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Bone Medical Research Studies

Up-to-date List of Bone Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Bone Medical Research Studies

Rank Status Study
1 Unknown  F-18 PET Bone Scans Versus Tc-99m Bone Scans for the Diagnosis of Bone Metastases
Conditions: Cancer;   Bone Metastases
Interventions: Device: F-18 PET Bone scan;   Device: Tc-99m Bone scan
Outcome Measures: Accurate identification of Bone metastases;   Change in clinical management;   Determine if F-18 PET Bone scans lead to fewer follow-up imaging studies.;   Quantify any adverse events from either type of scan.;   Perform subgroup analyses according to cancer cell type.
2 Recruiting Parallel Study Between BMP-2 and Autologous Bone Graft After Ilizarow Treatment
Conditions: Bone Degenerative Changes;   Osteoarthritis;   Degenerative Disorder of Bone
Interventions: Drug: Bone Morphogenetic Protein 2;   Procedure: Autologous Bone graft
Outcome Measures: Visible radiological signs of healing after 6 months.;   Change in serologic Bone markers
3 Recruiting Interest of Bone Substitute Material in Immediate Complete Denture
Conditions: Alveolar Bone Loss;   Denture Complete Immediate;   Bone Substitute;   Replacement Material;   Bone
Interventions: Device: Conventional protocol;   Device: Bone substitute material group
Outcome Measures: Comparison of Bone ridge height one year after maxillary immediate complete denture placement with or without Bone substitute material in incisive-canine sockets;   Height and width average between day 10th and day 90th after maxillary immediate complete denture placement, and between day 10th and one year
4 Recruiting Prospective Evaluation of Anorganic Bovine Bone Mineral Versus Calcium Phosphosilicate Alloplastic Bone Putty in Direct Sinus Augmentation: a Spilt-mouth Study
Conditions: Sinus Floor Augmentation;   Maxillary Sinus
Interventions: Procedure: Calcium phosphosilicate alloplastic Bone putty in direct sinus augmentation;   Procedure: Anorganic bovine Bone mineral in direct sinus augmentation
Outcome Measures: Percentage of new Bone growth in the maxillary sinus;   Gain in vertical Bone height;   Radiographic Bone density;   Primary implant stability;   Marginal Bone level maintenance
5 Recruiting Monitoring of Bone Free Flaps With Microdialysis
Conditions: Microsurgery;   Head and Neck Reconstructive Surgery;   Head and Neck Cancer;   Head and/or Neck Shotgun Trauma;   Bone Free Flap
Intervention: Device: CMA 70 catheter directly positioned in Bone tissue
Outcome Measures: Feasibility study of monitoring Bone free flaps with microdialysis (catheter directly positioned in Bone tissue);   Evaluation of "flush-out" period;   Compliance of the prescription
6 Recruiting A Migration and Bone Density Study Comparing Hi-Fatigue Bone Cement and Palacos Bone Cement
Condition: Hip Arthritis
Interventions: Device: Hi-Fatigue Bone Cement;   Device: Palacos Bone Cement
Outcome Measure: Femoral component migration (roentgen stereo photogrammetric analysis - RSA)
7 Recruiting F18PET/CT Versus TC-MDP Scanning to Detect Bone Mets
Condition: Bone Metastases
Intervention: Device: Bone Scan: F18-Fluoride PET/CT or TC-MDP
Outcome Measure: Analysis of the diagnostic performance of [18F]NaF fluoride PET/CT scanning
8 Unknown  Use of Adult Bone Marrow Mononuclear Cells in Patients With Long Bone Nonunion
Condition: Long Bone Nonunion
Intervention: Procedure: Osteosynthesis
Outcome Measures: Absence of adverse effects during timeframe as infections or complications related with the intervention;   Improvement and union of the Bone
9 Recruiting Bone Mineral Density Changes of the Acetabulum After Revision Hip Arthroplasty Using Bone Impaction Grafting
Conditions: Disorder of Bone Density and Structure, Unspecified;   Satisfaction
Interventions: Radiation: DEXA: dual energy X-ray absorptiometry;   Other: Short Form Health Survey 12;   Other: VAS-satisfaction;   Other: VAS-pain;   Other: Harris Hip Score
Outcome Measure: Bone mineral density changes
10 Recruiting Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone
Condition: Fibrous Dysplasia of Bone
Interventions: Drug: risedronate;   Drug: placebo
Outcome Measures: Intensity of Bone pain, assessed by visual analogical scale ranging from 0 to 10, on the most painful site.;   Surface of osteolytic lesions at three years. Radiological improvement.;   Variation of biochemical markers of Bone turnover at three years;   Number of painful sites;   Improvement in quality of life;   Variation in Bone mineral density of the femoral neck at three years
11 Recruiting A Comparison of Bone Formation With Three Different Bone Graft Materials Following Sinus Graft
Condition: Inadequate Bone Height in Maxillary Posterior Area
Interventions: Procedure: Sinus augmentation;   Drug: Equimatrix;   Drug: OSSIF-i sem;   Drug: Bio-oss
Outcome Measures: A histomorphometric measurement of the percentage of vital Bone in a total amount of Bone.;   A histomorphometric measurement of the percentage of non-vital Bone and connective tissue.
12 Recruiting Comparison of Bioactive Glass and Beta-Tricalcium Phosphate as Bone Graft Substitute
Condition: Bone Neoplasm
Interventions: Device: Bioactive glass;   Device: Beta-tricalcium phosphate (ChronOs);   Procedure: Autograft;   Procedure: Allograft (frozen femoral head)
Outcome Measures: Stratum I: Hand-grip strength test;   Stratum II: Healing of cortical Bone window based on CT scan evaluation;   Biomaterial incorporation assessed with radiographs;   Pain intensity (VAS);   Stratum I: DASH-questionnaire;   RAND-36;   Surgical wound healing;   Soft tissue complications;   Bone complications
13 Recruiting Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy
Condition: Osteoarthritis, Knee
Interventions: Procedure: Allogenic Bone graft;   Procedure: Synthetic Bone substitute (geneX®)
Outcome Measures: Temporal change of postoperative pain;   Pre&postoperative Hemoglobin level;   Total operation time;   Temporal change of weight bearing status;   Temporal change of pain with weight bearing;   Amount of drainage;   Working time for Bone defect filling;   Temporal progression of Bone healing on X-rays
14 Recruiting Comparative Efficacy of the Masquelet Versus Titanium Mesh Cage Techniques for the Treatment of Large Long Bone Defects
Condition: Segmental Long Bone Defects
Interventions: Procedure: Iliac crest autogenous Bone grafting;   Procedure: Reamer-Irrigator-Aspirator autogenous Bone grafting
Outcome Measures: Defect Healing;   Functional outcomes
15 Not yet recruiting rhBMP-2 vs Autologous Bone Grafting for the Treatment of Non-union of the Docking Site in Tibial Bone Transport
Conditions: Bone Healing;   Bone Morphogenetic Proteins;   Bone Transport
Intervention: Device: rhBMP-2
Outcome Measures: Bone healing in the docking site;   Infection;   Edema;   cancer
16 Recruiting Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement
Condition: Resorbed Alveolar Ridge Prior to Dental Implant Insertion
Interventions: Device: Bio-Oss (by Geistlich);   Device: BondBone (by Augma)
Outcome Measures: Volume of the new Bone formed after a GBR procedure;   Bone quality
17 Recruiting Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System
Conditions: Bone Cancer;   Bone Metastases;   Pain
Intervention: Device: ExAblate 2100
Outcome Measures: Safety;   Efficacy;   Effectiveness
18 Unknown  Mother Daughter Bone Microarchitecture
Condition: Bone Fragility
Interventions: Radiation: HRpQCT;   Biological: Sampling;   Radiation: Bone absorptiometry
Outcome Measures: Role of Bone microarchitecture in the hereditary determinism of Bone fragility;   Role of Bone mineral density in the hereditary determinism of Bone fragility;   Role of Bone turnover and hormones in the hereditary determinism of Bone fragility
19 Not yet recruiting 18F-NaF PET Imaging for Bone Scintigraphy
Condition: Bone Metastases From Breast or Prostate Cancer
Interventions: Procedure: NaF PET/CT Imaging;   Procedure: 99mTc-medronate whole body Bone scan with SPECT;   Drug: 18F-NaF (185-370 MBq)
Outcome Measures: Accuracy, sensitivity, and specificity of 18F-Sodium Fluoride (18F-NaF) Positron Emission Tomography compared to 99mTc-Methylene Diphosphonate (MDP) Bone SPECT imaging for detection of Bone metastasis.;   The secondary outcome is to monitor the short-term side-effects following 18F-NaF PET/CT to assess for adverse drug reactions
20 Recruiting Effect of Healing Time on New Bone Formation Following Tooth Extraction and Ridge Preservation With Demineralized Freeze-Dried Bone Allograft
Condition: Bone Augmentation
Intervention: Device: Ridge preservation using DFDBA
Outcome Measures: percent new vital Bone formation;   change in ridge width and ridge height

These studies may lead to new treatments and are adding insight into Bone etiology and treatment.

A major focus of Bone research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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