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Ambien Medical Research Studies

Up-to-date List of Ambien Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Ambien Medical Research Studies

Rank Status Study
1 Not yet recruiting A Comparison of Midazolam and Zolpidem as Oral Premedication in Children
Conditions: Parental/Caregiver Anxiety;   Child's Anxiety
Interventions: Drug: zolpidem;   Drug: Midazolam
Outcome Measures: Patient anxiety at the time of separation;   Other comparison measures will include preoperative parent/caregiver anxiety, anesthesia mask acceptance characteristics at the time of induction, and time to full recovery in the post operative period.
2 Recruiting Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T
Condition: Psychotropic Drugs Effects
Interventions: Drug: Zolpidem;   Drug: Alprazolam;   Drug: Caffeine;   Other: Placebo
Outcome Measures: Change in blood oxygen level-dependent (BOLD) signal as measured with fMRI;   Change in subjective drug effects as measured by self-report questionnaires
3 Recruiting Effects of Zolpidem CR® in Sleep and Heart Recovery in Cardiac Intensive Care Unit Patients
Conditions: Acute Coronary Syndrome;   Sleep Deprivation
Interventions: Drug: Zolpidem CR 12.5mg;   Drug: Placebo
Outcome Measures: Sleep efficiency;   Troponin T;   Creatine-kinase MB
4 Unknown  The Role of Partial Reinforcement in the Long Term Management of Insomnia
Condition: Primary Insomnia
Intervention: Drug: Zolpidem
Outcome Measures: sleep diary;   Sleep Diary
5 Recruiting The Role of Sleep in the Treatment of Cannabis Use Disorders
Condition: Drug Addiction
Interventions: Drug: Zolpidem extended-release;   Behavioral: MET/CBT
Outcome Measures: Sleep Efficiency;   Cannabis Abstinence
6 Recruiting Reducing Suicidal Ideation Through Insomnia Treatment
Conditions: Insomnia;   Depression;   Suicidal Ideation
Interventions: Drug: Zolpidem-CR;   Drug: Placebo
Outcome Measures: Suicide Severity Index (SSI);   Dysfunctional Beliefs and Attitudes About Sleep;   Disturbing Dreams and Nightmares Severity Index (DDNSI);   Beck Hopelessness Scale (BHS);   Hamilton Rating Scale for Depression (HAM-D);   Insomnia Severity Index (ISI)
7 Not yet recruiting Polysomnographic Study Comparing the Use of Dexmedetomidine and Zolpidem to Induce Natural Sleep
Condition: Insomnia
Interventions: Drug: Dexmedetomidine;   Drug: Zolpidem;   Drug: Oral Placebo;   Drug: Normal Saline placebo.
Outcome Measures: Subjective and objective measures of sleep quality;   Performance on a word-pair cognitive task after waking up from sleep
8 Recruiting Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance
Condition: Healthy Volunteers
Interventions: Drug: Almorexant;   Drug: Zolpidem 10mg;   Drug: Placebo
Outcome Measure: A comparison between dosing groups on performance on neurocognitive measures
9 Recruiting Alternative Dosing Regimens in the Pharmacotherapy of Insomnia
Condition: Insomnia
Interventions: Drug: Amitriptyline;   Drug: Zolpidem;   Drug: Placebo
Outcome Measures: Objective Total Sleep Time;   Objective Sleep Onset Latency;   Self-reported Total Sleep Time;   Self-Reported Sleep Onset Latency;   Percentage of REM sleep;   REM onset latency;   Objective Sleep Efficiency;   Self-Reported Total Sleep Time;   Self-reported Sleep Onset Latency (min);   Self-reported Sleep Onset Latency (evaluation)
10 Unknown  Risperidone and Zotepine in the Treatment of Delirium
Condition: Delirium
Intervention: Drug: Risperidone and Zolpidem for delirium
Outcome Measures: Delirium rating scale;   MMSE, CGI, side effect profile, HRV
11 Unknown  Memory Consolidation in Pharmacologically Enhanced Naps
Condition: Sleep
Interventions: Drug: Low-dose sodium oxybate;   Drug: High-dose sodium oxybate;   Drug: Low-dose zolpidem;   Drug: High-dose zolpidem;   Drug: Placebo
Outcome Measures: Pharmacological enhancement of specific sleep parameters in a dose-dependent manner;   Correlation of pharmacological interventions with changes in sleep-stage-specific memory tasks
12 Unknown  Age-Dependent Memory Benefits From Pharmacologically Enhanced Naps?
Condition: Older Adults
Interventions: Drug: Sodium Oxybate;   Drug: Zolpidem;   Drug: placebo
Outcome Measure:
13 Recruiting Sequenced Therapies for Comorbid and Primary Insomnias
Conditions: Insomnia Comorbid to Psychiatric Disorder;   Primary Insomnia
Interventions: Behavioral: Behavioral Insomnia Therapy;   Drug: Zolpidem;   Drug: Trazodone;   Behavioral: Cognitive Therapy
Outcome Measure: Insomnia Severity Index- Change from Baseline (Remission)
14 Recruiting Use of Benzodiazepines and Z Drugs in the Elderly
Condition: Chronic Benzodiazepines and Related Drugs Users
Intervention:
Outcome Measures: Dependence according to DSM IV criteria;   withdrawal syndrome;   psychiatric comorbidities;   Dependence scores
15 Not yet recruiting Effects of GABA Modulator AZD7325 on Cortical Excitability
Condition: Healthy
Interventions: Drug: 2 mg AZD7325;   Drug: 10 mg AZD7325;   Drug: Placebo
Outcome Measures: Change in conventional measure of percentage short interval intracortical inhibition (SICI) at an interstimulus interval (ISI) of 2.5 ms and conditioning stimulus intensity of 70 percent of resting motor threshold;   Change in the variables of kinematic analysis of circle drawing;   Change in the rating on a 0-100 mm Visual Analogue Scale (VAS) of degree of sedation and the score of Symbol Digit Modalities Test (SDMT);   Safety and tolerability of a single dose of AZD7325 by assessment of adverse events, vital signs, physical examination, ECG, and laboratory variables
16 Recruiting Effects of Hallucinogens and Other Drugs on Mood and Performance
Condition: Healthy
Intervention: Drug: Hallucinogens and psychoactive substances
Outcome Measures: Rating of "Drug Liking" on the End of Day Questionnaire;   Hallucinogen Rating Scale

These studies may lead to new treatments and are adding insight into Ambien etiology and treatment.

A major focus of Ambien research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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