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Apo-trihex Medical Research Studies

Up-to-date List of Apo-trihex Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Apo-trihex Medical Research Studies

Rank Status Study
1 Recruiting Glutamate, Brain Connectivity and Duration of Untreated Psychosis
Conditions: Schizophrenia;   Psychosis;   Schizoaffective Disorder
Intervention: Drug: Risperidone
Outcome Measures: Comparison of indices of glutamate as measured by 1H-MRS in unmedicated first episode psychosis patients before and after antipsychotic treatment and with healthy controls.;   Comparison of structural and functional brain connectivity in first episode psychosis patients before and after antipsychotic treatment and healthy controls;   Evaluation of the contribution of structural and functional connectivity to eventual antipsychotic treatment response in first episode psychosis patients.
2 Recruiting Psychosis and Affective Research Domains and Intermediate Phenotypes
Conditions: Bipolar I Disorder, Unspecified, With Psychotic Features;   Bipolar I Disorder, Unspecified, Without Psychotic Features
Outcome Measures: Differences in those with Bipolar disorder with psychosis, without psychosis, and healthy controls on functional and structural brain imaging, neurocognitive assessments, and neurophysiological tests;   Differences in those with Bipolar disorder with psychosis, without psychosis, and healthy controls on clinical assessment questionnaires
3 Recruiting Social Cognition in Longstanding Psychosis
Conditions: Schizophrenia;   Schizoaffective Disorder;   Bipolar Disorder With Psychotic Features;   Major Depression With Psychotic Features;   Psychosis Not Otherwise Specified (NOS)
Outcome Measures: Emotion Recognition;   Attribution Style;   Social Perception;   Social Knowledge;   Theory of Mind;   Anxiety;   Depression;   Psychosis;   Social Functioning;   Service Utilization;   Self-Determination Needs Satisfaction;   Locus of Control;   Cognitive representation of illness;   Emotional Awareness;   Mindfulness;   Medication adherence;   Neuropsychological functioning;   Social Support;   Illness Uncertainty;   Relationship with familial caregivers;   Self-efficacy;   Experience of Stigma;   quality of life;   stage of recovery;   Coping skills;   Time perspective
4 Recruiting Manualized Group Cognitive-behavioral Therapy for Social Anxiety in First Episode Psychosis
Conditions: Social Phobia;   Psychosis
Interventions: Behavioral: Manualized group Cognitive-behavioral therapy (CBT) for social anxiety in first episode psychosis;   Behavioral: Group Computer assisted cognitive remediation therapy
Outcome Measures: Social anxiety symptoms as measured by the Social Interaction Anxiety Scale (SIAS);   Social anxiety symptoms as measured by the Social Phobia Inventory (SPIN);   Social anxiety symptoms as measured by the the Brief Social Phobia Scale (BSPS);   Psychosis Symptoms Remission as measured by the Scale for Assessment of Positive Symptoms (SAPS) and Negative Symptoms (SANS);   Functional outcome as measured by the Recovery Assessment Scale (RAS);   Functional outcome as measured by the Social and Occupational Functioning Scale (SOFAS).
5 Recruiting Integrated Care in Psychotic Disorders With Severe Mental Illness
Conditions: Schizophrenia;   Schizophreniform Disorder;   Schizoaffective Disorder;   Delusional Disorder;   Psychotic Disorder NOS;   Bipolar Disorder;   Severe Major Depression With Psychotic Features
Intervention: Other: Integrated care
Outcome Measures: Time to service disengagement;   Change of functioning as measured with the Global Assessment of Functioning Scale (GAF);   Change of quality of life as measured with the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q-18);   Change of psychopathology as measured with the Brief Psychiatric Rating Scale (BPRS);   Change of satisfaction with care as measured with the Client Satisfaction Questionnaire (CSQ-8);   Service use data
6 Recruiting Screening for Childhood-Onset Psychotic Disorders
Conditions: Childhood Onset Psychotic Disorders;   Schizophrenia;   Psychosis;   Psychotic Disorder
Outcome Measure:
7 Recruiting Acceptance and Commitment Therapy for the Inpatient Treatment of Psychosis
Condition: Psychotic Disorders
Interventions: Behavioral: Acceptance and Commitment Therapy;   Other: Treatment as Usual (TAU)
Outcome Measures: Brief Psychiatric Rating Scale (Overall & Gorham, 1962);   Frequency, Believability, and Distress Symptom Scale (Gaudiano & Herbert, 2006);   Acceptance and Action Questionnaire - II (Bond et al.., 2011);   Positive and Negative Affect Scale (Watson et al., 1988);   Cost of Stay;   Barriers and Facilitators to implementation;   Experimental Treatment Feasibility;   Experimental Treatment Acceptability;   Experimental Treatment Safety
8 Recruiting Stage-specific Case Management for Early Psychosis
Condition: Psychotic Disorders
Intervention: Behavioral: stage-specific case-management
Outcome Measures: Functioning (social and occupational);   Health economics
9 Recruiting Mediators and Moderators of Treatment Outcome in Recent-Onset Psychosis
Conditions: Schizophrenia;   Schizoaffective Disorder;   Bipolar Disorder With Psychotic Features;   Major Depression With Psychotic Features;   Psychotic Disorder Not Otherwise Specified (NOS)
Interventions: Behavioral: Group Cognitive Behavioral Therapy;   Behavioral: Multifamily Group Psychoeducation
Outcome Measures: Change from baseline in General level of functioning at 6 months, 12 months, 18 months, and 24 months;   Change from baseline in self-reported Physical Health at 6 months, 12 months, 18 months, and 24 months;   Change from baseline in Social and vocational Functioning at 6 months, 12 months, 18 months, and 24 months;   Change from baseline in Stage of Recovery at 6 months, 12 months, 18 months, and 24 months;   Change from baseline Service Utilization at 6 months, 12 months, 18 months, and 24 months;   Change from Baseline Quality of Life at 6 months, 12 months, 18 months, and 24 months
10 Recruiting Group Training for Social Skills in Psychosis
Condition: Psychotic Disorders
Interventions: Behavioral: GRASP;   Behavioral: Standard care
Outcome Measures: Therapy drop-out rate;   Number of therapy session attended
11 Recruiting STEP-ED: Reducing Duration of Untreated Psychosis and Its Impact in the U.S.
Conditions: Psychosis;   Schizophrenia
Interventions: Behavioral: Early Detection (ED);   Behavioral: Usual Detection
Outcome Measures: Proportion of Participants with Duration of Untreated Psychosis (DUP);   Proportion of Participants with Duration of Untreated Psychosis DUP
12 Not yet recruiting Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic Disorders
Conditions: Mood Disorders;   Psychotic Disorders
Interventions: Behavioral: High Intensity Training;   Behavioral: Low Intensity Training
Outcome Measures: Therapist Competency and Adherence Rating;   Patient Health Questionnaire, 9;   Young Mania Rating Scale
13 Not yet recruiting Economic and Clinical Outcomes of Attendance in Psychosis Services Using SMS.
Condition: Psychosis
Intervention: Other: SMS reminder
Outcome Measures: Outcome of appointment (attended, missed, cancelled by the participant, cancelled by the service);   Economic outcome: Use of Psychosis Services and impact on cost;   Clinical outcome: Number of inpatient admissions;   Clinical outcome: Number of days in inpatient care;   Clinical outcome: Number of inpatient admissions under the mental health treatment act;   Clinical outcome: Number of referrals to a home treatment team;   Clinical outcome: Number of times patient has had changes to their medication;   Clinical outcome: Level of health and social functioning, as reflected in the patient's score on the Health of the Nation Outcome Scales (HoNOS);   Economic outcome: cost effectiveness of the SMS intervention
14 Unknown  Improving Cognitive Function of Aripiprazole in Treating Adolescents and Young Adults With Psychotic Disorder
Condition: Psychotic Disorders
Outcome Measure:
15 Unknown  A Randomized Controlled Trial of Individual Therapy for First Episode Psychosis
Condition: Psychosis
Interventions: Other: Cognitive Behavioural Therapy;   Other: befriending
Outcome Measures: Social Functioning;   Positive & negative symptoms;   Individual dimensions of psychotic symptoms;   Depression;   Substance use;   Alcohol and Drug Use;   Medication adherenceAdaptation to illness;   Self Esteem;   Coping Skills (MACS)
16 Unknown  Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry
Conditions: Schizophrenia;   Psychosis
Intervention: Drug: Quetiapine XR
Outcome Measures: The primary efficacy variable is the change in aggression between admission and day 8 of treatment with Quetiapine XR as measured by the OAS.;   Measuring psychotic symptomatology change from baseline in BPRS-Total Score in aggressive, psychotic patients managed with Quetiapine XR;   Measuring the incidence of adverse events (including Extrapyramidal symptoms) by the change from baseline in SAS and BAS and subjective reports;   Measuring the incidence of concomitant benzodiazepine and other permitted medication use
17 Unknown  Epidemiology Study of Psychosis
Condition: Psychotic Disorders
Outcome Measures: Functional Level;   Quality of Life;   Symptomatology
18 Not yet recruiting Mindfulness RCT for Early Psychosis
Condition: Psychosis
Interventions: Other: Mindfulness;   Other: Psychoeducation
Outcome Measures: Depressive mood;   Anxiety;   Quality of Life;   Life Functioning;   Mindfulness
19 Recruiting Probing the Cannabinoid System in Individuals With a Family History of Psychosis
Conditions: Psychosis;   Schizotypy;   Cannabis Use
Interventions: Drug: Placebo;   Drug: Very Low Dose THC;   Drug: Low Dose THC
Outcome Measures: Positive and Negative Symptom Scale for Schizophrenia (PANSS);   Clinician Administered Dissociative Symptoms Scale (CADSS);   Visual Analog Scale (VAS);   Hopkins Verbal Learning Test (HVLT);   Psychotomimetic States Inventory (PSI)
20 Unknown  Optimal Duration of Early Intervention for Psychosis
Condition: Psychotic Disorders
Intervention: Behavioral: Community Case Management
Outcome Measures: Functioning (social and occupational);   Symptoms, quality of life and health economics

These studies may lead to new treatments and are adding insight into Apo-trihex etiology and treatment.

A major focus of Apo-trihex research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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