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Aredia Medical Research Studies

Up-to-date List of Aredia Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Aredia Medical Research Studies

Rank Status Study
1 Not yet recruiting Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation
Conditions: Osteopenia;   Osteoporosis
Interventions: Drug: Pamidronate;   Drug: Calcium and vitamin D
Outcome Measures: Lumbar spine bone mineral content;   Total body bone mineral content (TBMC; excluding head; adjusted for height, age, sex, Tanner stage, and race);   Total bone mineral density (BMD), cortical BMD, trabecular BMD, and estimated bone strength measured by pQCT;   Cytokine levels (interleukin IL-6, IL-7, and TNF-α);   Receptor activator of the nuclear factor-κB ligand [RANKL], osteoprotegerin [OPG], RANKL/OPG ratio;   Markers of bone resorption (carboxy-terminal collagen crosslinks [CTX] and deoxypyridinoline [DPD]);   Markers of bone formation (procollagen type 1 N-terminal propeptide [P1NP] and osteocalcin [OCN])
2 Not yet recruiting Evaluate Time Associated With the Preparation & Administration of Denosumab/Pamidronate in Patients With Solid Tumors and Metastatic Bone Disease
Conditions: Solid Tumor;   Metastatic Bone Disease
Interventions: Biological: denosumab;   Drug: pamidronate
Outcome Measure: Total duration (in hours, minutes and seconds) for investigational product preparation and administration
3 Recruiting The ODYSSEY TRIAL Phase IV Trial Evaluating the Palliative Benefit of Pamidronate or Zoledronic Acid in Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Pamidronate;   Drug: Zoledronic acid;   Drug: placebo
Outcome Measures: sCTX values;   Palliative response
4 Recruiting Bisphosphonate Biomarker Study
Conditions: Osteoporosis, With or Without Treatment;   Bisphosphonate Treatment;   Atypical Femur Fracture;   Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ);   Healthy Volunteers
Outcome Measures: Absorption, Distribution, Metabolism, Excretion (ADME) Profiling of DNA from all sample types vs. normative data for the ADME panel and across study groups;   Differential expression of miRNA biomarkers across participant groups within the study

These studies may lead to new treatments and are adding insight into Aredia etiology and treatment.

A major focus of Aredia research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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