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Cerebyx Medical Research Studies

Up-to-date List of Cerebyx Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cerebyx Medical Research Studies

Rank Status Study
1 Recruiting Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus
Conditions: Status Epilepticus;   Epilepsy
Interventions: Drug: Clonazepam;   Drug: Fosphenytoin;   Drug: Placebo;   Drug: Lorazepam
Outcome Measures: Percentage of patient with a cessation of seizures and absence of recurrence;   Duration between the first cessation and the recurrence of seizures;   Percentage of patients having had a second injection of benzodiazepine;   Percentage of patients having had an injection of the second line treatment;   Percentage of patients having a general anesthesia for refractory status epilepticus;   Percentage of patients having had a side effect;   Percentage of patients having been mechanically ventilated;   Glasgow Coma Scale;   Mortality;   Length of stay in Intensive Care Unit;   Length of stay in hospital
2 Not yet recruiting A Study to Compare the Effectiveness of Three Drugs, Fosphenytoin, Levetiracetam and Valproic Acid in Terminating Prolonged Seizures (Status Epilepticus) That do Not Respond to Benzodiazepines.
Condition: Status Epilepticus ( Prolonged Seizures) Not Responding to Benzodiazepines
Interventions: Drug: Fosphenytoin;   Drug: Levetiracetam;   Drug: Valproic acid
Outcome Measures: Clinical cessation of SE without life threatening hypotension or cardiac arrhythmias.;   Admission to ICU, intubation and mortality
3 Recruiting Intravenous Lacosamide Compared With Fosphenytoin in the Treatment of Patients With Frequent Nonconvulsive Seizures
Condition: Nonconvulsive Seizures
Interventions: Drug: Lacosamide - 'Crossover';   Drug: Fosphenytoin - 'crossover'
Outcome Measures: Percentage of subjects who experience no NCSs for 24 hours following treatment with LCM vs. fPHT, as measured by continuous electroencephalography (cEEG) monitoring.;   Percentage of subjects who require a rebolus of the initial antiepileptic drug (AED) to control NCSs in the LCM vs fPHT arms.;   Percentage of subjects who require a second AED to control NCSs.;   Percent change in seizure time (defined as the number of minutes of electrographic seizure (ESz) activity per hour) before treatment and at the end of the first treatment arm.;   Percent change in seizure time (defined as the number of minutes of ESz activity per hour) before treatment and at the end of the second treatment arm.;   Time from bolus to time of the end of the last seizure for both first (initial bolus/rebolus)and second (crossover bolus/rebolus) treatment arms.;   Frequency of predefined adverse events (AEs) in the LCM vs fPHT arms.;   Percentage of subjects in whom study drug is withdrawn early;   Days in the intensive care unit/hospital from start of treatment in the LCM vs fPHT arms.;   Functional status as measured by the Functional Disability Scale at Day 7 to 9 postrandomization and Day 30 post-randomization in the LCM vs fPHT arms.;   Percentage of all subjects who have had a seizure, are on AED therapy, and are alive/dead at the 6-, 12-, and 24-month post-randomization follow-ups.

These studies may lead to new treatments and are adding insight into Cerebyx etiology and treatment.

A major focus of Cerebyx research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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