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ACTIQ Medical Research Studies

Up-to-date List of ACTIQ Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest ACTIQ Medical Research Studies

Rank Status Study
1 Recruiting Procedural Pain Treatment With Transmucosal Sublingual Fentanyl Tablet in Colonoscopy Patients
Conditions: Colonoscopy;   Pain
Interventions: Drug: Fentanyl;   Drug: Placebo
Outcome Measures: Efficacy of fentanyl transmucosal tablet to placebo in patients having colonoscopy.;   The safety of fentanyl transmucosal tablet to placebo in patients having colonoscopy.
2 Recruiting Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain
Conditions: Chronic Pain;   Sternotomy;   Remifentanil;   Fentanyl
Interventions: Drug: Fentanyl;   Drug: Remifentanil
Outcome Measures: Chronic thoracic pain;   Mean Numerical Rating Scale (NRS) score;   Quality of life;   Thermal detection and pain thresholds;   Pain variability;   Use of analgesics during and after hospitalization;   Genetic variances;   Total medical costs and productivity costs during one year, including costs of hospitalization days (ICU and non-ICU) and costs of medications;   Mean pain NRS (Numerical Rating Scale)
3 Not yet recruiting Study to Explore Effectiveness of Sublingual Fentanyl Spray in Emergency Department Patients With Acute Pain
Condition: Acute Pain
Interventions: Drug: Morphine 6 mg;   Drug: Fentanyl 100 µg;   Drug: Fentanyl 200 µg;   Drug: Fentanyl 400 µg;   Drug: Placebo Sublingual Spray;   Drug: Intravenous Placebo
Outcome Measures: Percentage of participants requiring additional doses of randomized pain medication;   Percentage of participants requiring additional doses of randomized pain medication at secondary time points;   Visual analogue scale (VAS) Summed Pain Intensity Difference (SPID) calculated as Area under the Curve (AUC) every 30 minutes;   Number of Investigational Product (IP) administrations;   Time to onset of pain relief (in minutes) using the stopwatch method;   Richmond Agitation Sedation Scale (RASS) score;   Percentage of Participants requiring rescue medication;   Time until rescue medication was required;   Percentage of participants experiencing a treatment-related adverse event;   Percentage of participants with clinically significant changes in vital signs
4 Not yet recruiting Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain
Condition: Labor Pain
Interventions: Drug: Clonidine or Fentanyl;   Drug: Clonidine or fentanyl
Outcome Measures: Pain Score on a VAS scale;   Maternal blood pressure;   Maternal heart rate;   Neonatal Apgar score;   Number of spontaneous vaginal deliveries
5 Unknown  Intranasal Fentanyl for Pain Management
Conditions: Trauma;   Pain
Interventions: Drug: intravenous fentanyl;   Drug: intra-nasal fentanyl
Outcome Measures: The primary measure will be the change recorded in patients subjective pain using a standardized scale;   Change in patients vital signs: blood pressure, respiratory rate, heart rate, pulse oximetry will be monitored at 5 and 10 minutes following Atomized Fentanyl
6 Recruiting Intranasal Fentanyl for Management of Pain Associated With Cystoscopic Procedures
Conditions: Other Acute Pain;   Pain Experienced During Cystoscopy
Intervention: Drug: Fentanyl pectin
Outcome Measures: Change from baseline in pain numeric rating scale;   Oxyhemoglobin saturation
7 Recruiting Safety and Efficacy Study of Fentanyl Buccal Tablet Use in the Emergency Department for Isolated Extremity Injury
Condition: Pain
Interventions: Drug: Fentanyl;   Drug: Oxycodone/acetaminophen;   Drug: oxycodone/acetaminophen
Outcome Measures: Pain Level;   Nausea level;   Occurrence of adverse events
8 Recruiting Fentanyl for Breakthrough Pain in the Emergency Department
Condition: Pain
Interventions: Drug: Fentanyl Nasal Spray;   Drug: Hydromorphone PCA;   Other: Placebo Nasal Spray
Outcome Measure: Total Pain Relief Score
9 Unknown  Epidural Volume Extension and Intrathecal Use of Local Anesthetics in Cesarean Sections
Condition: Stillborn Caesarean Section
Interventions: Drug: Bupivacaine- Fentanyl - Normal Saline;   Drug: Ropivacaine-Fentanyl-Normal Saline;   Drug: Levobupivacaine- Fentanyl- Normal Saline;   Drug: Bupivacaine + Fentanyl;   Drug: Ropivacaine + Fentanyl;   Drug: Levobupivacaine + Fentanyl
Outcome Measures: Dermatomes of Sensory block;   Motor block;   Arterial Blood Pressure
10 Unknown  Safety of Fentanyl TAIFUN Treatment
Condition: Breakthrough Cancer Pain
Interventions: Drug: Fentanyl TAIFUN;   Drug: Opioid
Outcome Measures: AE Profile;   To characterize the safety of Fentanyl TAIFUN treatment vs. the current BTP treatment based on the AE profile;   To estimate the proportion of patients taht can be titrated to an effective dose of Fentanyl TAIFUN;   To evaluate the efficacy of Fentanyl TAIFUN with the titrated dose and the current BTP treatment with the confirmed dose;   To evaluate patients's preference between Fentanyl TAIFUN and the baseline BTP medication;   To evaluate the sustained analgesic effect of Fentanyl TAIFUN and the current BTP treatment
11 Not yet recruiting An Assessment of the Ability of Fentanyl Citrate Nasal Spray to Manage Breakthrough Pain in Cancer Patients.
Condition: Pain
Intervention: Drug: Fentanyl Citrate Nasal Spray (FCNS)
Outcome Measures: Pain Intensity;   Pain Management Satisfaction
12 Not yet recruiting Effectiveness of Intranasal Versus Intravenous Fentanyl in Preterm and Term Newborns for Pain Prevention
Condition: Pain
Intervention: Drug: Fentanyl
Outcome Measure: Pain scale - N-PASS
13 Recruiting Compare Propofol to Fentanyl and Midazolam for Colonoscopy
Conditions: Colon Cancer;   Rectal Cancer;   Colonic Diverticulosis
Interventions: Drug: Fentanyl;   Drug: Propofol;   Drug: Midazolam
Outcome Measures: Patient satisfaction;   Patient discomfort
14 Recruiting Fentanyl Pectin Nasal Spray (FNPS) for Exercise-Induced Breakthrough Dyspnea
Condition: Advanced Cancers
Interventions: Drug: Fentanyl Pectin Nasal Spray;   Drug: Placebo Nasal Spray;   Other: Walk Test;   Behavioral: Questionnaires;   Behavioral: Mental Ability Tests
Outcome Measure: Effect of Prophylactic Fentanyl Pectin Nasal Spray (FPNS)
15 Recruiting Fentanyl in Colonoscopy
Condition: Pain
Interventions: Drug: Routine medication arm;   Drug: Fentanyl on-demand arm
Outcome Measures: Pain;   Additional medication
16 Recruiting The Value of Adding Either Meperdine or Fentanyl to Clonidine-bupivacaine
Condition: Amputation Stumps
Interventions: Drug: Meperdine;   Drug: Fentanyl
Outcome Measures: the hemodynamic effects .;   the analgesic efficacy.
17 Unknown  Subarachnoid Administration of Levobupivacaine for Cesarean Section
Condition: Stillborn Caesarean Section
Interventions: Drug: Bupivacaine plain;   Drug: Ropivacaine plain;   Drug: Levobupivacaine plain;   Drug: bupivacaine plain +fentanyl;   Drug: ropivacaine plain +. fentanyl;   Drug: Levobupivacaine plain +fentanyl
Outcome Measures: Sensory block;   Motor block;   Hemodynamics profile (arterial pressure. heart rate)
18 Recruiting Treatment of Pain in Head-and-Neck Cancer Patients: is Methadone More Effective?
Conditions: Pain;   Cancer of Head and Neck
Interventions: Drug: fentanyl;   Drug: methadone
Outcome Measures: significant pain relief (reduction of Numeric Rating Scale (NRS) of 50%);   time to achieve significant pain relief;   side-effect profile
19 Recruiting Comparison of Propofol-fentanyl and Midazolam-fentanyl for Conscious Sedation
Condition: Emergencies
Interventions: Drug: Propofol;   Drug: Midazolam;   Drug: Fentanyl
Outcome Measures: Recovery time;   Patients' Pain perception
20 Unknown  Epidural Morphine Versus Epidural Fentanyl Infusion Following Cesarean Section
Condition: Pain
Interventions: Drug: Preservative free morphine;   Drug: Fentanyl
Outcome Measures: Postsurgical pain;   Nausea

These studies may lead to new treatments and are adding insight into ACTIQ etiology and treatment.

A major focus of ACTIQ research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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