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Central Medical Research Studies

Up-to-date List of Central Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Central Medical Research Studies

Rank Status Study
1 Recruiting Central Auditory Processing and the Use of Hearing Aids
Condition: Auditory Processing Disorder, Central
Intervention: Device: Hearing aids
Outcome Measures: Change from the baseline in the Hearing In Noise Test (HINT) score at 6 months;   changes from the baseline in Central auditory processing disorder test score at 1, 3, 6, 9 and 12 months;   changes from the baseline in the HINT score at 3, 9, and 12 months
2 Not yet recruiting First-line Irinotecan, Lederfolin and 5FU (FOLFIRI) and Bevacizumab in Patients With Advanced Colorectal Cancer
Condition: Colorectal Cancer Stage II
Intervention: Drug: Bevacizumab and FOLFIRI
Outcome Measures: Response Rate;   Progression free survival;   evaluation of serum IL-8, bFGF, HGF, PlGF, SDF-1, MCP-3
3 Recruiting Pathophysiology of Central Apnoeas in Stroke Patients
Conditions: Central Apnoeas;   Stroke Patients
Outcome Measures: Baroreflexes;   Chemoreflexes;   Apnoea-hypopnoea index (AHI)
4 Recruiting Efficacy and Safety of Intravitreal Aflibercept Injection for Subacute Central Serous Chorioretinopathy
Condition: Central Serous Chorioretinopathy
Interventions: Drug: Intravitreal Aflibercept injection;   Drug: Sham injection;   Procedure: Half-fluence photodynamic therapy
Outcome Measures: Changes of Central subfield thickness from baseline with time;   Percentage of eyes achieving complete resolution of subretinal fluid;   Percentage of eyes achieving 20/20 vision;   Number of aflibercept injection to achieve a complete resolution;   Change in subfoveal choroidal thickness from baseline using EDI-OCT;   Adverse effect of intravitreal aflibercept (Eylea) injection
5 Unknown  Diet and Body Composition
Condition: Obesity
Interventions: Other: low-fat diet;   Other: low-carb diet
Outcome Measure: body fat composition
6 Unknown  Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma
Condition: Thyroid Cancer
Intervention: Procedure: Prophylactic Central lymph node dissection
Outcome Measures: Recurrence (Thyroglobulin level, antiTG level, results of follow-up imaging tools);   Postoperative complications(hypocalcemia, hoarseness)
7 Recruiting A Monocenter Prospective Study to Evaluate the Efficacy of Peripherally Inserted Central Catheter to Tunnelled Central Catheter With Cuff in Home Parenteral Nutrition for Long-term Used.
Condition: Chronic Intestinal Failure
Interventions: Device: group Piccnut;   Device: Tunnelled nutritional Central catheter
Outcome Measures: major complications;   Delay;   Questionnaire
8 Recruiting Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurological Intensive Care
Condition: Venous Thrombosis
Intervention: Procedure: Central venous catheter
Outcome Measures: The composite of death or catheter related large vein thrombosis;   Cumulative catheter related complications until discharge
9 Not yet recruiting A Pilot Study in Cancer Patients With Central Line Associated Blood Clots in the Upper Extremity Treated With Rivaroxaban (Catheter 2)
Conditions: Neoplasm;   Central Venous Catheter Thrombosis
Intervention: Drug: Rivaroxaban
Outcome Measures: Proportion of Central line failure, defined as infusion failure that does not respond to 2mg tPA.;   Recurrence of DVT or PE;   Major Bleeding;   Clinically Relevant Non-Major Bleeding;   Death;   Time to Central Line Failure
10 Not yet recruiting Comparison of Two Needle Insertion Techniques on Success Rate and Complications During Central Venous Catheterization
Condition: Complications of Central Venous Catheterization
Interventions: Procedure: modified Seldinger technique;   Procedure: Seldinger technique
Outcome Measures: number of attempts of guidewire advance;   complications of internal jugular vein Central catheterization
11 Recruiting Prospective Randomized Controlled Treatment Trial for Chronic Central Serous Chorioretinopathy
Condition: Chronic Central Serous Chorioretinopathy
Interventions: Procedure: Half-dose photodynamic therapy (PDT);   Procedure: Micropulse laser (ML) treatment
Outcome Measures: Absence of subretinal fluid on OCT scan;   Best-corrected visual acuity
12 Unknown  The Effect of Central Insulin on Insulin Sensitivity and Energy Metabolism
Condition: Diabetes
Interventions: Drug: Central insulin;   Drug: Placebo
Outcome Measures: Insulin sensitivity;   Energy metabolism
13 Not yet recruiting Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Condition: Central Post Stroke Pain
Intervention: Drug: Ultrasound-guided peripheral nerve block with 2% lidocaine
Outcome Measures: Reduction in spontaneous pain intensity in the painful extremity 20-30 minutes after a peripheral nerve block.;   Change in the intensity of cold sensation;   Change in the intensity of warm sensation;   Change in the intensity of pinprick sensation;   Change in the intensity of brush sensation;   Reported pain/dysesthesia descriptors on NPSI questionnaire;   Correlation between change in spontaneous pain vs. change in intensity of evoked hypersensitivity.
14 Unknown  EZIO Compared to Central Venous Lines for Emergency Vascular Access
Conditions: Catheters, Indwelling;   Central Venous Line;   Intraosseous Needle
Interventions: Device: Powered Intraosseous device (EZIO);   Device: standard Central line
Outcome Measures: Time taken to place the device;   Incidence of complications;   Costs for each of the two methods
15 Recruiting Virtual Reality With Ultrasound Versus Ultrasound For Central Line Insertion
Condition: Central Line Complication
Interventions: Device: Virtual Reality;   Device: Ultrasound
Outcome Measures: Time taken to insert needle;   Attempts;   Carotid Puncture;   Pneumothorax
16 Not yet recruiting Methotrexate for Central Serous Chorioretinopathy Treatment Trial
Condition: Central Serous Chorioretinopathy
Interventions: Drug: Methotrexate;   Drug: Delayed treatment
Outcome Measure: Optical Coherence Tomography indicating the level of Central serous detachment
17 Unknown  A Trial to Study the Influence of Ultrasound Guidance on the Complications of Central Catheter
Conditions: Catheterization;   Obesity
Interventions: Procedure: Central Venous Catheter Insertion;   Device: Ultrasound guidance
Outcome Measures: Rate of complications;   The rate of success/failure installation;   The time of installation;   Number of punctures;   Type of complications;   Mortality;   The duration of stay
18 Recruiting MyChoice: An Application of the TFEQ-R18v2
Condition: Central Nervous System Neoplasms
Interventions: Behavioral: Three-Factor Eating Questionnaire (TFEQ)-R18v2;   Behavioral: Multifactor Screener;   Behavioral: Eating Questionnaire-EMA (EQ-EMA)
Outcome Measure: Factor Structure Comparisons of Eating Questionnaires
19 Unknown  Reliability of Central Venous Pressure Measurements
Conditions: Hemodynamics;   Central Venous Pressure
Intervention: Other: PICC
Outcome Measures: Central venous pressure comparison with peripheral venous pressure;   CICC reading comparison with PICC
20 Recruiting Eplerenone for Central Serous Chorioretinopathy
Condition: Central Serous Chorioretinopathy
Intervention: Drug: Eplerenone 50mg
Outcome Measures: Resolution of Sub-retinal Fluid;   Change in macular thickness;   Best Corrected Visual Acuity;   Change in choroidal thickness, both eyes;   Safety and Tolerability Characteristics

These studies may lead to new treatments and are adding insight into Central etiology and treatment.

A major focus of Central research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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