
NAUSEA4.1% 2.8%
ARTHRALGIA1.1% 3.4%
RHEUMATOID ARTHRITIS0% 3.4%
DIARRHOEA3.3% 1.7%
PAIN1.7% 2.9%
WEIGHT DECREASED2.7% 0.9%
FATIGUE2.4% 2.5%
VOMITING2.5% 1.6%
INJECTION SITE PAIN1.1% 2.5%
HEADACHE1.8% 2.2%
DYSPNOEA2.1% 1.5%
DIZZINESS2.1% 1.1%
PAIN IN EXTREMITY1.2% 2%
LACTIC ACIDOSIS2% 0%
PYREXIA0.9% 1.8%
MALAISE1.7% 1.5%
PNEUMONIA1% 1.7%
ASTHENIA1.6% 1%
DECREASED APPETITE1.6% 0.5%
JOINT SWELLING0% 1.6%
RASH1% 1.4%
DRUG HYPERSENSITIVITY0.5% 1.4%
ACUTE KIDNEY INJURY1.4% 0%
FALL1.3% 1.1%
COUGH0.9% 1.3%
CONDITION AGGRAVATED0.7% 1.3%
DRUG DOSE OMISSION1.2% 0.7%
NASOPHARYNGITIS0.5% 1.2%
DRUG INTOLERANCE0% 1.2%
INJECTION SITE ERYTHEMA0% 1.2%
HYPOGLYCAEMIA1.2% 0%
BLOOD GLUCOSE DECREASED1.2% 0%
OFF LABEL USE1.1% 1.1%
BACK PAIN0.9% 1%
PRURITUS1% 0.8%
ABDOMINAL PAIN1% 0.8%
WEIGHT INCREASED1% 0.7%
HYPOTENSION1% 0.5%
ALOPECIA0.5% 1%
MYOCARDIAL INFARCTION1% 0.4%
PSORIASIS0% 1%
RENAL FAILURE ACUTE1% 0%
SINUSITIS0% 1%
INFECTION0% 1%
HYPERTENSION0.9% 0.8%
URINARY TRACT INFECTION0.7% 0.9%
CHEST PAIN0.9% 0.6%
SEPSIS0.5% 0.9%
PERIPHERAL SWELLING0.5% 0.9%
DEATH0.9% 0.5%
DRUG INTERACTION0.9% 0.5%
ABDOMINAL PAIN UPPER0.9% 0.5%
INSOMNIA0.9% 0.5%
FEELING ABNORMAL0.9% 0.5%
RENAL FAILURE0.9% 0.4%
DIABETES MELLITUS0.9% 0%
DEHYDRATION0.9% 0%
DRUG EFFECT INCOMPLETE0% 0.9%
MUSCULOSKELETAL STIFFNESS0% 0.9%
TREATMENT FAILURE0% 0.9%
DRUG EFFECT DECREASED0% 0.9%
ANAEMIA0.8% 0.7%
GAIT DISTURBANCE0.7% 0.8%
ANXIETY0.8% 0.4%
CONFUSIONAL STATE0.8% 0%
ARTHRITIS0% 0.8%
SOMNOLENCE0.8% 0%
CONSTIPATION0.8% 0%
ABDOMINAL DISCOMFORT0.7% 0.7%
DEPRESSION0.7% 0.6%
OEDEMA PERIPHERAL0.7% 0.6%
INCORRECT DOSE ADMINISTERED0.7% 0.5%
MUSCLE SPASMS0.7% 0.4%
TOXICITY TO VARIOUS AGENTS0.7% 0.4%
INJECTION SITE SWELLING0% 0.7%
INJECTION SITE PRURITUS0% 0.7%
PANCYTOPENIA0% 0.7%
BRONCHITIS0% 0.7%
GLYCOSYLATED HAEMOGLOBIN INCREASED0.7% 0%
TREMOR0.7% 0%
CEREBROVASCULAR ACCIDENT0.7% 0%
HYPERHIDROSIS0.7% 0%
MYALGIA0.7% 0%
METABOLIC ACIDOSIS0.7% 0%
PARAESTHESIA0.6% 0.5%
ERYTHEMA0.5% 0.6%
INJECTION SITE HAEMORRHAGE0.6% 0.5%
HYPOAESTHESIA0.5% 0.6%
BLOOD PRESSURE INCREASED0.6% 0.4%
HYPERSENSITIVITY0.4% 0.6%
HERPES ZOSTER0% 0.6%
ARTHROPATHY0% 0.6%
OSTEOARTHRITIS0% 0.6%
INJECTION SITE BRUISING0% 0.6%
INFLUENZA0% 0.6%
MUSCULOSKELETAL PAIN0% 0.6%
FEBRILE NEUTROPENIA0% 0.6%
HEPATIC ENZYME INCREASED0% 0.6%
NEUTROPENIA0% 0.6%
INJECTION SITE REACTION0% 0.6%
SWELLING0% 0.6%
CARDIAC FAILURE CONGESTIVE0.6% 0%
PRODUCT QUALITY ISSUE0.6% 0%
PANCREATITIS0.6% 0%
FLUSHING0.6% 0%
DIABETIC KETOACIDOSIS0.6% 0%
BLADDER CANCER0.6% 0%
VISION BLURRED0.6% 0%
MUSCULAR WEAKNESS0.5% 0.4%
COMPLETED SUICIDE0.5% 0%
INFUSION RELATED REACTION0% 0.5%
THROMBOCYTOPENIA0% 0.5%
MUCOSAL INFLAMMATION0% 0.5%
STOMATITIS0% 0.5%
OROPHARYNGEAL PAIN0% 0.5%
MOBILITY DECREASED0% 0.5%
HYPERGLYCAEMIA0.5% 0%
ATRIAL FIBRILLATION0.5% 0%
LOSS OF CONSCIOUSNESS0.5% 0%
OVERDOSE0.5% 0%
DYSPEPSIA0.5% 0%
GASTROINTESTINAL HAEMORRHAGE0.5% 0%
ABDOMINAL DISTENSION0.5% 0%
SYNCOPE0.5% 0%
BLOOD CREATININE INCREASED0.5% 0%
HYPERKALAEMIA0.5% 0%
DIABETES MELLITUS INADEQUATE CONTROL0.5% 0%
MEMORY IMPAIRMENT0.5% 0%
SYNOVITIS0% 0.5%
URTICARIA0.4% 0.4%
CONTUSION0% 0.4%
CHILLS0% 0.4%
HAEMOGLOBIN DECREASED0.4% 0%
PSORIATIC ARTHROPATHY0% 0.4%
CELLULITIS0% 0.4%
RENAL IMPAIRMENT0.4% 0%
INFLAMMATION0% 0.4%

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