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Adhesions Medical Research Studies

Up-to-date List of Adhesions Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Adhesions Medical Research Studies

Rank Status Study
1 Unknown  An Adhesion Reduction Plan in the Management of the Surgical Open Abdomen
Condition: Open Abdomen
Intervention: Procedure: Adhesion Reduction Plan
Outcome Measures: Extent and severity of Adhesions;   Time for lysis of Adhesions;   Incidence of complications
2 Not yet recruiting Adhesions After Open Versus Laparoscopic Resection of Colorectal Malignancies Detected During Liver Resection
Condition: Adhesions
Intervention: Procedure: Liver resection
Outcome Measures: Incidence of adhesion to ventral abdominal wall;   Incidence of Adhesions;   Extent of Adhesions;   Adhesion Score;   Adhesiolysis;   Duration of adhesiolysis;   Inadvertent bowel injury;   Postoperative mobidity
3 Not yet recruiting A Trial to Reduce Adhesions Following a Primary Cesarean Section
Condition: Tissue Adhesions
Intervention: Device: Seprafilm
Outcome Measures: Adhesion formation following a primary C-section with and without adhesion barrier;   Correlation between Adhesions and difficulty or delay in delivery of the infant(s)
4 Recruiting Intravitreal Gas for Vitreomacular Adhesion
Condition: Vitreomacular Adhesion
Intervention: Procedure: Intravitreal Injection of sulfahexafluoride gas
Outcome Measures: Proportion of patients with resolution of vitreomacular adhesion at Day 28;   Change in Visual Acuity;   Time to resolution of vitreomacular adhesion;   Proportion of patients requiring vitrectomy surgery;   Incidence of Retinal Tears and Retinal Detachment
5 Recruiting Comparative Effectiveness Multicenter Trial for Adhesion Characteristics of Ventral Hernia Repair Mesh
Conditions: Ventral Hernia;   Adhesions
Intervention: Procedure: Clinically-Indicated Abdominal Re-Exploration Surgery
Outcome Measures: Mesh adhesiolysis time:Mesh surface area;   Mesh Contracture;   Mesh adhesion tenacity;   Percentage mesh surface area covered with Adhesions;   Adhesiolysis time to abdominal wall;   Adhesiolysis time to mesh;   Incidence of adhesiolysis-related intra-operative complications;   Length of stay of hospital admission;   Length of stay in ICU;   Interval to return to bowel function;   Interval to return to independent ambulation or activities of daily living;   Interval to return to work or routine physical activity;   Incidence of postoperative complications;   Incidence of surgical site infection;   Incidence of initiation of antibiotics, blood and total parenteral nutrition;   Incidence of bedside procedures to address a postoperative surgical complication;   Incidence of surgery under local anesthesia to address a postoperative complication;   Incidence of single system organ failure;   Incidence of multiple-system organ failure;   Mortality rate
6 Not yet recruiting A Trial to Assess the Effect and Safety of the C-Qur™ Film
Condition: Postoperative Adhesions
Intervention: Device: C-Qur
Outcome Measure: Adhesions at the incision site
7 Unknown  Seprafilm™ for the Prevention of Intraperitoneal Adhesions and Improved Delivery of Therapy in Women Undergoing Staging and Intraperitoneal Chemotherapy for Advanced Ovarian Cancer
Condition: Epithelial Ovarian Cancer
Intervention: Procedure: Seprafilm™
Outcome Measures: The area of distribution of contrast dye in the intraperitoneal cavity as measured on three abdominal films taken 7-10 days following debulking surgery for epithelial ovarian cancer.;   The safety and side effects of placement of Seprafilm, including fever, elevated WBC count, nausea, blocked port, port infection, small bowel obstruction;   The safety and side effects of IP omnipaque dye injection, including fever, elevated WBC count, nausea, blocked port, port infection, small bowel obstruction;   The additional time taken for 1) placement of Seprafilm, 2) injection of IP contrast dye, 3) obtaining 3-way abdominal X-rays, and 4) interpretation of films
8 Not yet recruiting Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery
Condition: Intrauterine Adhesions
Interventions: Procedure: Uterine application of amnion membrane;   Device: Foley balloon;   Drug: Femoston
Outcome Measures: safety of intrauterine application of amnion membrane;   efficacy of intrauterine application of amnion graft in reducing adhesion formation following hysteroscopic adhesiolysis.
9 Recruiting The Role of 2-octyl Cyanoacrylate in Prevention of Recurrent Adhesions After Circumcision
Conditions: Phimosis;   Adhesions
Interventions: Procedure: application of 2-octyl cyanoacrylate skin adhesive in addition to stitches;   Procedure: standard stitches only
Outcome Measures: Post circumcision Adhesions;   Parent satisfaction and comfort level with circumcision results
10 Recruiting Effects of CoSeal on Bleeding & Adhesions in Pediatric Heart Surgery
Conditions: Congenital Heart Defect;   Surgery-Induced Tissue Adhesions;   Hemorrhage
Intervention: Device: CoSeal Surgical Spray Group
Outcome Measures: Severity of Adhesions at seven predefined sites;   Post-operative bleeding;   Adhesion Burden;   Ease of use;   Type and duration of surgery
11 Unknown  Safety Study of Use of Hyaluronic Acid Gel To Prevent Intrauterine Adhesions In Hysteroscopic Surgery
Condition: Tissue Adhesions
Intervention: Drug: Hyaluronan
Outcome Measure: Patient satisfaction following gel application
12 Recruiting Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy
Condition: Intrauterine Adhesions
Interventions: Device: Seprafilm;   Device: Sterile Saline Solution
Outcome Measures: Presence of iatrogenic intrauterine Adhesions;   Pregnancy within 12 months of treatment
13 Unknown  Cine-magnetic Resonance Imaging (MRI) Detecting Intra Abdominal Adhesions
Condition: Tissue Adhesions
Intervention: Other: CineMRI
Outcome Measure:
14 Not yet recruiting A Comparative Study to Evaluate Two Air-Activated Adhesive Backed Heat Patches
Condition: Healthy
Intervention: Device: Thermal Adhesion Patch
Outcome Measures: Heat Intensity;   Adhesion Evaluation;   Irritation Evaluation
15 Recruiting a Study to Evaluate Adhesion Risk in Fertility Patients' Status Post Laparoscopic Myomectomy.
Conditions: Uterine Fibroids;   Infertility
Intervention: Device: surgery utilizing V-Loc suture
Outcome Measures: Following Laparoscopic myomectomy utilizing V-Loc 180 suture , Post operative adhesion formation will be measured by an independent reviewer at the time of second look laparoscopy utilizing a scoring tool.;   The time required to close the incision as well as the ease of use to the surgeon will be measured utilizing a 1-5 ease of use scale.
16 Recruiting Sprayshield as Adhesion Barrier System for Obese Patients
Condition: Severe Obesity
Intervention: Procedure: ablation of gastric
Outcome Measures: During the second surgical step the intensity of the Adhesions in the operative field will be determined by the adhesion surface area and the adhesion intensity using;   Duration of surgery
17 Recruiting A Safety And Efficacy Study Of Alg-1001 In Human Subjects With Symptomatic Focal Vitreomacular Adhesion
Condition: Symptomatic Focal Vitreomacular Adhesion
Interventions: Drug: 2.0mg of ALG-1001;   Drug: Balanced Salt Solution
Outcome Measures: Release of Vitreo Macular Adhesion (VMA) by Optical Coherence Tomography (OCT);   1) Non-surgical closure of full thickness macular holes 2) Best Corrected Visual Acuity (BCVA) 3) Need for pars plana vitrectomy (PPV)
18 Recruiting Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: propranolol
Outcome Measures: measurement of the sickle red cell response to epinephrine;   Safety data regarding the use of propanolol in children with sickle cell disease
19 Recruiting Adhesion of Connective Tissue Around Laser-treated Abutments for Dental Implants - Clinical Trial in Humans
Condition: Periimplantitis
Intervention: Procedure: Dental implant placement with a final prosthetic abutment
Outcome Measure: Connective tissue adhesion
20 Not yet recruiting Trail to Investigate the Effectiveness of CoSeal in Reducing Adhesions Following the Kasai Hepatoportoenterostomy for Biliary Atresia
Condition: Biliary Atresia
Intervention: Device: CoSeal spray
Outcome Measures: Severity of Intra-abdominal Adhesions;   Liver transplantation- blood loss;   Liver Transplantation- Time taken

These studies may lead to new treatments and are adding insight into Adhesions etiology and treatment.

A major focus of Adhesions research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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