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Methotrexate and Diphenhydramine

Compare Side Effects

% of total side effects reported by users. DISCLAIMER: ALL DATA PROVIDED AS-IS. Data Source: openfda.gov.
Side EffectMethotrexateDiphenhydramine
DRUG INEFFECTIVE4.9% 1.5%
COMPLETED SUICIDE0% 4%
TOXICITY TO VARIOUS AGENTS0% 3.8%
ARTHRALGIA3.6% 1.3%
INJECTION SITE PAIN3.5% 0%
DRUG ABUSE0% 3.1%
RHEUMATOID ARTHRITIS3% 0.6%
PAIN2.9% 1.8%
NAUSEA2.7% 2.7%
DEATH0.6% 2.7%
HEADACHE2.4% 2.6%
FATIGUE2.5% 2.5%
DYSPNOEA1.6% 2.3%
SINUSITIS1.2% 2.2%
PYREXIA2.1% 2%
PAIN IN EXTREMITY2.1% 0.8%
VOMITING1.6% 1.9%
PNEUMONIA1.9% 1.6%
DIARRHOEA1.8% 1.7%
INFUSION RELATED REACTION0.6% 1.7%
INJECTION SITE ERYTHEMA1.7% 0%
MALAISE1.6% 0.9%
HYPOTENSION0.6% 1.5%
JOINT SWELLING1.5% 0.4%
CARDIAC ARREST0% 1.5%
RASH1.3% 1.4%
COUGH1.4% 1.1%
NASOPHARYNGITIS1.4% 1%
CARDIO-RESPIRATORY ARREST0% 1.4%
DIZZINESS1.2% 1.3%
ASTHENIA1.2% 1.1%
FALL1.2% 0.9%
CONDITION AGGRAVATED1.2% 0.5%
BACK PAIN1.1% 1%
OFF LABEL USE0.8% 1.1%
PRURITUS0.8% 1.1%
BLOOD PRESSURE INCREASED0.5% 1.1%
OVERDOSE0% 1.1%
RESPIRATORY ARREST0% 1.1%
WEIGHT DECREASED1% 0.9%
BRONCHITIS0.8% 1%
HYPERTENSION0.8% 1%
URINARY TRACT INFECTION1% 0.8%
SEPSIS1% 0.7%
INFECTION1% 0.6%
INJECTION SITE PRURITUS1% 0%
PSORIASIS1% 0%
ABDOMINAL PAIN0.9% 0.8%
CHEST PAIN0.7% 0.9%
CHILLS0.5% 0.9%
ANXIETY0.5% 0.9%
GAIT DISTURBANCE0.9% 0.4%
TACHYCARDIA0% 0.9%
INJECTION SITE SWELLING0.9% 0%
ANAEMIA0.8% 0.8%
WEIGHT INCREASED0.7% 0.8%
INSOMNIA0.6% 0.8%
OEDEMA PERIPHERAL0.8% 0.5%
INTENTIONAL DRUG MISUSE0% 0.8%
DRUG TOXICITY0% 0.8%
UPPER RESPIRATORY TRACT INFECTION0% 0.8%
ARTHRITIS0.8% 0%
MUSCULOSKELETAL STIFFNESS0.8% 0%
DRUG DOSE OMISSION0.8% 0%
INJECTION SITE BRUISING0.8% 0%
ERYTHEMA0.7% 0.7%
DRUG INTERACTION0.6% 0.7%
FEBRILE NEUTROPENIA0.6% 0.7%
HYPERSENSITIVITY0.6% 0.7%
HYPOAESTHESIA0.7% 0.5%
URTICARIA0.5% 0.7%
ALOPECIA0.7% 0%
HEART RATE INCREASED0% 0.7%
INCORRECT DOSE ADMINISTERED0.7% 0%
PANCYTOPENIA0.7% 0%
INJECTION SITE REACTION0.7% 0%
FLUSHING0% 0.7%
SOMNOLENCE0% 0.7%
DEHYDRATION0% 0.7%
INTENTIONAL OVERDOSE0% 0.7%
PERIPHERAL SWELLING0.7% 0%
NEUTROPENIA0.6% 0.6%
DEPRESSION0.6% 0.6%
ABDOMINAL PAIN UPPER0.6% 0.5%
INFLUENZA0.6% 0.5%
DRUG HYPERSENSITIVITY0.6% 0.5%
THROMBOCYTOPENIA0.5% 0.6%
DECREASED APPETITE0.5% 0.6%
PARAESTHESIA0.6% 0.5%
OROPHARYNGEAL PAIN0.6% 0.4%
POISONING0% 0.6%
PULMONARY OEDEMA0% 0.6%
HEPATIC ENZYME INCREASED0.6% 0%
CONSTIPATION0% 0.6%
FEELING ABNORMAL0.6% 0%
HAEMOGLOBIN DECREASED0% 0.6%
LOSS OF CONSCIOUSNESS0% 0.6%
ARTHROPATHY0.6% 0%
OXYGEN SATURATION DECREASED0% 0.6%
TREMOR0% 0.6%
DRUG EFFECT DECREASED0.6% 0%
MUSCULOSKELETAL PAIN0.6% 0%
INJECTION SITE HAEMORRHAGE0.6% 0%
CONFUSIONAL STATE0% 0.6%
HERPES ZOSTER0.6% 0%
MOBILITY DECREASED0.6% 0%
RENAL FAILURE0.5% 0.5%
MUSCLE SPASMS0.5% 0.5%
RESPIRATORY FAILURE0.5% 0.5%
MYALGIA0.4% 0.5%
MYOCARDIAL INFARCTION0.5% 0%
CHEST DISCOMFORT0% 0.5%
STOMATITIS0.5% 0%
CELLULITIS0.5% 0%
PLEURAL EFFUSION0% 0.5%
AGITATION0% 0.5%
HYPERHIDROSIS0% 0.5%
WHITE BLOOD CELL COUNT DECREASED0% 0.5%
CONVULSION0% 0.5%
OSTEOARTHRITIS0.5% 0%
SWELLING0.5% 0%
ABDOMINAL DISCOMFORT0.5% 0%
INJECTION SITE HAEMATOMA0.5% 0%
CONTUSION0.5% 0%
DRUG INTOLERANCE0.5% 0%
SUICIDE ATTEMPT0% 0.4%
UNRESPONSIVE TO STIMULI0% 0.4%
EAR INFECTION0% 0.4%
ATRIAL FIBRILLATION0% 0.4%
MENTAL STATUS CHANGES0% 0.4%
DRUG EFFECT INCOMPLETE0.4% 0%
INFLAMMATION0.4% 0%
MUSCULAR WEAKNESS0.4% 0%
MUCOSAL INFLAMMATION0.4% 0%
LOCAL SWELLING0.4% 0%
ACCIDENTAL OVERDOSE0% 0.4%

New treatments are found every day. View current Methotrexate research studies and Diphenhydramine clinical trials


Top 5 Methotrexate Reported Side Effects

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Top 5 Diphenhydramine Reported Side Effects

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Patient Forum

Recent Comments and Reports

**The reason i reccomend 300-350mg is because i did that ammount 2 times with benadryl and it wasnt the best but i dont think it was horrible, and the second time i did 325mg and mixed it with weed and a few mood helper pills i found at my sisters ho

A few days ago i took 450 mg of diphenhydramine in sleeping pills, i know it is extremely stupid and i regret it 100%, first off when i took it i was very stoned and i thought they were benadryl because all i read was the diphenhydramine, about a hal

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spo

I have been on methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is

I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause diss

I loved these strips. I have had allergic reactions to my own allergy shots. After waiting at the Dr.'s office for 15 minutes after my allergy shot, I leave to go shopping. Sometimes I can feel a little thickening in my throat, similar to when I'v

I only took it for 21 days but in that time, it put me into a full panic attack that lasted almost 8 days after I went off the medication. I had mental confusion, could not speak properly (I knew what I wanted to say but the words would not come out

I was diagnosed with Rheumatoid Arthritis about 4 years ago when I was 13 or 14, they looked at me and said I had it, they didn't do any blood tests and when they did, nothing showed. But they started me on about 5 mg of Methotrexate, Prednisone, and

Im a 44yrs old female who took methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.

Ive been taking Diphenhydramine 25-50mgms nightly for some years,and my pharmacist is concerned that there may be some long-term psychological problems if I continue taking them,is this a serious concern?

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it

Dear fellow members, Dioscoredes is a post doc biochemist looking for the cause of his daughters ab-reaction to a range of cytotoxic immuno-suppresants. She has been variously treated with mycophenolate, methotrexate, cyclophosphamide all with th

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

Hi, just wondering if anyone else had experienced severe stomach cramping several days after discontinuing METHOTREXATE? My daughter is 10 and going through this right now. Her Rheumy thinks it's all in her head. As a parent, I know better.

I have ankylosing spondilitis. I had severe side effects to methotrexate. like all possible side effects i mean suicide thoughts and depression the whole nine yards. Have been on Enbrel for almost two years and have seen spectacular results it was sa

I have been on methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is

I have had RA for 15 years and have been on numerous and various meds. I have stoped methotrexate and folic acid and now started taking Leflunomide (Arava). Three days in and I'm noticing I have alot more energy. I was o

I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause diss

I was diagnosed with Rheumatoid Arthritis about 4 years ago when I was 13 or 14, they looked at me and said I had it, they didn't do any blood tests and when they did, nothing showed. But they started me on about 5 mg of Methotrexate, Prednisone, and

Im a 44yrs old female who took methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.

Should a person with severe psoraisis be tested for Hep C before starting methotrexate or cyclosporin?