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Bronchospasm Medical Research Studies

Up-to-date List of Bronchospasm Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Bronchospasm Medical Research Studies

Rank Status Study
1 Recruiting Efficacy and Safety Evaluation in Recurrent Bronchospasms
Condition: Bronchospasm
Intervention: Biological: Biological vaccine
Outcome Measures: Recurrent Bronchospasm;   Shortening of the severity of the Bronchospasm episodes;   Medication consumption;   Number of Participants with Adverse Events as a Measure of Safety and Tolerability;   Direct costs;   Indirect costs
2 Unknown  Observational Study on Obese Patients During General Anesthesia
Conditions: Bronchospasm;   Surgery;   Obesity
Intervention:
Outcome Measures: The difference in the presence of Bronchospasm in obese and non obese patients;   The impact of intraoperative Bronchospasm on postoperative complications
3 Unknown  Effects of Montelukast on Occult Exercise-Induced Bronchospasm in Athletes
Condition: Exercise-Induced Bronchospasm
Intervention: Drug: Administration of montelukast or placebo
Outcome Measures: Effective blunting of the EIB response by Spirometric measurement;   Improvement in indices of ventilation and cardiopulmonary response measured on CPST
4 Unknown  Diagnosis of Exercise-Induced Bronchospasm (EIB) and Asthma in National Collegiate Athletic Association (NCAA) Division I Athletes
Condition: Exercise Induced Bronchospasm, Asthma
Intervention:
Outcome Measures: Change in FEV1 following eucapnic voluntary hyperventilation;   Protection from fall in FEV1 following eucapnic voluntary hyperventilation by preadministration of albuterol
5 Recruiting Therapeutic Utility of Xolair in Patients Undergoing Aspirin Desensitization
Condition: Aspirin Exacerbated Respiratory Disease
Intervention: Drug: omalizumab
Outcome Measures: Spirometry (FEV1) testing to assess the efficacy of Xolair on aspirin induced Bronchospasm during aspirin desensitization in patients with AERD.;   Changes in serum and urinary markers of eosinophil activation during desensitization and change in urinary LTE4 during Bronchospasm. Assessment of aspirin dose that provokes reaction.
6 Recruiting A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis
Conditions: Anaphylaxis;   Hypotension;   Bronchospasm;   Angioedema
Interventions: Drug: Epinephrine;   Procedure: Bone Marrow Apsiration;   Drug: Omalizumab (Xolair)
Outcome Measures: The primary objective of this study is to determine if treatment with omalizumab over 6 months will produce a reduction in the number and timing of anaphylactic events in subjects with a history of frequent idiopathic anaphylaxis.;   Assess the pharmacodynamics of omalizumab in subjects with anaphylaxis. Examine the effects of omalizumab in the immunopathogenesis of anaphylaxis. Identify subjects with the D816V mutation.
7 Not yet recruiting Mechanical Ventilation During Cardiac Surgery
Conditions: Respiratory Failure;   Pneumothorax;   Atelectasis;   Aspiration Pneumonia;   Bronchospasm
Interventions: Procedure: Non-ventilation during CPB;   Procedure: Ventilation with CPAP;   Procedure: Ventilation with 5 act/minute;   Device: CPAP;   Device: Ventilator: 5 act/minute
Outcome Measure: Incidence of postoperative pulmonary complications
8 Recruiting Pharmacokinetics of Nebulized Amikacin in Non Invasive Ventilated Healthy Volunteers.
Conditions: Acute Respiratory Insufficiency;   Chronic Respiratory Insufficiency;   Bronchospasm and Obstruction
Intervention: Device: Nebulizer
Outcome Measure: Pharmacokinetics of nebulized amikacin
9 Recruiting Bronchial Thermoplasty: Effect on Neuronal and Chemosensitive Component of the Bronchial Mucosa
Condition: Severe Persistent Asthma
Intervention: Device: catheter ALAIR
Outcome Measures: analysis of the risk and benefit profile with questionnaire ACT and AQLQ;   Analyze the changes in the state of innervation and nerve receptors before and after BT on histological samples of the bronchial mucosa
10 Not yet recruiting A Study of Levalbuterol Tartrate HFA Inhalation Aerosol Metered Dose Inhaler (MDI) in Pediatric Subjects
Condition: Asthma
Interventions: Drug: levalbuterol tartrate HFA inhalation aerosol;   Drug: placebo
Outcome Measures: The overall safety of treatment with levalbuterol tartrate HFA inhalation aerosol as measured by the number and percentage of subjects with treatment-emergent adverse events.;   The overall safety of treatment with levalbuterol tartrate HFA inhalation aerosol as measured by the number and percentage of subjects with serious adverse events.;   The overall safety of treatment with levalbuterol tartrate HFA inhalation aerosol as measured by the number and percentage of subjects with treatment-emergent adverse events leading to discontinuation.;   Change from baseline in Pulmonary Score (total score) to end of treatment;   Change from baseline in Pulmonary Score (individual component scores) to end of treatment;   Change from baseline in Pulmonary Score (total score) after each dose;   Change from baseline in Pulmonary Score (individual component scores) after each dose;   Number and percentage of subjects determined to be stabilized after treatment
11 Recruiting Cost of Hospitalization in Children Who Develop Perioperative Respiratory Event
Conditions: Hospitalization;   Cost of Illness
Intervention:
Outcome Measures: cost of hospitalization;   days of hospitalization
12 Recruiting Clinical Trial Corticoids For Empyema And Pleural Effusion In Children
Conditions: Parapneumonic Pleural Effusion;   Empyema
Interventions: Drug: Dexamethasone;   Drug: Placebo
Outcome Measures: time to resolution;   number of children with complications.;   Number of children with complications attributable to corticoids
13 Recruiting Effects of Pepper Gas Exposure in Non-combatant Bystanders.
Conditions: Cough;   Irritation in Throat;   Irritation in Skin;   Lacrimation
Intervention:
Outcome Measures: Development of cough, irritation in throat, nasal irritation, nasal discharge, wheezing, breathlessness, hemoptysis, chest pain upon exposure or worsening of already existing cough, breathlessness, wheezing of a previous respiratory illness.;   Duration of symptoms developed
14 Not yet recruiting POPULAR: POst-operative PULmonary Complications After Use of Muscle Relaxants in Europe
Conditions: Surgical Procedures, Operative;   Anaesthesia
Intervention:
Outcome Measures: The primary study outcome parameter is the rate of post-operative pulmonary Complications (POPC).;   in-hospital mortality;   length of in-hospital stay
15 Recruiting Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients.
Conditions: Hypertension, Pregnancy Induced;   Hydralazine Adverse Reaction;   Pre-eclampsia;   Pre-eclampsia Superimposed Pre-existing Hypertension
Interventions: Drug: Labetalol;   Drug: Hydralazine
Outcome Measures: Sever persistent hypertension;   Efficacy (Reduction in blood pressure below thresholds).;   Maternal tachycardia;   Bradycardia;   Bronchospasm;   Maternal hypotension
16 Not yet recruiting Laryngeal Mask Airway Removal During Deep Anesthesia in Children
Condition: Post Operative Sore Throat After LMA Removal
Intervention: Other: LMA removal
Outcome Measures: Incidence of Postoperative Sorethroat;   Dysphagia;   Dysphonia;   Adverse event: teeth or mucosal trauma;   laryngospasm;   Bronchospasm;   Desaturation;   Nausea and vomiting;   cough
17 Not yet recruiting APRICOT: Anaesthesia PRactice In Children Observational Trial
Conditions: Anaesthesia;   Children
Intervention:
Outcome Measures: Incidence of severe critical events;   Risk factors for the occurrence of severe critical events;   Consequences of the critical events: irreversible damage, in-hospital mortality
18 Unknown  Propofol Sedation During Upper Endoscopy With and Without Topical Pharyngeal Anesthesia
Condition: Conscious Sedation
Interventions: Drug: Lidocaine 10%;   Drug: Diluted gentian root solution
Outcome Measures: Number triggered gag reflex during the intubation of the endoscope;   Number of attempts of intubation with the endoscope through the upper esophageal sphincter;   Extent of salivation during intubation;   Amount of propofol used to successfully intubate the esophagus;   Total amount of propofol used during the investigation;   Overall assessment of the procedure by the endoscopist;   Assumption of the endoscopist if lidocaine or placebo has been used;   Overall assessment of the investigation by the patient;   Extent of amnesia in the patient;   Experienced problems (aspiration, Bronchospasm, desaturation);   The impact of the individual endoscopists or registered nurses involved in the endoscopy
19 Unknown  The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Condition: Cystic Fibrosis
Interventions: Procedure: Physiotherapy, exercise, percutaneous gastrostomy feeds;   Drug: Anti-reflux pharmacotherapy
Outcome Measure:
20 Not yet recruiting Postoperative Pulmonary Complications in Abdominal Surgery
Condition: Postoperative Pulmonary Complications
Intervention:
Outcome Measure:

These studies may lead to new treatments and are adding insight into Bronchospasm etiology and treatment.

A major focus of Bronchospasm research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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