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Cardio-respiratory Arrest Medical Research Studies

Up-to-date List of Cardio-respiratory Arrest Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cardio-respiratory Arrest Medical Research Studies

Rank Status Study
1 Unknown  Norwegian CARDIO-RESPIRATORY ARREST Study
Conditions: Cardiac Arrest;   Respiratory Arrest;   Resuscitation;   Coma
Outcome Measure:
2 Unknown  Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation
Conditions: Cardiopulmonary Arrest;   Cardiac Arrest
Interventions: Drug: Vasopressin;   Drug: Epinephrine
Outcome Measures: Combination vasopressin and epinephrine (CPA refractory to cardiopulmonary resuscitation and initial epinephrine dosing) will increase the proportion of patients surviving to hospital discharge by 25% compared to epinephrine alone.;   Combination vasopressin and epinephrine will decrease the time to ROSC;   Vasopressin and epinephrine will improve the proportion of CPA survivors with favorable neurologic outcome (short-term Pediatric Overall Performance Category) [POPC] score discharge of 1-3 or unchanged from hospital admission at the time of hospital .;   Vasopressin and epinephrine will improve the proportion of CPA survivors with favorable neurologic outcome (short-term Pediatric Cerebral Performance Category) [PCPC] score of 1-3 or unchanged from hospital admission at time of hospital discharge.;   Combination vasopressin and epinephrine will improve 24 hour survival.;   Combination vasopressin and epinephrine will decrease the proportion of patients who require prolonged CPR (CPR > 20minutes) to achieve sustained ROSC.;   Combination vasopressin and epinephrine will increase organ recovery in those patients who meet brain death criteria following the CPA event.;   Combination epinephrine and vasopressin will improve rates of return of spontaneous circulation (ROSC)
3 Unknown  Protein S100 Beta as a Predictor of Resuscitation Outcome
Condition: Cardiopulmonary Arrest Outcome
Outcome Measure:
4 Recruiting Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
Conditions: Heart Arrest;   Cardiac Arrest;   Cardiopulmonary Arrest;   Out of Hospital Cardiac Arrest;   Sudden Cardiac Death
Outcome Measures: Incidence of bystander Cardiopulmonary Resuscitation (CPR) in Out of Hospital Cardiac Arrest (OHCA);   Survival to hospital discharge or to December, 31 2013 whichever comes first
5 Not yet recruiting Plethysmographic Waveform for Monitoring the Quality of Cardiopulmonary Resuscitation
Conditions: Cardiopulmonary Arrest;   Cardiopulmonary Resuscitation;   Return of Spontaneous Circulation;   Pulse Oximeter Plethysmographic Waveform
Outcome Measure: survival rate
6 Not yet recruiting SNPeCPR In Cardiac Arrest REsuscitation
Condition: Cardiopulmonary Arrest
Interventions: Drug: Sodium nitroprusside enhanced cardiopulmonary resuscitation (SNPeCPR);   Drug: placebo
Outcome Measures: Rate of return of spontaneous circulation (ROSC);   ETCO2;   Blood pressure;   ECG;   SpO2;   Arterial blood gases with lactate;   Troponin;   Liver function;   Creatinine;   Echocardiography;   Survival;   Neurological score
7 Recruiting Measurement of Cerebral Flow Using Transfontanellar Doppler During Cardiopulmonary Bypass in Congenital Heart Disease Patients
Condition: Cardiopulmonary Arrest
Outcome Measure: cerebral blood flow velocity
8 Recruiting The Impact of Resuscitation Quality of CPR Team by Implantation of Electronic Checklist and Alarming System Through Video-recording Analyses
Condition: Cardiopulmonary Arrest
Intervention: Behavioral: E-checklist Group
Outcome Measures: return of spontaneous circulation;   Technical skill of CPR team;   Non-technical skill of CPR team;   survival for 2 hours;   survival to admission;   Survival to discharge
9 Unknown  Optimizing Resuscitation After Cardiac Arrest in the Community
Condition: Cardiopulmonary Arrest Outcome
Outcome Measure:
10 Recruiting Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial
Condition: Cardiac Arrest
Interventions: Procedure: Therapeutic Hypothermia;   Procedure: Therapeutic Normothermia
Outcome Measures: Survival with good neurobehavioral outcome;   Survival;   Change in neurobehavioral function from pre-cardiac arrest to 12 months post-cardiac arrest;   Neuropsychological scores (for participants who survive);   Neurological abnormality scores (for participants who survive)
11 Recruiting Evaluating Processes of Care & the Outcomes of Children in Hospital (EPOCH)
Condition: Intensive Care
Interventions: Other: Implementation of Bedside Paediatric Early Warning System;   Other: Hospital Standard of Care
Outcome Measures: All Cause Hospital Mortality (Baseline);   All Cause Hospital Mortality (Intervention);   Number of Significant Clinical Deterioration Events
12 Unknown  Relationship Between Tissue Markes in Patients With Post Cardio Respiratory Syndrome
Condition: Cardiac Arrest
Outcome Measures: mortality;   correlation of clearance markers of perfusion with the use of vasopressor and positive fluid balance
13 Recruiting Comparison Between Standard Treatment by Continuous Positive Airway Pressure (CPAP) and CPAP Combined to a Physical Activity Program for Reducing Blood Pressure in Sleep Apnea Patients With Resistant Hypertension: The RAP Randomized Controlled Trial
Conditions: Resistant Hypertension;   Sleep Apnea
Intervention: Other: Physical activity
Outcome Measures: Systolic arterial blood pressure assessed by 24-hours home blood pressure monitoring;   diastolic arterial blood pressure assessed by 24-hours home blood pressure monitoring;   Mean arterial blood pressure assessed by 24-hours home blood pressure monitoring;   Change in physical activity: number of hour per day of physical activity;   pulse wave velocity;   Change in physical activity : Metabolic Equivalents (METS);   Change in physical activity : Number of steps per day;   Change in sleep duration: Sleep to lying position duration ratio
14 Recruiting Effect of Obstructive Sleep Apnea Syndrome on Insulin Sensitivity and Cardiovascular Risk in PCOS Adolescents
Conditions: Obstructive Sleep Apnea Syndrome;   Polycystic Ovary Syndrome;   Sleep Apnea
Intervention: Device: Nasal Continuous positive airway pressure (CPAP)
Outcome Measures: The purpose of this study is to understand how insulin function is affected and how endothelial function as a surrogate marker for cardiovascular risk is affected in presence of sleep apnea as compared to girls (13-21 yrs) with PCOS without sleep apnea;   We also want to see if there is any change in the levels of adipocytokines (Leptin, adiponectin, C Reactive Protein (CRP), Tumor Necrosis Factor (TNF) alpha, Free fatty acids) because of sleep apnea in obese PCOS adolescents.
15 Unknown  Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine
Conditions: Spinal Anesthesia;   Neonates
Intervention: Drug: clonidine
Outcome Measures: number of "rescue" general anesthesia;   apnea and desaturation occurrence;   duration of spinal anesthesia
16 Recruiting Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study
Conditions: Sleep Apnea Syndrome;   Low Cardiovascular Risk
Intervention: Device: Continuous Positive Airway Pressure (CPAP) in sleep apnea patients
Outcome Measures: Change from baseline CPAP compliance at 6 months;   Subjective Sleepiness;   Fatigue;   Quality of Life;   Health status;   Cost analysis
17 Unknown  Protocol Memory Deficit in Patients With Obstructive Sleep Apnea Syndrome
Condition: Memory Deficit
Outcome Measure:
18 Recruiting PRevalence, Persistence and prOgnostic ValuE of Sleep Apnea Syndrome in Acute Heart Failure
Conditions: Sleep Apnea Syndrome;   Heart Failure
Intervention: Other: polygraphy and ECG
Outcome Measures: Persistence of the severity of SAS at the follow visit (AHI> 15).;   type of SAS;   Echocardiography parameters ECG Holter, biology;   Prognostic at 1 year (mortality and rehospitalization for HF)
19 Recruiting Intermittent Hypoxia 2: Cardiovascular and Metabolism
Conditions: Hypoxia;   Sleep Apnea;   Obstructive Sleep Apnea
Interventions: Drug: Placebo;   Drug: Valsartan;   Drug: Amlodipine
Outcome Measures: Change in sympathetic activity;   Measure of adrenergic, inflammatory and metabolic markers in adipose tissues by chronic intermittent hypoxia versus placebo in healthy nonobese subjects.;   Measure variations in parameters of inflammation in adipose tissue by chronic intermittent hypoxia versus placebo in healthy nonobese subjects.;   Measure of metabolic aspects of the OGTT test.;   Measure the activation of systemic inflammation by chronic HI versus placebo in healthy nonobese subjects. The systemic inflammation will be assessed in non-stress and during the OGTT.;   Assessing markers implicated in the pathophysiology of chronic metabolic diseases after HI versus placebo in healthy nonobese subjects during OGTT.;   Change  in vascular responsivness;   Change in Sympathetic and vascular determinant of Blood pressure
20 Recruiting Development of Algorithms to Predict Hemodynamic Instability
Condition: Sudden Cardiac Death
Outcome Measures: Autonomic Dysfunction;   Hemodynamic Deterioration

These studies may lead to new treatments and are adding insight into Cardio-respiratory Arrest etiology and treatment.

A major focus of Cardio-respiratory Arrest research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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