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Climopax Medical Research Studies

Up-to-date List of Climopax Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Climopax Medical Research Studies

Rank Status Study
1 Unknown  Premarin Versus Toviaz for Treatment of Overactive Bladder
Condition: Overactive Bladder
Intervention: Drug: Toviaz, Premarin Vaginal Cream
Outcome Measures: Urinary frequency as measured by a 3 day voiding diary;   Lifestyle Impact of Overactive Bladder as measured using 3 validated questionnaires: OAB-Q, PPBC, and Urgency Severity and Impact Questionnaire
2 Unknown  The Effect of Hormonal Add-Back Therapy in Adolescents Treated With a GnRH Agonist for Endometriosis: A Randomized Trial
Condition: Endometriosis
Interventions: Drug: Conjugated equine estrogens;   Drug: Placebo;   Drug: Norethindrone acetate
Outcome Measures: Bone mineral density;   Volumetric bone mineral density;   Quality of life
3 Recruiting Study Evaluating Effects of Multiple-Dose Administration of Itraconazole on the Single Dose Pharmacokinetics of Conjugated Estrogens/Bazedoxifene in Non-Obese and Obese Postmenopausal Women
Condition: Healthy
Interventions: Drug: CE/BZA;   Drug: Itraconazole
Outcome Measures: Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - inf)] for BZA, total estrone adjusted for baseline and total equilin.;   Maximum Observed Plasma Concentration (Cmax) for BZA, total estrone adjusted for baseline and total equilin.;   Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - inf)] for unconjugated estrone, unconjugated estrone adjusted for baseline, total estrone, and unconjugated equilin.;   Maximum Observed Plasma Concentration (Cmax) for unconjugated estrone, unconjugated estrone adjusted for baseline, total estrone, and unconjugated equilin.;   Apparent Oral Clearance (CL/F) for all analytes.;   Time to Reach Maximum Observed Plasma Concentration (Tmax) for all analytes.;   Apparent Volume of Distribution (Vz/F) for all analytes.;   Terminal Phase Elimination Half-Life (t1/2) for all analytes.
4 Recruiting Vaginal Estrogen for the Prevention of Recurrent Urinary Tract Infection in Postmenopausal Women
Condition: Recurrent Urinary Tract Infection
Interventions: Drug: Conjugated Estrogen Vaginal Cream;   Drug: Estradiol Ring
Outcome Measures: Frequency of UTIs;   Rates of UTI;   Quality of Life;   Compliance;   Efficacy
5 Recruiting Vaginal Estrogen With Pessary Treatment
Conditions: Vaginal Infection;   Urinary Tract Infection;   Quality of Life
Interventions: Drug: Premarin vaginal cream;   Drug: Placebo cream
Outcome Measures: Vaginal infections;   Frequency of urinary tract infection;   Quality of life
6 Unknown  Vascular Effect of Estrogens Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery
Condition: Unspecified Injury of Brachial Artery, Left Side, Initial Encounter
Interventions: Drug: Estrogens, Conjugated (USP);   Drug: Placebo
Outcome Measure: Flow-mediated dilation of the brachial artery
7 Recruiting Vaginal Estrogen and Pelvic Floor Physical Therapy in Women With Symptomatic Mild Prolapse
Condition: Pelvic Organ Prolapse
Interventions: Drug: Vaginal estrogen;   Drug: Placebo cream
Outcome Measures: Global impression of improvement in prolapse symptoms, using the PGI-I;   Pelvic floor symptoms, using the PFDI-20;   Quality of life, using the PFIQ-7;   Sexual function, using the PISQ-12;   Pelvic organ prolapse stage, using the POP-Q exam;   Collagenase activity
8 Recruiting Hormonal Status on Blood Flow and Tissue in Pelvic Organ Prolapse
Condition: Pelvic Floor Disorders
Intervention: Drug: Topical Vaginal Estrogen Cream/placebo
Outcome Measures: Composite of vaginal wall inflammatory markers and macrocirculatory and microcirculatory flow on pelvic floor dysfunction;   Composite of tissue matrix metalloproteinases, collagen/elastin structure, microvasculature and muscle thickness
9 Unknown  Monitoring of Breast Tissue Change Due to Hormone Replacement Therapy in Post-menopausal Women Using OBS
Condition: Breast Cancer
Outcome Measure: Changes in OBS parameters
10 Recruiting Hormonal Therapy for Teens With Anorexia Nervosa
Condition: Anorexia Nervosa (AN)
Interventions: Drug: DHEA (Prasterone) + ERT (Aviane);   Other: Placebo
Outcome Measures: Bone Marrow Fat by MRI/MRS;   BMD by DXA (spine, hip, whole body);   Bone biomarkers;   BMD by pQCT of tibia;   Hormonal panel (serum)

These studies may lead to new treatments and are adding insight into Climopax etiology and treatment.

A major focus of Climopax research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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