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Bisphosphonates Medical Research Studies

Up-to-date List of Bisphosphonates Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Bisphosphonates Medical Research Studies

Rank Status Study
1 Recruiting Bisphosphonates Effects On Alveolar Bone Among Osteoporotic Women
Condition: Osteoporosis
Intervention: Drug: Bisphosphonates
Outcome Measures: 3D-based Alveolar bone radiographic density;   Alveolar bone histomorphometry;   2D-based Alveolar bone radiographic density;   Periodontal Disease Index (PDI)
2 Recruiting Bisphosphonate Biomarker Study
Conditions: Osteoporosis, With or Without Treatment;   Bisphosphonate Treatment;   Atypical Femur Fracture;   Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ);   Healthy Volunteers
Outcome Measures: Absorption, Distribution, Metabolism, Excretion (ADME) Profiling of DNA from all sample types vs. normative data for the ADME panel and across study groups;   Differential expression of miRNA biomarkers across participant groups within the study
3 Recruiting Assessment of Platelet Rich Fibrin Efficiency on Healing Delay and on Jawbone Osteochemonecrosis Provoked by Bisphosphonates
Condition: Jawbone Osteochemonecrosis Induced by Bisphosphonates
Interventions: Procedure: Bone curettage + PRF;   Procedure: Bone curettage alone
Outcome Measures: Delay in cicatrisation at week 8;   The appearance of osteochemonecrosis during the follow-up period;   The characteristics of the received BP treatment: starting date of ongoing treatment, accumulated dose, type of BP, administration route;   The precise location of the extraction site according to the tooth classification number
4 Recruiting Radiographic Influences of Bisphosphonate Treatment on Femur
Condition: Femur Fracture
Outcome Measures: Influence of long-term bisphosphonate treatment on femur.;   Longitudinal effects of bisphosphonate treatments on femur
5 Recruiting Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty
Conditions: Osteoporotic Fractures;   Femoral Neck Fracture
Intervention: Drug: Risedronate
Outcome Measures: de Morton Mobility Index;   Barthel index;   Visual analog scale score;   Two minutes walking test;   Timed get up and go test;   EuroQoL-5D (EQ-5D)
6 Recruiting Osteonecrosis of the Hip and Bisphosphonate Treatment
Condition: Osteonecrosis
Interventions: Drug: Zoledronic Acid;   Drug: Placebo
Outcome Measures: reducing pain and disability in the hip;   reducing progression to femoral head collapse and the need for surgical intervention
7 Recruiting Zometa Study in Pediatric Acute Lymphoblastic Leukemia
Condition: Osteoporosis
Interventions: Drug: zolendronic acid;   Drug: calcium & vitamin D
Outcome Measures: Measure the change in the Bone densitometry due to secondary osteoporosis;   - To assess the percentage change in lumbar spine BMD at wk 48 relative to baseline in both arms.
8 Recruiting Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy
Condition: Osteoporosis
Interventions: Drug: Alendronate;   Drug: Placebo
Outcome Measures: Incidence of new osteoporotic fractures;   Equivalence of deaths with and without continued bisphosphonate therapy;   Incidence of the combination of fractures and deaths
9 Recruiting Clinical Results of Bisphosphonate and Denosumab Therapy Following Teriparatide Therapy for Japanese
Condition: Osteoporosis
Outcome Measure: Clinical results of bisphosphonate vs. denosmab following daily teriparatide treatment
10 Not yet recruiting The Effect of Alendronate on the Immune Response to Hepatitis B Vaccine in Healthy Adults
Condition: Healthy Volunteers
Interventions: Drug: Alendronate;   Drug: Hepatitis B Vaccine;   Drug: Placebo
Outcome Measures: Safety/Adverse events;   Efficacy
11 Not yet recruiting Genetics in Predicting Risk of Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid
Conditions: Malignant Neoplasm;   Musculoskeletal Complications
Interventions: Drug: zoledronic acid;   Other: pharmacological study
Outcome Measures: Plasma concentrations of Zol collected at visits 2, 3, 4, and 5;   Urine concentrations of Zol collected at visits 2, 3, 4, and 5;   Jawbone tissue concentrations of Zol collected during surgical treatment for BRONJ;   Identify potential risk factors for BRONJ
12 Unknown  Fosamax for Childhood Cancer Survivors
Condition: Osteoporosis
Interventions: Drug: Alendronate;   Drug: Placebo
Outcome Measures: The percent change in bone mineral density (BMD) at lumbar spine at 36-weeks in subjects who receive active and control treatments;   Changes in BMD at femoral neck;   Changes in biochemical markers of bone turnover;   Occurrence of clinical bone-related symptoms at 12-weeks and end of this study
13 Recruiting A Study of Changes in Bone Mineral Density as a Function of Consuming Two Different Forms of Calcium Carbonate
Condition: Osteopenia, Osteoporosis
Interventions: Dietary Supplement: Micronized Calcium Carbonate;   Dietary Supplement: Non-Micronized Calcium Carbonate;   Dietary Supplement: Vitamin D3
Outcome Measures: Change from baseline in Bone Mineral Density as a measurement by Dual Energy X-ray Absorptiometry;   Blood Chemistry Panel;   Systolic and Diastolic blood pressure;   Resting heart rate;   Self-reported quality of life;   Number of participants with adverse effects
14 Recruiting Pathogenesis of Atypical Femur Fractures on Long Term Bisphosphonate Therapy
Conditions: Osteoporosis;   Atypical Femoral Fractures;   Prodromal Bone Deterioration
Interventions: Other: 500 without BP treatment;   Other: 500 with BP treatment
Outcome Measures: Prodromal bone deterioration (PBD);   Diagnosis of PBD
15 Recruiting Pilot Study of Bisphosphonate Therapy (Zoledronic Acid) in Patients With Malignant Mesothelioma (UAB 0901)
Condition: Mesothelioma
Intervention: Drug: Zometa (zoledronic acid)
Outcome Measures: Evaluation of the tumor response rate following zoledronic acid;   Evaluation of the duration of tumor response
16 Not yet recruiting Compliance and Persistence With Osteoporosis Treatment and Attitude Towards Future Therapy Among Post-menopausal Israeli Women During Drug Treatment or Drug Holiday
Condition: Osteoporosis
Intervention: Other: Questionnaires about compliance and persistence with Bisphosphonates treatment
Outcome Measure: Compliance and persistence to osteoporosis drug therapy
17 Recruiting Efficacy and Safety of Odanacatib in Postmenopausal Women Previously Treated With Oral Bisphosphonate (MK-0822-076)
Condition: Osteoporosis
Interventions: Drug: odanacatib;   Other: placebo to odanacatib
Outcome Measures: Percent change from baseline to month 24 in femoral neck bone mineral density (BMD): odanacatib versus placebo;   Percent change from baseline to month 24 in femoral neck BMD: within-group comparison of odanacatib;   Percent change from baseline to month 24 in trochanter, total hip, and lumbar spine BMD;   Change from baseline to month 24 in serum C-telopeptides of Type 1 collagen (s-CTx) after log-transformation;   Change from baseline to month 24 in urine C-telopeptides of Type I collagen (u-CTx) after log-transformation;   Change from baseline to month 24 in urine N-telopeptides of Type 1 collagen corrected for creatinine (u-NTx/Cr) after log-transformation;   Change from baseline to month 24 in serum bone specific alkaline phosphatase (s-BSAP) after log-transformation;   Change from baseline to month 24 in serum N-terminal propeptide of Type 1 collagen (s-P1NP) after log-transformation
18 Recruiting Initial Fixation of Bisphosphonate-coated Dental Implants
Condition: Pre-integration Failure of Dental Implant
Intervention: Device: Zoledronate-coated dental implant
Outcome Measures: Vibration frequency ratio;   Marginal resorption;   Vibration: area under the curve
19 Unknown  Bisphosphonates and Impaction Grafting in Hip Revision
Condition: Aseptic Loosening of the Hip Prosthesis
Interventions: Drug: Clodronate;   Drug: Placebo
Outcome Measures: Decrease of prosthetic micromotion from 2.7 mm to 1.7 mm as measured by RSA (0-24 months);   Decrease of prosthetic micromotion from 2.7 mm to 1.7 mm as measured by RSA (late micromotion)
20 Recruiting Bisphosphonate Users Radiographic Characteristics of the Hip (BURCH) Study
Conditions: Osteoporosis;   Bone Diseases, Metabolic;   Hip Fractures
Outcome Measure:

These studies may lead to new treatments and are adding insight into Bisphosphonates etiology and treatment.

A major focus of Bisphosphonates research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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