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Chlorhexidine Medical Research Studies

Up-to-date List of Chlorhexidine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Chlorhexidine Medical Research Studies

Rank Status Study
1 Not yet recruiting Chlorhexidine Drying Time
Condition: Drying Time
Intervention: Drug: Chlorhexidine gluconate
Outcome Measure: Length of drying time
2 Not yet recruiting Waterless Hand Cleansing With Chlorhexidine During the Perinatal Period
Conditions: Hand Washing Behavior;   Hand Cleansing Behavior;   Chlorhexidine;   Neonatal Period
Interventions: Behavioral: Hand cleansing with Chlorhexidine;   Behavioral: Mother and neonatal health counselling
Outcome Measures: Observed hand cleansing behavior of mother with Chlorhexidine or soap and water at critical times;   Observed hand cleansing behavior of other household members and visitors to home with Chlorhexidine or soap and water at critical times
3 Recruiting Efficacy Study Comparing 2% Chlorhexidine in 70% Isopropyl Alcohol Versus 2% Aqueous Chlorhexidine
Condition: Anti-infecting Agents, Local
Interventions: Drug: 2% aqueous Chlorhexidine;   Drug: 2% Chlorhexidine 70% isopropyl alcohol
Outcome Measures: Bacterial colony count as assessed by pre- and post cleansing skin swab culture.;   Immediate or late Skin reactions.
4 Not yet recruiting Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients
Condition: Antibiotic Resistant Infection
Intervention: Drug: 2% Chlorhexidine wipe
Outcome Measures: The overall rate of Multidrug resistant bacteria acquisition at 7 days after received 2% Chlorhexidine wipe bathing versus with soap bathing;   The overall rate of hospital-acquired bloodstream infections per 1000 patient-days with Chlorhexidine wipe bathing versus with soap bathing
5 Not yet recruiting The Efficacy and Safety of Chlorhexidine Gluconate Chip (PerioChip®) in Therapy of Peri-implantitis
Condition: Peri-Implantitis
Intervention: Drug: 2.5 mg Chlorhexidine gluconate chip
Outcome Measures: Absolute change in mean probing Pocket Depth for selected target implants;   Absolute change in mean probing Pocket Depth of selected target implants in patients with baseline Pocket Depth measurement of 6-8 mm inclusive;   Change in percentage of selected target implants Bleeding on Probing;   Absolute change in mean probing Pocket Depth of selected target implants
6 Not yet recruiting Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)
Condition: Infection
Interventions: Drug: Skin antisepsis with Chlorhexidine;   Drug: povidone-iodine
Outcome Measures: Presence or absence of bacterial colonization of the distal femoral catheter tip 48 hours after antiseptic application;   Incidences of bacterial colonization of skin before/after skin antisepsis and skin/catheter interface
7 Unknown  Study of Chlorhexidine Gluconate as a Preoperative Antisepsis
Condition: Surgical Site Infection
Interventions: Drug: Povidone-Iodine;   Drug: Chlorhexidine gluconate
Outcome Measures: Number of patients with Surgical Site infection within 1month;   Identify the infection source;   Number of patients with Drug Side effect.;   Number of patients with the postoperative sepsis induced by wound infection
8 Not yet recruiting Chlorhexidine Skin Application for Prevention of Infection in Infants Weighing <1500 g at Birth
Conditions: Neonatal Sepsis;   Neonatal Mortality Rate
Interventions: Drug: 0.25% Chlorhexidine;   Drug: sterile water
Outcome Measures: Sepsis within first 7 days of life;   Readmissions & mortality rates within neonatal period;   Body temperature at 0, 5, 15, 30 minutes after application;   Skin condition;   Skin colonization rates;   Chlorhexidine percutaneous absorption
9 Not yet recruiting A Double-blind Evaluation of Adverse Effects of Bath With Wipes Impregnated With 2% Chlorhexidine Versus Placebo
Condition: Bed Bathing
Interventions: Procedure: Standardization phase;   Procedure: Control bath;   Procedure: Bath with Chlorhexidine
Outcome Measures: Skin reaction to Chlorhexidine;   Comparison of bacterial colony count of skin.
10 Recruiting Effect of Chlorhexidine on Bacteriuria
Conditions: Urinary Tract Infection;   Nosocomial Infection;   Bacteriuria
Interventions: Drug: Povidone-iodine;   Drug: Chlorhexidine;   Drug: Normal saline
Outcome Measures: Bacteriuria day 1;   Bacteriuria day 3;   Bacteriuria day 5;   Bacteriuria day 7;   Bacteriuria day 9;   Microorganism Type day 5;   Microorganism type day 10
11 Recruiting Chlorhexidine Gluconate for Prevention of Ventilator Associated Pneumonia in Children.
Condition: Mechanical Ventilation for More Than 48 Hours.
Interventions: Drug: 0.12% Chlorhexidine solution;   Drug: Placebo
Outcome Measures: Incidence of ventilator associated pneumonia;   Mortality;   Days of mechanical ventilation;   Length of stay
12 Unknown  Chlorhexidine Cordcare for Reduction in Neonatal Mortality and Omphalitis
Conditions: Neonatal Mortality;   Cord Care;   Omphalitis
Interventions: Drug: Chlorhexidine 4%;   Other: Control cord cleaning solution
Outcome Measures: Neonatal Mortality;   Omphalitis
13 Recruiting Chlorhexidine as Coadjuvant in Dentin Adhesion of Noncarious Cervical Lesions
Condition: Non-carious Cervical Lesions
Interventions: Procedure: Treatment with Chlorhexidine;   Procedure: Water pre-treatment
Outcome Measures: Change from baseline in Retention rates of the restoration at 24 months;   Change from baseline in Post-operative sensitivity at 6-month;   Change from baseline in marginal staining rates at 6. 12 and 24 months
14 Recruiting Chlorhexidine vs Lactobacillus Plantarum for Oral Care in Intubated ICU Patients
Conditions: Pathogenic Bacteria in the Oropharynx;   Ventilator-associated Pneumonia
Interventions: Procedure: Lactobacillus plantarum 299 for oral care;   Procedure: Chlorhexidine for standard oral care
Outcome Measures: To compare the number and frequency of cultures with pathogenic bacteria and fungi from the oropharynx and tracheal secretions and the spectra of these microbiological species;   Recovery of Lactobacillus plantarum 299 in tracheal secretions in the active treatment group as an indicator of aspiration;   SOFA score and Influence on lung function measured as Lung Injury Severity Score;   Difference in emerge of Ventilator Associated Pneumonia;   Validation of micobiological findings compared to the use of antibiotics;   C-reactive protein and white blood cell counts;   Evaluation of microbiological cultures taken on clinical grounds;   28 day mortality;   6 months mortality
15 Recruiting Prehospital Ventilator-Associated Pneumonia Prevention Trial
Conditions: Wounds and Injuries;   Respiratory Failure;   Pneumonia, Ventilator-Associated
Intervention: Drug: Chlorhexidine gluconate
Outcome Measures: Clinical Pulmonary Infection Score (CPIS);   Pneumonia - CPIS;   Pneumonia - CDC;   Pneumonia - Treated;   Pneumonia - Research;   28-day ventilator-free days;   28-day ICU-free days;   Hospital Mortality;   Tracheostomy Rate;   Tracheal colonization
16 Not yet recruiting Prevention of Surgical Site Infection After Cesarean Delivery
Condition: Surgical Site Infection
Interventions: Drug: Chlorhexidine-alcohol group;   Drug: Povidone-Iodine Group
Outcome Measures: Incidence of Surgical Site Infection within 30 days of Cesarean Delivery;   Type of SSI (based on CDC classification);   Time to diagnosis of SSI
17 Recruiting Open Prospective Study on Reduction of Bacteriuria Following Bladder Irrigation With Chlorhexidine
Condition: Bacteriuria, Intermittent Catheterization
Intervention: Device: Chlorhexidine
Outcome Measures: Proportion of patients with bacteriuria <10^3 CFU/ml;   Time (number of days) to reduction of bacteriuria (<10^3 CFU/ml)
18 Recruiting Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant
Conditions: Bacterial Infection;   Infection;   Neoplasm;   Methicillin-resistant Staphylococcus Aureus Infection
Interventions: Drug: Chlorhexidine gluconate;   Procedure: wound care management
Outcome Measures: Number of CLABSI events during the at-risk days;   Acquisition of MDRO;   Susceptibility to CHG as measured by minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs);   Number of bacteremia episodes during the at-risk days
19 Not yet recruiting Effect of Chlorhexidine Gel on Bacterial Count During Fixed Orthodontic Treatment
Conditions: Orthodontic Appliance Complication;   Dental Caries
Intervention: Drug: Chlorhexidine gluconate
Outcome Measures: mutants streptococcus count;   friction
20 Recruiting Zambia Chlorhexidine Application Trial
Condition: Sepsis
Interventions: Drug: Chlorhexidine gluconate (4%);   Procedure: Dry cord care
Outcome Measures: All-cause neonatal mortality;   All-cause neonatal mortality among newborns who survived at least first day of life;   Incidence of omphalitis;   Place of delivery;   Factors influencing delivery location;   Health facility characteristics

These studies may lead to new treatments and are adding insight into Chlorhexidine etiology and treatment.

A major focus of Chlorhexidine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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