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Alanine Aminotransferase Increased Medical Research Studies

Up-to-date List of Alanine Aminotransferase Increased Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Alanine Aminotransferase Increased Medical Research Studies

Rank Status Study
1 Recruiting Nottingham Community Liver Biomarkers Cohort
Conditions: Chronic Liver Disease;   Alcohol Use Disorder;   Type 2 Diabetes;   Persistently Elevated ALT;   Obesity
Intervention: Device: Fibrosis Biomarkers
Outcome Measures: Liver and cardiovascular-related mortality;   Liver Cirrhosis;   Cardiovascular Disease;   All-cause mortality
2 Unknown  Methacetin Breath Test in HCV Patients With Normal and Near-Normal ALT
Condition: Chronic Hepatitis C Virus Infection
Outcome Measure:
3 Recruiting Chemoembolization With or Without Antiviral Therapy for Unresectable HBV-related HCC With Low HBV DNA Replication
Condition: Hepatocellular Carcinoma
Intervention: Drug: Lamivudine 100mg once daily; or Entecavir 0.5mg once daily.
Outcome Measures: overall survival;   HBV reactivation
4 Recruiting Study of Losartan in the Treatment of NAFLD in Children
Condition: NAFLD
Intervention: Drug: Losartan
Outcome Measures: Change in ALT from baseline to week 8 and/or week 22;   Changes in cholesterol and fatty acid levels;   Changes in Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR), insulin and glucose;   Changes in Plasminogen activator inhibitor-1 (PAI-1)
5 Recruiting Ezetimibe-Ursodiol Combination Therapy on Biomarkers of Liver Function and Sterol Balance in Subjects With NASH
Condition: Nonalcoholic Steatohepatitis (NASH)
Intervention: Drug: EZ-Urso combination therapy
Outcome Measures: Reduction in serum alanine transaminase (ALT);   Increase in plasma lathosterol;   Reduction in hepatic fat fraction
6 Not yet recruiting Tesamorelin Effects on Liver Fat and Histology in HIV
Conditions: Human Immunodeficiency Virus (HIV);   Nonalcoholic Fatty Liver Disease (NAFLD);   Nonalcoholic Steatohepatitis (NASH)
Interventions: Drug: tesamorelin;   Drug: Placebo
Outcome Measures: Liver fat as measured by 1-H Magnetic resonance spectroscopy;   Nonalcoholic fatty liver disease activity score;   alanine aminotransferase (ALT);   aspartate aminotransferase (AST);   liver stiffness measured by FibroScan
7 Recruiting Safety and Efficacy of Clenbuterol on Motor Function in Individuals With Late-onset Pompe Disease and Receiving Enzyme Replacement Therapy
Condition: Pompe Disease
Interventions: Drug: Clenbuterol;   Drug: Placebo
Outcome Measures: Change in creatine kinase (CK) reflecting worsening of muscle involvement;   Change in aspartate aminotransferase (AST), alanine transaminase (ALT), and bilirubin representing liver toxicity;   Change 6 minute walk test;   Change in forced vital capacity in pulmonary function testing
8 Not yet recruiting Effects of Pitavastatin on Insulin Sensitivity and Liver Fat
Conditions: Obesity;   Fatty Liver, Nonalcoholic
Intervention: Drug: pitavastatin
Outcome Measures: Insulin-stimulated glucose uptake;   Liver fat;   alanine aminotransferase (ALT);   aspartate aminotransferase (AST);   hepatic insulin sensitivity;   hemoglobin A1c (HbA1c);   quantitative insulin sensitivity check index (QUICKI)
9 Unknown  Pregnancy Outcomes in Overweight Women With Prior Miscarriages Following a Structured Weight Loss Program Versus Weight-Loss Counseling
Conditions: Obese;   Overweight;   Miscarriage;   Recurrent Pregnancy Loss
Interventions: Behavioral: Structured Weight Loss Program;   Behavioral: Routine Weight Loss Counseling
Outcome Measures: Term live birth rate;   Weight loss - goal for weight loss defined as 5 percent of enrollment body weight lost;   Changes in triglyceride levels;   Changes in high density lipoprotein levels;   Changes in alanine aminotransferase (ALT) levels;   Changes in fasting insulin levels;   Changes in postprandial insulin levels;   Changes in fasting glucose levels;   Changes in postprandial glucose levels;   Changes in hemoglobin A1c levels
10 Recruiting The Health Influences of Puberty (HIP) Study
Conditions: Obesity;   Insulin Resistance;   Gonadal Dysfunction;   Type 2 Diabetes
Intervention: Drug: Metformin
Outcome Measures: Change in insulin sensitivity;   Change in insulin secretion;   Change in disposition index;   Change in lipid measures;   Change in insulin-like growth factor 1;   Change in testosterone;   Change in estradiol;   Change in sex hormone binding globulin;   Change in dehydroepiandrosterone sulfate;   Change in interleukin-6;   Change in high Sensitivity C-reactive protein;   Change in aspartate Aminotransferase (AST);   Change in alanine transaminase (ALT);   Change in urinary Luteinizing hormone;   Change in urinary Follicle-stimulating hormone;   Change in urinary estradiol metabolites;   Change in hemoglobin A1c;   Change in leptin;   Change in %body fat;   Change in visceral adipose;   Change in liver adipose
11 Unknown  Genetic Polymorphisms, Steatosis and Diabetes
Condition: Type 1 and 2 Diabetes
Interventions: Other: prise de sang;   Other: magnetic resonance imaging and magnetic resonance spectroscopy
Outcome Measures: Determination of the existence of liver steatosis measured by magnetic resonance spectroscopy spectrometry;   Measurement of monocyte expression of LDL receptors
12 Recruiting Effect of Artemisia Dracunculus on Glucose Intolerance, Insulin Sensitivity and Insulin Secretion
Condition: Glucose Intolerance
Interventions: Dietary Supplement: Artemisia dracunculus;   Other: Placebo
Outcome Measures: Postprandial glucose levels at week 12;   Fasting glucose levels at week 12;   Glycosylated hemoglobin at week 12;   First phase of insulin secretion at week 12;   Total insulin secretion at week 12;   Insulin sensitivity at week 12;   Weight at week 12;   Body Mass Index at week 12;   Total cholesterol at week 12;   Triglycerides levels at week 12;   High density lipoprotien (c-HDL) levels at week 12;   Alanine aminotransferase (ALT) levels at week 12;   Aspartate aminotransferase (AST) levels at week 12;   Creatinine levels at week 12;   Uric acid levels at week 12;   Blood pressure at week 12
13 Recruiting Umbilical Cord Mesenchymal Stem Cells for Patients With Liver Cirrhosis
Condition: Liver Cirrhosis
Interventions: Drug: conventional plus MSC treatment;   Drug: conventional plus placebo treatment
Outcome Measures: ascites volume;   the patient number of liver function worsening;   the number of patients with ascites after 12-week treatment;   The levels of serum alanine aminotransferase;   The levels of serum total bilirubin;   The levels of INR;   The levels of serum prothrombin activity;   liver function evaluation using MELD-Na score model;   plasma albumin level;   plasma HBV load;   complications;   blood routine examination;   renal function tests
14 Unknown  Cohort of Hepatitis B Research of Amsterdam
Condition: Hepatitis B
Outcome Measure:
15 Unknown  Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Duchenne Muscular Dystrophy
Condition: Duchenne Muscular Dystrophy
Intervention: Biological: human umbilical cord mesenchymal stem cells
Outcome Measures: Activities of Daily Living(ADL)scale;   Incidences of Adverse Event and Serious Adverse Event;   Change from baseline in CK;   Change from baseline in LDH;   Change from baseline in ALT;   Change from baseline in AST;   Change from baseline to manual muscle test(MMT);   Change from baseline in electromyography(EMG)

These studies may lead to new treatments and are adding insight into Alanine Aminotransferase Increased etiology and treatment.

A major focus of Alanine Aminotransferase Increased research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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