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Caffeine Medical Research Studies

Up-to-date List of Caffeine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Caffeine Medical Research Studies

Rank Status Study
1 Recruiting Early Versus Routine Caffeine Administration in Extremely Preterm Neonates
Condition: Caffeine
Intervention: Drug: Caffeine
Outcome Measures: Intubation;   hypotension;   systemic blood flow;   Cerebral blood flow
2 Recruiting Treatment for Caffeine Dependence
Condition: Caffeine Use Disorder (DSM-5 Condition for Further Study)
Intervention: Behavioral: Manual-based treatment for Caffeine dependence
Outcome Measures: Change in self-reported Caffeine use;   Change in biological measure of Caffeine use
3 Not yet recruiting Caffeine, Genetic Variation and Athletic Performance
Condition: Healthy
Intervention: Dietary Supplement: Caffeine
Outcome Measures: Efficacy of Caffeine to improve power, strength and speed;   Individual genotypes, Caffeine ingestion and athletic performance
4 Unknown  Neurophysiological Reserve With Caffeine Manipulation
Conditions: Cyclists;   Trained
Intervention: Dietary Supplement: Caffeine
Outcome Measures: Neurophysiological reserve evidenced by Caffeine;   Neurophysiological reserve evidenced by placebo
5 Recruiting Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in Young Infants
Conditions: Bronchiolitis;   Apnea;   Caffeine
Interventions: Drug: Caffeine citrate;   Drug: Normal saline
Outcome Measures: The length of pediatric intensive care unit stays (days).;   The duration of non-invasive respiratory support (days).;   The rate of endotracheal intubation;   The duration of total respiratory support (days);   The overall length of hospital stays (days);   The frequency of apneic episodes;   Duration of mechanical ventilation (days)
6 Unknown  Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study
Conditions: Obstructive Sleep Apnea;   Enlargement of Tonsil or Adenoid
Interventions: Drug: Caffeine and sodium Benzoate 10 mg/kg IV;   Drug: Caffeine and Sodium Benzoate 20 mg/kg IV;   Drug: 0.9 NS Saline
Outcome Measures: Effects of Caffeine;   Caffeine Drug Effects
7 Recruiting The Effect of Dosage of Caffeine on Intraocular Pressure
Conditions: Intraocular Pressure;   Caffeine Dosage
Interventions: Other: decaffeinated coffee;   Other: regular dose coffee;   Other: high dose coffee
Outcome Measure: change from baseline in intraocular pressure (mmHg)after Caffeine intake
8 Not yet recruiting Influence of Caffeine on HRV and Exercise Performance in Spinal Cord Injury
Conditions: Caffeine;   Spinal Cord Injury
Interventions: Dietary Supplement: Caffeine;   Dietary Supplement: Placebo (Mannitol)
Outcome Measures: Exercise performance;   Heart rate variability (HRV) before the ingestion of supplement;   Heart rate variability (HRV) after the exercise performance test;   Catecholamine;   Heart rate variability 40min after the ingestion
9 Unknown  Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence
Condition: Cocaine Dependence
Interventions: Drug: Caffeine;   Drug: Biperiden;   Drug: Placebo
Outcome Measures: survival;   cocaine use
10 Not yet recruiting The Effects of Caffeine on Force Loss Following Exercise-induced Muscle Damage
Condition: Healthy
Interventions: Drug: Caffeine;   Other: Flour
Outcome Measures: change in maximal voluntary strength;   change in h-reflex;   change in 20:100 hertz force ratio;   change in pain pressure threshold in the calf;   change in muscle activation;   change in the pain visual analog scales;   change in the hurt visual analog scales;   change in the soreness visual analog scales
11 Not yet recruiting The Influences of Caffeine on Heart Rate Variability of Preterm Infants
Condition: Autonomic Nervous System
Intervention: Drug: Caffeine
Outcome Measure: Heart rate variability
12 Recruiting "Potential Effect of Acute and Chronic Caffeine Administration on Platelet Reactivity in Patient With Coronary Artery Disease on Dual Antiplatelet Therapy"
Interventions: Other: Caffeine;   Other: not Caffeine
Outcome Measure: Assessment of platelet reaction units
13 Recruiting Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Conditions: Prematurity;   Apnea;   Respiratory Failure
Interventions: Drug: Caffeine citrate;   Other: Normal saline
Outcome Measures: Time to first elective extubation;   Survival;   Total duration of mechanical ventilation;   Total duration of oxygen supplementation;   Bronchopulmonary dysplasia (BPD);   Survival without BPD
14 Unknown  Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache
Condition: Headache
Interventions: Drug: Ibuprofen plus Caffeine;   Drug: Ibuprofen
Outcome Measures: Efficacy of study treatment compared with control to relieve headache symptoms.;   Tolerability of study treatment compared with control to relieve headache symptoms.
15 Recruiting Magnetic Resonance Imaging (MRI) and Neurodevelopmental Outcomes in Preterm Infants Following Administration of High-Dose Caffeine
Conditions: Apnea of Prematurity;   Intraventricular Hemorrhage;   White Matter Injury
Intervention: Drug: Caffeine citrate
Outcome Measures: Length of time requiring mechanical ventilation;   Brain injury;   Mortality rates;   Length of time requiring any respiratory support;   Length of time after birth until resolution of apnea of prematurity;   Rates of chronic lung disease;   Length of time requiring inotropic support;   Length of time after birth until reaching full enteral feeds;   Rates of necrotizing enterocolitis;   Infant neurobehavioral scoring by Dubowitz scale prior to discharge;   Evaluation of EEG seizure burden;   Rates of retinopathy of prematurity;   Advanced magnetic resonance imaging by diffusion analysis and cortical folding measures;   Bayley Scales of Infant Development scores at 2 and 4 years of age;   Rates of tachycardia and/or arrhythmias
16 Not yet recruiting Caffeine as a Therapy for Parkinson's Disease
Condition: Parkinson's Disease
Interventions: Drug: Caffeine;   Drug: Placebo
Outcome Measures: Motor manifestations associated with Parkinson's disease;   MDS-UPDRS components and subscales - each individual component will be assessed, including:;   Cognition;   Sleep;   Quality of life;   Medication utilization;   Tolerability and side effects of Caffeine
17 Not yet recruiting Inhibition of VAP-1 by Caffeine in Healthy Human Volunteers Study
Condition: Liver Disease
Intervention: Drug: Caffeine citrate
Outcome Measure: VAP-1 serum levels
18 Recruiting Arrhythmic Effects of Hight Dose Caffeine
Condition: Arrhythmia
Intervention: Dietary Supplement: Caffeine
Outcome Measure: Arrhythmias
19 Recruiting A Study of Caffeine on Cardiac Arrhythmias
Conditions: Supraventricular Tachycardia (SVT);   Atrial Fibrillation
Interventions: Drug: Caffeine;   Other: Placebo
Outcome Measures: Invasive group: Refractory period of the Right Ventricle (RV) and Right Atrium (RA), Non-Invasive group: Ambulatory monitoring number of atrial and ventricular extrasystoles;   Invasive group: Tachycardia inducibility
20 Recruiting Effects of a Cocoa Shot on the Human Brain 2
Condition: Caffeine
Interventions: Dietary Supplement: no Caffeine;   Dietary Supplement: high Caffeine;   Dietary Supplement: no theobromine;   Dietary Supplement: low theobromine;   Dietary Supplement: high theobromine
Outcome Measures: Change in Working Memory (% correct);   Change in Response Time (milliseconds);   Change in Short Term Memory (# correct);   Change in Mood (change in Likert scale score);   Change in Attention (% accuracy);   Change in Executive Function (# correct);   Change in Brain Blood Flow (ml/g/min);   % Change in Heart Rate (beats/minute);   % Change in Blood Pressure (mm Hg);   Change in Respiration (breaths/minute)

These studies may lead to new treatments and are adding insight into Caffeine etiology and treatment.

A major focus of Caffeine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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