Up-to-date List of Buscopan Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Buscopan Medical Research Studies

1 Recruiting Efficacy of Buscopan® in Comparison With 654-II (Anisodamine) in Acute Gastric or Intestinal Pain
Condition: Intestinal Diseases
Interventions: Drug: 654-II (anisodamine);   Drug: Buscopan® (hyoscine butylbromide)
Outcome Measures: Pain intensity difference (PID) from pre-dose baseline at 20 minutes after the first injection.;   PID from pre-dose baseline at 10, 30, 60 and 120 minutes after the first injection.;   Global assessment of efficacy by the patient at 120 minutes after the first injection using a 4-point rating scale (0=poor; 1=fair; 2=good; 3=very good).;   Proportion of patients who need the second injection at 20 minutes after the first injection.
2 Unknown  Does the Hyoscine N-Butylbromide Administered During Colonoscopy Increase the Adenoma Detection Rate?
Condition: Colonic Adenomas
Interventions: Drug: Hyoscine Butyl Bromide 20mg/2 ml i.v.;   Drug: Saline 2 ml i.v.
Outcome Measures: Effect of Hyoscine Butyl Bromide on Adenoma Detection Rate (ADR);   Tolerability of HBB
3 Unknown  A Double-blind Comparison of Scopolamine With Cinnarizin for Prevention of Simulator Sickness
Condition: Simulator Sickness
Interventions: Drug: scopolamine;   Drug: cinnarizine
Outcome Measure: Finding more effective treatment to the motion sickness symptoms during and after simulator training.
4 Recruiting A Study of the Use of IV Scopolamine to Augment the Efficacy of Electroconvulsive Therapy (ECT)
Condition: Depression
Intervention: Drug: Scopolamine
Outcome Measures: Ham D 17 scores;   Time to response/remission;   Number of ECT treatments to response/remission
5 Not yet recruiting Generalization of Extinction Learning
Condition: Social Anxiety Disorder
Interventions: Drug: Scopolamine;   Drug: intranasal placebo
Outcome Measures: Eye blink startle reflex;   Skin conductance responses and heart rate;   Subjective Units of Distress;   Self Statements During Public Speaking Scale;   Personal Report of Confidence as a Speaker Scale;   Subjective units of distress during in vivo speech
6 Recruiting Hyoscine Butyl Bromide for Management of Prolonged Labor
Condition: Prolonged Labor
Interventions: Drug: Hyoscine butyl bromide;   Drug: Normal saline
Outcome Measure: Caesarean section rate for failure to progress
7 Recruiting Role of Hyoscine Bromide in Latent and Active Labor
Condition: Labor, First Stage
Interventions: Drug: Hyoscine bromide;   Drug: Physiological serum
Outcome Measure: Time to complete dilation
8 Recruiting Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies
Conditions: Mood Disorders;   Healthy;   Unipolar Depression;   Bipolar Depression
Intervention: Drug: Transderm Scopolamine
Outcome Measure: Evaluation of the antidepressant effects of the antimuscarinic agent scopolamine
9 Recruiting Whole-body Diffusion MRI for Staging, Response Prediction and Detecting Tumor Recurrence in Patients With Ovarian Cancer
Condition: Ovarian Carcinoma
Intervention: Other: Whole body diffusion-weighted MRI
Outcome Measures: Validation of interpretation criteria of WB-DWI for staging and thresholding for treatment assessment in pilot study;   WB-DWI for tumor characterization and staging at primary diagnosis;   WB-DWI for response assessment during and early after neoadjuvant chemotherapy;   The prognostic value of DWI-determined imaging markers
10 Recruiting Effects of Hallucinogens and Other Drugs on Mood and Performance
Condition: Healthy
Intervention: Drug: Hallucinogens and psychoactive substances
Outcome Measures: Rating of "Drug Liking" on the End of Day Questionnaire;   Hallucinogen Rating Scale
11 Unknown  The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor
Conditions: Multiple Sclerosis;   Tremor
Intervention: Drug: Botulinum Toxin Type A
Outcome Measures: A decrease in tremor;   The safety profile of Botulinum Toxin in MS patients
12 Recruiting Detection of Disease-Related Changes in Pre-Symptomatic Alzheimer's Disease
Condition: Alzheimer's Disease
Intervention: Other: Observational Study
Outcome Measures: Groton Maze Learning Test;   CogState One-Back Learning (OBK) Task;   12-Item International Shopping List Test - Immediate and Delayed Recall (CogState);   Rentz Face-Name Association Test;   Stark Pattern Separation Test;   Minnesota Cognitive Acuity Scale (MCAS);   Saliva Sample for DNA Analyses (ApoE and BDNF genotyping);   Non-invasive imaging of macula, retinal function and visual fields;   CogState Once-Card learning (OCL) Task;   Amyloid and Alzheimer's Psycho-educational Session;   Tokyo Subway Navigation;   MAC-Q
13 Recruiting The Impact of Warmed Carbon Dioxide Insufflation During Colonoscopy on Polyp Detection
Conditions: Colonic Polyps;   Colonic Neoplasms
Interventions: Device: room temperature air insufflation;   Device: warmed carbon dioxide insufflation
Outcome Measures: Polyp Detection Rate;   adenoma detection rate;   advanced lesion per patient detection rate
14 Unknown  Explore the Nature Factors Relevant to Learning-Pioneering Natural Factors That Influences Science Learning II
Condition: Healthy
Outcome Measure: observational studies, related to core objectives of the study and learning.
15 Not yet recruiting Rectal Cancer: Local Staging, Re-staging and Assessment of Lymph Nodes Using Pet-Ct, CT-Perfusion and 3T MRI
Condition: Rectal Cancer
Intervention: Device: MRI,PET-CT and CT-Perfusion studies
Outcome Measure: efficacy of PET, CT-perfusion and MRI to stage patients with rectal cancer
16 Not yet recruiting PET/CT for the Quantification of Atherosclerotic Plaque Inflammation
Conditions: Coronary Artery Disease;   Acute Coronary Syndrome
Interventions: Other: [18F]-FDG positron emission computed tomography;   Procedure: Invasive coronary angiography;   Procedure: Intravascular ultrasound and virtual histology;   Other: Serum biomarkers
Outcome Measures: Association of FDG uptake and coronary plaque vulnerability;   Association of FDG-uptake and extent of the disease;   Association of FDG-uptake and risk profile / serum markers;   Association of FDG-uptake and cardiovascular events
17 Recruiting Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery
Conditions: Post-operative Nausea;   Post-operative Vomiting;   Post-discharge Nausea;   Post-discharge Vomiting
Intervention: Other: Anesthesia and postoperative medication and fluid protocol
Outcome Measures: Post-operative nausea and vomiting;   Hospital length of stay;   Post-discharge nausea and vomiting

These studies may lead to new treatments and are adding insight into Buscopan etiology and treatment.

A major focus of Buscopan research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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