PatientsVille.com Logo


Afrin Medical Research Studies

Up-to-date List of Afrin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Afrin Medical Research Studies

Rank Status Study
1 Not yet recruiting Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption
Conditions: Dental Anesthesia;   Nasal Surgical Procedures;   Intranasal Drug Administration
Intervention: Drug: Oxymetazoline
Outcome Measures: Oxymetazoline plasma concentration;   Heart rate;   Blood pressure
2 Recruiting Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Conditions: Preeclampsia;   Hypotension
Interventions: Drug: Ephedrine;   Drug: Phenylephrine
Outcome Measures: The umbilical artery pH in the phenylephrine group will be higher than in the ephedrine group, although the overall incidence of absolute fetal acidosis is not anticipated to be different between groups.;   Efficacy of study drug in preventing and treating hypotension associated with spinal anesthesia in women with preeclampsia
3 Unknown  Preventing Tolerance to Oxymetazoline in Allergic Rhinitis
Conditions: Allergic Rhinitis;   Tachyphylaxis;   Rhinitis Medicamentosa
Interventions: Drug: oxymetazoline-fluticasone propionate;   Drug: Oxymetazoline
Outcome Measures: The primary endpoint will be the difference in peak PNIF response to incremental doses of Oxymetazoline [i.e. as a dose response];   Active Anterior Rhinomanometry;   Laser Doppler Velocimetry for nasal blood flow;   Overnight urinary cortisol creatinine ratio;   Nasal nitric oxide levels;   Serum eosinophils, ECP
4 Unknown  Prophylactic Phenylephrine Infusion for Preventing Hypotension During Spinal Anesthesia
Condition: Orthopedic Surgery of Lower Limb
Interventions: Drug: phenylephrine infusion;   Drug: patients receiving saline infusion
Outcome Measures: number of hypotension episodes;   number of episodes of severe hypotension;   cardiovascular events;   neurologic events
5 Recruiting NoAL (HPMC) in Combination With Oxymetazoline in Patients With Allergic Rhinitis
Condition: Allergic Rhinitis
Interventions: Drug: Oxymetazoline;   Other: Hydroxyl-propyl-methyl cellulose powder;   Other: Placebo (lactose powder)
Outcome Measures: Peak nasal inspiratory flow (PNIF) area under the curve (AUC) change between the placebo and active NoAl treatment on day 1;   Difference between the PNIF AUC D1-D8 differences between the two groups;   Differences in nasal mucociliary clearance (Saccharine test) between both groups.;   Visual analogue scale (VAS) for the separate rhinitis symptoms between the two groups;   Change of each symptom score for congestion over 8 days;   Change of total rhinitis symptom score (TRSS) over 8 days;   Difference in the applied rescue decongestant (total number of additional puffs of oxymetazoline or any other medications indicated for the treatment of allergic rhinitis) as needed between the two groups;   Number and severity of adverse events
6 Not yet recruiting Phenylephrine Dose and Mode of Administration for Spinal Anesthesia Induced Hypotension
Conditions: Complications; Cesarean Section;   Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Intervention: Drug: Phenylephrine
Outcome Measures: Magnitude of cardiac output changes;   provider intervention;   vasopressor requirement;   Emetic symptoms;   hypertension;   hypotension;   bradycardia;   Anesthetic time
7 Unknown  Ephedrine vs Phenylephrine - ECG Changes
Conditions: Spinal Anesthesia;   Pregnancy
Interventions: Drug: Phenylephrine;   Drug: Ephedrine
Outcome Measures: ST segment changes on Holter monitoring;   Troponin levels;   Incidence of maternal low systolic blood pressure;   Maternal cardiac output
8 Recruiting Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI)
Condition: Hypotension
Interventions: Drug: Phenylephrine bolus;   Drug: phenylephrine infusion
Outcome Measures: incidence of nausea and vomiting;   incidence of hypotension;   neonatal acidosis
9 Not yet recruiting Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal Esketamine
Condition: Allergic Rhinitis
Interventions: Drug: Esketamine;   Drug: Mometasone;   Drug: Oxymetazoline
Outcome Measures: Maximum Plasma Concentration (Cmax);   Time to Reach Maximum Concentration (tmax);   Area Under the Plasma Concentration-Time Curve From Time Zero to Infinite Time (AUC [0-infinity]);   Elimination Half-Life (t [1/2] Lambda);   Number of participants with adverse events (AEs) and serious adverse events (SAEs)
10 Recruiting Vasopressors for Cerebral Oxygenation
Conditions: Hypoxia;   Hypotension
Interventions: Drug: dopamine;   Drug: phenylephrine
Outcome Measures: Cerebral oximeter reading;   cardiac output;   incidence of delirium;   incidence of acute renal injury
11 Recruiting Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu
Conditions: Upper Respiratory Tract Infection;   Nasal Congestion;   Rhinorrhea;   Sneezing
Interventions: Drug: Paracetamol (500 mg)/dimethindene maleate (1 mg)/ phenylephrine hydrochloride (10 mg) tablets;   Drug: Paracetamol (500 mg) tablets
Outcome Measures: Physician Global evaluation of effectiveness on Nasal Symptoms;   Sum of subject self assessment using a 100 mm Visual Analog Scale
12 Not yet recruiting Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury
Condition: Blood Loss, Surgical
Intervention: Drug: Phenylephrine
Outcome Measures: Mean arterial blood pressure (MAP);   Blood Pressure;   Heart Rate
13 Recruiting Vasoactive Drugs in Intensive Care Unit
Condition: Shock
Interventions: Drug: Norepinephrine;   Drug: Epinephrine;   Drug: Phenylephrine;   Drug: Vasopressin
Outcome Measures: Hospital mortality;   Heart rate;   Incidence of tachydysrhythmia
14 Recruiting Safety and Pharmacokinetics of Kovacaine Nasal Spray in Pediatric Subjects
Condition: Anesthesia
Intervention: Drug: Tetracaine HCl 3% and Oxymetazoline HCl 0.05%
Outcome Measures: Peak Plasma Concentration (Cmax) of tetracaine;   Time to Peak Plasma Concentration (Cmax) of tetracaine;   Terminal elimination rate constant (λz) of tetracaine;   Elimination half-life (t½) of tetracaine;   Area under the plasma concentration versus time curve (AUC) of tetracaine;   Peak Plasma Concentration (Cmax) of para- butylaminobenzoic acid (PBBA);   Time to Peak Plasma Concentration (Cmax) of para- butylaminobenzoic acid (PBBA);   Terminal elimination rate constant (λz) of para- butylaminobenzoic acid (PBBA);   Elimination half-life (t½) of para- butylaminobenzoic acid (PBBA);   Area under the plasma concentration versus time curve (AUC) of para- butylaminobenzoic acid (PBBA);   Peak Plasma Concentration (Cmax) of oxymetazoline;   Time to Peak Plasma Concentration (Cmax) of oxymetazoline;   Terminal elimination rate constant (λz) of oxymetazoline;   Elimination half-life (t½) of oxymetazoline;   Area under the plasma concentration versus time curve (AUC) of oxymetazoline;   Mean and Standard Deviation of Heart Rate;   Mean and Standard Deviation of Systolic Blood Pressure;   Mean and Standard Deviation of Diastolic Blood Pressure;   Mean and Standard Deviation of Temperature;   Mean and Standard Deviation of Oxygen Saturation
15 Unknown  Effect of Blood Pressure on rSO2 in Carotid Endarterectomy (CEA)
Conditions: Intra-operative Hypotension;   Carotid Stenosis
Interventions: Drug: Administration of phenylephrine;   Drug: Administration of ephedrine
Outcome Measures: cerebral perfusion (rSO2) measured using Near Infrared Spectroscopy;   Blood velocity (Vmca) measured using transcranial Doppler
16 Recruiting Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION)
Conditions: Stroke, Acute;   Progressing Stroke
Intervention: Drug: Phenylephrine
Outcome Measures: Primary outcome;   Secondary efficacy outcome;   Major safety outcome;   Minor safety outcome
17 Unknown  Efficacy and Safety of Combination of Brompheniramine and Phenylephrine for the Symptoms Relief of Rhinitis
Conditions: Nasal Congestion and Inflammations;   Rhinitis
Interventions: Drug: brompheniramine + phenylephrine;   Drug: Brompheniramine + pseudoephedrine
Outcome Measures: Improvement of nasal congestion and runny nose, after 48 hours of treatment;   Overall score of nasal and extranasal symptoms (nasal congestion, runny nose, sneezing, watery eyes and itching);   Clinical score of upper airway compromise;   Proportion of subjects who used at least once the rescue medication;   Safety descriptive about occurence of adverse events, evaluation of results of general physical examination.
18 Recruiting Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery
Conditions: Endovascular Carotid Surgery;;   Preoperative Hypotension;
Intervention: Drug: ephedrine and phenylephrine
Outcome Measures: Cerebral oxygen saturation (SctO2);   Incidence of post-treatment hypotension;   Incidence of post-treatment bradycardia;   Postoperative morbidity: cardiovascular, cerebral, renal, surgical;   Postoperative recovery
19 Unknown  Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery
Conditions: Vasopressor Agents;   Endarterectomy, Carotid;   Echocardiography, Transesophageal
Intervention: Drug: Comparison of Effects of Phenylephrine and Norepinephrine
Outcome Measures: Myocardial ischemia measures by transesophageal echocardiography and ST segment analyses;   Myocardial ischemia measures by cardiac troponin I
20 Recruiting Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo
Condition: Cough Reflex Sensitivity
Interventions: Drug: Phenylephrine;   Drug: Diphenhydramine;   Drug: Dextromethorphan
Outcome Measure: change in cough reflex sensitivity to capsaicin

These studies may lead to new treatments and are adding insight into Afrin etiology and treatment.

A major focus of Afrin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

Discuss Afrin