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Naproxen and Diphenhydramine

Compare Side Effects

% of total side effects reported by users. DISCLAIMER: ALL DATA PROVIDED AS-IS. Data Source: openfda.gov.
Side EffectNaproxenDiphenhydramine
COMPLETED SUICIDE1.1% 4.2%
TOXICITY TO VARIOUS AGENTS0.8% 4.2%
PAIN3.4% 1.8%
DRUG INEFFECTIVE3.4% 1.6%
NAUSEA3.2% 2.7%
DRUG ABUSE0% 2.9%
FATIGUE2.8% 2.5%
HEADACHE2.7% 2.5%
DEATH0.8% 2.6%
ARTHRALGIA2.4% 1.4%
DYSPNOEA2.2% 2.3%
DIZZINESS2.2% 1.3%
DIARRHOEA2.1% 1.8%
PYREXIA1.2% 2%
SINUSITIS0.6% 2%
VOMITING1.9% 1.9%
PAIN IN EXTREMITY1.8% 0.8%
INFUSION RELATED REACTION0% 1.7%
PNEUMONIA1% 1.6%
MALAISE1.6% 1%
ANXIETY1.6% 0.9%
FALL1.5% 0.9%
HYPOTENSION0.8% 1.5%
DEPRESSION1.5% 0.6%
RASH1.4% 1.4%
ASTHENIA1.4% 1.1%
BACK PAIN1.4% 0.9%
CHEST PAIN1.4% 0.9%
CARDIAC ARREST0% 1.4%
CARDIO-RESPIRATORY ARREST0% 1.4%
INSOMNIA1.3% 0.8%
COUGH1.1% 1.2%
ABDOMINAL PAIN1.2% 0.8%
OFF LABEL USE0.7% 1.2%
DRUG HYPERSENSITIVITY1.2% 0.6%
PRURITUS1.1% 1.1%
HYPERTENSION1.1% 1%
WEIGHT DECREASED1.1% 0.9%
BLOOD PRESSURE INCREASED0.7% 1.1%
ABDOMINAL PAIN UPPER1.1% 0.5%
OVERDOSE0.5% 1.1%
NASOPHARYNGITIS0.7% 1%
CONDITION AGGRAVATED1% 0.5%
FEELING ABNORMAL1% 0.4%
RESPIRATORY ARREST0% 1%
ANAEMIA0.9% 0.8%
WEIGHT INCREASED0.9% 0.8%
SOMNOLENCE0.9% 0.7%
RHEUMATOID ARTHRITIS0.9% 0.6%
CONSTIPATION0.9% 0.6%
HYPOAESTHESIA0.9% 0.5%
CHILLS0.5% 0.9%
BRONCHITIS0.5% 0.9%
GAIT DISTURBANCE0.9% 0.4%
GASTROINTESTINAL HAEMORRHAGE0.9% 0%
URINARY TRACT INFECTION0.8% 0.8%
URTICARIA0.7% 0.8%
CONFUSIONAL STATE0.8% 0.6%
MYALGIA0.8% 0.5%
PARAESTHESIA0.8% 0.5%
OEDEMA PERIPHERAL0.8% 0.5%
JOINT SWELLING0.8% 0.5%
MUSCLE SPASMS0.8% 0.5%
INJECTION SITE PAIN0.8% 0%
PULMONARY EMBOLISM0.8% 0%
DEEP VEIN THROMBOSIS0.8% 0%
TACHYCARDIA0% 0.8%
INJURY0.8% 0%
HYPERSENSITIVITY0.7% 0.7%
DRUG INTERACTION0.7% 0.7%
TREMOR0.7% 0.6%
ERYTHEMA0.6% 0.7%
DEHYDRATION0.6% 0.7%
DECREASED APPETITE0.7% 0.6%
HAEMOGLOBIN DECREASED0.7% 0.5%
HYPERHIDROSIS0.7% 0.5%
ABDOMINAL DISCOMFORT0.7% 0%
INTENTIONAL DRUG MISUSE0% 0.7%
DRUG DOSE OMISSION0.7% 0%
MYOCARDIAL INFARCTION0.7% 0%
INTENTIONAL OVERDOSE0% 0.7%
ARTHRITIS0.7% 0%
FEBRILE NEUTROPENIA0% 0.7%
HEART RATE INCREASED0% 0.7%
UPPER RESPIRATORY TRACT INFECTION0% 0.7%
DRUG TOXICITY0% 0.7%
VISION BLURRED0.7% 0%
FLUSHING0% 0.7%
RENAL FAILURE ACUTE0.7% 0%
SEPSIS0% 0.7%
LOSS OF CONSCIOUSNESS0.6% 0.6%
PERIPHERAL SWELLING0.6% 0.5%
INFECTION0.5% 0.6%
CEREBROVASCULAR ACCIDENT0.6% 0%
DYSPEPSIA0.6% 0%
MUSCULAR WEAKNESS0.6% 0%
OXYGEN SATURATION DECREASED0% 0.6%
THROMBOCYTOPENIA0% 0.6%
ACUTE KIDNEY INJURY0.6% 0%
PALPITATIONS0.6% 0%
PULMONARY OEDEMA0% 0.6%
NEUTROPENIA0% 0.6%
DIABETES MELLITUS0.6% 0%
CHEST DISCOMFORT0.5% 0.5%
POISONING0% 0.5%
PLEURAL EFFUSION0% 0.5%
RESPIRATORY FAILURE0% 0.5%
WHITE BLOOD CELL COUNT DECREASED0% 0.5%
RENAL FAILURE0% 0.5%
AGITATION0% 0.5%
INFLUENZA0% 0.5%
INJECTION SITE ERYTHEMA0.5% 0%
INCORRECT DOSE ADMINISTERED0.5% 0%
CONTUSION0.5% 0%
MEMORY IMPAIRMENT0.5% 0%
MUSCULOSKELETAL STIFFNESS0.5% 0%
EMOTIONAL DISTRESS0.5% 0%
MIGRAINE0.5% 0%
NO ADVERSE EVENT0.5% 0%
OSTEOARTHRITIS0.5% 0%
MUSCULOSKELETAL PAIN0.5% 0%
GASTROOESOPHAGEAL REFLUX DISEASE0.5% 0%
SUICIDAL IDEATION0.5% 0%
SYNCOPE0.5% 0%
ALOPECIA0.5% 0%
ACCIDENTAL OVERDOSE0% 0.4%
OROPHARYNGEAL PAIN0% 0.4%
SUICIDE ATTEMPT0% 0.4%
UNRESPONSIVE TO STIMULI0% 0.4%
ATRIAL FIBRILLATION0% 0.4%
DYSPHAGIA0% 0.4%

New treatments are found every day. View current Naproxen research studies and Diphenhydramine clinical trials


Top 5 Naproxen Reported Side Effects

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Top 5 Diphenhydramine Reported Side Effects

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Patient Forum

Recent Comments and Reports

**The reason i reccomend 300-350mg is because i did that ammount 2 times with benadryl and it wasnt the best but i dont think it was horrible, and the second time i did 325mg and mixed it with weed and a few mood helper pills i found at my sisters ho

A few days ago i took 450 mg of diphenhydramine in sleeping pills, i know it is extremely stupid and i regret it 100%, first off when i took it i was very stoned and i thought they were benadryl because all i read was the diphenhydramine, about a hal

I had a leg pain and my doctor prescribe naproxen for me. After I took the medicine for two days I felt the dizziness and back pain. The back pain cause me sleepless and burning arm.

I loved these strips. I have had allergic reactions to my own allergy shots. After waiting at the Dr.'s office for 15 minutes after my allergy shot, I leave to go shopping. Sometimes I can feel a little thickening in my throat, similar to when I'v

I took 2tablets of naproxen on wednesday and he next day i noticed twitching in mt face arms and legs i also started getting sores on the inside of my mouth it is now saturday and imstill experiencing the twitching and w

I was on 1000mg a day for months (then self medicated to 500mg) and developed difficulty breathing and trouble getting to sleep. My health professionals repeatedly didn't link it to naproxen. Recently i experienced tingling sensations in my hands and

I was prscribed Naproxen 500Mg tab to take twice daily. The morning of the 3rd day my upper lip was swollen twice the size, I also had sores inside my lip. I was not sure what the cause was until the fourth day, after researching

Increased blood glucose

Ive been taking Diphenhydramine 25-50mgms nightly for some years,and my pharmacist is concerned that there may be some long-term psychological problems if I continue taking them,is this a serious concern?

NEVER AGAIN....!! I have never felt more out of control whilst taking these pills. Pounding headaches, nightmares, fear of falling asleep. Who ever came up with this should be locked in a room with the stuff...!!

Nose bleeds

Reddening of cheeks

Hi i have been on ramipril about 4 years now. but i am also taking amlopdine'simvastatin'tramadol'naproxen'and lansoprazole.which are causing all sorts problems such as extreme muscle pain and stomach pain swollen eyelids swollen throat rashes. inso

I had a leg pain and my doctor prescribe naproxen for me. After I took the medicine for two days I felt the dizziness and back pain. The back pain cause me sleepless and burning arm.

I have taken Naproxen several times over the years as prescribed by my doctor. I was recently injured and have been taking Aleve (Naproxen with an easier to market name)over the past few weeks. I took 2 Aleve this morning, and within 20 min

I took 2tablets of naproxen on wednesday and he next day i noticed twitching in mt face arms and legs i also started getting sores on the inside of my mouth it is now saturday and imstill experiencing the twitching and w

I was on 1000mg a day for months (then self medicated to 500mg) and developed difficulty breathing and trouble getting to sleep. My health professionals repeatedly didn't link it to naproxen. Recently i experienced tingling sensations in my hands and

I was prscribed Naproxen 500Mg tab to take twice daily. The morning of the 3rd day my upper lip was swollen twice the size, I also had sores inside my lip. I was not sure what the cause was until the fourth day, after researching