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ACE Medical Research Studies

Up-to-date List of ACE Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest ACE Medical Research Studies

Rank Status Study
1 Recruiting Megestrol Acetate Plus Metformin to Megestrol Acetate in Patients With Endometrial Atypical Hyperplasia or Early Stage Endometrial Adenocarcinoma
Conditions: Endometrial Atypical Hyperplasia;   Endometrial Adenocarcinoma
Interventions: Drug: Megestrol acetate and metformin;   Drug: Megestrol acetate
Outcome Measures: Pathological response rate;   Toxicity evaluation;   Rate of relapse;   Rate of pregnancy
2 Not yet recruiting Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients With Atypical Endometrial Hyperplasia or Endometrial Cancer
Conditions: Atypical Endometrial Hyperplasia;   Endometrial Adenocarcinoma;   Recurrent Endometrial Carcinoma;   Stage IA Endometrial Carcinoma;   Stage IB Endometrial Carcinoma;   Stage II Endometrial Carcinoma;   Stage IIIA Endometrial Carcinoma;   Stage IIIB Endometrial Carcinoma;   Stage IIIC Endometrial Carcinoma;   Stage IVA Endometrial Carcinoma;   Stage IVB Endometrial Carcinoma
Interventions: Drug: megestrol acetate;   Device: levonorgestrel-releasing intrauterine system;   Other: laboratory biomarker analysis;   Other: questionnaire administration
Outcome Measures: Histologic regression from endometrioid adenocarcinoma or complex atypical hyperplasia to benign endometrium;   Change in weight;   Change in mood ascertained using the self-reported Beck Depression Inventory-Primary Care (BDI-PC);   Compliance
3 Unknown  Phase 1 Study of Daewon-ES(B) & Megace in Healthy Male Volunteers Under Fasting and Fed Condition
Condition: Healthy
Interventions: Drug: Megace;   Drug: DW-ES(B)
Outcome Measure: Safety (normal results for safety tests)
4 Unknown  A Clinical Trial to Evaluate Pharmacokinetics of Daewon DW-ES(A) 625mg/5ml, Daewon DW-ES(B) 625mg/5ml and Megace 800mg/20ml in Healthy Male Volunteers Under Fed Condition
Condition: Healthy Volunteers
Interventions: Drug: Megace;   Drug: DW-ES(A);   Drug: DW-ES(B)
Outcome Measure:
5 Recruiting A Study Using MABp1 To Increase Overall Survival In Patients With Colorectal Cancer And Weight Loss
Conditions: Metastatic Colorectal Cancer;   Cachexia;   Weight Loss
Interventions: Drug: MABp1;   Drug: Megestrol Acetate
Outcome Measures: Overall Survival;   Change in Lean Body Tissue;   Quality of life questionnaire
6 Recruiting Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age
Condition: Chronic Oral Food Refusal
Interventions: Drug: Amitriptyline 1 mg/kg;   Drug: Placebo
Outcome Measures: To assess the efficacy of amitriptyline in a 24-week outpatient multi-disciplinary protocol for transitioning children from tube to oral feeding;   To assess the role of pain in the efficacy of amitriptyline in the 24-week outpatient multidisciplinary protocol.
7 Not yet recruiting Virexxa (Sodium Cridanimod) in Conjunction With Progestin Therapy in Patients With Progesterone Receptor Negative Recurrent or Persistent Endometrial Carcinoma
Condition: Recurrent or Persistent Endometrial Carcinoma
Intervention: Drug: Sodium cridanimod
Outcome Measures: Objective Response Rate;   Progression-free survival;   Time to response;   Time to progression;   Overall survival;   Overall Disease Control Rate
8 Recruiting Choice of Estrogens and Longterm Investigation of Nomegestrol Acetate - International Active Surveillance Study (INAS-CELINA)
Condition: Contraception
Intervention:
Outcome Measures: Venous thromboembolisms (VTE);   Arterial thromboembolisms (ATE);   Depressive disorders;   Cholelithiasis;   Inflammatory bowel disease;   Short- and long-term fertility;   Drug utilization pattern;   Pregnancy outcomes;   Weight change;   General hepatobiliary disorders;   Acne

These studies may lead to new treatments and are adding insight into ACE etiology and treatment.

A major focus of ACE research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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