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Ascorbic Medical Research Studies

Up-to-date List of Ascorbic Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Ascorbic Medical Research Studies

Rank Status Study
1 Recruiting Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma
Condition: Uterine Leiomyoma
Intervention: Drug: Ascorbic acid
Outcome Measure: blood loss
2 Recruiting Study of Oral Arsenic Trioxide With or Without Ascorbic Acid in Adults With Myelofibrosis
Condition: Primary Myelofibrosis
Intervention: Drug: Dose Escalating Arsenic Trioxide plus Ascorbic Acid
Outcome Measures: To determine the safety and maximum tolerated dose of oral arsenic trioxide with or without Ascorbic acid is subjects with JAK2-positive myelofibrosis;   To estimate the incidence, severity and attribution of treatment-emergent adverse events
3 Unknown  Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicity
Condition: Drug Safety
Interventions: Drug: Colistin;   Drug: Colistin + Ascorbic acid
Outcome Measures: number of patients with Renal toxicity associated with colistin;   number of subjects with cure or improvement
4 Recruiting Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca
Condition: Stage IV Pancreatic Cancer
Intervention: Drug: Ascorbic Acid
Outcome Measures: Safety of Ascorbic acid in combination with gemcitabine and erlotinib for stage IV Pancreatic cancer;   Efficacy of Ascorbic acid in combination with gemcitabine and erlotinib for stage IV Pancreatic cancer;   quality of life
5 Recruiting High-dose Ascorbic Acid Intravenous Injection Decreases Mitochondrial DNA Damage in Chronic Fatigue Patients: Randomized-controlled Study
Condition: Chronic Fatigue
Interventions: Drug: Ascorbic acid 10g/20ml;   Drug: Normal Saline 150ml
Outcome Measures: fatigue scale;   mitochondrial DNA copy number on blood and salivary samples
6 Not yet recruiting Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid.
Condition: Colonoscopy Preparation
Interventions: Drug: Polyethylene glycol 4000;   Drug: Macrogol 3350 plus Ascorbic acid
Outcome Measures: Colon cleansing;   Tolerance of bowel preparation;   Detection of colorectal neoplasia
7 Recruiting Comparison of 4L Polyethylene Glycol and 2L Polyethylene Glycol With Ascorbic Acid in Inactive UC Patients
Condition: Ulcerative Colitis
Interventions: Drug: polyethylene glycol;   Drug: Ascorbic Acid
Outcome Measures: Number of patients who are willing to use the same preparation method for the next colonoscopy.;   Number of patients who have ulcerative colitis symptom aggravation within 30 days after bowel preparation, measured by simple clinical colitis activity index (SCCAI).
8 Recruiting Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA
Condition: Stage IV Colorectal Cancer
Intervention: Drug: Vitamin C
Outcome Measures: Safety;   Efficacy;   Survival
9 Recruiting Evaluation of Intravenous Ascorbic Acid
Condition: Safety and Pharmacokinetics of Intravenous Ascorbate
Intervention: Drug: IV Vitamin C
Outcome Measures: identify the maximum tolerated dose (MTD);   measure how the body absorbs, distributes and excretes intravenous Ascorbic acid;   measure the biochemical and physiological effects of intravenous Ascorbic
10 Recruiting A Study of Vitamin C in the Treatment of Liver Cancer to Determine if it is Safe and Effective
Conditions: Metastatic Hepatocellular Carcinoma;   Advanced Liver Cancer
Interventions: Drug: Ascorbic Acid + Sorafenib;   Drug: Sorafenib alone
Outcome Measures: Safety;   Efficacy;   Quality of Life;   Survival
11 Not yet recruiting Vitamin C and Atrial Fibrillation After Cardiac Surgery
Condition: Atrial Fibrillation
Interventions: Drug: Ascorbic Acid;   Other: Identical Placebo
Outcome Measures: Post-operative atrial fibrillation;   Hospital length of stay;   Intensive care unit length of stay;   Stroke;   Transient ischemic attack;   Mortality;   Hospital Readmission for atrial fibrillation
12 Recruiting Changes of Serum Electrolytes During Bowel Prep With PEG 3350 + Ascorbic Acid - a Prospective Study
Condition: Colonoscopy
Intervention:
Outcome Measures: Proportion of patients with serum sodium concentration beyond the limits of normal after the completion of bowel preparation;   Proportion of patients with serum potassium or calcium or chloride or magnesium concentration beyond the limits of normal after the completion of bowel preparation
13 Recruiting PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation
Condition: Bowel Cleansing in Preparation for Colonoscopy
Intervention: Other: preparation cleaning solution
Outcome Measure: Bowel preparation quality
14 Recruiting The Body's Affect on Vitamin C
Condition: Healthy
Intervention:
Outcome Measure:
15 Recruiting Local Vasoconstriction in Postural Tachycardia Syndrome
Condition: Postural Tachycardia Syndrome
Interventions: Drug: Losartan;   Drug: Ascorbic Acid (Vitamin C);   Drug: Normal Saline
Outcome Measures: Orthostatic tolerance measured by the heart rate and blood pressure response to upright tilt;   Sympathetic activation and blood flow measured by sympathetic nerve recordings and Doppler blood flow in the leg
16 Recruiting Fluorescence-guided Surgery for Low- and High-grade Gliomas
Condition: Glioma
Interventions: Drug: 5-Aminolevulinic acid (ALA);   Drug: Placebo - Ascorbic acid
Outcome Measures: Volumetric extent of resection;   Overall Survival rate(OS);   Progression-free survival rate (PFS);   National Institute of Health Stroke Scale (NIHSS)
17 Recruiting High Dose Vitamin C in the Critically Ill Patient
Condition: Shock
Interventions: Drug: Ascorbic Acid;   Other: Ringers Lactate or Normal Saline
Outcome Measure: Efficacy of high dose vitamin C therapy in shock patients
18 Not yet recruiting Ph 2 Trial of Vitamin C & G-FLIP (Low Doses Gemcitabine, 5FU, Leucovorin, Irinotecan, Oxaliplatin) for Pancreatic Cancer
Condition: Stage IV Pancreatic Cancer
Interventions: Drug: G-FLIP;   Drug: G-FLIP-DM;   Dietary Supplement: Vitamin C
Outcome Measures: 12-month survival rate;   Overall Survival
19 Recruiting 2L Oral Bi-PegLyte Versus 2L Oral MoviPrep Regimen for Outpatient Colonic Preparation
Condition: Colonoscopy
Interventions: Drug: Polyethylene Glycol (PEG) and 15 mg Bisacodyl;   Drug: Polyethylene Glycol (PEG) + Ascorbic acid
Outcome Measures: Bowel cleansing efficacy as rated by a Boston Bowel Preparation Scale score of greater than 8;   Patient tolerability to each 2L product
20 Recruiting Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes
Conditions: Type 2 Diabetes;   Oxidative Stress
Intervention: Biological: Ascorbic acid (Vitamin C)
Outcome Measure: Vitamin C levels

These studies may lead to new treatments and are adding insight into Ascorbic etiology and treatment.

A major focus of Ascorbic research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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