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Cholestagel Medical Research Studies

Up-to-date List of Cholestagel Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Cholestagel Medical Research Studies

Rank Status Study
1 Recruiting Colesevelam Pediatric Type 2 Diabetes Mellitus Study
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Welchol for oral suspension placebo proxy;   Drug: Welchol for oral suspension
Outcome Measures: mean change in hemoglobin A1c from baseline (day 1) to 6 months;   mean change in fasting plasma glucose from baseline (day 1) to 6 months;   percentage of subjects with HbA1c decreasing >= 0.7% from baseline (day 1) to 6 months;   percentage of subjects with final HbA1c < 7.0% at 6 months;   percentage of subjects with decrease in fasting plasma glucose >= 30 mg/dL from baseline (day 1) to 6 months;   mean change in plasma lipids from baseline (day 1) to 6 months
2 Recruiting Ability of Mayo Clinic HPLC Method to Measure Fecal Bile Acids
Condition: Diarrhea Predominant Irritable Bowel Syndrome
Intervention: Drug: Colesevelam
Outcome Measures: Ability to measure change in fecal bile acids from baseline in response to treatment with colesevelam.;   Change in fasting serum C4;   Change in fecal fat excretion;   Change in stool consistency;   Change in stool frequency;   Relative composition of the main individual bile acids
3 Not yet recruiting Effects of Colesevelam
Condition: Sitosterolemia
Interventions: Drug: Colesevelam;   Other: Placebo
Outcome Measures: Plasma plant sterol level;   Cholesterol absorption;   cholesterol synthesis
4 Recruiting The Role of Metformin and Colesevelam in Human GLP-1 Secretion
Condition: Type 2 Diabetes
Interventions: Drug: Colesevelam;   Drug: Metformin;   Other: Placebo
Outcome Measure: Change in the gut hormone glucagon-like peptide 1 (GLP-1)
5 Recruiting Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication
Conditions: Coronary Artery Disease;   Carotid Artery Diseases;   Atherosclerosis
Interventions: Drug: Atorvastatin;   Drug: Niacin;   Drug: Colesevelam;   Drug: Placebo Niacin;   Drug: Placebo Colesevelam
Outcome Measures: Changes in carotid plaque composition, as assessed by MRI;   Composite of cardiovascular disease death, non-fatal heart attack, stroke, and worsening ischemia requiring medical interventions
6 Recruiting The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion
Condition: To Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion
Intervention: Drug: Colesevelam
Outcome Measures: GLP-1 response as incremental area under curve (iAUC);   Insulin

These studies may lead to new treatments and are adding insight into Cholestagel etiology and treatment.

A major focus of Cholestagel research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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