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Bicarbonate Medical Research Studies

Up-to-date List of Bicarbonate Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Bicarbonate Medical Research Studies

Rank Status Study
1 Unknown  Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Spontaneously Breathing Adult Volunteers
Conditions: Infiltration;   Extravasation
Interventions: Drug: sodium Bicarbonate 4.2%;   Drug: diluted sodium Bicarbonate 2.1%;   Drug: normal saline
Outcome Measures: transient increase in end tidal carbon dioxide;   Change in venous blood pH;   Subjective adverse symptoms associated with injection of sodium Bicarbonate;   change in venous blood sodium;   change in venous blood Bicarbonate level;   change in venous blood potasium level
2 Recruiting Comparison of High Versus Low Bicarbonate Hemodialysis
Conditions: Chronic Kidney Disease;   End-stage Renal Disease;   Metabolic Acidosis
Intervention: Other: Low Bicarbonate
Outcome Measures: Pre-dialysis serum Bicarbonate;   serum beta-hydroxybutyrate;   beta-hydroxybutyrate clearance;   interleukin-6;   serum free fatty acids;   Time to recover from dialysis;   Dialysis symptom questionnaire
3 Recruiting Musculoskeletal Effects of Bicarbonate
Conditions: Age-related Bone Loss;   Age Related Muscle Loss;   Falls;   Fractures
Interventions: Dietary Supplement: potassium Bicarbonate;   Other: placebo
Outcome Measures: The primary aim is to identify the dose of KHCO3 needed for maximal suppression of 24-hr urinary N-telopeptide/creatinine ratio;   The secondary aim is to identify the dose of KHCO3 needed for maximal suppression of 24-hr urinary nitrogen/creatinine ratio
4 Unknown  Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Anesthetized Children
Condition: General Anesthesia
Interventions: Drug: Sodium Bicarbonate;   Drug: normal saline
Outcome Measure: change in end-tidal carbon dioxide
5 Unknown  A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
Condition: Preserving Kidney Function in People Who Are at High Risk of Developing Contrast-induced Nephropathy
Interventions: Drug: Oral N-Acetylcysteine;   Drug: Intravenous Sodium Bicarbonate
Outcome Measure: to compare the effectiveness of two medications, oral N-acetylcysteine (mucomyst) and intravenous sodium Bicarbonate, used to protect the kidneys from contrast injury during a cardiac catheterization
6 Recruiting Bicarbonate and Lipocalin in Systemic Inflammatory Response Syndrome (SIRS) Study
Conditions: Systemic Inflammatory Response Syndrome;   Oliguria;   Renal Impairment
Interventions: Drug: Sodium Bicarbonate;   Drug: Sodium chloride
Outcome Measures: The ability to deliver the study protocol safely and rapidly with a trend to improved renal outcomes;   Attenuation in lipocalin levels;   Decrease in the magnitude in serum creatinine rise;   Ability to deliver the study protocol without significant biochemical side effects
7 Unknown  Sodium Bicarbonate in Cardiopulmonary Resuscitation
Condition: Sudden Cardiac Arrest
Intervention: Drug: sodium Bicarbonate
Outcome Measure: Short-term survival
8 Recruiting Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain
Conditions: Tumor;   Cancer;   Pain;   Malignant Solid Tumor;   Unresectable Malignant Neoplasm;   Hematologic Malignancy;   Multiple Myeloma;   Lymphoma;   Neoplasm Metastasis
Intervention: Drug: Sodium Bicarbonate
Outcome Measures: Phase I - Maximum Tolerated Dose (MTD);   Phase II - Percent of Participants With Desired Response;   Pain Measurement Ranking;   Quality of Life (QOL)
9 Recruiting Intravenous Bicarbonate To Verify The Correct Position of IV Catheters in Oncological Patients Oncological Patients Receiving Chemotherapy
Condition: Detection of the Correct Position of Intravenous Line
Intervention: Drug: sodium Bicarbonate 4.2%
Outcome Measure: change in exhaled end tidal co2
10 Recruiting Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery
Conditions: Acute Kidney Injury;   Cardiac Surgery
Interventions: Drug: Sodium Bicarbonate;   Drug: Sodium Chloride
Outcome Measures: Acute Kidney Injury;   Duration of acute kidney injury;   Cumulative fluid balance;   Hospital and intensive care unit length of stay;   Need for dialysis;   Incidence of acute kidney injury according to changes in serum NGAL.;   Length of mechanical ventilation;   Change in acid-base status
11 Recruiting Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy
Condition: Kidney Failure, Acute
Interventions: Drug: Sodium Bicarbonate;   Drug: Sodium chloride
Outcome Measures: Increase in serum creatinine of 44 micromol/L or by 25% within the first 3 days after surgery.;   Postoperative vasoactive medication, intra-aortic balloon pump, mechanical ventilation, reintubation, reoperation, myocardial infarction, stroke, infection, hypokalemia, dialysis, ICU and hospital length of stay and survival.
12 Recruiting The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
Condition: Acute Kidney Injury
Interventions: Drug: sodium Bicarbonate;   Drug: Saline
Outcome Measure: Comparison of the incidence of postoperative acute kidney injury in patients with or without sodium Bicarbonate
13 Unknown  Prevention of Contrast Induced Nephropathy With Sodium Bicarbonate
Condition: Contrast Induced Nephropathy
Intervention: Drug: 3 amps of sodium Bicarbonate mixed in one liter of D5W
Outcome Measures: Development of contrast-induced nephropathy, defined as an increase in serum creatinine of 25% or more within 2 day after administration of contrast;   change in mean arterial pressure after initial bolus, mmHg;   urine pH after initial bolus;   contrast volume;   change in serum Bicarbonate;   change in serum potassium;   change in serum glucose;   change in serum creatinine;   change in estimated glomerular filtration rate;   incidence of contrast induced nephropathy
14 Recruiting Sulphate-Bicarbonate-calcium Water, Body Weight and Gut Microbiota
Conditions: Overweight;   Obesity
Interventions: Dietary Supplement: "Acqua Santa di Chianciano"® (sulphate-Bicarbonate-calcium water);   Dietary Supplement: Tap water
Outcome Measures: weight loss;   gut microbiota composition;   body composition;   bile acids pool;   energy expenditure;   thyroid function
15 Unknown  Sodium Bicarbonate and N-Acetylcysteine for Nephroprotection in Acute Myocardial Infarction
Conditions: Acute Myocardial Infarction;   Acute Kidney Injury
Interventions: Drug: Sodium Bicarbonate plus NAC;   Drug: Saline hydration plus NAC
Outcome Measure: All cause mortality, contrast-induced nephropathy and need of dialysis.
16 Recruiting Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.
Conditions: Chronic Renal Insufficiency;   Diabetes Mellitus
Interventions: Drug: Sodium Bicarbonate;   Drug: Placebo
Outcome Measures: Change in urinary transforming growth factor beta 1 (TGF-b1);   Change in urinary Bb and membrane attack complex (MAC)
17 Recruiting Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
Conditions: Sickle Cell Anemia;   Chronic Kidney Disease;   Metabolic Acidosis
Intervention: Drug: Sodium Bicarbonate
Outcome Measures: Serum Bicarbonate level;   Hemolysis markers
18 Unknown  Prevention of Contrast-Induced Nephropathy in Diabetic Patients With Undergoing Coronary Angiography
Condition: Contrast Induced Nephropathy
Interventions: Drug: Sodium Bicarbonate;   Drug: saline
Outcome Measures: Incidence of contrast-induced nephropathy;   all-cause mortality;   stroke;   Dialysis;   Myocardial infarction;   dialysis;   myocardial infarction
19 Unknown  Study Comparing Esomeprazole Associated With Sodium Bicarbonate From Eurofarma and Esomeprazole in Treatment of Gastroesophageal Reflux Disease ESOBIC
Condition: Gastroesophageal Reflux Disease
Interventions: Drug: Nexium®;   Drug: Esomeprazol (40mg) + Sdium Bicarbonate (721mg)
Outcome Measure: Efficacy
20 Recruiting Effect of Sodium Bicarbonate on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass (OPCAB)
Condition: Acute Kidney Injury
Interventions: Drug: sodium Bicarbonate;   Drug: normal saline
Outcome Measure: compare the incidence of acute kidney injury

These studies may lead to new treatments and are adding insight into Bicarbonate etiology and treatment.

A major focus of Bicarbonate research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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