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Metformin and Methotrexate

Compare Side Effects

% of total side effects reported by users. DISCLAIMER: ALL DATA PROVIDED AS-IS. Data Source: openfda.gov.
Side EffectMetforminMethotrexate
DRUG INEFFECTIVE2.9% 7.1%
BLOOD GLUCOSE INCREASED4.8% 0%
NAUSEA4.1% 2.7%
ARTHRALGIA1.1% 3.5%
RHEUMATOID ARTHRITIS0% 3.3%
DIARRHOEA3.2% 1.7%
PAIN1.7% 2.9%
INJECTION SITE PAIN1% 2.8%
WEIGHT DECREASED2.7% 1%
FATIGUE2.4% 2.5%
VOMITING2.5% 1.6%
HEADACHE1.8% 2.3%
DYSPNOEA2.1% 1.5%
DIZZINESS2.1% 1.1%
PAIN IN EXTREMITY1.2% 2%
PYREXIA0.9% 1.9%
LACTIC ACIDOSIS1.9% 0%
MALAISE1.7% 1.6%
PNEUMONIA1% 1.7%
ASTHENIA1.6% 1.1%
DECREASED APPETITE1.6% 0.5%
JOINT SWELLING0% 1.6%
FALL1.4% 1.2%
RASH1% 1.3%
COUGH0.9% 1.3%
CONDITION AGGRAVATED0.7% 1.3%
BLOOD GLUCOSE DECREASED1.3% 0%
INJECTION SITE ERYTHEMA0% 1.3%
DRUG DOSE OMISSION1.2% 0.7%
NASOPHARYNGITIS0.5% 1.2%
DRUG HYPERSENSITIVITY0.4% 1.2%
HYPOGLYCAEMIA1.2% 0%
ACUTE KIDNEY INJURY1.2% 0%
OFF LABEL USE1.1% 1%
RENAL FAILURE ACUTE1.1% 0%
BACK PAIN0.9% 1%
ABDOMINAL PAIN1% 0.9%
PRURITUS1% 0.8%
WEIGHT INCREASED1% 0.7%
HYPOTENSION1% 0.5%
MYOCARDIAL INFARCTION1% 0.4%
INFECTION0% 1%
SINUSITIS0% 1%
PSORIASIS0% 1%
DRUG INTOLERANCE0% 1%
HYPERTENSION0.9% 0.8%
GAIT DISTURBANCE0.7% 0.9%
URINARY TRACT INFECTION0.7% 0.9%
CHEST PAIN0.9% 0.7%
ABDOMINAL PAIN UPPER0.9% 0.6%
ALOPECIA0.5% 0.9%
PERIPHERAL SWELLING0.5% 0.9%
FEELING ABNORMAL0.9% 0.5%
DEATH0.9% 0.5%
DRUG INTERACTION0.9% 0.5%
INSOMNIA0.9% 0.5%
SEPSIS0.4% 0.9%
DEHYDRATION0.9% 0%
MUSCULOSKELETAL STIFFNESS0% 0.9%
DIABETES MELLITUS0.9% 0%
ANAEMIA0.8% 0.7%
DEPRESSION0.8% 0.6%
ANXIETY0.8% 0.5%
RENAL FAILURE0.8% 0.4%
DRUG EFFECT INCOMPLETE0% 0.8%
DRUG EFFECT DECREASED0% 0.8%
INJECTION SITE PRURITUS0% 0.8%
TREATMENT FAILURE0% 0.8%
SOMNOLENCE0.8% 0%
CONSTIPATION0.8% 0%
ARTHRITIS0% 0.8%
CONFUSIONAL STATE0.8% 0%
OEDEMA PERIPHERAL0.7% 0.6%
ABDOMINAL DISCOMFORT0.6% 0.7%
INCORRECT DOSE ADMINISTERED0.7% 0.5%
ERYTHEMA0.5% 0.7%
MUSCLE SPASMS0.7% 0.4%
MYALGIA0.7% 0.4%
BRONCHITIS0% 0.7%
INJECTION SITE SWELLING0% 0.7%
PANCYTOPENIA0% 0.7%
GLYCOSYLATED HAEMOGLOBIN INCREASED0.7% 0%
HYPERHIDROSIS0.7% 0%
CEREBROVASCULAR ACCIDENT0.7% 0%
PANCREATITIS0.7% 0%
TREMOR0.7% 0%
INJECTION SITE REACTION0% 0.7%
PARAESTHESIA0.6% 0.5%
BLOOD PRESSURE INCREASED0.6% 0.5%
HYPOAESTHESIA0.5% 0.6%
TOXICITY TO VARIOUS AGENTS0.6% 0.4%
HYPERSENSITIVITY0.4% 0.6%
HERPES ZOSTER0% 0.6%
SWELLING0% 0.6%
OSTEOARTHRITIS0% 0.6%
NEUTROPENIA0% 0.6%
ARTHROPATHY0% 0.6%
FEBRILE NEUTROPENIA0% 0.6%
INJECTION SITE BRUISING0% 0.6%
HEPATIC ENZYME INCREASED0% 0.6%
INFLUENZA0% 0.6%
MUSCULOSKELETAL PAIN0% 0.6%
OROPHARYNGEAL PAIN0% 0.6%
METABOLIC ACIDOSIS0.6% 0%
PRODUCT QUALITY ISSUE0.6% 0%
VISION BLURRED0.6% 0%
DIABETIC KETOACIDOSIS0.6% 0%
BLADDER CANCER0.6% 0%
FLUSHING0.6% 0%
CARDIAC FAILURE CONGESTIVE0.6% 0%
COMPLETED SUICIDE0.6% 0%
INJECTION SITE HAEMORRHAGE0.5% 0.5%
MUSCULAR WEAKNESS0.5% 0.4%
BLOOD CREATININE INCREASED0.5% 0%
HYPERKALAEMIA0.5% 0%
MEMORY IMPAIRMENT0.5% 0%
MOBILITY DECREASED0% 0.5%
THROMBOCYTOPENIA0% 0.5%
INFUSION RELATED REACTION0% 0.5%
STOMATITIS0% 0.5%
SYNCOPE0.5% 0%
DIABETES MELLITUS INADEQUATE CONTROL0.5% 0%
ABDOMINAL DISTENSION0.5% 0%
GASTROINTESTINAL HAEMORRHAGE0.5% 0%
HYPERGLYCAEMIA0.5% 0%
OVERDOSE0.5% 0%
ATRIAL FIBRILLATION0.5% 0%
LOSS OF CONSCIOUSNESS0.5% 0%
DYSPEPSIA0.5% 0%
URTICARIA0.4% 0.4%
CELLULITIS0% 0.4%
INFLAMMATION0% 0.4%
SYNOVITIS0% 0.4%
MUCOSAL INFLAMMATION0% 0.4%
CONTUSION0% 0.4%
RENAL IMPAIRMENT0.4% 0%
CHILLS0% 0.4%
CARDIAC ARREST0.4% 0%

New treatments are found every day. View current Metformin research studies and Methotrexate clinical trials


Top 5 Metformin Reported Side Effects

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Top 5 Methotrexate Reported Side Effects

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Patient Forum

Recent Comments and Reports

At what age should stop taking this drug?

Been on metformin for 4 days so far for Pcos and have eaten it with food and i am having sever diahrea and cramps. i have to take 500mg once a day for 2 weeks and then 2 times a day for 2 weeks and then 3 times a day and i dunno how to make

Bleeding gums

By using the medicine for 3 months,there was symptoms of impotency.

Coma causing motor cycle accident. brain damage. family difficulties not being able to work causing financial problems

Ever since I started taking Metformin almost a year now, I have had a cough and it will not go away.

Fatigue severe pain down left arm dizziness shortness of breath palputations and shere lack of get up and go

Feeling nervous

Feeling sleepy, fatigue, and tiredall the time. My vision is also gone seriously blurred.

Got up this morning and I was covered with a rash much like poisen ivy, and very itchy. Also my eyes were almost swelled shut. and the bag part under my eyes was full of fluid. Quit the Med formin immedietly and seem bet

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spo

I have experienced weight loss of a pound a month for the last 2 years, since taking 100 mcg per day. My dr. can find no cause for this loss. I also have taken Metformin for about the same amount of time.

48YO male, obese, diabetic, hypertensive, mild anxiety and depression. R BKA, R Acetabula fracture 13 years ago from motorcycle accident. Swollen gall bladder removed during hospitalization. Current meds include Metformin (withheld pre- and post- ct)

61 years old male. Metformin 2,000 mg + Actos 15 mg/day After losing 20% body weight in one year, apparently began 14 month episode of hypoclycemia unawareness (bad crashes without warning, impaired cognitive function). Finally s

A few weeks ago I went to see the doctor because my hand was so swollen that I could not open them in the morning. I take metformin as well and now my fingers have swelled and they have turned a bit of purplish in color now the color has faded and my

A wound in my right foot (on which I have to step) is very painful. I have diabetics and take some medicines such as metformin, Cardiloc and other medicines for diabetics, high blood pressure, high triglicydes and risk of heart problems and aspirin.

After just 7 days of starting pioglitazone(15 mg.daily) ,I developed loss of taste for mainly sugar and salt,but unfortunatyely i couldnot guess pioglitazone as possible cause. I am type 2 diabetic and hypertensive and taking metformin,glimeperide,li

Been on metformin for 4 days so far for Pcos and have eaten it with food and i am having sever diahrea and cramps. i have to take 500mg once a day for 2 weeks and then 2 times a day for 2 weeks and then 3 times a day and i dunno how to make

Can i buy glyburide/metformin 5/500 in the philippines?

Ever since I started taking Metformin almost a year now, I have had a cough and it will not go away.

I am 59 years Indian male. Have been on diabetes medication for the past 14 years. Presently, I am on gliclazide 80 mg and metformin 500mg twice a day and Januvia 100 mg OD. This combination was prescribed in Sept 2009.