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Citrucel Medical Research Studies

Up-to-date List of Citrucel Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Citrucel Medical Research Studies

Rank Status Study
1 Recruiting Phase II Clinical Trial of Purified Isoflavones in Prostate Cancer: Comparing Safety, Effectiveness
Condition: Prostate Cancer
Interventions: Drug: Purified isoflavones;   Drug: Methyl cellulose blend
Outcome Measures: Incidence of Change in Percent Ki-67;   Incidence of Adverse Events (AEs);   Biomarkers of Disease Progression.;   Expression Levels of Isoflavone Participants
2 Recruiting NoAL (HPMC) in Combination With Oxymetazoline in Patients With Allergic Rhinitis
Condition: Allergic Rhinitis
Interventions: Drug: Oxymetazoline;   Other: Hydroxyl-propyl-methyl cellulose powder;   Other: Placebo (lactose powder)
Outcome Measures: Peak nasal inspiratory flow (PNIF) area under the curve (AUC) change between the placebo and active NoAl treatment on day 1;   Difference between the PNIF AUC D1-D8 differences between the two groups;   Differences in nasal mucociliary clearance (Saccharine test) between both groups.;   Visual analogue scale (VAS) for the separate rhinitis symptoms between the two groups;   Change of each symptom score for congestion over 8 days;   Change of total rhinitis symptom score (TRSS) over 8 days;   Difference in the applied rescue decongestant (total number of additional puffs of oxymetazoline or any other medications indicated for the treatment of allergic rhinitis) as needed between the two groups;   Number and severity of adverse events
3 Unknown  Oral Sodium Blood Pressure in Normal Weight, Overweight and Obese Volunteers
Condition: Obesity
Interventions: Other: sodium chloride;   Other: Methylcellulose crystalline
Outcome Measure:
4 Unknown  Photodynamic Therapy for Oral Precursor Lesions
Conditions: Leukoplakia;   Lichen
Interventions: Other: Aminolaevulinic acid;   Other: Methylcellulose Placebo
Outcome Measures: Changes in percent (%) of the initial area in mm2 assessed on recall appointment and by a blinded examiner on photographs with a caliper.;   pain due to treatment, assessed by visual analogue scale (VAS)
5 Unknown  Evaluation of Blood as a Submucosal Cushion During Endoscopic Polypectomy and Mucosal Resection
Condition: Large Polyps in the Gastrointestinal Tract
Interventions: Drug: Autologous blood injection;   Drug: Normal saline;   Drug: HPMC
Outcome Measures: Duration of the submucosal cushion Ease of injection Ability to complete lesion removal Post-procedure complications;   Ability to perform lesion removal Ability to visualize during the procedure
6 Recruiting Pilot Study Evaluating Broccoli Sprouts in Advanced Pancreatic Cancer [POUDER Trial]
Condition: Pancreatic Ductal Adenocarcinoma
Interventions: Dietary Supplement: Verum, broccoli sprout grain;   Dietary Supplement: placebo
Outcome Measures: Feasibility of a randomized controlled trial;   Disease status (imaging and tumor markers)
7 Unknown  Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
Interventions: Drug: Saccharomyces boulardii;   Drug: Methyl cellulose powder (low viscosity)
Outcome Measures: Any Improvement in symptoms of number of bowel habits, urgency, straining,sense of incomplete evacuation, stool form (evaluated by Bristol stool form scale, abdominal pain and bloating/flatulence;   Improvement in quality of life in diarrhea dominant IBS by validated IBS-QOL questionnaire.
8 Recruiting Safety Study of Post Tonsillectomy Ibuprofen Use in Adults
Conditions: Secondary Post Tonsillectomy Hemorrhage;   Primary Post Tonsillectomy Hemorrhage
Intervention: Drug: Ibuprofen
Outcome Measures: clinically defined tonsil bleed rate (percentage);   Hospital readmission rate (percentage);   Subclinical (not requiring intervention) subjectively reported tonsil bleed rate (percentage);   Pain scale rating;   Nausea Scale
9 Unknown  Treatment of Keratoconus Using Collagen Cross-Linking
Condition: Keratoconus
Interventions: Drug: Riboflavin-5-phosphate;   Drug: Sham cross-linking
Outcome Measures: Best corrected visual acuity;   Spherical equivalent power of the cornea (Best spectacle refraction);   KMax: the maximum corneal curvature;   Average corneal power of the cornea in the central 4 mm.;   Corneal resistance factor.;   Maximal posterior surface elevation of the cornea.;   Apical corneal thickness.;   Endothelial count.
10 Recruiting A Phase I Trial to Assess the Safety of Tenofovir Gel and Film Formulations: FAME 04
Condition: HIV
Interventions: Drug: 1% vaginally applied tenofovir gel;   Drug: Tenofovir film- 10mg;   Drug: Tenofovir Film-40 mg
Outcome Measures: Grade 2 or higher Adverse Events deemed related to study product;   Levels of glycoproteins and mucins measured in CVL samples;   Levels of tenofovir and its metabolite in CVL, genital tissue (one cervical and one vaginal biopsy), rectal fluid and vaginal fluid (as sampled by an absorptive material, such as sponge and/or wick);   Quantitative vaginal cultures;   Nugent score;   Levels of anti-HIV-1, anti HSV and anti-bacterial activity in CVL;   Levels of cytokine and innate immunity factors in the genital compartment;   Levels of tenofovir and its metabolite in plasma
11 Recruiting Vitamin D Supplementation for Bipolar Depression
Conditions: Bipolar Disorder;   Bipolar Depression
Interventions: Drug: Vitamin D3, Cholecalciferol;   Drug: Placebo
Outcome Measure: Change in Montgomery-Åsberg Depression Rating Scale
12 Unknown  Nicotinic Modulation of the Default Network
Conditions: Magnetic Resonance Imaging;   Cognition;   Nicotine;   Mecamylamine
Interventions: Drug: Nicotine;   Drug: Mecamylamine;   Drug: Placebo
Outcome Measures: Effects of nicotine on cognitive performance;   Effects of nicotine on default network activity;   Effects of mecamylamine on cognitive performance;   Effects of mecamylamine on default network activity;   Effects of nicotine on subjective state;   Effects of nicotine on vital signs;   Effects of mecamylamine on subjective state;   Effects of mecamylamine on vital signs
13 Recruiting Cimetidine Biowaivers
Condition: Healthy
Intervention: Drug: cimetidine
Outcome Measure: amount of drug in blood
14 Recruiting North American Study of Epistaxis in HHT
Conditions: Telangiectasia, Hereditary Hemorrhagic;   Epistaxis
Interventions: Drug: Sterile saline;   Drug: Bevacizumab;   Drug: Estriol;   Drug: Tranexamic Acid
Outcome Measures: Frequency of epistaxis;   Duration of epistaxis;   Hoag Epistaxis Severity Score;   Short Form-36 Health Survey;   Supplemental Epistaxis Questionnaire;   Hemoglobin level and ferritin levels;   Units of RBC transfused;   Treatment failure
15 Recruiting Study of Selective BRAF Kinase Inhibitor Dabrafenib Monotherapy Twice Daily and in Combination With Dabrafenib Twice Daily and Trametinib Once Daily in Combination Therapy in Subjects With BRAF V600E Mutation Positive Metastatic (Stage IV) Non-small Cell Lung Cancer.
Condition: Cancer
Interventions: Drug: Dabrafenib;   Device: Trametinib
Outcome Measures: Overall response rate (ORR).;   Progression free survival (PFS).;   Duration of response.;   Overall survival.;   Number of subjects with adverse events as a measure of safety and tolerability;   Dabrafenib population pharmacokinetic (PK) parameters such as apparent clearance (CL/F), volume of distribution (V/F) and possible influencing factors such as age, weight or disease-related factors.

These studies may lead to new treatments and are adding insight into Citrucel etiology and treatment.

A major focus of Citrucel research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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