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Abscesses Medical Research Studies

Up-to-date List of Abscesses Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Abscesses Medical Research Studies

Rank Status Study
1 Recruiting Treatment of Abdominal Abscesses With or Without Fibrinolysis
Conditions: Abdominal Abscess;   Tissue Plasminogen Activator
Interventions: Procedure: Tissue plasminogen activator abscess flush;   Procedure: Saline flush of abscess
Outcome Measure: Length of hospital stay
2 Unknown  Abscess Packing Versus Wick Placement After Incision and Drainage
Condition: Superficial Abscess Packing
Interventions: Procedure: Full packing into abscess cavity;   Procedure: Wick placement into abscess cavity
Outcome Measures: Abscess healing based upon clinical criteria and clinical judgement;   Pain since abscess drainage;   Parent/guardian comfort with removing the packing material or wick from the abscess cavity;   Parent/guardian assessment of the abscess wound at 2 weeks;   Parent/guardian assessment of pus drainage at 2 weeks;   Need for further treatment of same abscess within 2 weeks
3 Recruiting A Comparison of Techniques for Treating Skin Abscesses
Condition: Cutaneous Abscess
Interventions: Procedure: Incision and Drainage with wick placement;   Procedure: Abscess drainage with loop placement
Outcome Measures: Abscess Resolution;   Patient Satisfaction Immediately After Procedure;   Cosmetic Outcome;   Patient Satisfaction after Abscess Resolution;   Number of Follow Up Visits;   Number of Complications
4 Not yet recruiting Packing of Perianal Abscess Cavities Trial: A Randomised Multicentre Trial Comparing Packing With Non-packing of the Abscess Cavity
Condition: Perianal Abscess
Interventions: Other: Packing of abscess cavity;   Other: External dressing
Outcome Measures: Time to wound healing in days, defined as complete epithelialisation of the abscess cavity.;   Quality of life scores as determined by the Euro QoL EQ-5D-3L
5 Unknown  Moxifloxacin Plus Metronidazole Versus Piperacillin/Tazobactam for the Treatment of Patients With Intra-abdominal Abscesses
Condition: Abscess, Intra-Abdominal
Intervention: Drug: Moxifloxacin/Metronidazole or Piperacillin/Tazobactam
Outcome Measures: Clinical success / failure rate at the Test-of-Cure visit;   Clinical + Bacteriological response at End-of-Treatment-visit;   Time to discharge from hospital;   Course of disease on the basis of clinical and laboratory parameters;   safety and tolerability of the study medication;   cost effectiveness of treatment regimes
6 Recruiting Laparoscopic Management of Periappendicular Abscess
Conditions: Appendicitis;   Abdominal Abscess
Interventions: Procedure: Laparoscopic appendectomy;   Procedure: Conservative management with percutaneous drainage
Outcome Measures: Time of hospitalization within the first 60 days after randomization;   Need of additional interventions;   Residual abscess;   Attempted procedure not successfully performed;   The number of complications;   Number recurrent Abscesses
7 Unknown  Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department
Condition: Abscess
Interventions: Drug: Trimethoprim-sulfamethoxazole;   Drug: Sugar pill
Outcome Measures: The objective of this study is to compare clinical indicators of abscess resolution for two different treatment methods: 1) incision and drainage plus placebo (I&D/P) and 2) incision and drainage plus trimethoprim-sulfamethoxazole (TMP-SMX) (I&D/T-S).;   Comparison of medication adverse effect profiles between the groups, comparison of outcomes between MRSA isolates versus other pathogens between the groups, and analysis of interrater reliability of physical exam findings for a subgroup of patients.
8 Recruiting Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease
Conditions: Radiofrequency Ablation;   Liver Abscesses -Staphylococcus Infection;   CGD;   Chronic Granulomatous Disease;   RFA
Interventions: Procedure: RFA - Radiofrequency Ablation;   Procedure: Scans - Liver;   Procedure: Liver;   Procedure: Drawn
Outcome Measure: The primary endpoint for this study is patient safety, defined as no occurrences of Grade 3 or higher toxicities and are at least possibly related to the study intervention.
9 Unknown  Moxifloxacin Versus Ceftriaxone in the Treatment of Primary Pyogenic Liver Abscess
Condition: Liver Abscess
Interventions: Drug: Moxifloxacin (Avelox);   Drug: ceftriaxone (Rocephin/Cefin)
Outcome Measures: Treatment efficacy;   Clinical response;   Clinical and radiological response;   All cause mortality;   Mortality attributable to liver abscess during treatment;   Rates of complication (metastatic infections to the central nervous system and/or eyes);   Rates of gastrointestinal colonization of Klebsiella pneumoniae in patients and rates of resistance post-antibiotic use.
10 Recruiting Irrigation Versus no Irrigation for Cutaneous Abscess
Condition: Cutaneous Abscess
Interventions: Procedure: Irrigation;   Other: No Irrigation
Outcome Measures: Patients needing further treatment after irrigation for I&D;   VAS is correlated with decreased pain after I&D
11 Recruiting Prevalence of Colon Cancer in Pyogenic Liver Abscess
Condition: Cryptogenic Pyogenic Liver Abscess
Outcome Measures: The prevalence of colonic neoplasm;   Prevalence of colon polyp;   Prevalence of colonic diverticulitis;   Prevalence of inflammatory bowel disease;   Prevalence of intestinal tuberculosis
12 Unknown  Study to Look at Benefit of Surgical Drainage Before Beginning Medical Therapy for Crohns Perianal Fistulas
Conditions: Crohns Disease;   Fistula;   Abscess
Intervention: Other: Surgically established drainage of perianal fistulas &/or Abscesses BEFORE medical tx
Outcome Measure: Surgical drainage of all perianal fistulas & Abscesses prior to start of medical tx improves rate of healing & prevents further abscess formation.
13 Recruiting Assessing the Necessity of Prescribing Antibiotics (Clavulin or Clindamycin Versus Placebo) Post-peritonsillar Abscess Drainage
Condition: Peritonsillar Abscess
Interventions: Drug: Clavulin;   Drug: Randomization to Placebo;   Drug: Clindamycin
Outcome Measure: Re-accumulation of the patient's peri-tonsillar abscess
14 Recruiting Antibiotics for Klebsiella Liver Abscess Study
Condition: Liver Abscess, Pyogenic
Interventions: Drug: Ciprofloxacin;   Drug: Ceftriaxone;   Drug: Trimethoprim/sulfamethoxazole;   Drug: Ertapenem
Outcome Measures: Clinical cure;   Clinical response
15 Not yet recruiting A Randomized Blinded Trial of Abscess Management With Packing vs No Packing
Condition: Uncomplicated Cutaneous Abscess
Intervention: Procedure: Packing vs No Packing
Outcome Measures: Proportion of complications (defined as a composite of the following: need for repeat incision and drainage by physician, need for admission to hospital, or need for escalation to intravenous antibiotics);   Proportion of wounds "closed" at 1 week (wound size <0.5 cm length and depth and no drainage)
16 Unknown  Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Skin and Soft Tissue Abscess Undergoing Incision and Drainage
Conditions: Skin and Soft Tissue Abscess;   Methicillin-resistant Staphylococcus Aureus (MRSA) Infection
Intervention: Drug: Oral Clindamycin
Outcome Measures: The primary objective is to measure clinical resolution of skin abscess at routine follow-up visit 10-14 days post operation.;   Secondary outcomes measured include incidence of additional skin and soft tissue infections in patient and in household contacts as determined by healthcare provider. Compliance to antibiotic regime will also be assessed at this time.
17 Unknown  The Effect of Adding Pain Relievers to Local Anesthesia Before Preforming Drainage in Peritonsillar Abscess
Condition: Peritonsillar Abscess
Intervention: Drug: dypiron, tramadol
Outcome Measure: the vas scale
18 Recruiting Antimicrobial Stewardship Through MRSA Diagnosis in Emergency Department (ED) Patients With Abscesses
Condition: Cutaneous Abscess
Intervention: Device: Xpert MRSA/SA SSTI
Outcome Measures: antibiotic usage;   clinical improvement
19 Unknown  The Treatment of Bartholin´s Cyst or Abscess With Silver Nitrate
Condition: Bartholin´s Cyst
Interventions: Procedure: silver nitrate application to the Bartholin´s cyst;   Procedure: silver nitrat stick
Outcome Measures: Recidive of bartholin´s cyst or abscess and Dyspareunia after treatment;   Wound healing, local burning, sequelae, hospitalisation time
20 Unknown  Safety and Efficacy of the Use of Tissue Plasminogen Activator (tPA) in Intra-Abdominal Collections in Children - A Prospective Study
Condition: Intra-abdominal Abscess
Interventions: Drug: Cathflo (Alteplase);   Drug: Saline
Outcome Measures: Length of time the drain remains insitu;   Documentation of any adverse event;   The length of hospital stay;   Rate of resolution of abscess;   Return of clinical parameters to normal

These studies may lead to new treatments and are adding insight into Abscesses etiology and treatment.

A major focus of Abscesses research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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