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Carbamide Medical Research Studies

Up-to-date List of Carbamide Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Carbamide Medical Research Studies

Rank Status Study
1 Recruiting Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)
Conditions: High Risk Polycythemia Vera;   High Risk Essential Thrombocythemia
Interventions: Drug: PEGASYS;   Drug: Hydroxyurea;   Drug: Aspirin
Outcome Measures: To compare hematologic response rates in patients randomized to treatment with Pegylated Interferon Alfa-2a vs Hydroxyurea in two strata of patients with high risk polycythemia vera (PV) or high risk essential thrombocythemia (ET).;   To compare the toxicity, safety and tolerability of therapy (Pegylated Interferon Alfa-2a vs. Hydroxyurea) in the study populations by recording the adverse events that occur during the study using the CTC 4.0 as the guide.;   To compare the hematologic partial response rates on therapy (Pegylated Interferon Alfa-2a vs. Hydroxyurea).;   To compare specific pre-defined toxicity and tolerance of therapy (Pegylated Interferon Alfa-2a vs. Hydroxyurea) and validate the utility of sequential structured symptom assessment package of patient reported outcome instruments.;   To compare the impact of therapy (Pegylated Interferon Alfa-2a vs. Hydroxyurea) on key biomarkers of the disease(s) by measuring the JAK2 allele burden.;   To compare the impact of therapy on JAK2-V617F (JAK2), hematopoietic cell clonality in platelets and granulocytes in females, bone marrow histopathology, and cytogenetic abnormalities.;   To estimate survival and incidence of development of myelodysplastic syndrome, myelofibrosis, or leukemic transformation after therapy (Pegylated Interferon Alfa-2a vs. Hydroxyurea).;   To estimate incidence of major cardiovascular events after therapy (Pegylated Interferon Alfa-2a vs. Hydroxyurea).
2 Not yet recruiting Realizing Effectiveness Across Continents With Hydroxyurea (REACH)
Condition: Sickle Cell Disease
Intervention: Drug: Hydroxyurea
Outcome Measures: Safety;   Efficacy;   Feasibility
3 Recruiting Pharmacokinetics (PK) of Liquid Hydroxyurea in Pediatric Patients With Sickle Cell Anemia
Condition: Sickle Cell Anemia
Intervention: Drug: Hydroxyurea
Outcome Measures: Composite of Pharmacokinetics;   Pharmacokinetics of HU;   Bioavailability of HU
4 Recruiting Sickle Cell Disease - Stroke Prevention in Nigeria Trial
Conditions: Sickle Cell Anemia;   Sickle Cell Disease;   Stroke
Intervention: Drug: Hydroxyurea
Outcome Measures: Hydroxyurea Therapy Acceptance and Adherence;   Hydroxyurea Safety protocol for Children with Sickle Cell Anemia
5 Recruiting Sleep Respiratory Disorders Evaluation in Sickle Cell Disease Children: Hydroxycarbamide Effect on Isolated Hypoxemia
Conditions: Sickle Cell Disease;   Respiration Disorders
Intervention: Drug: Hydroxycarbamide
Outcome Measures: Vaso-occlusive and cerebral complications frequency;   Hydroxycarbamide versus placebo efficacy;   Respiratory sleep abnormalities frequency;   Relationship between sleep abnormalities and transcranial doppler abnormalities;   Polysomnography relevance compared to sleep ventilatory polygraphy
6 Unknown  Therapeutic Effect and Safety of Combined Hydroxyurea With Recombinant Human Erythropoietin.
Condition: Thalassemia Intermedia
Interventions: Drug: Hydroxyurea ,Epiao;   Drug: hydroxyurea, blood transfusion
Outcome Measures: Change in baseline transfusion frequency with increase of pre-transfusion hemoglobin;   Change in baseline quality of life assessment.
7 Recruiting A Study of Low Dose Interferon Alpha Versus Hydroxyurea in Treatment of Chronic Myeloid Neoplasms
Conditions: Polycythemia Vera;   Essential Thrombocythemia;   Primary Myelofibrosis
Interventions: Drug: PegIntron;   Drug: Pegasys;   Drug: Hydrea
Outcome Measures: molecular response (changes from baseline);   toxicity (discontinuation of therapy due to intolerability);   Quality of life (changes from baseline);   Histopathological response (changes from baseline);   Sustained molecular response (changes from level at time of discontinuation of therapy);   Neutralizing antibodies against PegIntron and Pegasys;   hematological response
8 Recruiting Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease
Conditions: Sickle Cell Disease;   Stroke
Interventions: Drug: Hydroxyurea;   Drug: Placebo
Outcome Measures: Central Nervous System Complications;   Proportion of participants with severe adverse events attributed to study procedures;   Proportion of participants undergoing randomization
9 Recruiting Study of SANGUINATE™ Versus Hydroxyurea in Sickle Cell Disease (SCD) Patients
Condition: Sickle Cell Disease
Interventions: Biological: SANGUINATE™;   Drug: Hydroxyurea
Outcome Measure: To Compare SANGUINATE™ and Hydroxyurea in Sickle Cell Disease patients.
10 Recruiting Primary Thrombocythaemia 1 Trial
Conditions: Thrombocythemia;   Myeloproliferative Disorder
Interventions: Drug: Hydroxyurea;   Drug: Aspirin
Outcome Measures: Does hydroxyurea reduce thrombosis and major haemorrhage when added to aspirin?;   Does treatment modality alter the risk of leukaemic or myelofibrotic transformation?
11 Recruiting Pegylated Interferon Alpha-2b Versus Hydroxyurea in Polycythemia Vera
Condition: Polycythemia Vera
Interventions: Drug: Peg-P-IFN-alpha-2b (AOP2014);   Drug: Hydroxyurea
Outcome Measures: Disease response rate;   Disaese response;   JAK2 allelic burden changes;   time to response;   duration of response;   number of phlebotomies;   blood parameters;   spleen size;   disease related symptoms;   adverse events;   protocol-specific adverse events of special interest
12 Recruiting Prediction of Maximum Tolerated Dose for Hydroxyurea Treatment in Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: Hydroxyurea
Outcome Measures: Time to patients reaching the maximum tolerated dose (MTD) of the medication;   Safety Analysis
13 Recruiting Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention:
Outcome Measures: DNA damage from hydroxyurea therapy-variable-diversity-joining (VDJ) recombination events defined as the number of events per microgram of genomic DNA;;   DNA damage from hydroxyurea therapy-percentage of HJB in immature (CD71+) erythrocytes;   Brain function as measured by MRI/MRA and TCD;   Splenic function as measured by Spleen Scan;   Kidney function as measured by BUN/creatinine and Urinalysis, glomerular filtration rate (GFR);   Lung function as measured by forced vital capacity (FVC) (%), forced vital volume in 1 second (FVC1) (%), and tricuspid regurgitation (TR) jet on Echocardiogram (ECHO);   Growth as measured by height and weight
14 Recruiting Hydroxyurea in Pulmonary Arterial Hypertension
Condition: Pulmonary Hypertension
Intervention: Drug: Hydroxyurea
Outcome Measure: The change in concentration of CD34+ circulating progenitors from baseline to 6 months (24 weeks (+/- 7 days)) on hydroxyurea.
15 Not yet recruiting Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment
Conditions: Sickle Cell Disease;   Sickle Cell Anemia
Intervention: Drug: hydroxyurea
Outcome Measures: Cytopenia;   Development of infection evaluated by a physician at the point of care
16 Not yet recruiting Novel Use Of Hydroxyurea in an African Region With Malaria
Conditions: Sickle Cell Anemia;   Sickle Cell Disease;   Malaria
Interventions: Drug: Hydroxyurea;   Drug: Placebo
Outcome Measures: Malaria incidence;   Incidence of SCA-related adverse events;   Incidence of hematologic toxicities;   Change in fetal hemoglobin (HbF) level;   Change in plasma concentration of soluble intracellular adhesion molecule-1 (sICAM-1);   Change in plasma concentration of nitric oxide (NO);   Malaria incidence (using additional criteria);   Change in plasma concentration of vascular cellular adhesion molecule-1 (VCAM-1);   Change in plasma concentration of von Willebrand factor (VWF);   Change in plasma concentration of tumor necrosis factor-alpha (TNF-alpha)
17 Unknown  Hydroxyurea With or Without Imatinib Mesylate in Treating Patients With Recurrent or Progressive Meningioma
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: hydroxyurea;   Drug: imatinib mesylate
Outcome Measures: Progression-free survival, defined as ≥ 25% increase in tumor volume or new tumor on MRI;   Survival;   Response rate according to MacDonald criteria;   Toxicity as assessed by NCI CTCAE v. 3.0
18 Recruiting Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABIT
Condition: Sickle Cell Disease
Interventions: Behavioral: Community Health Worker (CHW);   Behavioral: Education
Outcome Measures: Effect size of the intervention on hydroxyurea (HU) adherence;   Effect size of the intervention on youth-parent communication about self-management responsibility;   Effect size of the intervention on youth-parent communication about quality of life (QOL);   Effect size of the intervention on youth-parent communication about resource use
19 Recruiting Phase II of Chemotherapy for Relapsed Epstein Barr Virus Associated Lymphoma
Conditions: Epstein Barr Virus Associated Non Hodgkin's Lymphoma;   Epstein Barr Virus Associated Hodgkin's Lymphoma;   Post-Transplant Lymphoproliferative Disease
Interventions: Drug: Doxorubicin;   Drug: Methotrexate;   Drug: Leucovorin;   Biological: Hydroxyurea;   Drug: Zidovudine;   Procedure: Urine Alkalization
Outcome Measure: Overall Survival Rate of Subjects
20 Recruiting Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia
Condition: Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
Interventions: Drug: Montelukast added to Hydroxyurea;   Drug: Placebo added to Hydroxyurea
Outcome Measure: Improvement in soluble vascular cell adhesion molecule-1 (sVCAM)

These studies may lead to new treatments and are adding insight into Carbamide etiology and treatment.

A major focus of Carbamide research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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