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Amiodaron Medical Research Studies

Up-to-date List of Amiodaron Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Amiodaron Medical Research Studies

Rank Status Study
1 Not yet recruiting Safety and Efficacy of Oral Versus Intravenous Amiodarone in the Treatment of AF
Condition: Atrial Fibrillation
Intervention: Drug: Amiodarone
Outcome Measures: Incidence rate of phlebitis;   incidence of hypotension;   Cumulative incidence of restored sinus rhythm
2 Recruiting Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation
Condition: Atrial Fibrillation
Intervention: Drug: Amiodarone
Outcome Measures: Recurrence of atrial arrhythmia;   Relapse of AF
3 Not yet recruiting Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death
Conditions: Chagas Cardiomyopathy;   Non-sustained Ventricular Tachycardia;   At Least 10 Points in Rassi Risk Score for Death
Interventions: Procedure: ICD implantation;   Drug: Amiodarone hydrochloride
Outcome Measures: all cause mortality;   Cardiac mortality;   Sudden cardiac death;   Worsening heart failure warranting hospitalization;   Need for cardiac stimulation in the ICD arm;   Need for pacemaker implantation in the Amiodarone therapy arm
4 Unknown  Amiodarone Compared to Dronedarone , Post Cardioversion Maintenance of Sinus Rhythm
Condition: Atrial Fibrillation
Interventions: Drug: Amiodarone;   Drug: Dronedarone
Outcome Measures: maintenance of sinus rhythm at one year post DC Cardioversion;   tolerability of Amiodarone compared to dronedarone;   measures of quality of life and symptoms in Amiodarone compared to dronedarone
5 Unknown  Study of Amiodarone Given Before Lung Surgery to Prevent Atrial Fibrillation After Lung Resection
Conditions: Atrial Fibrillation;   Lung Cancer
Interventions: Drug: Amiodarone;   Other: Control arm, standard care
Outcome Measures: Incidence of post-operative atrial fibrillation;   Hospital charges;   Length of post-operative hospital stay;   Incidence of other post-operative complications
6 Recruiting Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia
Condition: Cardiac Arrest
Interventions: Drug: Amiodarone;   Drug: Lidocaine;   Other: Normal saline
Outcome Measures: Survival to hospital discharge;   The secondary endpoint of the trial is survival to discharge with a Modified Rankin Score (MRS) ≤ 3 and will be compared in patients randomized to PM101 versus placebo, lidocaine versus placebo, and PM101 versus lidocaine in the efficacy population.
7 Unknown  Amiodarone Prophylaxis for Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer
Condition: Atrial Fibrillation
Intervention: Drug: Amiodarone
Outcome Measures: Free of atrial fibrillation;   Cost-benefit analysis of Amiodarone prophylactic
8 Recruiting Ablation vs Amiodarone for Treatment of AFib in Patients With CHF and an ICD
Condition: Heart Failure
Interventions: Procedure: Atrial Fibrillation ablation;   Drug: Amiodarone
Outcome Measures: Time to Recurrence of AF lasting longer than 15 seconds;   Change in distance walked in 6-minute walk test;   Total number of hospitalizations during the trial period for each group;   Change in MLHF Quality of Life during trial period;   Change in EF during trial period
9 Not yet recruiting Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation
Condition: Atrial Fibrillation
Interventions: Drug: Amiodarone;   Drug: Propafenone;   Drug: Sotalol
Outcome Measures: Average AF burden in minutes per day;   Persistent AF free survival rate;   Left ventricular function;   SF-36 health survey;   comorbidity and mortality
10 Recruiting Comparison of Treatment of Atrial Fibrillation (AF) Between Surgical Ultrasonic Technology or Drug Therapy for Patients With AF Requiring Mitral Valve Surgery
Conditions: Mitral Valvulopathy;   Atrial Fibrillation
Interventions: Device: EPICOR;   Drug: Amiodarone
Outcome Measures: Atrial Fibrillation episode;   Adverse drug effects of Amiodarone;   major cardiovascular event;   Atrial tachycardia;   Death
11 Recruiting Pulmonary Vein Ablation Versus Amiodarone in the Elderly
Condition: Atrial Fibrillation
Interventions: Procedure: PVI ablation;   Drug: Amiodarone
Outcome Measures: Recurrence of episodes of AF, atypical atrial flutter or left sided atrial tachycardia;   Composite end point of hospitalization, stroke, major bleeding and death
12 Recruiting Necessity of Anti-Arrhythmic Medication After Surgical Ablation for Atrial Fibrillation
Condition: Atrial Fibrillation
Intervention: Other: No Amiodarone
Outcome Measures: Change in Status of Rhythm Between Baseline and Follow-Up - Recurrence of Atrial Fibrillation;   Major Adverse Event Rate
13 Unknown  Combined Amiodarone and Electrical Cardioversion for Postoperative Atrial Fibrillation After Cardiac Surgery
Condition: Cardiac Surgery
Interventions: Drug: Amiodarone;   Procedure: Cardioversion
Outcome Measure: Subject rhythm
14 Unknown  Iv Amiodarone Versus Iv Procainamide to Treat Haemodynamically Well Tolerated Ventricular Tachycardia
Conditions: Ventricular Tachycardia;   Wide QRS Tachycardia
Intervention: Drug: iv Amiodarone and iv Procainamide
Outcome Measures: To compare clinically significant cardiac adverse events occurring within 40 minutes from treatment initiation;   To compare efficacy of both therapies in relation to episode termination;   To compare the rate of total adverse events, cardiac and non cardiac, occurring during an observation period of 24 hours after treatment was applied
15 Unknown  Safety of Amiodarone and Ranolazine Together in Patients With Angina
Conditions: Chronic Stable Angina;   Coronary Artery Disease;   Atrial Fibrillation;   Ventricular Tachycardia
Interventions: Drug: ranolazine;   Drug: placebo
Outcome Measures: ventricular arrhythmia;   atrial arrhythmia burden;   Electrocardiogram (EKG) corrected QT (QTc) interval measurement;   hospitalization;   syncope hospitalization;   liver function assay
16 Not yet recruiting Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study
Conditions: Atrial Fibrillation;   Heart Failure
Interventions: Drug: Amiodarone;   Procedure: External electrical cardioversion (EEC);   Drug: Pharmacotherapy to slow and control ventricular rate;   Procedure: Atrioventricular junction ablation (AVJA)
Outcome Measures: BiVp%;   6MWT distance;   peak VO2;   NYHA class;   Ejection fraction;   LVEDD reduction from baseline at 1 year;   LVEDV reduction from baseline at 1 year;   LVESD reduction from baseline at 1 year;   LVESV reduction froma baseline at 1 year;   Reduction of LA diameter at 1 year;   Reduction of mitral regurgitation at 1 year;   Heart failure exacerbations;   Mortality;   Stroke/TIA;   CV mortality;   Cardiovascular hospitalizations;   Quality of Life;   AF prevalence;   Ventricular arrhythmia;   Electrotherapy;   Side effects;   LVEDD reduction;   LVEDV reduction;   Reduction of LA area;   Reduction of LA diameter;   Reduction of mitral regurgitation
17 Not yet recruiting Atrial Fibrillation and By-pass Surgery
Condition: Patients With Coronary Artery Disease Scheduled for by Pass Surgery
Interventions: Drug: Amiodarone tab 200 mg x 3;   Drug: rosuvastatin 20 mg tab x1;   Drug: beta blockers Bisoprolol in adjusted dose
Outcome Measure: atrial fibrillation
18 Recruiting Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation
Condition: Postoperative Atrial Fibrillation
Interventions: Drug: Amiodarone;   Procedure: DC-cardioversion;   Drug: Rate Control
Outcome Measures: Total number of days in hospital;   AF- or treatment-related events;   Time to conversion to sustained, stable non-AF rhythm;   Heart rhythm comparison;   Length of Stay (index hospitalization);   Length of Stay (rehospitalization, including ED visits);   Outpatient Interventions;   Cost (hospital)
19 Recruiting Trial Comparing Ablation With Medical Therapy in Patients With Ventricular Tachycardia
Conditions: Ventricular Tachycardia;   Coronary Artery Disease
Interventions: Procedure: Catheter Ablation;   Drug: Medical therapy (sotalol or Amiodarone)
Outcome Measures: Recurrence of Ventricular Tachycardia;   Time to First Shock/ATP for VT or to First Presentation of Sustained VT;   Total mortality;   Sudden cardiac death;   Syncope;   Number of hospitalizations;   QOL measures
20 Recruiting Ventricular Tachycardia (VT) Ablation Versus Enhanced Drug Therapy
Condition: Recurrent Ventricular Tachycardia
Interventions: Procedure: Catheter Ablation;   Drug: Aggressive Antiarrhythmic Therapy (Amiodarone)
Outcome Measures: Appropriate ICD shocks,VT storm and death;   All cause mortality

These studies may lead to new treatments and are adding insight into Amiodaron etiology and treatment.

A major focus of Amiodaron research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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