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Antidepressants Medical Research Studies

Up-to-date List of Antidepressants Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Antidepressants Medical Research Studies

Rank Status Study
1 Recruiting Development of Pharmacogenomic Method to Predict Antidepressant Responsiveness
Conditions: Depression;   Antidepressant Drug Adverse Reaction
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measures: all pharmacogenetic and biological marker variables cause drug response;   all clinical cause drug response
2 Unknown  Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients
Condition: Depression
Intervention: Drug: Antidepressants
Outcome Measures: Antidepressant Response at 6 weeks;   Biological value at 0 and 6 weeks
3 Recruiting Pharmacogenomic Study to Predict Antidepressant Responsiveness in Depressed Patients
Conditions: Depression;   Adverse Reaction to Drug
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measures: Antidepressant Response at 2,4,6 weeks A/E monitoring at 1,2,4,6 weeks;   Biological value at 0 and 6 weeks
4 Unknown  Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype
Condition: Depression
Intervention: Drug: Antidepressants
Outcome Measures: Antidepressant Response at 6 weeks;   Biological value at 0 and 6 weeks
5 Recruiting Lamotrigine Alone Compared to Lamotrigine Plus Antidepressant for the Treatment of Bipolar II Depression
Condition: Bipolar II Disorder, Most Recent Episode Major Depressive
Intervention: Drug: Lamotrigine
Outcome Measures: Efficacy of Lamotrigine monotherapy versus Lamotrigine plus antidepressant in the acute and maintenance treatment of Bipolar II depression as evidence by decrease in Montgomery-Asberg Depression Rating Scale (MADRS) score from baseline to endpoint.;   Rates of response to treatment and remission in both treatment arms maintenance efficacy of treatments as evidenced by relapse rates. Rates of treatment associated mania or hypomania as evidenced by increased score on the Young Mania Rating Scale (YMRS).
6 Recruiting Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients
Conditions: Depression;   Continuous Antidepressant Abuse;   Adverse Reaction to Drug
Intervention: Drug: SSRI class antidepressant
Outcome Measures: Antidepressant Response at 2,4,6 weeks;   Biological value at 0 and 6 weeks
7 Recruiting Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder.
Condition: Bipolar I Disorder
Interventions: Drug: Escitalopram;   Drug: Wellbutrin XL
Outcome Measures: Patients who respond to acute treatment with an antidepressant in combination with a mood stabilizer.;   Does continuing antidepressant treatment for 12 months increase the risk of developing a manic or hypomanic episode?
8 Recruiting Antidepressants During Pregnancy and Lactation: Pharmacokinetics and Clinical Implications
Conditions: Depressive Disorder;   Lactation
Intervention: Drug: SSRI/SNRI
Outcome Measures: Evaluate the pharmacokinetics of SSRI/SNRI antidepressant drugs in breast milk secretion;   Examine neonatal adaptation;   Examine neurodevelopment;   Study of growth;   Examine early mother-infant relationship
9 Recruiting Effects of Adding Motivational Interviewing to Antidepressant Treatment for Hispanic Adults With Depression
Condition: Depression
Interventions: Drug: Standard antidepressant therapy (SADT);   Behavioral: Motivational antidepressant therapy (MADT)
Outcome Measures: Number of days in ADT (retention);   Hamilton Depression Scale -17-item version (symptoms);   Sheehan Disability Scale (impairment);   Perceived quality of life;   Client Satisfaction Questionnaire (patient satisfaction);   Composite Adherence Score (medication adherence)
10 Not yet recruiting Mobile Technology to Engage and Link Patients and Providers in Antidepressant Treatment
Condition: Depressive Disorder, Major
Intervention: Behavioral: Medlink system
Outcome Measures: Objective patient adherence to antidepressant medication;   Patient Adherence Questionnaire (PAQ);   Adequency of anti depressant medication dosage;   Number of contacts with Primary Care team;   Depression;   Usability and Satisfaction with system;   Medication side effects;   Attitudes towards Anti Depressant Medication
11 Recruiting Interpersonal Psychotherapy for Treatment Resistant Depression
Condition: Treatment Resistant Depression
Interventions: Other: IPT+ antidepressant drugs;   Drug: fluoxetine;   Drug: sertraline;   Drug: paroxetine;   Drug: Citalopram;   Drug: escitalopram;   Drug: fluvoxamine;   Drug: Venlafaxine;   Drug: Duloxetine;   Drug: Bupropion;   Drug: Lithium;   Drug: Risperidone;   Drug: tranylcypromine;   Drug: Imipramine;   Drug: amitriptyline;   Drug: Clomipramine;   Drug: nortriptyline;   Drug: trazodone;   Drug: Mirtazapine;   Drug: sulpiride
Outcome Measures: Hamilton Depression Scale (HAM-D) - continuous;   Beck depression Inventory (BDI)
12 Recruiting Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults
Conditions: Major Depressive Disorder;   Dysthymic Disorder;   Depressive Disorder, NOS
Intervention: Drug: Antidepressant Medication
Outcome Measures: Hamilton Rating Scale for Depression;   Beck Depression Inventory;   World Health Organization Disability Assessment Scale 2;   Measure of Everyday Cognition;   Short Physical Performance Battery;   Selective Reminding Task;   Stroop Color-Word test;   Trailmaking Test A & B
13 Recruiting The Metabolic Effects of Antidepressants in Patients Diagnosed With Major Depressive Disorder
Condition: Major Depressive Disorder
Outcome Measure: the influence of antidepressant medications on the metabolic profiles (5) of patients suffering from Major Depressive Disorder.
14 Recruiting Cytochrome P450-2D6 Screening Among Elderly Using Antidepressants (CYSCE)
Conditions: Depression;   Depressive Disorder;   Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant;   Intermediate Metabolizer Due to Cytochrome P450 CYP2D6 Variant;   Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant
Intervention: Other: Genotype information accompanied by a drug dosing advice
Outcome Measures: Serum drug levels of nortriptyline or venlafaxine;   Adverse drug events Questionnaire;   Quality of life questionnaire;   Productivity Questionnaire;   Self reported Severity of depression Questionnaire;   Drug use;   Data on health care associated resource use
15 Recruiting Predict Antidepressant Responsiveness Using Pharmacogenomics
Conditions: Depression;   Depressive Symptoms
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measure: Presences of each individual symptom of depression at 1,2,4,6,12 weeks
16 Recruiting VA Augmentation and Switching Treatments for Improving Depression Outcomes
Condition: Major Depressive Disorder
Interventions: Drug: Augmenting: Antidepressant + Aripiprazole;   Drug: Augmenting: Antidepressant + Bupropion-SR;   Drug: Switching: Bupropion-SR
Outcome Measures: Remission of symptoms of major depressive disorder;   Relapse in symptoms of major depression;   Response in symptoms of major depression;   Onset or cessation of akathisia;   Onset or cessation of anxiety;   Onset or cessation of suicide ideation;   Change in Clinical Global Impression Scale;   Emergence of adverse experiences;   Cost and Cost-Effectiveness
17 Recruiting Antidepressant Plus Asenapine Versus Antidepressant Plus Placebo for Depression
Condition: Major Depressive Disorder Without Psychotic Features
Interventions: Drug: Asenapine 5-20 mg daily;   Drug: Placebo 1-4 tablets daily
Outcome Measures: Change in MADRS total score;   Study completion rate;   Rates of response, remission, and sustained remission
18 Recruiting Comparative Trial of Antidepressant Treatment Models in HIV Care in Uganda
Condition: Depression
Intervention: Drug: antidepressant therapy
Outcome Measures: Depression diagnostic evaluation;   Antidepressant prescription;   Depressive symptoms;   Consistent condom use;   ART adherence
19 Recruiting Compliance With Antidepressant Medication in Treatment of Functional Dyspepsia
Conditions: Dyspepsia;   Compliance;   Depression
Interventions: Drug: Omeprazole;   Drug: Flupentixol and Melitracen Tablets(for dyspepsia symptoms) + Omeprazole;   Drug: Flupentixol and Melitracen Tablets(for depression symptoms) + Omeprazole;   Drug: Flupentixol and Melitracen Tablets(without explanation) + Omeprazole
Outcome Measures: compliance of antidepressant medication;   dyspepsia symptom questionnaire;   psychiatric symptom on Hospital Anxiety and Depression Scale;   quality of life rating;   adverse reaction
20 Unknown  Antiglucocorticoid Augmentation of Antidepressants in Depression
Condition: Depression
Interventions: Drug: Metyrapone;   Drug: placebo
Outcome Measures: The primary outcome will be the change in Montgomery-Asberg Depression Rating Scale (MADRS) from week 0 to +5 weeks.;   Secondary outcomes related to mood will be the Montgomery-Asberg Depression Rating Scale (MADRS) measured at time +3, +5, +8, +16 and + 24 weeks relative to baseline.;   Clinical Anxiety Scale (CAS);   Quality of life will be assessed using the self-completed EuroQol EQ-5D instrument (http://www.euroqol.org/). The EQ-5D will be completed at 0, +3, +5, +8, +16 and + 24, weeks.

These studies may lead to new treatments and are adding insight into Antidepressants etiology and treatment.

A major focus of Antidepressants research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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