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Antihypertensive Medical Research Studies

Up-to-date List of Antihypertensive Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Antihypertensive Medical Research Studies

Rank Status Study
1 Not yet recruiting Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control
Condition: Hypertension
Intervention: Drug: Anti-hypertensive Medication -
Outcome Measures: 3mm Hg difference in mean 24 hour systolic Blood Pressure;   Mean day-time ABPM systolic BP;   Mean day-time ABPM diastolic BP;   Μean night time ABPM systolic BP;   Μean night time ABPM diastolic BP;   Mean clinic - systolic BP;   Mean clinic - diastolic BP;   Concordance with taking drug treatment;   Self reported side effects;   Quality of Life;   Clinical events (extra GP or hospital visits and procedures and hospitalization)
2 Recruiting The Efficacy of Nitric Oxide in Stroke (ENOS) Trial
Condition: Stroke
Interventions: Drug: Transdermal glyceryl trinitrate patch;   Drug: Pre-stroke Antihypertensives
Outcome Measure: Reduced death or dependency (modified Rankin score)
3 Unknown  Comparison Fetal Hemodynamic Measurements Antihypertensive Versus Control
Conditions: Hypertension;   Pregnancy
Intervention: Procedure: ultrasound evaluation in pregnancy
Outcome Measure: Fetal ultrasound assessment of middle cerebral artery and umbilical artery blood flow
4 Not yet recruiting Morning Versus Evening Dosing of Antihypertensive Medications: A Pilot Study to Assess Feasibility and Efficacy
Condition: Hypertension
Intervention: Behavioral: Medication therapy management
Outcome Measures: Adherence to timing instructions;   General medication adherence
5 Unknown  A Comparison of Two Target Mean Arterial Pressures in the Resuscitation of Hypotensive Trauma Patients
Conditions: Hemorrhagic Shock;   Trauma;   Wounds, Penetrating;   Shock, Traumatic;   Multiple Trauma
Intervention: Procedure: Intraoperative Hypotensive Resuscitation
Outcome Measures: 30 day survival;   Sequential Organ Failure Assessment (SOFA) score;   APACHE II;   ARDS;   ICU length of stay;   Ventilator-free days;   Myocardial ischemia;   Stroke;   Acidosis (pH and BE);   Coagulopathy by conventional labs and thromboelastogram;   Estimated blood loss;   Transfusion requirements;   Glasgow Outcome Score;   Quantification of leukocyte apoptosis;   Rate of infectious complications (VAP, UTI, wound infections).
6 Unknown  Combined Antihypertensive Therapy and Sexual Dysfunction
Conditions: Hypertension;   Sexual Dysfunction
Interventions: Drug: Felodipine add Irbesartan;   Drug: Felodipine add Metoprolol
Outcome Measures: Female Sexual Function Index (FSFI);   International Index of Erectile Function(IIEF);   Change of Systolic Blood Pressure in 2 Weeks;   Change of Systolic Blood Pressure in 4 Weeks;   Change of Systolic Blood Pressure in 8 Weeks;   Change of Systolic Blood Pressure in 12 Weeks;   Change of Systolic Blood Pressure in 24 Weeks;   Change of Systolic Blood Pressure in 48 Weeks;   Change of Diastolic Blood Pressure in 2 Weeks;   Change of Diastolic Blood Pressure in 4 Weeks;   Change of Diastolic Blood Pressure in 8 Weeks;   Change of Diastolic Blood Pressure in 12 Weeks;   Change of Diastolic Blood Pressure in 24 Weeks;   Change of Diastolic Blood Pressure in 48 Weeks;   Serum Estradiol in 24 Weeks;   Serum Estradiol in 48 Weeks;   Serum Testosterone in 24 Weeks;   Serum Testosterone in 48 Weeks;   Serum MDA in 24 Weeks;   Serum MDA in 48 Weeks;   Serum 8-OHdG in 24 Weeks;   Serum 8-OHdG in 48 Weeks;   Serum HNE in 24 Weeks;   Serum HNE in 48 Weeks
7 Recruiting Clinical Study to Evaluate the Antihypertensive Efficacy and Changes of Neurohormonal Markers of Fimasartan and Atenolol With Exaggerated Blood Pressure Response During Exercise in Essential Hypertensive Patients
Condition: Hypertension
Interventions: Drug: Fimasartan;   Drug: Atenolol
Outcome Measures: The difference of sitting Systolic Blood Pressure(SiSBP) between at the peak compared to at resting;   The difference of sitting Diastolic Blood Pressure(SiDBP) at the peak compared to at resting;   The difference of sitting Systolic Blood Pressure(SiSBP) at each exercising stage compared to at resting;   The difference of sitting Systolic Blood Pressure(SiSBP) among at resting, each exercising stage and recovery
8 Not yet recruiting Treatment of Masked Hypertension
Conditions: Masked Hypertension;   Hypertension;   Chronic Renal Insufficiency
Interventions: Other: Antihypertensive medication intensification;   Other: Usual care
Outcome Measures: Percentage of participants with masked hypertension;   Change from baseline in urine albumin to creatinine ratio at 4 months;   Change from baseline in pulse wave velocity at 4 months;   Change from baseline in 24hr ambulatory systolic blood pressure at 4 months
9 Recruiting Impact of a Multidisciplinary Self-care Management Program on Quality of Life, Self-care Behavior, Adherence to the Anti-hypertensive Treatment, Glycemic Control, and Renal Function in Adults Living With Diabetic Kidney Disease
Condition: Diabetic Kidney Disease
Intervention: Behavioral: Self-care management program
Outcome Measures: Quality of life;   Self-care;   The adherence to anti-hypertensive medication;   Blood glucose control;   Kidney function
10 Recruiting Stop Vasodepressor Drugs in Reflex Syncope
Condition: Hypotensive Syncope
Interventions: Drug: Vasoactive drug therapies;   Other: Stop/reduce vasoactive drugs
Outcome Measures: Recurrence of syncope or presyncope and adverse events;   Syncope;   Presyncope
11 Unknown  Antihypertensive Effect of Simvastatin in Hypertensive Patients
Condition: Hypertension
Interventions: Drug: Simvastatin 40mg;   Drug: Placebo
Outcome Measure: Blood Pressure measured with 24-Ambulatory Blood Pressure Monitoring (24h-ABPM)
12 Recruiting Blood Volume Analysis of Total Hip Arthroplasty Patients Under Hypotensive Anesthesia
Condition: Blood Volume Analysis
Intervention: Radiation: 1mL of I-131 Human Serum Albumin is injected prior to the measurements
Outcome Measures: change in Total Blood Volume;   Intraoperative Fluid Substitution
13 Unknown  Intensification of Care to Improve Adherence to Anti-hypertensives
Condition: Medication Adherence
Interventions: Behavioral: Intensification of Care;   Other: Usual Care
Outcome Measures: Means difference and risk ratio between and within groups of adherence to treatment;   Means difference and/or risk ratio between and within groups of clinical outcomes
14 Recruiting The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Prognosis
Condition: Hypertension, Resistant to Conventional Therapy
Outcome Measures: acute coronary syndrome;   stroke
15 Unknown  Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape)
Condition: Preeclampsia
Interventions: Drug: methildopa;   Drug: placebo
Outcome Measures: Arterial blood pressure stabilization after methildopa use;   Complications in stable pregnant women with severe preeclampsia after methildopa use
16 Recruiting Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy
Conditions: Hypertension in Pregnancy;   Preeclampsia
Interventions: Drug: Nifedipine;   Drug: Labetalol;   Drug: Methyldopa
Outcome Measures: Successful outcome;   number of hourly BP's in severe range
17 Unknown  Clinical Trial to Evaluate the Antihypertensive Effect of AGSCT101 in Patient With Hypertension
Condition: Essential Hypertension
Interventions: Drug: Carvedilol 25mg;   Drug: AGSCT101 12.5mg
Outcome Measures: Change from baseline in diastolic blood pressure (DBP);   Change from baseline in systolic blood pressure (SBP);   Proportion of patients who reach overall blood pressure control (defined as BP <140/90);   Incidence of adverse effects
18 Unknown  Clinical Trial to Evaluate the Efficacy and the Safety of Antihypertensive Tablets
Condition: Essential Hypertension
Intervention: Drug: OJP-2028
Outcome Measures: Average SiDBP Differences of test group vs control group per each dosage by comparison with the baseline.;   Average SiSBP Differences of each group by comparison with the baseline.;   Responder rate of each group by comparison with the baseline.;   Average SiDBP and SiSBP Differences of each group by comparison with the baseline.
19 Unknown  Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine
Conditions: HIV Infections;   Hypertension
Interventions: Drug: candesartan;   Drug: lercanidipine
Outcome Measures: morpho-functional left ventricle characteristics;   metabolic profile;   systolic and diastolic blood pressure
20 Recruiting A Valsartan 80 Mg-Referenced, Therapeutic Exploratory Clinical Study to Evaluate the Antihypertensive Efficacy of Fimasartan 30 mg During 24 Hours in Patients With Mild to Moderate Essential Hypertension
Condition: Essential Hypertension
Interventions: Drug: Fimasartan;   Drug: Valsartan
Outcome Measures: Mean Systolic Blood Pressure during 24 hours;   Mean Diastolic Blood Pressure during 24 hours;   Mean Diastolic Blood pressure and Systolic Blood pressure during daytime or nighttime;   Sitting Diastolic Blood pressure and Systolic Blood pressure;   Trough-to-peak ratio;   Smoothness index

These studies may lead to new treatments and are adding insight into Antihypertensive etiology and treatment.

A major focus of Antihypertensive research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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