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Amiloride Medical Research Studies

Up-to-date List of Amiloride Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Amiloride Medical Research Studies

Rank Status Study
1 Recruiting Amiloride Clinical Trial In Optic Neuritis
Conditions: Optic Neuritis;   Multiple Sclerosis
Interventions: Drug: Amiloride;   Drug: Placebo
Outcome Measures: Scanning laser polarimetry determined retinal nerve fibre layer thickness;   Optical coherence tomography determined difference in retinal nerve fibre layer thickness.;   Differences between the Amiloride and placebo groups in non-conventional MRI surrogate marker of white matter and grey matter injury and connectivity by 3T scanning.;   Visual Function;   Visual Electrophysiology;   Quality of life questionnaires
2 Not yet recruiting Amiloride Hydrochloride as an Effective Treatment for ADHD
Condition: ADHD
Interventions: Drug: Amiloride;   Behavioral: Behavioral;   Drug: placebo
Outcome Measures: Improvement in ADHD symptoms;   Improvement in executive function and emotional self-regulation.
3 Unknown  Safety and Efficacy of Chlorthalidone + Amiloride to Elderly Patients Treatment With Arterial Hypertension
Condition: Arterial Hypertension
Interventions: Drug: Chlorthalidone 25 mg + Amiloride hydrochloride 5 mg;   Drug: Higroton® Laboratório Novartis
Outcome Measures: Potassium level;   Blood Pressure
4 Recruiting Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve
Condition: Acute Autoimmune Optic Neuritis
Interventions: Drug: Amiloride hydrochlorothiazide;   Drug: Sugar pill
Outcome Measure: Change in thickness of retinal nerve fiber layer (RNFL)
5 Recruiting Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes
Conditions: Proteinuria;   Hypertension;   Type II Diabetes
Interventions: Drug: Amiloride;   Drug: HCTZ
Outcome Measures: Blood Pressure;   Hypertension
6 Recruiting Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension
Condition: Prehypertension
Intervention: Drug: Amiloride
Outcome Measure: Vascular phenotypes
7 Not yet recruiting MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial
Condition: Secondary Progressive Multiple Sclerosis
Interventions: Drug: Amiloride;   Drug: Riluzole;   Drug: Ibudilast;   Drug: Placebo
Outcome Measures: MRI-derived Percentage Brain Volume Change (PBVC).;   Multi-arm trial strategy assessment;   Count of new and enlarging T2 lesions;   Pseudo-atrophy;   Clinical measure of neuroprotection;   Health economics
8 Recruiting Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients
Condition: Essential Hypertension
Intervention: Drug: Amlodipine, Telmisartan, Amiloride Compound , Simvastatin
Outcome Measures: The primary study outcomes are composite of non-fatal stroke, non-fatal myocardial infarction and cardiovascular death.;   All cardiovascular events;all-cause death, hospitalization for angina pectoris, coronary revascularization, aortic dissection, cerebrovascular disease, heart failure, renal insufficiency, tumor, new onset of atrial fibrillation and diabetes mellitus
9 Unknown  Double Blind Crossover Comparison of Diuretics in the Young
Condition: Low-Renin Hypertension
Interventions: Drug: Bendroflumethiazide 2.5mg - 5mg;   Drug: Amiloride 20-40mg;   Drug: Spironolactone 50-100mg;   Drug: Frusemide 20-40mg;   Drug: Bendroflumethiazide 1.25-2.5mg/ Amiloride 10-20mg combined
Outcome Measures: Difference in systolic blood pressure for subjects' best drug and second best drug.;   Difference in plasma renin for subjects' best drug and second best drug.;   Predictions of best drug
10 Not yet recruiting Effect of Antihypertensive Agents Over Sleep Apnea
Conditions: Hypertension;   Obstructive Sleep Apnea
Interventions: Drug: Chlorthalidone/Amiloride;   Drug: Amlodipine
Outcome Measures: Apnea-Hypopnea Index;   Blood Pressure;   Adverse events;   Somnolence scale (Epworth) and ventilatory parameters;   C reactive protein
11 Unknown  Extracellular Fluid in Resistant Hypertension
Condition: Hypertension
Interventions: Drug: Cardura XL 4 mg bd;   Drug: Amiloride 5 mg bd;   Drug: Furosemide 40 mg bd
Outcome Measure: Change in ECV; change in BP
12 Recruiting Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B
Condition: Patients With Indications for AmB Treatment
Interventions: Drug: Spironolactone 100mg;   Drug: Spironolactone 200mg;   Drug: Placebo
Outcome Measures: Incidence of hypokalemia ≤3.5mEq/L;   Average potassium supplementation;   Incidence of hyperkalemia;   Acute kidney injury;   Incidence of renal tubular damage;   Incidence of hypomagnesemia
13 Recruiting RAS Blockade at Bedtime Versus on Awakening for Aldosterone Breakthrough
Condition: Chronic Kidney Disease
Intervention: Other: Randomization that determine the time of treatment
Outcome Measures: Serum aldosterone levels at one year;   Serum aldosterone/renin ratio;   Significant aldosterone breakthrough Significant aldosterone breakthrough
14 Recruiting Role of ASICs in Human Inflammatory Pain
Conditions: Arthritis;   Osteoarthritis;   Chondrocalcinosis;   Gouty Arthritis;   Rheumatoid Arthritis
Outcome Measure: activation or miodulation to Electrical potential of ionic channel in the synovial fluid
15 Recruiting Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer
Condition: Operable Breast Cancer
Intervention: Drug: 0.5% lignocaine 60mM
Outcome Measures: • To assess the in-vivo ability of local anesthetics agents like lignocaine to decrease the dissemination of cancer cells during surgery and improve the disease free interval;   • To assess the in-vivo ability of local anesthetics agents like lignocaine on impacting long term survival

These studies may lead to new treatments and are adding insight into Amiloride etiology and treatment.

A major focus of Amiloride research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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