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Arestin Medical Research Studies

Up-to-date List of Arestin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Arestin Medical Research Studies

Rank Status Study
1 Recruiting Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy
Condition: Lung Cancer
Interventions: Drug: Minocycline;   Other: Placebo;   Behavioral: Questionnaires
Outcome Measures: AUC Value Symptom Severity Differences;   Effectiveness of Minocycline in Reducing Treatment-Induced Inflammatory Response
2 Recruiting Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer
Condition: Head And Neck Cancer
Interventions: Drug: Minocycline;   Drug: Placebo;   Behavioral: Questionnaires
Outcome Measures: Efficacy of Minocycline for Reducing Patient-Reported Symptoms;   Time-to-Symptom-Recovery
3 Recruiting The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With Depression
Condition: Depressive Disorder
Interventions: Drug: Minocycline;   Drug: Placebo;   Drug: Ketamine
Outcome Measures: Proportion of patients (among responders) who survive relapse-free;   Change in MADRS total score among non-responders from pre-randomization to end-of-study;   Change in the MADRS total score from baseline during IV ketamine treatment phase;   Change in the MADRS total score from baseline after IV ketamine treatment phase;   Response (reduction ≥ 50% in MADRS total score relative to baseline) rate during IV ketamine treatment phase;   Time to relapse (among responders) following completion of the IV ketamine infusion schedule and after first dose of minocycline/placebo;   Change in C-SSRS from baseline to any time in the study
4 Recruiting A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer
Condition: Esophageal Cancer
Interventions: Drug: Armodafinil;   Other: Placebo;   Drug: Minocycline;   Behavioral: Questionnaires
Outcome Measure: Mean Symptom Increase During Chemoradiation Therapy
5 Recruiting Minocycline Study in Pancreatic Cancer Patients
Condition: Pancreatic Cancer
Interventions: Drug: Minocycline;   Other: Placebo;   Behavioral: Questionnaires
Outcome Measures: Symptom Reduction During FOLFIRINOX Chemotherapy;   Changes Between Inflammation Biomarkers and Symptom Outcomes
6 Recruiting Minocycline and Aspirin in the Treatment of Bipolar Depression
Condition: Bipolar Disorder Depression
Interventions: Drug: Minocycline;   Drug: Aspirin;   Drug: placebo
Outcome Measure: Montgomery-Asberg Depression Rating Scale
7 Recruiting Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients
Condition: Colorectal Cancer
Interventions: Drug: Minocycline;   Drug: Placebo;   Behavioral: Questionnaires;   Behavioral: Sensory Test
Outcome Measure: Reduction of Acute Peripheral Neuropathy During Oxaliplatin-Based Chemotherapy
8 Recruiting Study to Evaluate the Efficacy and Safety of Minocycline in Angelman Syndrome
Condition: Angelman Syndrome
Interventions: Drug: MINOCYCLINE;   Drug: PLACEBO (for Minocycline)
Outcome Measures: Increased on the equivalent age of development;   Improved specific cognitive, language and communication, motor development, social-emotional and adaptive behavior;   Improvement of EEG.;   Safety and tolerability;   Clinical Global impression (CGI)
9 Recruiting Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax
Condition: Pneumothorax
Interventions: Procedure: Simple aspiration with minocycline pleurodesis;   Procedure: simple aspiration
Outcome Measures: to compare the rates of ipsilateral recurrence between the minocycline and observation groups after simple aspiration of the pneumothorax.;   Safety profile of minocycline pleurodesis;   Early results, including immediate success rates, one-week success rates, complication rates, rates of hospitalization, duration of hospitalization, and the degrees of chest pain.;   Long-term effects of minocycline pleurodesis, including degrees of residual chest pain and pulmonary function test
10 Recruiting Intervention for Symptom Burden During Maintenance Therapy for Multiple Myeloma
Condition: Myeloma
Interventions: Drug: Minocycline;   Other: Placebo;   Behavioral: Questionnaires
Outcome Measure: Symptom Reduction
11 Unknown  Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression
Conditions: Bipolar Disorder;   Bipolar Depression;   Bipolar I Depression;   Bipolar II Depression
Intervention: Drug: Minocycline
Outcome Measures: Change from baseline to week 8 on the Montgomery Asberg Depression Rating Scale (MADRS);   Change from baseline to week 8 on the Hamilton Depression Rating Scale 17-item (HAMD-17);   Change from baseline to week 8 on the Somatic Symptom Inventory (SSI);   Change from baseline to week 8 on the Clinical Global Impression (CGI) Rating Scale;   Change from baseline to week 8 in the in neurocognitive function;   Monitoring of Side-effects from baseline to week 8 with the Toronto Side Effect Scale (TSES);   Monitoring of suicide severity from baseline to week 8 with the Columbia Suicide Severity Rating Scale (C-SSRS).;   Change from baseline to week 8 in concentrations of pro-and anti-inflammatory cytokines (i.e. TNFα, IL-1β, IL-2, IL-6, IL8, IFNγ, IL-4, IL-5, IL-10)
12 Recruiting Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD
Condition: Obsessive Compulsive Disorder
Interventions: Drug: Minocycline;   Other: Placebo
Outcome Measures: Yale-Brown Obsessive Compulsive Scale, Child version (CYBOCS);   Striatal glutamate level measured by MRS.
13 Not yet recruiting Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement
Condition: Spinal Tumors, Trauma Patients, Minocycline.
Interventions: Drug: Minocycline;   Drug: placebo
Outcome Measures: Efficacy of administrating minocycline in minimizing the neurological damage among acute spinal cord injury patients and spinal cord tumors (primary and metastases) patients;   Efficacy of administrating minocycline at changing the natural history and rehabilitation of spinal cord trauma patients.;   Safety of applying minocycline in spinal cord injuries patients and spinal cord tumors?
14 Recruiting Minocycline Augmentation in Schizophrenia
Condition: Schizophrenia
Interventions: Drug: Minocycline;   Drug: Placebo
Outcome Measures: Treatment-induced change in total score on Positive and Negative Syndrome Scale (PANSS);   Treatment-induced change in MATRICS Cognitive Consensus Battery (MCCB);   Treatment-induced changes in plasma level of cytokines
15 Unknown  The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus
Condition: Oral Lichen Planus
Interventions: Drug: Minocycline;   Drug: Dexamethasone
Outcome Measure: symptoms relief
16 Recruiting Minocycline to Treat Branch Retinal Vein Occlusion
Condition: Retinal Vein Occlusion
Intervention: Drug: Minocycline
Outcome Measures: The primary outcome is the comparison between the minocycline and placebo groups of the mean change in best-corrected visual acuity (BCVA) in the study eye at 12 months compared to baseline.;   Number of intravitreal bevacizumab injections in the minocycline group vs. placebo.;   Change in retinal thickness as measured by OCT at 6, 12, 18 and 24 months vs. baseline.;   Change in BCVA at 24 months vs. baseline.
17 Unknown  Evaluation of Neuroprotective Effect of Minocycline
Condition: Retinal Detachment
Interventions: Drug: placebo;   Drug: Minocycline
Outcome Measures: BCVA;   finding of ERG changes;   finding of OCT changes;   finding of FAF changes
18 Recruiting Minocycline to Treat Central Retinal Vein Occlusion
Condition: Retinal Vein Occlusion
Intervention: Drug: Minocycline
Outcome Measures: The primary outcome is the comparison between the minocycline and placebo groups of the mean change in best-corrected visual acuity (BCVA) in the study of the eye at 12 months compared to baseline.;   Secondary outcomes include the number of intravitreal bevacizumab injections in the minocycline group vs. placebo, change in retinal thickness as measured by OCT at 6, 12, 18 and 24 months vs. baseline, and change in BCVA at 24 months vs. baseli...;   Safety outcomes include the number of participant withdrawals, the number and severity of systemic and ocular toxicities and the number of adverse events.
19 Not yet recruiting Minocycline Augmentation to Clozapine
Conditions: Schizophrenia;   Schizoaffective Disorder
Interventions: Drug: Minocycline;   Drug: Sugar Pill
Outcome Measures: Positive symptoms of schizophrenia/schizoaffective disorder;   Negative symptoms of schizophrenia/schizoaffective disorder;   Cognitive symptoms of schizophrenia/schizoaffective disorder;   Perceived quality of life and general well being;   Social, occupational, and psychological functioning;   Number of patients with adverse events;   Markers of inflammation, including C-Reactive Protein
20 Unknown  Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression
Condition: Unipolar Depression
Intervention: Drug: Minocycline
Outcome Measures: Depression symptoms;   Depression symptoms - CGI;   depression symptoms - (QIDS-SR);   depression symptoms - HDRS-21;   Safety

These studies may lead to new treatments and are adding insight into Arestin etiology and treatment.

A major focus of Arestin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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