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Aloxi Medical Research Studies

Up-to-date List of Aloxi Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Aloxi Medical Research Studies

Rank Status Study
1 Recruiting Raloxifene as an Adjuvant Treatment of the Negative Symptoms of Schizophrenia in Post-menopausal Women
Condition: Negative Symptoms of Schizophrenia in Post-menopausal Women.
Interventions: Drug: Raloxifene;   Drug: Lactosa (placebo arm)
Outcome Measures: To assess the efficacy of Raloxifene (SERM - Selective Estrogen Receptor Modulator) as an adjuvant of antipsychotic treatment in the management of negative symptoms of schizophrenia in post-menopausal women.;   To assess the efficacy of Raloxifene as an adjuvant of antipsychotic treatment in the management of global symptoms of schizophrenia in postmenopausal women.;   To assess the efficacy of Raloxifene as an adjuvant of antipsychotic treatment in the global functioning of postmenopausal women with schizophrenia.;   To assess the efficacy of Raloxifene as an adjuvant of antipsychotic treatment in the neuropsychological functioning of post-menopausal women with schizophrenia;   To control response to treatment as a function of genetic variants in the form of SNP (Single Nucleotide Polymorphisms) that patients present in the alfa (ESR1) and beta (ESR2) estrogenic receptor genes.;   To assess the safety of the medication used in this patient population.
2 Unknown  Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome
Condition: Polycystic Ovary Syndrome
Interventions: Drug: clomiphene citrate;   Drug: Raloxifene
Outcome Measures: Ultrasound sign of ovulation;   endometrial biopsy compatible with the +/- 3days of the cycle;   Serum levels of Progesterone
3 Unknown  Raloxifene in Treatment of Schizophrenia and Schizoaffective Disorder
Conditions: Schizophrenia;   Schizoaffective Disorder
Interventions: Drug: Raloxifene;   Drug: placebo
Outcome Measures: PANSS total score at the end of the trial.;   PANSS,CGI-S, CGI-I, BACS and rates of drop outs before the end of the trial.
4 Recruiting Selective Estrogen Receptor Modulators (SERMs) - A Potential Treatment for Psychotic Symptoms of Schizophrenia in Men?
Conditions: Schizophrenia;   Schizoaffective Disorder;   Schizophreniform Disorder
Interventions: Drug: Raloxifene Hydrochloride;   Drug: Placebo
Outcome Measures: Change from Baseline to 12 week follow up in PANSS-positive and negative syndrome scale;   Montgomery Asberg Depression Rating Scale (MADRS):;   MATRICS Consensus Cognitive Battery;   Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
5 Recruiting Comparison Between Raloxifene and Bazedoxifene
Condition: Selective Estrogen Receptor Modulator
Intervention:
Outcome Measure: Effects of Raloxifene vs. bazedoxifene on bone mineral density, bone turnover markers and bone quality markers in postmenopausal osteoporosis.
6 Recruiting Raloxifene and Rimostil for Perimenopause-Related Depression
Conditions: Perimenopausal Depression;   Depression
Interventions: Drug: Raloxefine (Evista);   Drug: Rimostil;   Drug: Evista, Rimostil, Alora
Outcome Measures: Hamilton Depression Rating Scale 17 item; Beck Depression Inventory; Center for Epidemiologic Studies Depression Scale; Visual Analogue Scale symptom inventory.;   Sexual interest (Derogatis Inventory of Sexual Function); paragraph memory test; Rey figure recall; N-back test. Blood hormone levels; daily symptom diary, SCID interview.
7 Recruiting Selective Estrogen Receptor Modulators - A Potential Treatment for Psychotic Symptoms of Schizophrenia
Conditions: Schizophrenia;   Schizoaffective Disorder;   Schizophreniform Disorder
Interventions: Drug: Raloxifene hydrochloride;   Other: Lactose Capsules
Outcome Measures: PANSS score at trial completion (12 weeks);   MADRS score at trial completion (12 weeks);   Cognitive Test scores at trial completion (12weeks);   Adverse Symptom Checklist score at trial completion (12 weeks);   Hormone level change over study duration (12 weeks)
8 Not yet recruiting Factors Influencing Decision-Making About the Use of Chemoprevention in Women at Increased Risk for Breast Cancer
Condition: Breast Cancer
Interventions: Behavioral: telephone-based intervention;   Drug: Raloxifene;   Drug: tamoxifen citrate;   Other: communication analysis;   Other: communication intervention;   Other: counseling intervention;   Other: educational intervention;   Other: questionnaire administration;   Other: study of socioeconomic and demographic variables;   Procedure: psychosocial assessment and care
Outcome Measures: Social, environmental, and psychological influences on the decision of women at risk for breast cancer as to whether or not to take a SERM;   Factors hindering women from taking chemoprevention for breast cancer;   Reasons for the choice of Raloxifene vs tamoxifen among menopausal women
9 Recruiting Johns Hopkins Breast Cancer Program Hormone Therapy Longitudinal Database
Condition: Breast Cancer
Interventions: Other: Sample collection;   Behavioral: Patient-reported outcomes
Outcome Measure: Sample and data collection

These studies may lead to new treatments and are adding insight into Aloxi etiology and treatment.

A major focus of Aloxi research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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