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Arcalyst Medical Research Studies

Up-to-date List of Arcalyst Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Arcalyst Medical Research Studies

Rank Status Study
1 Recruiting Rilonacept (Arcalyst ®) in the Treatment of Subacromial Bursitis
Condition: Subacromial Bursitis
Interventions: Drug: Rilonacept;   Drug: Corticosteroid (Triamcinolone (Kenalog) )
Outcome Measures: Improvement in shoulder function;   Improvement in pain;   Number of Participants with Adverse Events as a Measure of Safety and Tolerability
2 Recruiting Rilonacept for Deficiency of the Interleukin-1 Receptor Antagonist (DIRA)
Condition: DIRA
Intervention: Drug: Rilonacept
Outcome Measures: To assess the ability of rilonacept administration to achieve/maintain inflammatory remission in patients with DIRA who have shown a response to treatment with Anakinra [Kineret].;   To assess the ability of rilonacept to prevent new organ damage in patients with DIRA who have shown a response to treatment with Anakinra [Kineret], and in patients with DIRA treatment na(SqrRoot) ve.;   To evaluate the safety of rilonacept in subjects with DIRA;   To evaluate the safety and pharmacokinetics in young children on Rilonacept.;   To evaluate bone mineralization in patients with DIRA;   To evaluate health-related quality of life in children and adolescents with DIRA
3 Recruiting Interleukin-1 Trap to Treat Vascular Dysfunction in Chronic Kidney Disease (CKD)
Condition: Renal Insufficiency, Chronic
Interventions: Drug: Rilonacept;   Drug: Placebo
Outcome Measures: Change in flow-mediated dilation (FMD);   Change in aortic pulse-wave velocity (aPWV);   Change in contribution of oxidative stress to FMD;   Change in contribution of oxidative stress to aPWV
4 Recruiting IL1-TRAP, Rilonacept, in Systemic Sclerosis
Conditions: Scleroderma;   Systemic Sclerosis;   Diffuse Scleroderma;   Diffuse Systemic Sclerosis
Interventions: Drug: Rilonacept;   Drug: Placebo
Outcome Measures: 4- gene biomarker;   Modified Rodnan Skin Score
5 Not yet recruiting A Safety and Efficacy Study of Mycophenolate Mofetil and Rilonacept in Patients With Alcoholic Hepatitis
Condition: Alcoholic Hepatitis
Interventions: Drug: Rilonacept;   Drug: Mycophenolate mofetil;   Drug: Prednisolone
Outcome Measures: Survival;   Change in Bilirubin;   Safety;   MELD and DF Score
6 Recruiting Inflammation in Chronic Kidney Disease and Cardiovascular Disease - The Role of Genetics and Interleukin-1 Receptor Antagonist (IL-1ra)
Conditions: Chronic Kidney Disease;   Cardiovascular Disease
Interventions: Drug: Rilonacept;   Drug: Placebo
Outcome Measures: High Sensitivity C-Reactive Protein (hsCRP);   Interleukin-6 (IL-6)

These studies may lead to new treatments and are adding insight into Arcalyst etiology and treatment.

A major focus of Arcalyst research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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