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Botulinum Medical Research Studies

Up-to-date List of Botulinum Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Botulinum Medical Research Studies

Rank Status Study
1 Recruiting The Comparison Study of Intralesional Botulinum Toxin A and Corticosteroid Injection for Alopecia Areata
Condition: Alopecia Areata
Interventions: Drug: Botulinum toxin type A;   Drug: Triamcinolone acetonide
Outcome Measures: The percentage of terminal hair regrowth after intralesional Botulinum toxin A injection;   Possible side effects of intralesional Botulinum toxin a injection
2 Recruiting The Impact of Botulinum Toxin Treatment in Quality of Life of Cervical Dystonia Patients
Conditions: Botulinum Toxin;   Quality of Life;   Cervical Dystonia
Intervention: Drug: Nuronox
Outcome Measures: To investigate the change of quality of life of cervical dystonia patients after Botulinum toxin treatment measured by CDQ-24.;   To investigate the change of QoL of cervical dystonia patientsafter Botulinum toxin treatment measured by SF-36 (Thai version);   To Investigate the change of symptom after Botulinum toxin treatment measured by TWSTRS score
3 Unknown  Effects of Botulinum Toxin in Cervical Dystonia
Conditions: Torticollis;   Cervical Dystonia
Intervention: Drug: Botulinum Toxin A
Outcome Measures: Evidence of Cortical organizational changes with Botulinum toxin treatment in patients with torticollis utilizing magnetoencephalography;   Tsui Torticollis Rating scale
4 Not yet recruiting Study of the Effect of Botulinum Toxin Injection in Rectus Femoris and Triceps on the Length and the Strength During Locomotion in Chronic Hemiparetic Patients
Condition: COMPARISON BETWEEN GROUP TREATED WITH Botulinum TOXIN AND PLACEBO
Interventions: Drug: Botulinum toxin type A;   Drug: injection of NaCl 0.9%
Outcome Measures: Measure of the maximal length of the muscles treated by Botulinum;   The maximal strength measure;   Inter-segmental coordination measure;   Measure of joint torque at knee and ankle level.
5 Recruiting Injections of Botulinum Toxin A in Treatment of Patients With Detrusor Overactivity and Impaired Contractility
Condition: Botulinum Toxins, Type A
Intervention: Drug: Botulinum toxin A
Outcome Measures: Net change of the Patients Perception of Bladder Condition (PPBC);   Net change of the International Prostate Symptom Score (IPSS);   Net change of the bladder capacity;   Net change of the voiding frequency at daytime;   Net change of the voiding frequency at night time;   Net change of voiding urgency severity score;   Net change of the first sensation of bladder filling;   Net change of the urge sensation;   Net change of the presence of detrusor overactivity;   Net change of the cystometric bladder capacity;   Net change of the first sensation of detrusor pressure;   Net change of the first sensation of bladder compliance;   Net change of the maximum flow rate;   Net change of the first sensation of voided volume;   Net change of the postvoid residual volume
6 Recruiting Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke
Conditions: Stroke;   Spasticity
Interventions: Procedure: Tenotomy of the proximal rectus femoris tendon;   Drug: Botulinum Toxin injection in the rectus femoris muscle
Outcome Measures: Ashworth scale at the rectus femoris;   Stroke impairment assessment set (SIAS;   Tardieu scale;   MRC (Medical research Council) scale;   Isometric muscle strenght assessment;   10 meter walking test;   Instrumented gait analysis;   ABILOCO scale;   EQ-5D-5L scale
7 Unknown  Botulinum Toxin to Improve Results in Cleft Lip Repair
Condition: Scar
Interventions: Drug: Botulinum Toxin Type A;   Drug: Botulinum Type A;   Drug: Normal Saline
Outcome Measures: Vancouver Scar scale;   Ultrasonography scar measurement;   Photographic measurement
8 Unknown  Efficacy of Botulinum Toxin Type A in Patients With Bladder Pain Syndrome/Intersticial Cystitis and Hunners' Lesions
Condition: Interstitial Cystitis
Interventions: Procedure: intratrigonal injection of Botulinum toxin;   Procedure: cystoscopy
Outcome Measures: Change from baseline in pain intensity;   Change from baseline of intensity of bladder bother symptoms;   Change from baseline of quality of life;   Postvoid residual urine volume;   Upper urinary tract retention
9 Recruiting Botulinum Toxin Injection in Hypercontractile Esophagus
Condition: Esophageal Hypercontractile Motility Disorders
Interventions: Drug: Endoscopic injection of Botulinum toxin in the esophageal muscle;   Other: Upper gastro-intestinal endoscopy without any injection
Outcome Measures: Clinical response;   Clinical symptoms improvement;   Safety;   Quality of life improvement;   Weight gain;   Modification of HRM pattern;   Clinical and paraclinical characteristics of responders versus non-responders
10 Recruiting Use of Botulinum Toxin to Treat Psoriasis
Condition: Psoriasis Vulgaris
Intervention: Biological: injection of Botulinum toxin type A.
Outcome Measures: psoriasis scoring scale;   3mm skin biopsy.
11 Unknown  Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism
Condition: Sleep Bruxism
Intervention: Drug: Botulinum toxin type A (Meditoxin®)
Outcome Measures: The change of bruxism events;   The change of masticatory force(%);   The change of Pain;   Sleep-related movement disorders;   Sleep-related breathing disorders
12 Not yet recruiting Effectiveness of Two Techniques in Injection Site Spotting for Botulinum Toxin Injections: Echography or Electro Stimulation.
Condition: Stroke
Intervention: Device: Botulinum toxin injection
Outcome Measures: Passive range of motion of ankle dorsiflexion (Tardieu scale) while keeping knee straight;   Tardieu scale: quality of muscle reaction at slow speed and fast speed;   Angle of apparition of the muscle reaction at slow speed and fast speed;   Spasticity of the triceps surae on the modified Ashworth scale;   Walking speed;   Extent of pain at the injection site by visual analogue scale;   Duration of tracking and injection
13 Recruiting Botulinum Toxin for Pelvic Pain in Women With Endometriosis
Conditions: Endometriosis;   Botulinum Toxin A;   Chronic Pelvic Pain;   Pelvic Muscle Spasms;   Quality of Life
Intervention: Drug: Botuninum toxin A
Outcome Measures: Improvement in pain - a binary measurement of improvement/no improvement will be used.;   1) Need for re-injection at 1 month as a binary measurement of yes/no; 2) Change in Pelvic Pain: Pain visual analog score; 3) Botulinum toxin patient response inventory; 4) Standardized Pelvic Pain questionnaire; 5) Standardized QOL questionnair...
14 Recruiting Multicenter Randomized Double-blind Study Evaluating the Effects of Botulinum Toxin A Associated With ropivacaïne Versus ropivacaïne Alone in the Treatment of the Myofascial Pelviperineal Pain
Condition: Myofascial Pelviperineal Pain
Interventions: Drug: Botulinum toxin A + ropivacaïne;   Drug: Ropivacaïne
Outcome Measures: Evolution of the PGI-I (Patient Global Impression of Improvement);   Evaluation of pain on digital scale (EN);   To assess the changing parameters of quality of life: global improvement score / treatment satisfaction assessed by digital scale, international pain scales (MPI, QDSA, QCD) / Beck and HAD score;   To assess the evolution of analgesics consumption (score MQS)
15 Unknown  Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm
Condition: Hemifacial Spasm
Interventions: Drug: preseptal injection of Botulinum toxin type A;   Drug: pretarsal injection of Botulinum toxin type A
Outcome Measures: tear break up time;   schirmer's test
16 Recruiting Effect of Vocal Exercise After Botulinum Toxin Injection for Spasmodic Dysphonia
Conditions: Spasmodic Dysphonia;   Dystonia
Intervention: Behavioral: Vocal Exercise
Outcome Measures: Self-rating of vocal function;   Number of voice breaks during connected speech;   Duration of voice onset time in speech
17 Unknown  The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor
Conditions: Multiple Sclerosis;   Tremor
Intervention: Drug: Botulinum Toxin Type A
Outcome Measures: A decrease in tremor;   The safety profile of Botulinum Toxin in MS patients
18 Not yet recruiting New Approaches in Evaluating Patients' Response to Botulinum Toxins in the Treatment of Chronic Neck Pain and Back Pain
Conditions: Cervicalgia;   Low Back Pain
Intervention: Drug: Botulinum Toxins
Outcome Measures: VAS score;   Neck Disability Index;   Oswestry Scale;   Cervical and Lumbar Range of Motion;   surface EMG (sEMG);   Cervicalgia Rating Scale;   Lumbar Pain Rating Scale;   digital thermography
19 Unknown  Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches
Condition: Refractory Migraine
Intervention: Drug: Botulinum toxin A
Outcome Measure: 1- Pain Intensity (VAS) 2- Pain frequency
20 Recruiting Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction
Conditions: Breast Cancer;   Pain, Postoperative;   BRCA1 Mutation;   BRCA2 Mutation;   Breast Diseases;   Neoplasms
Interventions: Drug: Botulinum Toxin Type A;   Drug: Sodium Chloride Solution
Outcome Measures: Change from Baseline in average pain scores using a numeric pain intensity scale;   Change from Baseline in Physical Well-Being using the BREAST-Q Physical Well-Being scale;   Initial percent volume expansion intra-operatively;   Rate of tissue expansion;   Rate of reconstruction failure;   Incidence of side effects attributable to the injection of BTX-A at doses of 100 units and 200 units.

These studies may lead to new treatments and are adding insight into Botulinum etiology and treatment.

A major focus of Botulinum research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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