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Amyl Medical Research Studies

Up-to-date List of Amyl Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Amyl Medical Research Studies

Rank Status Study
1 Recruiting Amylase and Hypersomnia
Condition: Hypersomnia in Children
Intervention: Procedure: saliva collection
Outcome Measures: Determination of the expression and enzymatic activity of salivary Amylase.;   Measurement of the mean sleep onset latency using the Multiple Sleep Latency Test (MSLT);   Measurement of the somnolence using Epworth and Karolinska scales
2 Unknown  Tracheal Dosage of Amylase : a New Surrogate for Microaspirations in Ventilated ICU Patients
Condition: Ventilated-acquired Pneumonia
Intervention: Other: dosage of Amylase
Outcome Measure: oral/tracheal Amylase ratio
3 Recruiting Acute Preoperative Stress and Hypotension After Spinal Anesthesia. SAS for "Salivary Amylase and Stress "
Condition: Planned Cesarean Section
Intervention:
Outcome Measures: Severity of maternal hypotension assessed with the total dose of vasoactive drugs required to keep systolic blood pressure between 95-105% of preinduction values.;   Salivary Amylase activity
4 Unknown  Does Having a Spouse Present During Epidural Analgesia Affect Stress Levels in the Parturient and Her Spouse?
Condition: Labor Pain
Intervention: Behavioral: stress level
Outcome Measures: Stress levels;   hemodynamic parameters
5 Not yet recruiting Comparison of Two Strategies of Oropharyngeal and Tracheal Suctioning in Mechanically Ventilated Patients
Conditions: Ventilator Acquired Pneumonia;   Aspiration
Interventions: Procedure: Optimized oral care;   Other: Routine oral care
Outcome Measures: tracheal to oropharyngeal ratio of Amylase enzymatic activity;   volume of the tracheal, subglottic, and oral suctions;   length of each mouth care;   cost of the optimized oral suctioning compared with routine care
6 Recruiting Investigating Inter-individual Variability in Glycemic and Insulin Responses
Conditions: Hyperglycemia;   Insulin Sensitivity
Interventions: Other: Jasmine rice;   Other: Parboiled basmati rice
Outcome Measures: Postprandial glycemic and insulin responses;   Physiological digestive functions
7 Recruiting Exercise Treatment of Dental Anxiety
Condition: Dental Anxiety
Interventions: Behavioral: Aerobic treadmill exercise;   Behavioral: placebo exercise
Outcome Measures: Change from Baseline in VAS - visual analog scale;   Change from Baseline in cortisol level;   Change from Baseline in alpha-Amylase
8 Recruiting Pilot Study: Sectio Bonding/Early Skin-to-skin Contact (SSC) After Caesarean Section
Condition: Early Skin-to-skin Contact
Interventions: Procedure: early SSC;   Procedure: late SSC
Outcome Measures: Change of oxytocin level;   Change of cortisol level;   Change of alpha Amylase level;   Change of chromogranin A level
9 Recruiting An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
Conditions: Pancreatic Fistula;   Distal Pancreatectomy Complications;   Falciform Patch Pancreatic Closure;   Fibrin Glue Pancreatic Closure
Interventions: Procedure: Falciform patch and fibrin glue application;   Procedure: standard pancreatic closure
Outcome Measures: Pancreatic fistula development post distal pancreatectomy;   Morbidity- wound infection,delayed gastric emptying,abscess formation;   Mortality;   Surgical re-intervention/percutaneous interventions
10 Unknown  Yoga And Cardiovascular Health Trial
Condition: Cardiovascular Health
Interventions: Other: Yoga;   Other: Usual care
Outcome Measures: Cardiopulmonary function;   Blood pressure;   Heart rate and heart rate variability;   Stress hormones;   Exercise capacity;   Body fat;   Glucose and lipids
11 Recruiting Mind-Body Rehabilitative Program for Veterans With mTBI (Mild Traumatic Brain Injury)
Conditions: Sleep Disturbance;   Traumatic Brain Injury
Interventions: Behavioral: Mind-Body Bridging Program;   Behavioral: Supportive Education
Outcome Measures: Change in self-reported measures of sleep using Medical Outcomes Study -Sleep Scale, from baseline (Pre) to 6 months follow-up;   Change in latency to sleep onset using the Sleep Diary, from baseline (Pre) to 6 months follow-up.;   Change in self-reported mTBI symptoms using the Neurobehavioral Symptom Inventory (NSI), from baseline (Pre) to 6 months follow-up.;   Change in self-reported Quality of Life using the Medical Outcomes Study (MOS) Short Form-36 (SF-36) for Veterans (MOS SF-36V), from baseline (Pre) to 6 months follow-up.;   Change in duration of sleep using the Sleep Diary, from baseline (Pre) to 6 months follow-up.;   Change in number of awakenings using the Sleep Diary, from baseline (Pre) to 6 months follow-up.;   Change in physical activity during sleep for assessment of sleep quality using a heart rate and motion detection device, from baseline (Pre) to 3 months follow-up;   Change in heart rate variability for assessment of sleep quality using a heart rate and motion detection device, from baseline (Pre) to 3 months follow-up;   Change in self-reported PTSD using the PTSD Checklist - Military Version (PCL-M), from baseline (Pre) to 6 months follow-up.;   Change in self-reported pain symptoms using the Brief Pain Inventory (BPI), from baseline (Pre) to 6 months follow-up.;   Change in self-reported depression symptoms using the Center for Epidemiologic Studies Depression Scale (CES-D), from baseline (Pre) to 6 months follow-up.;   Change in self-reported resilience using the Connor-Davidson Resilience Scale (CD-RISC), from baseline (Pre) to 6 months follow-up.;   Change in self-reported perceived stress symptoms using the Perceived Stress Scale (PSS), from baseline (Pre) to 6 months follow-up.;   Change in self-reported self-compassion using the Self-Compassion Scale (SCS), from baseline (Pre) to 6 months follow-up.;   Change in self-reported mindfulness using the Five Facet Mindfulness Questionnaire (FF-MQ), from baseline (Pre) to 6 months follow-up.;   Change in self-reported well-being using the Well-Being Index (WBI), from baseline (Pre) to 6 months follow-up.;   Change in self-reported type D (distressed) symptoms using the Type D Scale-14 (TYPE-D), from baseline (Pre) to 6 months follow-up.;   Change in self-reported suicidal ideation using the Beck Scale for Suicide Ideation (BSI), from baseline (Pre) to 6 months follow-up.;   Change in self-reported interoceptive awareness using the Multidimensional Assessment of Interoceptive Awareness (MAIA), from baseline (Pre) to 6 months follow-up.;   Change in sustained attention using the Computerized Cognitive Assessment, from baseline (Pre) to 3 months follow-up;   Change in diurnal salivary cortisol levels, from baseline (Pre) to 3 months follow-up;   Change in diurnal salivary α-Amylase levels, from baseline (Pre) to 3 months follow-up;   Change in salivary cortisol awakening response, from baseline (Pre) to 3 months follow-up;   Change in salivary α-Amylase awakening response, from baseline (Pre) to 3 months follow-up
12 Recruiting Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients
Conditions: Critical Illness;   Sepsis;   Diabetes;   Cardiac Arrest;   Acute Renal Failure;   Shock
Intervention: Dietary Supplement: Enteral nutrition (EN)
Outcome Measures: Screening and risk factors of exocrine pancreatic insufficiency in critically ill adult patients receiving enteral nutrition;   Effects of pancreatic enzyme supplementation on nutritional status and clinical outcomes in critically ill patients with sepsis
13 Recruiting Stereotactic Body Radiation Therapy With or Without Gemcitabine Hydrochloride in Treating Patients With Pancreatic Cancer That Can Be Removed By Surgery
Condition: Pancreatic Cancer
Interventions: Drug: gemcitabine hydrochloride;   Radiation: stereotactic body radiation therapy
Outcome Measures: Preoperative treatment-related toxicity, defined as adverse events occurring prior to surgical resection;   Postoperative surgical morbidity, defined as all other adverse events occurring within 90 days of surgery;   Total dose of chemotherapy and radiotherapy delivered;   Pre-treatment and post-treatment characteristics of the primary tumor on preoperative axial imaging including, but not limited to, tumor size, percentage of encasement/abutment of mesenteric vessels, and progression of disease;   Postoperative complications including, but not limited to, need for reoperation, need for interventional radiology fluid collection drainage, systemic infection, wound infection, prolonged ICU stay, and delayed gastric emptying;   Operative drain Amylase at days 3 and 5 postoperatively;   Length of hospital stay following pancreatic resection;   Degree of histologic response of tumor in the resected specimen;   Tumor samples for RNA and protein harvesting (when possible) from pretreatment biopsies and surgical specimens
14 Not yet recruiting Hair Cortisol Level as a Predictor of PTSD Development
Condition: Post Traumatic Stress Disorder
Intervention:
Outcome Measures: Change from Baseline in PTSD Symptoms;   ASD Development;   Change from Baseline in Hair Cortisol Levels
15 Unknown  Cipralex® for Anxiety Disorders in Adolescents
Condition: Anxiety Disorder
Intervention: Drug: Cipralex®
Outcome Measures: Treatment Efficacy;   Physiological response to stress;   Suicide risk
16 Recruiting Transmission of Mother-Infant Stress Communication
Condition: Stress
Intervention:
Outcome Measures: Salivary Cortisol;   Salivary Amylase
17 Recruiting The Diagnosis of Chronic Pancreatitis
Condition: Chronic Pancreatitis
Intervention: Other: diagnostic test
Outcome Measures: Development of pancreatic insufficiency;   Peak enzyme Concentration IE;   development of diabetes;   Development of pain;   weight loss;   peak Amylase
18 Recruiting Indomethacin Decreases Post-ERCP Pancreatitis
Condition: Post ERCP Acute Pancreatitis
Interventions: Drug: Indomethacin;   Drug: 2.6-g suppository of glycerin
Outcome Measures: Post ERCP Acute Pancreatitis;   Severity of post-ERCP pancreatitis;   Acute Pancreatitis;   Asymptomatic hyperAmylasemia;   Measurement of serum Amylase;   Routine laboratory examinations
19 Not yet recruiting Evaluation of A New Digestive Reconstruction Procedure Following Pancreatoduodenectomy
Conditions: Pancreatic Cancer;   Periampullary Carcinoma
Interventions: Procedure: Modified method of digestive tract reconstruction;   Procedure: Routine digestive tract reconstruction
Outcome Measures: Incidence of Pancreatic Leakage;   Life Quality Score;   Amylase Test of Abdominal Drainage Fluid
20 Recruiting AcuTA: Acupuncture in Test Anxiety
Conditions: Test Anxiety;   Experimental Setting (Trier Social Stress Test TSST)
Interventions: Device: Acupuncture;   Device: Laser Acupuncture
Outcome Measures: Cortisol in saliva;   Test Anxiety on a Visual Analogue Scale;   Primary Appraisal Secondary Appraisal;   Multidimensional Mood State Questionnaire;   State Trait Anxiety Questionnaire;   alpha Amylase in saliva

These studies may lead to new treatments and are adding insight into Amyl etiology and treatment.

A major focus of Amyl research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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