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Brethine Medical Research Studies

Up-to-date List of Brethine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Brethine Medical Research Studies

Rank Status Study
1 Unknown  Terbutaline Concentrations in Blood and Urine
Condition: Asthma
Intervention: Drug: inhaled and oral terbutaline
Outcome Measure: Terbutaline concentrations in serum and urine
2 Not yet recruiting A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma.
Condition: Asthma
Interventions: Drug: budesonide/formoterol 'as needed' + budesonide placebo bid;   Drug: terbutaline 'as needed' + placebo budesonide bid;   Drug: budesonide bid + terbutaline 'as needed'
Outcome Measures: 'Well-controlled asthma week' - a derived binary variable (Yes/No);   Time to first severe asthma exacerbation;   Time to first moderate or severe asthma exacerbation;   Average change from baseline in pre-dose FEV1;   Average change from baseline in Morning PEF;   Average change from baseline in Evening PEF;   Average change from baseline in number of inhalations of 'as needed' medication;   Average change from baseline in symptom score;   Percentage of Nighttime awakenings due to asthma;   Percentage of Symptom-free days;   Percentage of 'As needed' free days;   Percentage of Asthma control days;   Time to asthma related discontinuation;   Poorly controlled asthma weeks;   Time to additional steroids for asthma;   Average change from baseline in Asthma Control Questionnaire (ACQ-5);   Average change from baseline in Asthma Quality of Life Questionnaire; standard version (AQLQ(S))
3 Not yet recruiting Study to Evaluate is ECV Success is Improved and the Side Effects Reduced With the Use of IV NTGL Versus Terbutaline
Condition: External Cephalic Version
Interventions: Drug: Intravenous Terbutaline;   Drug: Intravenous Nitroglycerine
Outcome Measures: Successful version of the fetus into the vertex position;   Hypotension;   need for cesarean delivery;   tachycardia
4 Recruiting Intravenous Terbutaline to Facilitate Labor Epidural Catheter Placement
Condition: Labor Pain
Interventions: Drug: Terbutaline;   Drug: Fentanyl;   Drug: 0.9% NaCl
Outcome Measures: reduction of pain score on a visual analog scale (VAS) of 1-10;   movement during epidural placement;   position during epidural placement
5 Unknown  Analgesic Effect of Beta 2-mimetics in the Treatment of Neuropathic Pain
Conditions: Postthoracotomy Pain;   Postthoracoscopy Neuropathic Pain
Intervention: Drug: Terbutaline sustained release 5 mg
Outcome Measure: Change from baseline in the average intensity of pain during the last 24 hours reported by the patient on a 11 points Numeric Scale
6 Recruiting Evaluation of Benefit of Nebulized Bronchodilators at Home in Severe Chronic Obstructive Pulmonary Disease and Very Severe Steady State
Condition: Severe Chronic Obstructive Pulmonary Disease
Interventions: Drug: Atrovent + Bricanyl or Atrovent + Ventoline;   Drug: Placebo
Outcome Measures: Score for quality of life, assessed by the questionnaire St Georges;   Score for quality of life, assessed by the questionnaire VQ11;   Dyspnea score according Medical Research Council;   Prognostic Score Mortality assessed by the score BODE
7 Unknown  Cervical Foley Plus Vaginal Misoprostol for Labor Induction
Condition: Induction of Labor
Intervention: Device: Foley bulb
Outcome Measures: Time from start of labor induction to vaginal delivery;   Successful number of vaginal deliveries;   tachysystole requiring terbutaline use;   Post-partum hemorrhage;   Chorioamnionitis;   neonatal APGAR scores;   NICU admission;   Time to complete cervical dilation
8 Unknown  Propofol Sedation During Upper Endoscopy With and Without Topical Pharyngeal Anesthesia
Condition: Conscious Sedation
Interventions: Drug: Lidocaine 10%;   Drug: Diluted gentian root solution
Outcome Measures: Number triggered gag reflex during the intubation of the endoscope;   Number of attempts of intubation with the endoscope through the upper esophageal sphincter;   Extent of salivation during intubation;   Amount of propofol used to successfully intubate the esophagus;   Total amount of propofol used during the investigation;   Overall assessment of the procedure by the endoscopist;   Assumption of the endoscopist if lidocaine or placebo has been used;   Overall assessment of the investigation by the patient;   Extent of amnesia in the patient;   Experienced problems (aspiration, bronchospasm, desaturation);   The impact of the individual endoscopists or registered nurses involved in the endoscopy
9 Unknown  LTOT in COPD Patients With Moderate Chronic Hypoxemia and Chronic Heart Failure
Conditions: Lung Diseases, Obstructive;   Chronic Heart Failure;   Chronic Hypoxemia
Interventions: Other: LTOT (oxygen therapy);   Other: Pharmacological therapy of COPD and CHF
Outcome Measures: The primary outcome of the study is mortality.;   Secondary endpoint of the study is to evaluate whether the appropriate medical treatment without LTOT is not inferior to medical treatment with LTOT in terms of quality of life, rate and severity of exacerbation, number of hospital admissions.
10 Recruiting Effects and Safety of Different Dose of Bambuterol on Chinese COPD Patients
Condition: COPD
Interventions: Drug: bambuterol;   Drug: Placebo
Outcome Measures: the change in FEV1(L) and FVC(L);   difference of AUC(0-12h) FEV1(L) as well as AUC(0-12h) FVC(L) among 3 dose groups;   change of PEFR(L/min)
11 Recruiting The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma
Conditions: Eosinophilic Bronchitis;   Cough Variant Asthma
Intervention: Drug: Bambuterol Hydrochloride tablets
Outcome Measures: Day-time and night-time cough symptom total-score changes from baseline to day 3.;   cough sensitivity from baseline to day 3

These studies may lead to new treatments and are adding insight into Brethine etiology and treatment.

A major focus of Brethine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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