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Cerucal Medical Research Studies

Up-to-date List of Cerucal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cerucal Medical Research Studies

Rank Status Study
1 Recruiting Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
Condition: Drug Metabolism, Poor, CYP2D6-RELATED
Interventions: Drug: Diphenhydramine;   Drug: Metoclopramide
Outcome Measures: Area under curve of metoclopramide (MCP);   Area under curve of diphenhydramine(DPH);   Cmax of metoclopramide;   Tmax of metoclopramide;   Cmax of diphenhydramine;   Tmax of diphenhydramine
2 Recruiting Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department
Conditions: Probable Migraine;   Migraine With Aura;   Migraine Without Aura
Interventions: Drug: Ketorolac Tromethamine;   Drug: Metoclopramide
Outcome Measures: Mean reduction in pain intensity;   Pain freedom;   Headache relief - 33;   Headache relief - 50;   Presence of nausea;   Presence of vomiting;   Use of rescue medications;   Sustained pain-free;   Sustained headache relief;   Minimum clinically significant difference;   Adverse events
3 Unknown  Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness
Conditions: Acute Mountain Sickness;   High Altitude Headache
Interventions: Drug: Ibuprofen;   Drug: Metoclopramide
Outcome Measures: Headache and Nausea Visual Analog Scales;   Lake Louise Acute Mountain Sickness Score
4 Recruiting Study to Evaluate the Efficacy of Oral Dissolving Metoclopramide Before Video Capsule Endoscopy
Condition: Gastric Transit Time
Intervention: Drug: metoclopramide
Outcome Measure: Gastric Transit Time
5 Unknown  Trial on Metoclopramide and Ketoprofen in Acute Migraine of Childhood
Condition: Migraine
Interventions: Drug: metoclopramide;   Drug: placebo;   Drug: ketoprofen
Outcome Measures: evaluation of healing times from pain in the 3 groups;   comparison of percentage of healing from acute migraine and of relapses of pain in the three arms of trial;   need of a rescue drug for lack of effect in every arms of the trial
6 Recruiting Metoclopramide Pilot Trial
Condition: Gastroschisis
Interventions: Drug: intravenous metoclopramide;   Other: Placebo
Outcome Measures: Days to achieve full enteral feeding;   Duration until initiation of enteral feeds;   Duration on parenteral nutrition;   Weight gain;   Occurrence of adverse effects;   Rate of catheter-related sepsis episodes;   Incidence of necrotizing enterocolitis (NEC);   Duration of hospitalization;   Conjugated bilirubin levels
7 Recruiting Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Women With Diabetic Gastroparesis
Condition: Diabetic Gastroparesis
Interventions: Drug: Metoclopramide Nasal Spray;   Drug: Placebo Nasal Spray
Outcome Measures: Patient Reported Outcome (PRO) Symptom Diary;   Population Pharmacokinetics
8 Recruiting Diphenhydramine for Acute Migraine
Condition: Migraine
Interventions: Drug: metoclopramide;   Drug: diphenhydramine;   Drug: placebo
Outcome Measure: Sustained headache relief
9 Recruiting Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Men With Diabetic Gastroparesis
Condition: Diabetic Gastroparesis
Interventions: Drug: Metoclopramide Nasal Spray;   Drug: Placebo Nasal Spray
Outcome Measures: Patient Reported Outcome (PRO) Symptom Diary;   Population Pharmacokinetics
10 Recruiting A Randomized, Double-Blind Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of a Single Dose of Intravenous TD-8954 Compared With Metoclopramide in Critically Ill Patients With Enteral Feeding Intolerance
Condition: Enteral Feeding Intolerance
Interventions: Drug: TD-8954;   Drug: Metoclopramide
Outcome Measures: To evaluate the safety and tolerability of a single IV dose of TD-8954 in subjects with enteral feeding intolerance (EFI)by measuring AEs and ability to tolerate feeding.;   To evaluate the pharmacokinetics (PK) of IV TD-8954 with lab values of Tmax.;   To evaluate the pharmacodynamics (PD) of IV TD-8954 in subjects with EFI based on gastric emptying as measured by scintigraphy.;   To evaluate the pharmacokinetics (PK) of IV TD-8954 with lab values of AUC.;   To evaluate the pharmacokinetics (PK) of IV TD-8954 with lab values of Cmax.;   To evaluate the pharmacokinetics (PK) of IV TD-8954 with breath tests
11 Recruiting A Randomized Trial of Valproate Versus Ketorolac Versus Metoclopramide for Acute Migraine
Condition: Acute Migraine
Interventions: Drug: Metoclorpamide;   Drug: Ketorolac;   Drug: Valproate
Outcome Measures: Headache level;   Sustained pain free;   Satisfaction with medication;   Adverse event
12 Unknown  Comparison of Olanzapine and Metoclopramide For Treatment Of bReakThrough Emesis
Condition: Emesis
Interventions: Drug: olanzapine;   Drug: metoclopramide
Outcome Measures: Clinical benefit rate;   safety;   Quality of life;   change in urinary excretion of 5 hydroxy indole acetic acid
13 Recruiting MEtoclopramide, DExamethasone or Axoli to Prevent or Delay Chemotherapy-induced Nausea and Vomiting in Moderately Emetogenic Non-AC-based Chemotherapy
Condition: Solid Tumors
Interventions: Drug: metoclopramide;   Drug: dexamethason;   Drug: palonosetron
Outcome Measures: efficacy;   tolerability;   cost-effectiveness
14 Recruiting Use of an Antiemetic to Shorten the Length of Labor in Nulliparous Women
Condition: Prolonged First Stage of Labor
Interventions: Drug: Metoclopramide;   Drug: Placebo
Outcome Measures: Cervical dilatation rate;   Duration of the first stage of labor
15 Unknown  Bowel Preparation and Prokinetics in Capsule Endoscopy
Conditions: Small Bowel Disease;   Gastrointestinal Hemorrhage;   Refractory Anemia
Interventions: Drug: Senna;   Drug: Citramag powder;   Drug: Metoclopramide
Outcome Measures: Quality of capsule endoscopic images, stomach and small bowel transit times and capsule completion rates to the end of the small bowel;   The tolerance of the bowel preparation to indicate future usage
16 Recruiting Use of Prokinetics in Early Enteral Feeding in Preterm Infants
Conditions: Feeding Disorder;   Nutrition Disorder;   Infant,Premature
Interventions: Drug: Metclopramide;   Drug: Erythromycin;   Drug: placebo
Outcome Measures: Comparison of Prokinetics and PLACEBO IN EARLY ENTERAL NUTRITION OF EXTREME PRETERM INFANTS; DOUBLE BLIND CROSS OVER TRIAL;   Comaparison of Prokintics and Placebo in Early Enteral Nutrition of Extreme Preterm Infants; Double blind cross over trial.
17 Recruiting Nutritional Adequacy Therapeutic Enhancement in the Critically Ill. The NUTRIATE Study
Condition: Gastroparesis
Interventions: Drug: GSK962040 50 mg;   Drug: Metoclopramide 10 mg;   Drug: Placebo NG;   Drug: Placebo IV
Outcome Measures: Daily adequacy of enteral feed delivered via NG tube and average percent goal volume delivered (prior to development of intolerance);   Daily adequacy of enteral feed delivered via NG tube, average per cent goal calories and protein delivered (prior to intolerance);   Time to delivery of 80% prescribed calories;   Number of subjects with adverse events as a measure of safety and tolerability;   Trends in and change from baseline in measure of clinical laboratory test values to access safety and tolerability;   Trends in and change from baseline for vital signs;   Trends in and change from baseline in measure of 12-lead ECG to access safety and tolerability;   Total GRV for each 24h period;   Pharmacokinetic parameters following repeated doses of GSK962040: Cmax, Tmax, AUC(0-tau), AUC(0-infinity) for single-dose, and, if possible, accumulation ratio (Ro);   Development of feeding intolerance (FI);   Pharmacokinetic parameters of acetaminophen C60 min), Tmax, (AUC)0-60 min, AUC(0-120 min), AUC(0-180 min) and AUC(0-360 min) and 3-OMG AUC(0-60 min), C60 min, Cmax and Tmax
18 Unknown  Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial
Conditions: Post Concussive Headache;   Post Concussive Syndrome
Intervention: Drug: metoclopramide
Outcome Measures: The primary outcome of acute PCH relief will be determined by measuring the difference between VAS score at baseline and after the last dose of study drug.;   The secondary outcome of PCS will be measured by telephone questionnaire using the Rivermead Post Concussion Symptoms Questionnaire at 1, 4 and 8 weeks after injury
19 Unknown  Rescue Emetic Therapy for Children Having Elective Surgery
Conditions: Post Operative Nausea and Vomiting;   Rescue Emetic Therapy
Interventions: Drug: Metaclopramide;   Drug: Ondansetron;   Drug: diphenhydramine;   Drug: Saline
Outcome Measures: Primary-Incidence of POV after rescue antiemetic in PACU, car ride home, day of surgery, and POD #1 and 2;   Secondary - a. Discharge times;   Adverse events (headaches, sedation, dystonic reaction, dry mouth);   POV risk factors. age, personal or family history of PONV, history of motion sickness, personal or family history of smoking
20 Recruiting Treatment of Orthostatic Hypotension
Conditions: Autonomic Nervous System Diseases;   Orthostatic Hypotension;   Dopamine Beta-Hydroxylase Deficiency;   Orthostatic Intolerance
Interventions: Drug: droxidopa;   Drug: placebo;   Drug: alpha-methyldopa;   Drug: carbidopa;   Drug: metyrosine;   Drug: levodopa;   Drug: atomoxetine;   Drug: metoclopramide
Outcome Measures: Change in blood pressure with standing;   length of time subject is able to stand

These studies may lead to new treatments and are adding insight into Cerucal etiology and treatment.

A major focus of Cerucal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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