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Cerebral Medical Research Studies

Up-to-date List of Cerebral Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cerebral Medical Research Studies

Rank Status Study
1 Recruiting Reversing Cerebral Oxygen Desaturations Greater That 10% of Baseline Values Using NIRS in the ICU
Condition: Cerebral Ischemia
Interventions: Device: NIRS and Algorithm;   Device: NIRS derived Cerebral oximetry
Outcome Measure: The incidence in the two groups of postoperative Cerebral desaturation
2 Recruiting Erlotinib With Concurrent Brain Radiotherapy and Secondary Brain Radiotherapy After Recurrence With Erlotinib in NSCLC Non-increased-intracranial-pressure Symptomatic Brain Metastases
Conditions: Non-small-cell Lung Cancer;   Brain Metastases
Interventions: Drug: Erlotinib;   Radiation: concurrent brain radiotherapy;   Radiation: secondary brain radiotherapy
Outcome Measure: overall survival
3 Not yet recruiting Hippocampal Sparing Whole Brain Radiotherapy vs Conventional Whole Brain Radiotherapy in Patients With Brain Metastases
Condition: Brain Metastases
Interventions: Radiation: Hippocampal sparing whole brain radiotherapy;   Radiation: Conventional whole brain radiotherapy
Outcome Measures: Total recall assessed using Hopkins Verbal Learning Test-Revised (HVTLR) at 4 months;   Neurocognitive function;   Quality of life;   Length of time functionally independent;   Local control of surgery/SRS treated metastases, local and distant intracranial control (treated and new metastases), and disease control within the hippocampal regions;   Overall survival;   Steroid and antiepileptic medication requirements;   Acute and late side effects of radiotherapy
4 Not yet recruiting Blood-brain Barrier Quantification in Cerebral Small Vessel Disease
Conditions: Blood-Brain Barrier Permeability;   Cerebral Small Vessel Disease;   Cerebral Hemorrhage;   Cortical Stroke
Intervention: Procedure: Dynamic contrast enhanced Brain MRI
Outcome Measures: pharmacokinetic parameter values Ki and vb;   pharmacokinetic parameter values: Ki and vb for the retrospectively shortened dynamic scans
5 Recruiting Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy
Condition: Internal Carotid Stenosis
Interventions: Other: Cerebral oximetry monitoring using INVOS™ and hemodynamic optimisation;   Other: standard Cerebral monitoring and hemodynamic optimisation
Outcome Measures: The number of new Cerebral ischemic lesions;   Incremental cost-effectiveness ratio comparing the group monitored by Cerebral oximeter and the standard care group;   Hospitalization length of stay and direct medical costs;   Neurologic and neurocognitive postoperative disorders;   Postoperative quality of life (SF36, EQ5D tests);   Cerebral desaturation threshold assessment
6 Unknown  Whole-Brain Radiotherapy (WBRT) Versus WBRT and Integrated Boost Using Helical Tomotherapy for Multiple Brain Metastases
Condition: Brain Metastases
Interventions: Radiation: whole brain radiotherapy;   Radiation: whole brain radiotherapy with simultaneous boost
Outcome Measures: time to morphologic progression in the brain as evidenced on MRI (RECIST criteria);   local tumor control as evidenced by MRI;   time to neurocognitive progression;   time to deterioration of functional independence;   quality of life;   overall survival, cause of death distribution;   toxicity as evidenced by CTC-criteria
7 Not yet recruiting Non-invasive Measuring of Cerebral Perfusion After Severe Brain Injury With Near-infrared-spectroscopy and ICG
Conditions: Subarachnoid Hemorrhage, Aneurysmal;   IntraCerebral Hemorrhage (ICH);   Traumatic Brain Injury
Intervention: Procedure: measuring Cerebral perfusion by NIRS with ICG
Outcome Measures: with near-infrared-spectroscopy detected Cerebral perfusion deficit;   Determining a threshold value for Cerebral autoregulation measured with near-infrared-spectroscopy as a predictive value for the clinical outcome
8 Recruiting MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy
Condition: Brain Metastases
Interventions: Radiation: Single Fraction Stereotactic Radiosurgery (SRS);   Radiation: Fractionated Whole Brain Radiation Therapy (WBRT);   Radiation: Fractionated Stereotactic Radiation Therapy (FSRT);   Device: Magnetic Resonance Imaging (MRI) Assessments
Outcome Measures: Change in Blood Brain Barrier (BBB)/Blood Tumor Barrier (BTB) permeability (per minute) in patients with brain metastases undergoing radiation therapy.;   Change in magnitude and regional variability of Blood Tumor Barrier (BTB)/Blood Brain Barrier (BBB) permeability (per minute) in tumor, tumor margin, normal brain and brain metastases;   Effect of radiation dose on vascular permeability (per minute) of the Blood Tumor Barrier (BTB)/Blood Brain Barrier (BBB);   Investigate whether changes in Magnetic Resonance Imaging (MRI) parameters can be used as a marker for early prediction of treatment response in brain metastases.
9 Unknown  Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
Conditions: Traumatic Brain Injury;   Subdural Hematoma;   Cerebral Contusion;   Head Injury;   Cerebral Edema
Interventions: Drug: Induced, sustained hypernatremia using hypertonic saline;   Drug: Standard of care (hypertonic saline and mannitol; serum sodium)
Outcome Measures: Primary Efficacy Objective;   Primary Safety Objective;   Short term neurological outcome
10 Recruiting Study of Cerebral Tissue Oxygenation During Transfusion in Traumatic Brain Injury
Conditions: TBI (Traumatic Brain Injury);   Acute Brain Injuries
Intervention:
Outcome Measures: Applicability of a 4 wavelength near-infrared spectroscopy (NIRS) to monitor the CHANGE in absolute Cerebral oximetry over time;   The impact of PRBC transfusion on absolute Cerebral oximetry compared to peripheral values over time.
11 Recruiting Phase II Trial of Conventional Versus IMRT Whole Brain Radiotherapy for Brain Metastases
Condition: Metastatic Brain Cancer
Interventions: Radiation: Whole Brain IMRT;   Radiation: Conventional Whole Brain RT
Outcome Measures: Alopecia;   The study will also look at the effectiveness of both techniques in controlling the growth of the tumor.;   Quality of life
12 Recruiting Sector Irradiation Versus Whole Brain Irradiation for Brain Metastasis
Condition: Metastatic Malignant Neoplasm to the Adult Brain
Interventions: Radiation: sector irradiation;   Radiation: whole brain irradiation
Outcome Measures: local tumor control;   distant brain metastasis;   time to clinical deterioration;   local progression free survival;   quality of life;   neurocognitive functions;   steroid dosage;   overall survival
13 Recruiting Icotinib Treat the Patient With Brain Metastasis Epidermal Growth Factor Receptor(EGFR) Mutant Non Small Cell Lung Cancer Comparing With Whole Brain Radiotherapy
Conditions: Brain Metastasis;   Non Small Cell Lung Cancer
Interventions: Radiation: whole brain radiation(WBI);   Drug: Icotinib
Outcome Measures: iPFS;   progress-free survival (PFS);   time of controlling brain metastasis symptom;   Response rate of brain metastasis;   Cognitive function;   overall survival(OS)
14 Not yet recruiting Cerebral Oximetry in Single Lung Ventilation Thoracic Surgery
Condition: Hypoxia
Interventions: Drug: Vasoconstrictor Agents;   Other: Head/neck repositioning;   Other: Increase ETCO2;   Other: IV fluid bolus;   Drug: Additional anesthesia;   Biological: RBC transfusion;   Drug: Increase FiO2
Outcome Measures: The primary objective of this pilot study is to identify the most relevant clinical outcome variables which significantly diverge as a result of being randomized to the intervention cohort vs. the control cohort.;   Relationship of assignment group to PACU length of stay.;   Relationship of Area under the curve (AUC) of Cerebral desaturations to PACU LOS;   Relationship of assignment group to Hospital length of stay (HLOS);   Relationship of Area under the curve (AUC) of Cerebral desaturations to HLOS;   Relationship of assignment group to ICU LOS;   Relationship of AUC Cerebral desaturations to ICU LOS;   Relationship of assignment group to AUC of mean arterial blood pressure;   Relationship of AUC Cerebral desaturations to AUC of mean arterial blood pressure;   Relationship of assignment group to observed intraoperative mLs urine/kg/hr;   Relationship of AUC Cerebral desaturations to observed intraoperative mLs urine/kg/hr;   Relationship of assignment group to transfusion of red blood cells;   Relationship of AUC Cerebral desaturations to transfusion of red blood cells;   Relationship of assignment group to observed frequency of any change in surgical procedure;   Relationship of AUC Cerebral desaturations to observed frequency of any change in surgical procedure;   Relationship of assignment group to observed frequency of intraoperative or postoperative stroke;   Relationship of AUC Cerebral desaturations to observed frequency of intraoperative or postoperative stroke;   Relationship of assignment group to observed frequency of transient ischemic attack;   Relationship of AUC Cerebral desaturations to observed frequency of transient ischemic attack;   Relationship of assignment group to observed frequency of myocardial infarction;   Relationship of AUC Cerebral desaturations to observed frequency of myocardial infarction;   Relationship of assignment group to observed frequency of atrial fibrillation;   Relationship of AUC Cerebral desaturations to observed frequency of atrial fibrillation;   Relationship of assignment group to observed frequency of AUC glucose > 110 mg/dL;   Relationship of AUC Cerebral desaturations to observed frequency of AUC glucose > 110 mg/dL;   Relationship of assignment group to observed operating room time;   Relationship of AUC Cerebral desaturations to observed operating room time;   Relationship of assignment group to observed amount of narcotic administered in the operating room;   Relationship of AUC Cerebral desaturations to observed amount of narcotic administered in the operating room;   Relationship of assignment group to observed volume of crystalloid/colloid administered in the operating room;   Relationship of AUC Cerebral desaturations to observed volume of crystalloid/colloid administered in the operating room;   Relationship of assignment group to observed amount of anti-emetic meds administered in the operating room;   Relationship of AUC Cerebral desaturations to observed amount of anti-emetic meds administered in the operating room;   Relationship of assignment group to reported surgical procedure performed;   Relationship of AUC Cerebral desaturations to reported surgical procedure performed;   Relationship of assignment group to observed time on single lung ventilation;   Relationship of AUC Cerebral desaturations to observed time on single lung ventilation;   Relationship of assignment group to observed use of epidural catheter;   Relationship of AUC Cerebral desaturations to observed use of epidural catheter;   Relationship of assignment group to observed post anesthesia care unit Aldrete score;   Relationship of AUC Cerebral desaturations to observed post anesthesia care unit Aldrete score;   Relationship of assignment group to observed frequency and severity of nausea/vomiting in the post anesthesia care unit/intensive care unit;   Relationship of AUC Cerebral desaturations to observed frequency and severity of nausea/vomiting in the post anesthesia care unit/intensive care unit;   Relationship of assignment group to observed duration of mechanical ventilation in the post anesthesia care unit/intensive care unit;   Relationship of AUC Cerebral desaturations to observed duration of mechanical ventilation in the post anesthesia care unit/intensive care unit;   Relationship of assignment group to observed need for postoperative discharge to skilled nursing/rehabilitation facility;   Relationship of AUC Cerebral desaturations to observed need for postoperative discharge to skilled nursing/rehabilitation facility;   Relationship of assignment group to observed need for hospital readmission;   Relationship of AUC Cerebral desaturations to observed need for hospital readmission;   Relationship of assignment group to observed change in CAM or MMSE scores from baseline;   Relationship of AUC Cerebral desaturations to observed change in CAM or MMSE scores from baseline;   Relationship of assignment group to observed change in renal function from baseline;   Relationship of AUC Cerebral desaturations to observed change in renal function from baseline;   Relationship of assignment group to observed time to return of bowel function time;   Relationship of AUC Cerebral desaturations to observed time to return of bowel function time;   Relationship of group assignment to any observed postoperative infection;   Relationship of AUC Cerebral desaturations to any observed postoperative infection;   Relationship of assignment group to observed time to wean from postoperative supplemental oxygen;   Relationship of AUC Cerebral desaturations to observed time to wean from postoperative supplemental oxygen;   Relationship of assignment group to observed incidence of postop morbidity composite endpoint (defined in description section below);   Relationship of AUC Cerebral desaturations to observed incidence of postoperative morbidity composite endpoint (defined in description section below);   Assess the frequency of Cerebral desaturations in both cohorts by examining both the total number of patients experiencing any Cerebral desaturation as well as the total number of events among patients experiencing any Cerebral desaturation.;   Adverse clinical events and serious adverse events overall and in each cohort;   Perform a comprehensive assessment of the frequency and efficacy of predefined rSO2 desaturation mitigation interventions and their collective ability to affect the observed Cerebral oximetry values.;   Assess the interventional cohort's preoperative demographics and collected covariates for association with the ease or difficulty of mitigating observed Cerebral desaturation events.
15 Recruiting Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer
Conditions: Breast Cancer;   Brain Metastasis
Intervention: Radiation: Radiation therapy Brain metastasis in breast cancer
Outcome Measures: To assess cognitive toxicity;   Quality of life;   Intra-Cerebral progression;   Overall survival
16 Recruiting Cerebrolysin Neural Repair Therapy in Children With Traumatic Brain Injury and Cerebral Palsy
Conditions: Cerebral Palsy Children;   Children With Traumatic Brain Injury;   Mental Handicap;   Delayed Speech Development
Intervention: Drug: Cerebrolysin (Nerve growth factor)
Outcome Measure: neurodevelopment
17 Recruiting Deep Brain Stimulation for Traumatic Brain Injury
Condition: Traumatic Brain Injury
Intervention: Device: Deep Brain Stimulation
Outcome Measure: Improvement in Brain Functioning
18 Recruiting Cerebral Palsy Hip Health Related Quality of Life
Conditions: Cerebral Palsy;   Patient Undergoing Hip Surgery;   Quality of Life
Intervention: Procedure: Cerebral palsy, post hip surgery
Outcome Measures: Change in quality of life from pre-op to one year post-op;   Changes in variables obtained from physical and radiological examination
19 Recruiting Whole-Brain Radiation Therapy With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer
Conditions: HER2-positive Breast Cancer;   Male Breast Cancer;   Recurrent Breast Cancer;   Stage IV Breast Cancer;   Tumors Metastatic to Brain
Interventions: Drug: lapatinib ditosylate;   Radiation: whole-brain radiation therapy
Outcome Measures: CR rate in the brain measured by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 based on MRI scan of the brain;   CR rate in the brain measured using revise RECIST version 1.1 based on MRI scan of the brain;   Objective response rate (ORR) (CR + PR) measured using RECIST version 1.1 based on MRI scan of the brain;   ORR (CR + PR) measured using RECIST version 1.1 based on MRI scan of the brain;   Lesion-specific ORR (CR + PR);   Overall response (CR, PR, or stable disease [SD]);   Treatment-related toxicity as measured by Common Terminology Criterial for Adverse Events version 4;   CNS PFS;   PFS;   OS
20 Recruiting Effects of Cerebral Protection With Filters vs. Flow Reversal on Cerebral Embolization After Carotid Artery Stenting
Conditions: Carotid Artery Disease;   Stroke
Intervention: Procedure: Type of embolic protection method
Outcome Measures: Cerebral embolization;   Any Stroke, TIA, MI or death;   Technical success of carotid artery stenting;   Stent thrombosis

These studies may lead to new treatments and are adding insight into Cerebral etiology and treatment.

A major focus of Cerebral research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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