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Centrum Medical Research Studies

Up-to-date List of Centrum Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Centrum Medical Research Studies

Rank Status Study
1 Recruiting Clinical Evaluation of a New Cancer Diagnosis Center at Kristianstad General Hospital, Sweden
Condition: Cancer
Intervention: Procedure: Diagnostiskt Centrum
Outcome Measures: Time from first contact with primary care to information on diagnosis;   Time from first contact with primary care to decision to refer to Diagnostiskt Centrum/Helsingborg General Hospital;   Time from decision to refer to Diagnostiskt Centrum/Helsingborg General Hospital to information on diagnosis;   Survival after diagnosis of cancer or another serious disease;   Sick leave;   Health care utilization;   Overall medication use;   Use of analgesics, antidepressants, and other psychotropic drugs;   Time from information on diagnosis to decision about treatment;   Time from information on diagnosis to initiation of treatment
2 Recruiting Characterization and Elimination of Mother Rotors
Condition: Atrial Fibrillation
Interventions: Procedure: standard circumferential pulmonary vein isolation by radiofrequency ablation catheter;   Procedure: CPVI + rotors' identification and ablation
Outcome Measures: freedom from symptomatic AF, atrial tachycardia, and atrial flutter;   Freedom from asymptomatic AF, atrial tachycardia, and atrial flutter off antiarrhythmic drug;   One year clinical/partial success rate;   Number of Rotors electrograms;   anatomical locations of Rotors electrograms;   characteristics of Rotors electrograms
3 Recruiting Single Scope Staging of Lung Cancer With Endosonography
Conditions: Non Small Cell Lung Cancer (NSCLC);   Indication Mediastinal Staging;   Complete Endosonography
Intervention: Procedure: Endosonography
Outcome Measures: Sensitivity for locoregional disease (N2, N3, T4 disease).;   Sensitivity for locally advanced disease (N2-3 metastases, T4). Systematic assessment and sampling of mediastinal lymph nodes versus PET-CT directed assessment of the mediastinum.
4 Not yet recruiting Supine Sleeping After Total Hip Replacement
Conditions: Osteoarthritis;   Hip Dislocation
Interventions: Behavioral: Sleep position: no restrictions;   Behavioral: Sleep position: supine
Outcome Measures: Percentage early hip dislocations;   HOOS;   VHS;   EQ-5D;   VAS/NRS hip;   Compliance anti-dislocation instructions
5 Recruiting DARE-trial: A Trial Studying the Effect of the SeQuent Please Drug-eluting Balloon Compared to the Xience Prime Drug-eluting Stent for the Treatment of Stenosis of an Earlier Implanted Stent.
Condition: In-stent Restenosis
Interventions: Device: PCI with a drug-eluting balloon;   Device: PCI with a drug-eluting stent
Outcome Measures: The primary objective of this study is the minimal lumen diameter (MLD) assessed by quantitative coronary angiography (QCA) at 6 months after PCI;   In-stent and in-segment percent Diameter Stenosis;   In-stent and in-segment Angiographic binary restenosis;   Persisting dissection (i.e. dissection post-index-procedure that remained present at follow-up), thrombosis and aneurysm
6 Unknown  Atrial Fibrillation Ablation and Autonomic Modulation Via Thorascopic Surgery
Condition: Atrial Fibrillation
Intervention: Procedure: Totally Thoracoscopic PV isolation
Outcome Measures: The primary endpoint of the study is freedom of AF after one year after the procedure without the use of antiarrhythmic drugs.;   Freedom of AF after two years after the procedure without the use of any antiarrhythmic drug;   Quality of life
7 Recruiting Ultrasound-guided Catheterization of the Axillary Vein
Condition: Critical Illness
Intervention: Procedure: ultrasound
Outcome Measures: to define venipuncture, catheterization and entire procedure success rates;   to assess the erly complication rate of ultrasound-guided axillary vein catheterization;   to assess the correlation between entire procedure success rate and the side of catheterization;   to assess the correlation between patients weight, height and depth, diameter of the axillary vein
8 Recruiting Volar Internal Plate Fixation vs. Plaster in Extra- Articular Distal Radial Fractures
Condition: Displaced Extra-articular Distal Radius Fractures
Interventions: Procedure: open reduction and internal fixation;   Other: Closed reduction and plaster
Outcome Measures: Wrist function/pain/disability at one year assessed with DASH score and PRWE score;   Quality of Life;   Pain;   Patient satisfaction;   Range of motion;   Grip strength;   Radiological parameters;   Complications
9 Recruiting Ofatumumab With IVAC Salvage Chemotherapy in Diffuse Large B Cell Lymphoma Patients
Condition: Diffuse Large B Cell Lymphoma
Interventions: Drug: Ofatumumab;   Drug: Etoposide;   Drug: Ifosfamid;   Drug: Mesna;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Leukovorin;   Drug: G-CSF
Outcome Measures: Response rate;   Progression-free survival;   Event-free survival;   Overall survival;   Number of participants with adverse events as a measure of safety and tolerability
10 Not yet recruiting the PRECious Trial: PREdiction of Complications
Condition: Postoperative Complications
Intervention: Procedure: PRECious
Outcome Measures: Morbidity and mortality after major complications;   Quality of life;   Add-on value of CRP;   Length of stay;   Length of Intensive Care admission;   Cost-efficiency
11 Recruiting Micronutrients and Antioxidants in HIV Infection
Condition: HIV Infection
Interventions: Dietary Supplement: Micronutrients and antioxidants;   Dietary Supplement: Multivitamins and minerals
Outcome Measures: Time from baseline to CD4+ cell count <350 cells/mm3 (confirmed by two measures at least one week apart), or emergence of documented CDC-defined AIDS-defining illness, or start of ART;   Non-AIDS related adverse events;   Tolerance of and adherence to study medication;   Time from baseline to CD4+ cell count <350 cells/mm3 (confirmed by two measures at least one week apart);   Time from baseline to emergence of documented CDC-defined AIDS-defining illness;   Time from baseline to start of ART;   Serial quarterly lymphocyte measures (ALC, CD4+, CD8+, and CD3+ cell counts, CD4%, CD8%, CD4:CD8);   Serial quarterly HIV RNA plasma viral load;   Serum chemistries: Glucose, BUN, creatinine, total protein, albumin, alkaline phosphatase, ALT, AST, total bilirubin,;   Serum micronutrient levels: carotene (quarterly), vitamin B12 (quarterly), folate (six monthly) and vitamin D (25-OHD six monthly);   Quality of Life measures
12 Unknown  SUPER Study; SUPERvised Exercise or Angioplasty for Intermittent Claudication Due to an Iliac Artery Obstruction.
Conditions: Intermittent Claudication;   Peripheral Arterial Disease
Interventions: Procedure: Percutaneous Transluminal Angioplasty;   Other: Supervised Exercise Therapy
Outcome Measures: Disease specific Quality of Life;   Maximum Walking Distance;   Painfree Walking Distance;   Functional Status;   Generic Quality of Life;   Complications;   Treatment failures;   Costs
13 Recruiting Amsterdam Investigator-initiateD Absorb Strategy All-comers Trial
Conditions: Coronary Artery Disease;   Myocardial Infarction
Interventions: Device: ABSORB BVS™;   Device: XIENCE™
Outcome Measures: Target Vessel Failure (TVF);   Device success;   Procedural success;   Target vessel failure (TVF);   Target lesion failure;   All revascularizations;   Major adverse cardiac events;   All cause mortality;   Myocardial Infarction;   Target Lesion Revascularization (TLR);   Target Vessel Revascularization (TVR);   Non-Target Vessel Revascularization (NTVR);   Scaffold/Stent Thrombosis;   Seattle Angina Questionnaire (SAQ);   Quality of Life Questionnaire (QOL)
14 Recruiting Rectal Cancer And Pre-operative Induction Therapy Followed by Dedicated Operation. The RAPIDO Trial
Condition: Rectal Cancer
Interventions: Other: M1 scheme;   Other: standard long course chemoradiotherapy
Outcome Measures: disease-free survival;   Overall survival;   CRM negative (margin > 1 mm) rate;   Pathological complete response (pCR) rate;   Short and long-term toxicity;   Surgical complications;   Quality of life
15 Recruiting CrossBoss and Hybrid Registry on Coronary Chronic Total Occlusions
Condition: Chronic Total Occlusion of Coronary Artery
Intervention: Other: Data registration
Outcome Measures: Outcome of CTO PCI procedure;   Outcome of PCI procedures in which CrossBoss™ technology is used (as a stand alone device);   Outcome of PCI procedures in which CrossBoss™ technology is used (combined with other techniques).;   Complications;   Clinical status after PCI procedure
16 Recruiting Hypothermic Perfusion During Hemihepatectomy
Condition: Hepatic Ischemia-reperfusion Injury
Intervention: Procedure: In situ hypothermic perfusion
Outcome Measures: Postoperative hepatocellular damage;   Intraoperative blood loss;   Postoperative complications;   Regeneration of liver function and volume
17 Recruiting Biological Mesh Closure of the Pelvic Floor After Extralevator Abdomino Perineal Resection for Rectal Cancer
Condition: Rectal Cancer
Interventions: Procedure: Biological mesh assisted perineal closure;   Procedure: Primary perineal closure
Outcome Measures: The primary endpoint is the percentage of uncomplicated perineal wound healing;   Perineal wound healing according to the Southampton wound grading;   Incidence of persistent perineal or presacral sinuses, both clinically and by imaging;   Need for re-intervention or re-admission related to pre-sacral abscess or other perineal wound problems;   Length of hospital stay;   Need for nursing home admission;   Need for home nursing wound care: frequency per week and total period of time;   Use of wound care material and devices like vacuum assisted closure;   Incidence of symptomatic and asymptomatic perineal hernia;   Quality of life;   Costs
18 Recruiting Chemotherapy Followed By Surgery Vs Radiotherapy Plus Chemotherapy in Patients With Stage IB or II Cervical Cancer
Condition: Cervical Cancer
Interventions: Procedure: conventional surgery;   Procedure: neoadjuvant chemotherapy;   Radiation: brachytherapy;   Radiation: radiation therapy;   Drug: cisplatin
Outcome Measures: Overall survival as measured by Kaplan Meier after each course, every 3 months for 1 year, every 6 months for 4 years, and then annually;   Progression-free survival as measured by Kaplan Meier and RECIST after each course, every 3 months for 1 year, every 6 months for 4 years, and then annually;   Toxicity as measured by NCIC Common Toxicity Criteria v2.0 after each course;   Health-related quality of life as measured by Quality of Life Questionnaire-C30 at baseline and at 6, 12, 18, and 24 months
19 Recruiting MEtoclopramide, DExamethasone or Axoli to Prevent or Delay Chemotherapy-induced Nausea and Vomiting in Moderately Emetogenic Non-AC-based Chemotherapy
Condition: Solid Tumors
Interventions: Drug: metoclopramide;   Drug: dexamethason;   Drug: palonosetron
Outcome Measures: efficacy;   tolerability;   cost-effectiveness
20 Unknown  Treatment of M.Graves With Radioactive Iodine: Follow-up Study
Condition: Hyperthyroidism
Intervention:
Outcome Measure:

These studies may lead to new treatments and are adding insight into Centrum etiology and treatment.

A major focus of Centrum research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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