sponsored
PatientsVille.com Logo

PatientsVille

Avinza Medical Research Studies

Up-to-date List of Avinza Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Avinza Medical Research Studies

Rank Status Study
1 Unknown  0.05 Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy
Conditions: Pain;   Vaginal Hysterectomy
Interventions: Drug: Spinal morphine 0.05 mg;   Drug: Spinal morphine 0.1 mg
Outcome Measure: The total amount of morphine that the patient required during the first 24-h postoperative.
2 Unknown  0.05 mg Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy
Condition: Pain
Intervention: Drug: Morphine
Outcome Measure: the amount of 24 hours morphine
3 Unknown  Efficacy Study of Nebulized Morphine and Intravenous Morphine in Post Traumatic Pain
Condition: Post Traumatic Pain
Interventions: Drug: nebulized morphine;   Drug: Intravenous morphine
Outcome Measures: 1. Resolution rate;   rate of side effects;   Resolution time
4 Recruiting Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
Condition: Acute Pain
Interventions: Drug: Ketamine;   Drug: Morphine;   Drug: placebo
Outcome Measures: Change in Numeric pain score;   Total amount of morphine and other pain medications administered;   Number of participants with adverse events;   Adequate pain control at 30 minutes;   Adequate Pain control at 1 hour
5 Recruiting 0.15 mg Spinal Morphine vs. no Treatment for Morphine Requirement After VATs.
Condition: Postoperative Pain
Intervention: Drug: Spinal morphine
Outcome Measures: Total morphine requirement in 48 hours;   Pain
6 Unknown  The Use of Intraoperative Intrathecal Morphine Versus Epidural Extended Release Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion
Conditions: Pain Management;   Spinal Fusion;   Scoliosis
Intervention: Drug: DepoDur™
Outcome Measure: Objective data to analyze the primary outcomes of Time to first post-operative opioid-analgesic administration and Total opioid requirements during the first 48 hours after surgery
7 Recruiting Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department
Conditions: Abdomen, Acute;   Other Acute Pain;   Flank Pain, Acute;   Back Pain, Acute;   Extremity Pain, Acute
Interventions: Drug: Ketamine;   Drug: Morphine
Outcome Measures: Maximal change in NRS pain score as a percentage of initial NRS pain score;   Time to change in NRS pain score;   Time to maximal change in NRS pain score;   Duration of maximal change in NRS pain score;   Incidence of treatment failure;   Incidence of side effects, including outlying vital signs;   Maximum deviation from 0 on the Richmond Agitation Sedation Scale (RASS);   Nurse and physician satisfaction scores
8 Recruiting Pharmacokinetics of Oral Morphine and Pharmacogenomics of CYP2D6 and UGT2B7, in an Urban Pediatric Population Presenting for Elective Surgery
Condition: Pain
Intervention: Drug: Morphine
Outcome Measures: 1 mL blood sample will be obtained at 30, 60, 90, 120, 180 and 240 min after morphine administration.;   Face, Legs, Activity, Cry and Consolability (FLACC) pain score
9 Unknown  Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section
Condition: Postoperative Pain
Intervention: Drug: Morphine
Outcome Measures: Milligrams of intravenous morphine used by patient in first 24 hours postoperatively;   Pain scores at 6, 12, 18, and 24 hours;   nausea;   itching;   patient satisfaction with analgesia
10 Recruiting Spinal Morphine for Patients With Obstructive Sleep Apnea
Condition: Obstructive Sleep Apnea
Interventions: Drug: Intrathecal Morphine;   Drug: No Intrathecal Morphine
Outcome Measure: Average Oxygen Desaturation Index (ODI) for the first 72 hours postoperatively.
11 Unknown  Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department
Condition: Low Back Pain
Interventions: Drug: Morphine-Promethazine;   Drug: morphine
Outcome Measures: Pain relief;   Ambulatory status
12 Recruiting Oxycodone Versus Intravenous Morphine for Postoperative Analgesia After Hip Surgery
Condition: Arthroplasty, Replacement, Hip
Interventions: Drug: Standard Care morphine hydrochloride;   Drug: Oxycodone
Outcome Measures: Composite score of complications;   Number of opioid boluses in the post-intervention surveillance room;   Time to obtain a VAS score < 30/100 (from the first administration; minutes);   Length of stay in the post-intervention surveillance room (minutes);   Total dose of opioids during the first 24 hours (mg);   Total number of opioid requestions (patient controlled analgesia = PCA);   Total number of opioid requestions accepted / refused (PCA);   Ramsay score;   Presence / absence of an overdose of morphine/oxycodone (Ramsay score > 4);   Presence / absence of an overdose of morphine/oxycodone (Ramsay score> 4);   Presence/absence of complications;   Patient satisfaction, VAS scale;   Pain while at rest at while moving (Visual Analog Scale);   DN4 score;   Length of hospital stay (hours)
13 Recruiting The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients
Conditions: Postoperative Pain;   Chronic Pain;   Analgesics
Interventions: Drug: (S)-(+)-Ketamine Hydrochloride Solution 25 mg/ml;   Drug: Isotonic sodium chloride 0.9 percent;   Drug: Paracetamol 1 g;   Drug: Morphine Sulphate 1 mg/ml Solution;   Drug: Ondansetron 2 mg/ml;   Drug: Usual daily opioids
Outcome Measures: Morphine consumption;   Pain during mobilization;   Pain at rest;   Nausea;   Vomiting;   Ondansetron;   Sedation;   Hallucinations and nightmares;   Chronic pain
14 Unknown  The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery
Condition: Acute Pain Following Decompressive Lumbar Spinal Surgery
Interventions: Drug: Intrathecal Morphine;   Drug: Intrathecal Saline
Outcome Measures: The primary aim of this study is to assess the impact of intrathecal morphine on post-operative pain following instrumented fusion for lumbar spinal stenosis.;   Secondary objectives of this study aim to assess side effects, overall narcotic use and duration of hospital stay following administration of intrathecal morphine.
15 Recruiting Two Dose Epidural Morphine for Post-cesarean Analgesia
Condition: Quality of Post-cesarean Analgesia During the 2nd 24 Hours After Surgery
Interventions: Drug: Epidural Morphine;   Drug: Epidural Saline
Outcome Measure: The amount of intravenous morphine patients self-administer in the 2nd 24 hours post-surgery.
16 Recruiting Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain
Condition: Cancer
Interventions: Drug: Morphine;   Drug: Oxcarbazepine
Outcome Measures: Number of patients with adverse events as a measure of safety and toxicity;   Changes in Pain control;   Changes in Consumption;   Changes in Quality of Life
17 Recruiting Post-market Study of Intrathecal Morphine Compared to Conventional Medical Management for Pain Control and Improvement of Opioid-related Side Effects
Conditions: Nonmalignant Pain;   Chronic Pain;   Chronic Intractable Pain
Intervention: Device: SynchroMed Infusion System and Intrathecal Morphine Sulfate
Outcome Measures: Clinical Success;   Pain Assessment;   Opioid-Related Side Effects
18 Recruiting Efficacy of Topical Morphine in the Treatment of Severe Local Pain of Chronic Wounds
Conditions: Local Pain;   Chronic Wounds
Interventions: Drug: Morphine gel;   Other: Neutral gel
Outcome Measures: Proportion of patients whose maximum daily consumption in immediate-release oral morphine is less than or equal to 30 mg for the last 72 hours of the study;   Reduction in average daily pain intensity score on a numerical rating scale self assessment, measured on an 11-point between day 1 and day 11;   Evaluate the percentage of local pain relief for 24 hours on a rating scale from 0 to 100%;   Assess and characterize the evolution of local pain on a global impression scale change : Pain related Patient Global Impression of Change (PGIC) and Clinical Global Impression of Change (CGIC);   Assess patient satisfaction with treatment of local pain (score 0-4);   Evaluate the impact score of local pain on sleep (self-report scale of 0 to 100%);   Determine the time (in hours) before using oral immediate-release morphine after application of local treatment;   Determination of cumulative dose of oral immediate-release morphine (in milligrams) of the 11 days of treatment for relieving painful access of local origin;   Evaluate systemic and local side effects of analgesic treatment (incidence, severity and location);   Evaluate the systemic absorption of topical morphine blood test after the first application
19 Recruiting Optimizing the Use of Morphine in Pre-Term Neonates
Condition: Premature Neonates
Intervention: Drug: Morphine
Outcome Measures: Safety: Infants will have continuous monitoring of vital signs, oxygen saturation, movements and adverse events to determine the safety of morphine.;   Pharmacodynamics: The Neonatal Infant Pain (NIP) and Premature Infant Pain Profile (PIPP) will be performed at baseline, (prior to drug administration)and at pre-determined time intervals after the dose to assess pain for the efficacy of morphine.;   Pharmacokinetics: The concentrations of morphine and its metabolites will be measured in plasma and urine at pre-determined time points and will be used to calculate the formation and elimination clearances of morphine and its metabolites.;   Pharmacogenetics: Impact of genetic variation in the UGT2B7 gene on the formation clearances of the morphine metabolites will be studied as well as the genetic variation in the µ-opioid receptor, COMT, and β-arrestin 2 genes on the PD of morphine use
20 Recruiting The Efficacy of Peripheral Nerve Blocks With Intrathecal Morphine in Improving Analgesia After Unilateral Total Knee Arthroplasty
Conditions: Anesthesia;   Total Knee Arthroplasty
Interventions: Drug: Combined spinal epidural anesthesia technique with intrathecal morphine;   Drug: A combination of combined spinal-epidural (with intrathecal morphine) and femoral nerve block;   Drug: A combination of combined spinal-epidural (with intrathecal morphine) and femoral nerve block as well as sciatic nerve block
Outcome Measures: Postoperative parenteral morphine consumption;   Visual analogue pain scores (VAS) in anterior and posterior knee;   Severity of pain in anterior and posterior knee;   Time to first IV PCA bolus;   Total IV PCA consumption upon discontinuation of PCA;   Side effects;   Patient satisfaction with pain control;   complications

These studies may lead to new treatments and are adding insight into Avinza etiology and treatment.

A major focus of Avinza research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


Discuss Avinza