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Chorioamnionitis Medical Research Studies

Up-to-date List of Chorioamnionitis Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Chorioamnionitis Medical Research Studies

Rank Status Study
1 Unknown  Treatment of Chorioamnionitis After Delivery
Condition: Chorioamnionitis
Interventions: Drug: saline;   Drug: ampicillin gentamicin;   Drug: Ampicillin gentamicin clindamycin;   Drug: ampicillin gentamicin clindamycin
Outcome Measure: To determine the courses of antibiotics needed after vaginal delivery and after cesareans in pregnancies complicated by Chorioamnionitis.
2 Unknown  Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)
Conditions: Chorioamnionitis;   Brain Injury
Interventions: Drug: N-acetylcysteine;   Drug: Saline
Outcome Measures: mean blood pressure, cerebral perfusion, PT, histaminergic reactions;   Pharmacokinetics of placental transport and CSF penetration- efficacy outcomes: NAA/choline ratio in MRS at 36 weeks gestation, cytokine levels in plasma and CSF, as related to NAC concentrations
3 Recruiting Intrapartum Study of Sterile and Clean Gloves
Condition: Chorioamnionitis
Intervention: Other: Type of glove used for intrapartum vaginal exams
Outcome Measure: Clinical Chorioamnionitis
4 Unknown  Changes in Blood Flow in MCA of Fetuses to Mothers Having Clinical Chorioamnionitis
Condition: Chorioamnionitis
Intervention:
Outcome Measure:
5 Recruiting Closure of Skin in Chorioamnionitis Research Pilot Study
Conditions: Chorioamnionitis;   Pregnancy Complications, Infectious;   Complications; Cesarean Section;   Postoperative Complications
Interventions: Procedure: Suture closure;   Procedure: Staples closure
Outcome Measures: Patient recruitment rate;   Follow-up rates;   Wound infection;   Wound disruption;   Wound cosmesis;   Patient satisfaction;   Participation rate
6 Not yet recruiting Early Identification of Brain Insult in Chorioamnionitis
Conditions: Chorioamnionitis;   Cerebral Palsy
Intervention:
Outcome Measure: Developmental assessment
7 Unknown  Treatment Utility of Postpartum Antibiotics in Chorioamnionitis
Condition: The Primary Outcome of This Study Will be the Rate of Endometritis in the Study Population.
Interventions: Drug: Postpartum Antibiotics;   Drug: No postpartum antibiotics
Outcome Measures: Endometritis;   Infection-related complications;   Duration of hospital stay
8 Not yet recruiting Maternal Plasmatic Regulatory T Cells and Th17 as Possible Diagnosis Markers of Acute Chorioamnionitis
Condition: Pathology of Pregnancy
Intervention: Other: Blood and placenta samples
Outcome Measure: Evaluate the percentage of Treg in maternal blood at the time of admission
9 Recruiting N-acetylcysteine in Intra-amniotic Infection/Inflammation
Conditions: Labor, Premature;   Preterm Premature Rupture of the Membranes;   Infection;   Inflammation;   Chorioamnionitis
Interventions: Procedure: amniocentesis;   Drug: N-acetylcysteine or placebo
Outcome Measures: early onset neonatal sepsis;   maternal and umbilical cord plasma N-acetylcysteine levels;   maternal and umbilical cord plasma antioxidant capacity;   maternal and umbilical cord blood glutathione concentration;   umbilical cord levels of inflammatory cytokine concentrations;   funisitis grades;   other neonatal outcomes (respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, late-onset sepsis, bronchopulmonary dysplasia)
10 Recruiting Foley Bulb Induction With and Without Simultaneous Use of Oxytocin
Condition: Induction of Labor
Intervention: Drug: Oxytocin
Outcome Measures: induction time to delivery;   Mode of delivery;   estimated blood loss;   uterine atony;   Chorioamnionitis;   neonatal birthweight
11 Recruiting FOLCROM Trial: Foley Catheter in Rupture of Membranes
Conditions: Premature Rupture of Membranes;   Cervical Ripening
Interventions: Device: Foley Catheter;   Drug: Oxytocin
Outcome Measures: Time from induction of labor until delivery;   Rate of Chorioamnionitis excluding all those who were hospitalized with preterm premature rupture of membranes (PPROM) prior to 34 0/7 weeks;   Rate of vaginal delivery within 12 hours from placement of Foley catheter or start time of oxytocin;   Rate of vaginal delivery within 24 hours from placement of Foley catheter or start time of oxytocin;   Duration of first, second and third stage of labor (minutes) for those undergoing vaginal deliveries;   Rate of failed induction of labor as the indication for cesarean;   Rate of Endomyometritis;   Maternal length of stay, from admission to discharge and from delivery to discharge;   Rate of five minute Apgar score < 5;   Arterial Cord blood gas (pH), when obtained;   Rate of Neonatal Sepsis;   Neonatal Intensive Care Unit (NICU) admission rate;   Neonatal length of stay;   Histologic Chorioamnionitis/funisitis;   Time from induction to delivery (minutes) excluding all those who were hospitalized with PPROM prior to 34 0/7 weeks;   Overall Cesarean Delivery;   Rate of Chorioamnionitis
12 Unknown  Evaluation of Fever Occurring in Labor in Patients Receiving Epidural Anesthesia
Condition: Fever
Intervention:
Outcome Measure:
13 Unknown  Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery
Conditions: Vaginosis, Bacterial;   Abortion, Spontaneous;   Premature Birth
Intervention: Device: VS Sense
Outcome Measure: Does screening for BV using VS-SENSE in pregnant women with h/o preterm delivery or with premature contractions, and treatment will reduce or prevent Late miscarriage, preterm birth, preterm PROM, Chorioamnionitis, and postpartum endometritis.
14 Recruiting Vaginal Progesterone for the Prevention of Preterm Birth in Women With Arrested Preterm Labor
Conditions: Premature Birth;   Obstetric Labor, Premature
Intervention: Drug: Micronized progesterone suppository
Outcome Measures: Delivery before 37 weeks;   Delivery before 34 weeks;   Delivery within 2 weeks of randomization;   Number of days pregnancy prolongation;   Infant birth weight;   Neonatal intensive care unit admission;   Chorioamnionitis;   Composite neonatal outcome
15 Recruiting Prevention of Preterm Birth With a Pessary in Twin Gestations
Conditions: Premature Birth;   Short Cervix
Intervention: Device: Bioteque cup pessary
Outcome Measures: Preterm delivery;   Gestational age;   Birth weight;   Spontaneous preterm birth rates;   Spontaneous rupture of membranes;   Cesarean section rate;   Neonatal death;   Composite adverse neonatal outcome;   Chorioamnionitis;   Significant adverse maternal effects;   Intolerance to pessary
16 Unknown  Cervical Foley Plus Vaginal Misoprostol for Labor Induction
Condition: Induction of Labor
Intervention: Device: Foley bulb
Outcome Measures: Time from start of labor induction to vaginal delivery;   Successful number of vaginal deliveries;   tachysystole requiring terbutaline use;   Post-partum hemorrhage;   Chorioamnionitis;   neonatal APGAR scores;   NICU admission;   Time to complete cervical dilation
17 Recruiting Prevention of Preterm Birth With a Pessary in Singleton Gestations
Conditions: Preterm Birth;   Short Cervix
Intervention: Device: Bioteque cup pessary
Outcome Measures: Preterm birth;   Gestational age at delivery;   Birth weight;   Spontaneous preterm birth;   Spontaneous rupture of membranes;   Neonatal death;   Composite adverse neonatal outcome;   Chorioamnionitis;   Significant adverse maternal effects;   Intolerance to pessary
18 Recruiting Foley OR MisO for the Management of Induction
Condition: Difference in Time to Delivery in Women Who Undergo an Induction of Labor With Four Different Methods.
Interventions: Device: Cervical Foley & Misoprostol;   Drug: Misoprostol Alone;   Device: Cervical Foley Alone;   Device: Cervical Foley & Pitocin
Outcome Measures: Time to Delivery;   Length of Stay;   Severe perinatal/neonatal morbidity;   Mode of Delivery;   Time to Active Labor;   Tachysystole;   Regional Anesthesia;   Chorioamnionitis;   Maternal Morbidity;   Non-severe perinatal/neonatal morbidity
19 Recruiting Evaluation of a Novel Diagnostic Kit for the Detection of Placental Alpha-Microglobulin-1 in the Prediction of Preterm Birth
Conditions: Preterm Labour;   Preterm Birth
Intervention: Device: novel kit for the detection of PAMG-1
Outcome Measures: Time to delivery;   Number of patients who have a positive PAMG-1-Test and deliver within 48 hours, 7 days and 14 days after taking the test;   Number of patients who have a negative PAMG-1-Test and do not deliver within 48 hours, 7 days and 14 days after taking the test;   Time of delivery;   Number of babies admitted to NICU;   Number of babies with histological Chorioamnionitis;   Number of babies with respiratory distress syndrome;   Time to Delivery;   Number of babies with infection;   Number of babies with intracranial hemorrhage;   Number of babies with necrotizing enterocolitis;   Number of babies with patent ductus arteriosus;   Number of babies with neonatal sepsis;   Birthweight;   Number of perinatal deaths
20 Unknown  The Cervical Cap in the Diagnosis of Rupture of Membranes in the Second Trimester
Conditions: Fetal Membranes, Premature Rupture;   Ultrasonography
Intervention: Device: insemination cervical cap
Outcome Measures: Changes in amniotic fluid index and single vertical pocket before and after placement of the cervical cap/;   Chorioamnionitis and abortion

These studies may lead to new treatments and are adding insight into Chorioamnionitis etiology and treatment.

A major focus of Chorioamnionitis research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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