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Aggression Medical Research Studies

Up-to-date List of Aggression Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Aggression Medical Research Studies

Rank Status Study
1 Not yet recruiting A Brief Intervention to Prevent Adolescent Dating Aggression Perpetration
Conditions: Offensive Aggression;   Sexual Aggression;   Dating Violence Perpetration and Victimization
Intervention: Behavioral: Brief Motivational Interview
Outcome Measures: Dating Aggression Perpetration;   Knowledge and Attitudes about Dating Aggression
2 Recruiting Cognitive Behavioral Aggression Treatment
Condition: Aggression
Intervention: Behavioral: Psychotherapy
Outcome Measures: Aggressive Acts;   Brain activation to emotional stimuli
3 Unknown  Healthy Brains & Behavior: Understanding and Treating Youth Aggression
Condition: Aggression
Interventions: Behavioral: CBI;   Dietary Supplement: NUT
Outcome Measure: Diagnostic interviews and questionnaires will be used to see measure changes in Aggression and antisocial behavior. We will also check for levels of Omega-3 before and after the interventions to see whether there are changes in Omega-3.
4 Recruiting Cognitive-Behavioral Therapy for Disruptive Behavior in Children and Adolescents
Conditions: Disruptive Behavior;   Aggression;   Anger;   Irritability;   Noncompliance
Interventions: Behavioral: Cognitive-Behavioral Therapy for Aggression;   Behavioral: Supportive Psychotherapy (SPT)
Outcome Measures: The Clinical Global Impression - Improvement (CGI-I) Score;   Modified Overt Aggression Scale (MOAS);   The Child Behavior Checklist (CBCL)
5 Unknown  Preventing Aggression In Veterans With Dementia (PAVED) - Telephone Sub-Study With Rural Veterans
Conditions: Dementia;   Pain
Intervention: Behavioral: Preventing Aggression in Veterans with Dementia (PAVeD)
Outcome Measure: Incidence of Aggression
6 Unknown  Pilot Trial of Neural Correlates of Response to Treatment of PTSD-Associated Impulsive Aggression
Conditions: Impulsive Aggression;   Posttraumatic Stress Disorder
Interventions: Drug: Phenytoin;   Behavioral: Cognitive Behavioral Therapy
Outcome Measures: change in impulsive aggressive acts measured by OAS-M;   change in regional brain activation as measured by FMRI;   change in PTSD symptoms as measured by CAPS;   change in depression symptoms as measured by BDI
7 Unknown  Aggressive Behavior Induced by Selective Serotonin Reuptake Inhibitors (SSRIs) During the First Month of Treatment
Conditions: Adverse Effects;   Aggression
Intervention: Behavioral: comparative computer simulation
Outcome Measure: aggressiveness level
8 Unknown  Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry
Conditions: Schizophrenia;   Psychosis
Intervention: Drug: Quetiapine XR
Outcome Measures: The primary efficacy variable is the change in Aggression between admission and day 8 of treatment with Quetiapine XR as measured by the OAS.;   Measuring psychotic symptomatology change from baseline in BPRS-Total Score in aggressive, psychotic patients managed with Quetiapine XR;   Measuring the incidence of adverse events (including Extrapyramidal symptoms) by the change from baseline in SAS and BAS and subjective reports;   Measuring the incidence of concomitant benzodiazepine and other permitted medication use
9 Recruiting Treatment of Children With Peer Related Aggressive Behavior (ScouT)
Condition: Oppositional Defiant Disorder
Interventions: Behavioral: Social Skills Training;   Behavioral: Treatment Program with techniques to activate resources
Outcome Measures: total score for peer related Aggression in the Questionnaire for Aggressive Behavior of Children (FAVK) parent rating;   total score for peer related Aggression in the Questionnaire for Aggressive Behavior of Children (FAVK) teacher rating, patient self-report;   ODD-Score of the Symptom Checklist for Oppositional Defiant and Conduct Disorder (FBB-SSV), parent, teacher and patient self-report;   ODD-Score of the Diagnostic Checklist for Oppositional Defiant and Conduct Disorder (DCL-SSV);   Externalizing Problems Score of the Child Behavior Checklist (CBCL), the Teacher Report Form (TRF), and the Youth Self-Report (YSR);   Internalizing Problems Score of the Child Behavior Checklist (CBCL) and the Teacher Report Form (TRF) , and the Youth Self-Report (YSR);   ADHD Symptom Checklist (FBB-ADHS) ,report parent, teacher and patient self-report ADHD Symptom Checklist (FBB-ADHS);   ICU (Inventory of Callous-Unemotional Traits);   KINDL rating scale for quality of life, parent and patient self-report;   FABEL rating scale for family burden;   Harter rating scale for self-concept;   Modified WFIRS (Weiss Functional Impairment Rating Scale);   Individual Problem Checklist (IPC);   ScouT-Social Problem Solving Test (ScouT-SPST);   Depression Anxiety and Stress Questionnaire (DASS)
10 Unknown  Effect of Massage Therapy on Aggression in a Psychiatric Inpatient Unit
Condition: Acute Psychiatric Disorders
Intervention: Procedure: Massage therapy
Outcome Measures: Aggression;   Irritability;   Anxiety;   Depression;   Cortisol levels;   Psychosocial climate;   PRN medication;   Incidence of seclusion or restraint;   Duration of hospitalisation
11 Recruiting Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression
Condition: Traumatic Brain Injury
Interventions: Drug: Buspirone;   Drug: Placebo
Outcome Measures: Neuropsychiatric Inventory-Irritability Domain;   Neuropsychiatric Inventory-Aggression Domain;   Neuropsychiatric Inventory-Distress Irritability Domain;   Neuropsychiatric Inventory-Distress Aggression Domain;   St. Andrews-Swansea Neurobehavioural Outcome Scale;   Personal Health Questionnaire;   Traumatic Brain Injury-Quality of Life Anger;   Global Impressions of Change;   Clinical Global Impressions;   Aggression and Irritability Impact Measure;   Generalized Anxiety Disorder
12 Recruiting Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
Condition: Alzheimer's Disease
Interventions: Drug: ELND005;   Drug: Placebo
Outcome Measures: Change from Baseline in NPI-C combined agitation and Aggression subscores;   Change from Baseline in modified-ADCS-CGIC agitation scores;   Change from Baseline in NPI total scores;   Change from Baseline in MMSE scores;   Change from Baseline in ADCS-ADL scores;   Incidence and severity of adverse events
13 Recruiting Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis
Conditions: Desmoid Tumors;   Aggressive Fibromatosis
Intervention: Drug: PF-03084014
Outcome Measures: Determine the response rate (CR+PR) of PF-03084014 in patients with desmoid tumors/aggressive fibromatosis;   Correlate clinical response to therapy with genotyping data.;   Assess symptoms at baseline/intervals on study.;   Perform genotyping for germline and somatic mutations in APC and CTNNB1 genes.
14 Unknown  The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis
Condition: Aggressive Periodontitis
Intervention: Procedure: orthodontic treatment
Outcome Measures: periodontal pocket depth;   PAR index
15 Unknown  Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order
Conditions: Psychotic Disorders;   Antisocial Personality Disorder;   Impulse Regulation Disorder;   Intermittent Explosive Disorder
Interventions: Drug: naratriptan;   Drug: placebo
Outcome Measures: number of aggressive incidents;   Aggression scores
16 Recruiting Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study)
Condition: Attention Deficit Disorder With Hyperactivity
Interventions: Drug: Valproate;   Drug: Risperidone;   Drug: Placebo;   Drug: Stimulant medication;   Behavioral: Behavioral family counseling
Outcome Measures: Aggressive behavior;   ADHD symptoms
17 Recruiting Memantine on Aggression and Agitation of Alzheimer's Disease (AD)
Condition: Alzheimer's Disease
Intervention: Drug: Memantine
Outcome Measures: CMAI score;   CBI score;   RUD;   NPI score
18 Unknown  Strength at Home Couples Program (PTSD-Focused Relationship Enhancement Therapy for Returning Veterans)
Conditions: Aggression;   Post Traumatic Stress Disorders
Interventions: Behavioral: Strength at Home Couples Group;   Behavioral: Supportive Group Therapy
Outcome Measures: Evidence of reduced incidence and frequency of intimate partner physical assault and psychological Aggression assessed by questionnaires and clinical interviews.;   Evidence of decreased risk factors (i.e. PTSD symptoms, anger, relationship satisfaction) implicated in the development of IPA assessed by questionnaires, clinical interviews, and psychophysiological measurements.
19 Recruiting Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder
Conditions: Intermittent Explosive Disorder;   Childhood Aggression;   Oppositional Defiant Disorder;   Attention Deficit Disorder
Interventions: Behavioral: Parent Management Training;   Other: Placebo;   Drug: Intuniv
Outcome Measures: Responder vs Non-Responder Assessment Form;   Percent change in score on the Attention Deficit Hyperactivity Disorder [ADHD] Rating Scale;   Percent change in the Modified Overt Aggression Scale;   Percent Change in the Score on Hostility Subscale of the Hopkins Symptom Checklist
20 Recruiting Randomized Trial of Aggressive Fluid Hydration to Prevent Post ERCP Pancreatitis
Condition: Pancreatitis
Interventions: Other: Aggressive Intravenous Hydration Group;   Other: Standard Fluids Arm
Outcome Measures: Acute Pancreatitis;   Clinical volume overload;   Serum amylase three times the upper limit of normal;   Increased abdominal pain

These studies may lead to new treatments and are adding insight into Aggression etiology and treatment.

A major focus of Aggression research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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