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Atropen Medical Research Studies

Up-to-date List of Atropen Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Atropen Medical Research Studies

Rank Status Study
1 Unknown  Atropine Versus no Atropine for Neonatal Rapid Sequence Intubation
Conditions: Bradycardia;   Hypoxemia
Interventions: Drug: atropine;   Drug: Placebo
Outcome Measures: Heart rate less than 80 BPM and oxygen saturation less than 80%;   Heart rate < 100 BPM;   Oxygen saturation < 85%;   Duration of intubation attempts;   Number of intubation attempts;   Lowest heart rate after premedication;   Lowest oxygen saturation after premedication
2 Not yet recruiting Adding Nebulized Salbutamol to Intravenous Atropine and Oxygen in OP Poisoning
Conditions: Salbutamol;   Organophosphate Poisoning;   Atropine
Interventions: Drug: ventolin 2.5 mg;   Drug: ventolin 5 mg;   Drug: Atropine and Oxygen
Outcome Measures: Improvement of oxygen saturation;   Heart rate, respiratory rate and Blood pressure
3 Recruiting The Role of Cholinergic Signaling for Mediating the Effects of GIP and/or Xenin-25 on Insulin Secretion
Condition: Pre-diabetes
Interventions: Drug: Control;   Drug: Xenin-25 without atropine;   Drug: GIP without atropine;   Drug: Placebo with atropine;   Drug: Xenin-25 with atropine;   Drug: GIP with atropine;   Drug: GIP plus Xenin-25 without atropine;   Drug: GIP plus Xenin-25 with atropine
Outcome Measures: Insulin secretion rates during each treatment.;   Plasma glucose levels during each treatment.;   Plasma glucagon levels during each treatment.;   Plasma pancreatic polypeptide levels during each treatment.
4 Recruiting Premedication Trial for Tracheal Intubation of the NEOnate
Conditions: Premedication;   Endotracheal Intubation
Interventions: Drug: atropine+ propofol;   Drug: atropine + atracurium + sufentanil
Outcome Measures: Desaturation;   Number of intubation attempts;   Duration of intubation procedure;   Heart rate;   Short term neurological outcome;   Long term neurodevelopmental outcome;   Pulse oxymetry;   Mean blood pressure;   Transcutaneous PCO2 (TcPCO2) measurement
5 Recruiting Low Concentration Atropine for Myopia Progression in School Children
Condition: Myopia Progression
Intervention: Drug: Atropine
Outcome Measures: Cycloplegic spherical refraction change;   Axial length change
6 Unknown  Use of Atropine in Tredmill Stress Testing
Condition: Chest Pain
Intervention: Drug: Atropine
Outcome Measure: 1- To characterize patients who can't achieve target heart rate at treadmill exercise test.2- To evaluate atropine added during treadmill stress testing in order to increase heart rate and achieave conclusive test.
7 Unknown  Study of Myopia Prevention in Children With Low Concentration of Atropine
Condition: Myopia
Interventions: Drug: atropine;   Drug: tropicamide
Outcome Measures: cycloplegic refraction, visual acuity;   axial length
8 Unknown  Safety and Accuracy Study of Regadenoson Atropine Combination for Stress Echocardiography in Identification of Coronary Artery Disease
Condition: Coronary Artery Disease
Outcome Measures: Evaluate the sensitivity, specificity, positive and negative predictive value and accuracy of REGAT stress echocardiography protocol in the detection of coronary artery disease, using > 70% luminal stenosis on coronary angiogram as gold standard.;   Evaluate the safety and tolerability (using patient questionnaire) of REGAT stress echocardiography;   Compare sensitivity, specificity, positive and negative predicative value and accuracy of a REGAT stress echocardiography protocol to other stress imaging modalities used in the patient cohort as per design of study
9 Recruiting Olfactory Deficits in MCI as Predictor of Improved Cognition on Donepezil
Condition: Mild Cognitive Impairment
Interventions: Drug: Donepezil;   Drug: Atropine
Outcome Measures: Selective Reminding Test (SRT);   Alzheimer's Disease Assessment Scale - Cognitive (ADAS-Cog);   Pfeffer Functional Activities Questionnaire (FAQ);   Measurement of Everyday Cognition (Ecog);   Clinician's Interview Based Impression of Change plus Caregiver Input (CIBIC-plus)
10 Unknown  Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine
Conditions: Hemorrhoids;   Fissure in Ano
Interventions: Drug: Administration of 0,7 mg of atropine;   Device: Measurement of skin conductance with Pain detector
Outcome Measure: Number of skin conductance fluctuations
11 Recruiting Atropine Effects in Anaesthesia With Sufentanil vs. Remifentanil
Condition: Haemodynamic Fluctuations During Off-pump CABG.
Interventions: Drug: Remifentanil;   Drug: Sufentanil
Outcome Measures: CO;   MAP;   Tissue oxygen saturation
12 Unknown  Ocular Response Analyzer Assessment of Intraocular Pressure and Corneal Biomechanical Properties in Myopic and Anisometropic Patients Under Atropine Treatment
Conditions: Myopia;   Anisometropia
Outcome Measures: axial length, corneal hysteresis;   Refractive error, visual acuity, , intraocular pressure, , and corneal thickness
13 Recruiting Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly
Conditions: Alzheimer Disease;   Mild Cognitive Impairment;   Delirium, Dementia, Amnestic, Cognitive Disorders
Intervention: Drug: Donepezil
Outcome Measures: Change over time in Selective Reminding Test (SRT) Scores;   Alzheimer's Disease Assessment Scale - Cognitive (ADAS-Cog);   Clinician's Interview Based Impression (CIBIC-plus);   Pfeffer Functional Activities Questionnaire (FAQ);   Measurement of Everyday Cognition (Ecog)
14 Recruiting Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability
Condition: Dental Care for Disabled
Interventions: Drug: Midazolam Mylan;   Drug: Lorazepam Mylan;   Drug: Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
Outcome Measures: Level of cooperation of patient when receiving regular dental care;   Recording of vital parameters during regular dental care delivery;   Level of patient comfort and possible side-effects after dental treatment session
15 Recruiting A Prospective, Randomized Controlled Trial Comparing Traditional Methods of Neuromuscular Block Reversal to Sugammadex for Extubation in the Operating Room in ASA 4 and 4E Patients
Condition: Neuromuscular Blockade
Interventions: Drug: Sugammadex Reversal;   Drug: Atropine/Neostigmine
Outcome Measures: Extubation in the operating room before transfer to the PACU or ICU versus keeping the patient intubated when transferred.;   Time to extubation - measure the difference in time from application of the surgical dressing until extubation.;   Atelectasis - comparison of chest x-rays (CXR): prior to surgery, on admission to PACU or ICU and 24 hours after admission to PACU or ICU (This is the routine practice at Hadassa hospital for ASA IV patients.)
16 Recruiting Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery
Conditions: Post Bariatric Surgery;   Hypoglycemia
Interventions: Drug: Exendin-(9-39);   Drug: Atropine;   Drug: GLP-1 and GIP
Outcome Measure: Gut hormones and neural signaling contribution to insulin secretion rate and glucose tolerance
17 Recruiting Optimal Relaxation Technique for Laparotomies With Rocuronium Infusion Followed by Sugammadex Reversal
Conditions: Underdosing of Skeletal Muscle Relaxants for Laparotomy;   Reversal of Skeletal Muscle Relaxant
Interventions: Drug: Neostigmine, atropine;   Drug: Sugammadex
Outcome Measures: speed of reversal;   Vital signs, i.e. heart rate and blood pressure;   intraoperative events;   incidence of residual neuromuscular blockade
18 Recruiting Atropin and Glucose Stimulated Insulinsecretion and the Cephalic Insulin Response
Condition: The Focus of This Study is to Evaluete the Significances of the Vagal Cholinerg Nervuos System for the Effect of GLP-1 by Using Atropin Administration.
Interventions: Drug: Atropine;   Drug: Placebo
Outcome Measures: insulin secretion;   Plasma PP;   Plasma glucose;   Plasma GLP-1;   Plasma GLP-2;   Plasma GIP;   Plasma glucagon
19 Recruiting Modern Myorelaxation Procedure and Reversal of Neuromuscular Blockade With General Anesthesia for Caesarean Section
Conditions: Caesarean Section;   Pregnancy
Interventions: Drug: Rocuronium + sugammadex;   Drug: Succinylcholine + Neostigmine
Outcome Measures: time needed to tracheal intubation;   total procedure time
20 Unknown  Comparison of Two Neuromuscular Anesthetics Reversal in Obese Patient Undergoing Bariatric Surgery
Conditions: Anesthesia;   Surgery
Intervention: Drug: Sugammadex vs. Neostigmine
Outcome Measures: Safety of Sugammadex reversal - number of drug-related adverse events with Sugammadex <= that of Neostigmine.;   Use of Sugammadex for neuromuscular anaesthesia reversal higher patient satisfaction compared to Neostigmine.

These studies may lead to new treatments and are adding insight into Atropen etiology and treatment.

A major focus of Atropen research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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